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Shaoyang cold treating granule detecting method

A detection method and particle technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems that affect the safety and effectiveness of drugs, harm the interests of patients, and reduce the efficacy of drugs

Active Publication Date: 2017-08-11
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no complete set of detection methods for the corresponding detection of its active ingredients. Unscrupulous manufacturers may not strictly follow the prescription dosage ingredients in the production of drugs, and wantonly reduce high-priced raw materials, resulting in a significant decline in the efficacy of drugs. , affect the safety and effectiveness of drugs, and seriously damage the interests of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Prescription: Bupleurum 100g, Scutellaria baicalensis 149.4g, raw sun-dried ginseng 50g, licorice 100g, Pinellia 149.4g, dried ginger 100g, jujube 100g, Artemisia annua 149.4g.

[0039] Preparation method: the above eight flavors, extract the volatile oil from Bupleurum and dried ginger, the dregs of the medicine and the remaining scutellaria baicalensis and other six flavors, add water and decoct three times, the first time is 3 hours, the second time is 2 hours, the third time is 1 hour, and combined Decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.40, spray dry, add 446g of sucrose, 150g of dextrin, mix well, granulate with 70% ethanol, dry spray into volatile oil, mix well, that is, divide Each bag weighs 8g.

[0040] Properties: This product is brown granules; fragrant, sweet and slightly bitter.

[0041] Inspection: It should comply with the relevant regulations under the granule ("Chinese Pharmacopoeia" 2015 edition).

...

Embodiment 2

[0057] In this embodiment, except that step (1) to step (5) of component identification is different from that of embodiment 1, the rest of the methods are the same.

[0058] Among them, ingredient identification:

[0059] (1) The identification of Scutellaria baicalensis is to take 6g of this product, grind it finely, add 22ml of ethanol, treat it ultrasonically for 30 minutes, filter, evaporate the filtrate to dryness, add 22ml of water to dissolve the residue, adjust the pH value to 2-3 with hydrochloric acid, and use ethyl acetate Shake and extract twice, 22 ml each time, combine the ethyl acetate extracts, evaporate to dryness, add 1 ml of methanol to the residue to dissolve, and use it as the test solution, and take another baicalin reference substance, add methanol to make 1 mg per 1 ml Solution, as the reference substance solution, according to the thin-layer chromatography test, draw 10 μl of each of the above two solutions, and spot them on the same silica gel G thin...

Embodiment 3

[0065] In this embodiment, except that step (1) to step (5) of component identification is different from that of embodiment 1, the rest of the methods are the same.

[0066] Among them, ingredient identification:

[0067] (1) The identification of Scutellaria baicalensis is to take 6g of this product, grind it finely, add 20ml of ethanol, ultrasonicate for 20 minutes, filter, evaporate the filtrate to dryness, add 20ml of water to dissolve the residue, adjust the pH value to 2-3 with hydrochloric acid, and use ethyl acetate Shake and extract twice, 20 ml each time, combine the ethyl acetate extracts, evaporate to dryness, add 1 ml of methanol to the residue to dissolve, and use it as the test solution, and take another baicalin reference substance, add methanol to make 1 mg per 1 ml Solution, as the reference substance solution, according to the thin-layer chromatography test, draw 10 μl of each of the above two solutions, and spot them on the same silica gel G thin-layer boa...

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Abstract

The invention relates to a Shaoyang cold treating granule detecting method including character, identification, inspection and content determination projects. The identification includes scutellaria baicalensis identification, radix bupleuri identification, anemone vitifolia root identification sun-dried ginseng and oriental wormwood and sweet wormwood herb identification. For solving the problem that at present, a complete set of perfect detection method for correspondingly detecting effective ingredients of Shaoyang cold treating granules is not disclosed and accordingly illegal manufacturers adopt few corresponding raw materials or do not adopt the materials and mix counterfeit anemone vitifolia roots and the adulterant oriental wormwood, a scientific, reasonable and feasible ingredient identifying and content determining method is formulated, the clinical effect of the Shaoyang cold treating granules is ensured, several medicinal materials have definite quality indexes, usage of the medicinal materials in the Shaoyang cold treating granules is ensured, and accordingly the treating effect of the drug is ensured. In addition, the counterfeit anemone vitifolia roots of the radix bupleuri and the adulterant oriental wormwood of the sweet wormwood herb can be also effectively detected, and poisonous and harmful ingredients are prevented from harming the health of patients.

Description

technical field [0001] The invention relates to a detection method of traditional Chinese medicine preparations, in particular to a detection method of Shaoyang Ganmao Granules. Background technique [0002] Shaoyang Ganmao Granules is a variety recorded in the first volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The granules of traditional Chinese medicine have the functions of strengthening the body and relieving the exterior, clearing heat and harmonizing the middle. It is a commonly used medicine on the market to treat alternating cold and heat, bitter mouth and dry throat, dizziness, lack of appetite, upset and nausea. [0003] The prescription of this medicine comes from the famous prescription Shaoyang Ganmao Decoction in "Treatise on Febrile and Miscellaneous Diseases". Bupleurum is the most used in the prescription, accounting for one-third of the entire prescription. Its main effect is to reconcile Shaoyang an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
CPCG01N30/02G01N30/90
Inventor 钟茂团任红古莉何德中
Owner SICHUAN FENGCHUN PHARMA
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