252results about How to "Improve the effect of treatment" patented technology

The invention discloses a recombinant adeno-associated virus-NADH dehydrogenase sigmasubunit 4 gene total length for treating Leber hereditary optic neuropathy and a medicament. The total length of the gene is shown in a nucleotide sequence SEQ ID NO:1, wherein the nucleotide sequence, consisting of a CAG starter sequence, a coded sequence of ND4 of a mitochondrial localization sequence with Cox10 and UTR with the length of 625bp, has the total length of 3824bp. The medicament is injected into an eye vitreous chamber and is used for treating Leber hereditary optic neuropathy; because the medicament can be injected into the vitreous chamber, the activity can be kept in the vitreous chamber, and the medicament can be effectively subjected to transfection to optic nerve cells; signal peptide at the front end of the protein N directionally guides the protein to enter mitochondria, and the mature protein ND4 enters the mitochondria to play a function; therefore, the Leber hereditary optic neuropathy can be effectively treated by using the medicine.

The invention discloses a surgical training and evaluation method on the basis of virtual reality. The surgical training and evaluation method is implemented by a database module and execution modules. The database module is divided into a training and evaluation question bank, a surgical stage scene model library, a medical equipment and medicine model library and a disease and therapeutic schememodel library, the execution modules include a training and evaluation selection module, a surgical stage selection module, a medical equipment and medicine selection module and a disease and therapeutic scheme selection module, and the training and evaluation selection module is sequentially connected with the surgical stage selection module, the medical equipment and medicine selection module and the disease and therapeutic scheme selection module. The surgical training and evaluation method has the advantages that surgical training and evaluation can be accomplished by the aid of virtual reality systems, therapeutic schemes can be verified and simulated by the aid of the virtual reality systems, evolution mechanisms of diseases can be observed by the aid of the virtual reality systems,and environment-friendly and safe modes can be provided to surgical skill training and evaluation and therapeutic scheme design emulation; the technical problems of low efficiency, severe waste and high surgical risks of existing surgical training and evaluation methods can be solved by the aid of the surgical training and evaluation method.

The invention discloses a Chinese medicinal preparation for treating avian coccidiosis and its preparing process, wherein the medicament is prepared from the following constituents (by weight portions): sweet wormwood 200-400g, dichroa febrifuga lour 200-400g, Chinese pulsatilla root 100-300g, astragalus root 100-300g. The preparing process for the product comprises the steps of weighing, poaching, drying, disintegrating, sieving, extracting, filtering, concentrating, flocculating setting, encapsulating and sterilizing.

The invention relates to a novel light-emitting diode (LED) phototherapy health-care device. The novel LED phototherapy health-care device comprises a shell, a central control module, a keystroke module and a display module, wherein the central control module is installed inside the shell and is connected with the keystroke module and the display module, both of which are embedded on the shell; the central control module is connected with a controlled terminal of a power supply control module; an input terminal of the power supply control module is connected with mains supply; an output end of the power supply control module is connected with multiple sockets embedded on the shell; and a plug inserted in each socket is connected with an LED module embedded on a substrate through cables. In the novel LED phototherapy health-care device provided by the invention, a host is connected with multiple LED modules on the substrate, so that the single treatment function of the conventional equipment is solved; and the novel LED phototherapy health-care device can be used for the treatment of multiple diseases and different treatment stages of one disease, has good integral treatment effect, and is multifunctional medical treatment and prevention health-care equipment used clinically in hospitals and households in communities.

The invention discloses a customized tongue side orthodontic bracket and a manufacturing method thereof. The tongue side orthodontic bracket comprises a bracket body commonly defined by a tooth direction surface and tongue direction surface, wherein a sunken part is formed in the middle region of the tongue direction surface of the bracket body, an upper wing and a lower wing are arranged in the sunken part and a groove is formed in the sunken part; a circular-arc-shaped outline is maintained among the tongue direction surface of the bracket body and the outer surfaces of the upper wing and the lower wing. The manufacturing method of the bracket comprises the main steps of establishing a virtual bracket body in a computer, setting a central line of the groove, acquiring a tooth arrangement model with ideal tooth rows, determining a virtual forming position of the groove, matching the central line of the groove with the virtual forming position of the groove, rotating the bracket body around the central line so as to regulate the position of the bracket body and the thickness of the bracket body, cutting the groove along the central line to obtain the bracket body with the groove, and finally generating the real bracket by virtue of 3D printing. The tongue direction surface of the whole bracket body is machined into a circular arc shape, so that the stimulation to a tongue of a patient can be greatly relieved, and the comfort level of the patient is increased.

The invention belongs to the field of pharmaceutical preparations, and relates to macrophages membrane coated breast cancer targeted nanoparticles and a preparation method thereof. The macrophage membrane coated paclitaxel-loaded nanoparticles are prepared into a paclitaxel-loaded nanometer medicine delivery system from paclitaxel, macrophage membranes, amphiphilic high molecular materials, an injection solvent and the like. The macrophage membrane coated medicine carrying nanoparticles are good in biocompatibility, simple in preparation method and uniform in nanoparticle size distribution. Tumor cells are actively recognized through biological molecules on the surface of the macrophage membranes, so that active collection of medicine-containing carriers to a tumor region is effectively increased, retention of the medicine-containing carriers in tumor tissue is increased, controllability of medicine release is realized, and the anti-tumor treatment effects of medicines are increased.

The invention relates to an anorectal examination and drug administration device capable of achieving precise drug administration. The device comprises a fixed base disc, a rotating disc for adjustingthe expansion degree, N arc expansion plates for achieving anal expansion and a drug administration assembly for applying drugs on the affected part; the fixed base disc comprises a base plate, an outer cylinder covering the base plate and an annular disc arranged in the outer cylinder, the rotating disc comprises a circular cover and N control blocks arranged in the circular cover, and the drugadministration assembly comprises a plurality of drug administration insertion plates, a main drug delivery tube, branch drug delivery tubes and a multi-way valve. The anorectal examination and drug administration device has the advantages that not only can the expansion degree be adjusted according to different patients, but also local precise drug administration can be achieved for the patients,and the treatment effect is good.

The invention discloses a multifunctional cold-circulating bundling microwave treatment probe comprising an operating handle and a bundle, wherein the bundle consists of two ore more than two liquid medium strengthened hollow cooling microwave probes; the center of the bundle is provided with a multifunctional passage used for infusing a liquid medium or embedding a solid medium into a target tissue or carrying out temperature measurement or tissue biopsy; and the multifunctional passage and the bundle are fixed on the operating handle. The invention can outstandingly enlarge the melting volume of a microwave tissue and has a function of enhancing the treatment effect by infusing the liquid medium or embedding the solid medium into the target tissue and multiple functions, i.e. the biopsy, the temperature measurement, and the like.

The invention discloses a method for reducing irradiation deviations caused by respiration during radiotherapy. During the process of controlling the beam emerging time of radiation therapy device, chest motion of a patient during respiration can be tracked, and the starting and the ending times of the radiation therapy device can be controlled according to the tracks of the chest motion of the patient during respiration. The invention further provides a device for achieving the method, wherein the device comprises a radiation therapy device, a camera and a computer. A luminous reference marker is used for following the up-and-down motions of the chest of the patient during the respiration, the camera is used for collecting the motion images of the luminous reference marker in real time, the computer is used for computing the motion tracks, a beam emerging start point and a beam emerging end point of the radiation therapy device can be determined according to motion tracks, the method provided by the invention can meet the requirements of smooth aspiration of the patient, irradiation position precision deviations caused by offset of tumor position during aspiration are reduced, the therapeutic effect is improved, therefore, a high therapeutic gain ratio can be achieved, and the process of radiotherapy is enabled to be more humanized.

The invention relates to a health food and medicine, in particular to a composition which is capable of shortening the course of treatment, is remarkable in functions and can be used for preventing and treating prostatitis. The composition comprises the following components by weight: 5-60 parts of desert cistanche, cynomorium or medlar, 20-150 parts of pumpkin seeds and 20-150 parts of pollen.

The invention discloses a built-in bone support device. In the built-in bone support device, the edge of a circular top disc is provided with a cylindrical side wall which is extended outward; and the middle part of the cylindrical side wall is provided with longitudinal grids which are distributed uniformly. The designed support device can be used for treating large-area osteonecrosis and bone collapses caused by the large-area osteonecrosis, and achieves the effects of easing pain, repairing the inner structure of a femoral head, and recovering the femoral head. The built-in bone support device can only be used for treating femoral head necrosis and can also be used for treating osteonecrosis of other parts.

A multifunctional tractor for cervical vertebra and lumbar vertebra is composed of chair, vertical column, horizontal arm for tracting cervical vertebra, a main control box for controlling chair and bed, and the reposition physiotherapeutic equipment.

The invention discloses a multi-functional cupping and acupuncture device and a use method thereof. The top end of a piston rod is in threaded connection with a fixing handle through an insert hole of the piston rod, the other end is connected with a piston, the piston is placed in a negative pressure cylinder, a needle guide sieve plate is arranged in the negative pressure cylinder, a sterile casing is arranged on an opening of the needle guide sieve plate, threads are formed in the outer circle of the upper piston rod, a needle feeding depth regulating nut is arranged at the middles of the threads, a central through hole and peripheral through holes are opened in the axial direction of the middle of the piston rod, the peripheral through holes are formed in the periphery of the central through hole, needle insert blind holes are opened in the bottom of the piston, a piece of rubber film covers the surface of each needle insert blind hole, a magnetic suction head is arranged at the end of each needle handle, and the needle handles of acupuncture needles pass through the rubber films to insert in the needle insert blind holes in the bottom of the piston and the lower ends of the central through hole and peripheral through holes of the piston rod. The multi-functional cupping and acupuncture device integrates acupuncture, cupping and electrotherapy, gets twofold results with half the effort and has a good popularization and application prospect.

The invention discloses an ROS-responsive nanoparticle and application thereof in precise tumor treatment mediated by acoustic dynamic. An ROS sensitive molecule TL is utilized to be connected with anantitumor drug PTX and a hydrophilic fragment NH2-PEG1K-NH2 to obtain an amphipathic ROS sensitive fragment PTX-TL-PEG1K-NH2, and then an ultrasonic emulsification method is utilized to obtain the ROS-responsive nanoparticle loaded with a sensitizer IR780; the prepared nanoparticle can generate ROS under the action of external ultrasound to not only kill tumor cells, but also make the nanoparticle release the PTX to kill the tumor cells, thereby forming a cascading amplification synergistic effect during tumor treatment by the acoustic dynamic to achieve precise tumor treatment.

The invention discloses a thyroid cyst aspiration device which comprises a cannula base, a puncture needle and a negative-pressure aspirator. A soft indwelling needle is arranged at the front end of the cannula base, the puncture needle comprises a needle head and a needle handle, the needle head penetrates through the cannula base to be sleeved by the soft indwelling needle, the needle handle isslidingly in sleeved connection with the cannula base, a reset spring is arranged between the needle handle and the inner wall of the cannula base, an air bag is arranged at the position, close to theneedle tip, of the soft indwelling needle, an air cavity is formed in the soft indwelling needle, the outer surface of the soft indwelling needle is provided with an inflation ball communicated withthe air cavity, the air bag is communicated with the air cavity through an inflation tube, and a drainage channel is formed between the outer wall of the needle head and the inner wall of the soft indwelling needle. The cannula base is provided with a liquid suction port and a medicine injection port, one end of the liquid suction port is communicated with the drainage channel, the other end of the liquid suction port is communicated with the negative-pressure aspirator, the medicine injection port is communicated with the drainage channel and is provided with a valve, and a stop valve adjustable in angle is arranged in the inner cavity of the cannula base. The thyroid cyst aspiration device with the structure can reduce the infection possibility and can also improve a treatment effect.

The invention provides an underwater rehabilitation training treadmill which comprises a treadmill body, a display screen, a water tank, a water incoming pump, a water draining pump, a display screencontroller, an air pump, a vortex motor, a treadmill motor and a power source module. A caterpillar track for running is arranged in the treadmill body, a vortex nozzle, a bubble nozzle, a water outlet and a water inlet are arranged inside the treadmill body, the output end of the vortex motor is connected with the vortex nozzle, and the output end of the air pump is connected with the bubble nozzle through an airflow pipeline. The underwater rehabilitation training treadmill has the advantages that buoyancy of water is utilized to relieve load of body weight of users on their lower limbs, paralyzed patients with weak lower limb myodynamia are enabled to walk in water for training, and the treadmill is also suitable for patients in the recovery phase of lower limb muscle, arthropathy or bone fracture. Patients needing aerobic training can adopt a mode of walking in water in an acceleration manner, and exercise load can be increased through resistance of the water; underwater exercise can protect knee joints from being worn to achieve the objective of rehabilitation exercise training.

The invention relates to a memantine hydrochloride slow-release pellet preparation and a preparation method thereof. The memantine hydrochloride slow-release pellet preparation comprises a blank pellet core as a nuclear parent and memantine hydrochloride medicine slow-release composite layer wrapped as an outer layer. The preparation is characterized in that the blank pellet core and the memantine hydrochloride medicine slow-release composite layer are in the weight ratio of 2-6:1; the memantine hydrochloride medicine slow-release composite layer contains 10-40% of memantine hydrochloride, 50-70% of a slow-release material and 0.1-20% of other accessories. The slow-release pellet prepared by the invention has high roundness and good fluidity, can obtain high yield during wrapping of medicine and the slow release material, and has good reappearance. The simple preparation technology of the slow-release pellet is not restrained by place or equipment and suitable for industrialized production.

The invention relates to a preparation method of a 5-fluorouracil-carried pH-sensitive drug-bearing microsphere, which is characterized in that: monomer sodium styrene sulfonate is put into a cross-linked polyvinyl alcohol microsphere after being soaked, then ceric ammonium sulfate and concentrated sulfuric acid are added to obtain a grafted microsphere CPVA-g-PSSS, 5-fluorouracil is dissolved inhydrochloric acid, and the grafted microsphere CPVA-g-PSSS prepared in the previous step is added to obtain the 5-fluorouracil-carried pH-sensitive drug-bearing microsphere. The drug-bearing microsphere has pH sensitivity, is basically not released in stomach and small intestines and is greatly released in colon. Due to adoption of the preparation method, the treatment effect of the 5-fluorouracil can be improved, the selectivity is improved, the dosage can be reduced, and the toxic side effect can be reduced.

A process for producing cytokine-induced killer cells, comprising the steps of (a) culturing a cell mass that contains cells capable of being differentiated into CD3-positive CD56-positive cells and/or CD3-positive CD56-positive cells in the presence of a CD3 ligand, (b) culturing the cell mass produced in step (a) in the absence of a CD3 ligand, and (c) culturing the cell mass produced in step (b) in the presence of a CD3 ligand.

The invention provides a gene sequence construct for the treatment of central nervous system diseases. Tyrosine hydroxylase (TH), GTP-cyclase hydrolase I (GCH1), aromatic amino acid dopa decarboxylase(AADC) and the like are simultaneously expressed through construction of an auto-processing expression vector; proteins are connected by auto-processing units (APU); and viral vectors are utilized tointroduce the proteins into target cells to finally produce high-efficiently expressed tyrosine hydroxylase (TH), GTP-cyclized hydrolase I (GCH1), aromatic amino acid dopa decarboxylase (AADC) and the like, which have independent functions and are used for prevention or treatment of Parkinson's disease, Alzheimer's disease and other neurodegenerative diseases.

The invention provides Nanxing Compound Pain Paste Cataplasma Combination, which is prepared from the following by the following weight parts: 267 grams of raw arisaema tuber, 200 grams of radix aconiti, 167 grams of cloven, 167 grams of cinnamon, 300 grams of angelica, 1250 grams of asarum, 200 grams of hemlock parsley, 125 grams of panicled swallowwort root, 83 grams of frankincense, 83 grams of myrrh, and 63 grams of borneol. The auxiliary materials used for preparing Nanxing Compound Pain Paste Cataplasma Combination are as follows by the following weight parts: 1.5kg of Np-700, 60 grams of dihydroxyaluminium aminoacetate, 60 grams of tartaric acid, 15 grams of EDTA, 6kg of glycerol, 362 grams of crosslinking polyvingypyrrolidone, 11kg of purified water, 100 grams of gelatin, 100 grams of azone, 200 grams of propylene glycol, 160 grams of methyl salicylate. By adopting the materials, 1000 pieces of cataplasma herb paste are prepared. The camphor and the borneol are in powder shape. Other medicaments ethanol extracts. The invention further provides a method used for preparing the combination. Nanxing Compound Pain Paste Cataplasma Combination carries large dosage, conserves water, preserves moisture, has excellent air permeability and skin permeability, can be removed and attached repetitively without such side effects as irritability and so on.

The invention relates to a traditional Chinese medicine for treating wind-fire toothache and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 5-15 parts of root of doubleteeth pubescent angelica, 6-18 parts of divaricate saposhnikovia root, 5-10 parts of manchurian wildginger, 5-10 parts of liquorice root, 5-10 parts of safflower, 10-25 parts of pericarpium zanthoxyli, 8-20 parts of root of straight ladybell, 8-20 parts of dwarf lilyturf tuber, 10-25 parts of prepared rhizome of rehmannia, 10-25 parts of rhizoma corydalis, 10-20 parts of fructus toosendan, 8-20 parts of common anemarrhena rhizome, 10-20 parts of amur corktree bark, 15-30 parts of raw gypsum, 10-25 parts of honeysuckle flower, 3-10 parts of scorpion, 6-15 parts of stiff silkworm, 5-10 parts of goldthread root, 5-10 parts of baikal skullcap root, 5-10 parts of weeping forsythia capsule, 10-20 parts of figwort root and 15-25 parts of rhizome of rehmannia. By virtue of reasonable compatibility, the traditional Chinese medicine disclosed by the invention can be used for fundamentally eliminating wind-fire heat toxin and removing diseases of the gums and tooth roots caused by fire toxin attack, has the effects of clearing heat, decreasing fire and diminishing inflammation, and can be used for effectively relieving the pain caused by wind-fire teeth.

The invention provides a therapeutic apparatus and a control method thereof. The therapeutic apparatus comprises a control module, an ultrasonic driving unit, a low-frequency driving unit, an ultrasonic output part, a low-frequency output part and a power module, wherein the control module is used for simultaneously generating a first control signal and a second control signal in accordance with preset parameters; the ultrasonic driving unit is used for generating an ultrasonic driving signal in accordance with the first control signal; the low-frequency driving unit is used for generating a low-frequency driving signal in accordance with the second control signal; the ultrasonic output part is used for converting an electric signal into focused ultrasonic wave in accordance with the received ultrasonic driving signal; the low-frequency output part is used for generating low-frequency pulse current of an asymmetric exponential wave; and the power module is used for supplying power to the driving module (the ultrasonic driving unit and the low-frequency driving unit), the ultrasonic output part, the low-frequency output part and the control module. The therapeutic apparatus disclosed by the invention, by virtue of the low-frequency driving unit and the ultrasonic driving unit, can simultaneously drive the ultrasonic output part and the low-frequency output part to work, and the low-frequency pulse current and the focused ultrasonic wave can be generated on a same therapeutic head, so that a good therapeutic effect is taken on patients with arthritis, and treatment efficiency is greatly improved.

Disclosed is a medicament for treating bone fracture through keritherapy, which is prepared from the following raw materials (by weight ratio): frankincense 20, myrrh 20, drynaria 30, dipsacus root 30, eucommia bark 30, cortex acanthopanacis 30, wood louse 30, and buck grass 50.

The invention discloses a tea for lowering lipid and reducing blood pressure. The tea comprises, by weight, 8-10 parts of broadleaf holly leaf, 3-5 parts of kendir (leaf), 1-3 parts of prunella vulgaris, 3-5 parts of wild chrysanthemum flower and 2-3 parts of uncaria. The tea for lowering lipid and reducing blood pressure employs common easily available medicinal materials; through many tests and studies, the formula is optimized to achieve the most rationalization, so that the effects of comprehensive health care, prevention and treatment of the traditional Chinese medicines are utilized, and no side effect exists; and the materials are processed into packed tea for drinking, and the drugs taking water as the carrier are convenient for the human body to absorb, so as to improve the treatment effect.

The invention discloses a device and method for in-vivo micro-bubble control and imaging. The device comprises a support type in-vivo implanting structure, drug-loading micro-bubbles, a control arraytransducer unit and an imaging array transducer unit. Drug particles are loaded on the surfaces of the micro-bubbles or in the micro-bubbles, the drug-loading micro-bubbles are captured and gathered by the support type in-vivo implanting structure under the action of a local-area sound field, the micro-bubbles are broken by changing the ultrasonic intensity, and the drug particles are released. The control array transducer unit is used for transmitting power ultrasonic to excite the support type in-vivo implanting structure to vibrate and capture the drug-loading micro-bubbles in blood vessels. The imaging array transducer unit is used for emitting pulse waves, receiving echo signals from different positions, and imaging the micro-bubbles, the support type in-vivo implanting structure andtissue structures. According to the device, the resonance sound field generated by the support type in-vivo implanting structure is utilized, so that the micro-bubble aggregation in the blood vesselsis controlled; an ultrasonic transducer used for imaging is additionally arranged, and the micro-bubble control effect can be observed in real time.

The invention discloses an automatic administration-type cup for healthcare treatment, comprising a cup body and an administration device, wherein the cup body is a self-ignition cup, the administration device comprises a medicine bag rod and a liquid medicine bag, the medicine bag rod is fixed inside the cup body and the liquid medicine bag is installed on the medicine bag rod; under the action of negative pressure inside the cup, liquid medicine in the liquid medicine bag is automatically coated, in a dropping manner, on sites to be treated while cupping, thus cupping and medicine administration are simultaneously adopted for treatment.

The invention relates to the technical field of nano biomedical materials, and particularly discloses a novel long-acting degradable biological nano membrane slowing releasing VEGF and bFGF and a preparation method of the nano membrane. The nanofiber membrane obtained by the method of the invention has the following characteristics: 1, The nano membrane is non-toxic to human tissues, does not produce harmful substances after degradation in the body, and has good biocompatibility; 2, the nano membrane can avoid the inactivation of growth factors by organic solvents, strong acids and alkalis, high temperature and other factors, ensures that the growth factors loaded on the membrane maintain good activity and has a best therapeutic effect; and 3, the nano membrane avoids trauma caused by direct injection of growth factors into a ventricle and the problem of uncontrollable concentration, has a good effect of promoting vascular and nerve regeneration, can be applied to insufficient vascularregeneration after indirect vascular bypass surgery in neurosurgery, improves the therapeutic effect of related ischemic cerebrovascular diseases, and reduces the risk of recurrence of ischemic stroke.

An adjustable probe of a semiconductor laser treatment instrument comprises a fixing block, wherein a bulb groove is formed in the right side of the upper portion of the fixing block, a universal bulbis arranged in the bulb groove, a first sleeve is arranged on the right side of the fixing block and penetrates through the universal bulb, a second sleeve is arranged in the first sleeve, the left side of the first sleeve and the left side of the left sleeve are jointly and fixedly provided with a sealing plate, a plurality of evenly distributed through holes are formed in the periphery of the left end of the first sleeve, a plurality of evenly distributed air bag are arranged in the cavity between the first sleeve and the second sleeve, water-absorbing cotton is fixedly installed on the peripheries of the air bags, an air inlet pipe is fixedly installed on the right side of each air bag, a probe body is arranged in the second sleeve, and the left side of the probe is fixedly connected with the right side of the sealing plate. The adjustable probe can adjust the laser emergence position according to the position of a patient, improve the comfort of a treatment environment, does not need long-term handheld operation, is simple in use, has the good treatment effect on pharyngitis, laryngitis, dental ulcer, gingivitis and periodontitis and is suitable for application.

The invention discloses a flowing-liquid temperature control method capable of automatically correcting the dissipation factor. According to the flowing-liquid temperature control method, the temperature and the tolerant dissipation factor of target liquid are set, so that the temperature value which the temperature of initial liquid needs to reach through heating is worked out; next, according to the actual temperature of the final target liquid, the correction factor of the dissipation factor is worked out; a new temperature value which the temperature of the initial liquid needs to reach through heating is worked out according to the correction factor, heating is conducted again, and then the target liquid meeting the demand for the temperature can be obtained finally. By the adoption of the flowing-liquid temperature control method, the dissipation factor can be automatically corrected; the flowing-liquid temperature control method can be adapted to the influence of different environment changes on the temperature; the temperature of dialyzate is kept stable all the time, and therefore the treatment effect on a patient is further improved.