Detection method of common goldenrop particles

Abstract

The invention relates to a detection method of common goldenrop particles. The detection method comprises inspection items of identifying characters and measuring content. The identification item comprises identification of scutellaria baicalensis, identification of liquorice, identification of radix bupleuri and identification of bupleurum longiradiatum; the item of measuring content is used for measuring the content of baicalin. In order to solve the problem of incapability of monitoring insufficiency or absence of corresponding raw materials of illegal manufacturers and monitoring the interfusion of bupleurum longiradiatum caused by the lack of one set of complete detection method for detecting active ingredients of common goldenrop particles at present, the method disclosed by the invention can be used for identifying components and measuring content scientifically, reasonably and feasibly; the method is capable of guaranteeing the clinical efficacy of common goldenrop particles, making clear quality indexes of several medicine materials and guaranteeing the use of all medicine materials in the common goldenrop particles, thereby guaranteeing the curative effect of the common goldenrop particles; in addition, bupleurum longiradiatum serving as a counterfeit drug of radix bupleuri can also be effectively detected, thereby avoiding the damage to the health of patients caused by two toxic ingredients comprising radix bupleuri toxin and acetyl radix bupleuri toxin in bupleurum longiradiatum.

Description

technical field [0001] The invention relates to a detection method of bupleurum granules. Background technique [0002] Xiaochaihu granule is a variety recorded in the 2010 edition of "Chinese Pharmacopoeia". The prescription is Bupleurum, Jiang Pinellia, Scutellaria, Codonopsis, Licorice, Ginger, and Jujube. It is a granule of pure Chinese medicine. The role of the stomach, commonly used medicines on the market for the treatment of alternating cold and heat, chest fullness, loss of appetite, upset and vomiting, bitter mouth and dry throat. But so far, there is no set of perfect detection methods for corresponding detection of its active ingredients. Unscrupulous manufacturers may not strictly follow the prescription dosage ingredients in the production of drugs, and wantonly reduce high-priced raw materials, resulting in obvious curative effects of the drugs. The decline will affect the safety and effectiveness of drugs and seriously damage the interests of patients. On t...

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Problems solved by technology

But so far, there is no set of perfect detection methods for corresponding detection of its active ingredients. Unscrupulous manufacturers may not strictly follow the prescription dosage ingredients in the production of drugs, and wantonly reduce high-priced raw materials, resulting in obvious curative effects of the drugs. decline, affecting the safety and effectiveness of drugs and seriously damaging the interests of patients

On the other hand, the prescription of this medicine comes from Xiaochaihu Decoction, a famous prescription in "Treatise on Febrile and Miscellaneous Diseases". In the prescription, Bupleurum is used in the largest amount, accounting for one-third of the total prescription. Its effect is mainly to reconcile Shaoyang. , harmonize the stomach and subdue the adverse, strengthen the body and eliminate evil, but because Bupleurum is a commonly used medicine and its use is relatively large, and the production of Bupleurum is limited, so its counterfeit product, Daye Bupleurum, is also used intentionally or unintentionally. Daye Bupleurum It contains Bupleurum toxin and acetyl Bupleurum toxin, both of which are poisonous substances. There have been many poisoning incidents caused by taking medicines mixed with Bupleurum bupleuri. Therefore, it is very important to control Bupleurum bupleurum. necessary

"Shandong Pharmaceutical Industry" published the article "Supplement to the Inspection Method of Bupleurum Radix in 2000 Edition of the Chinese Pharmacopoeia" in the fifth issue of Volume 22 in 2003. There are obvious deficiencies: 24 hours of storage, the detection time is too long, which is not conducive to the control of drug production process and drug quality supervision and inspection; because the content of Bupleurum toxin and acetyl Bupleurum toxin is relatively low, the sample is only 2 μl, and the sample volume is too small , which affects the accuracy of the test; because the content of Bupleurum toxin and acetylbupleurum toxin is relatively low, it is not good to observe under ultraviolet light without color development, and the more important thing is the prescription of Xiaochaihu granules. It contains many ingredients and complex ingredients, and other ingredients will cause confusion and interference. Therefore, it is urgent to find a better way to control Dayebupleurum