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Six-flavor hematinic capsule, its quality control method and application thereof

A technology of Liuwei Buxue Capsules, which is applied in the field of Liuwei Buxue Capsules and its quality control, and can solve problems such as easy moisture absorption and hardening

Active Publication Date: 2013-11-06
GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the shortcomings of the existing traditional Chinese medicine capsules, such as easy moisture absorption and hardening, a new preparation method of Liuwei Buxue Capsules is provided, and a comprehensive quality control method is developed for it. In order to effectively control the quality of this product, the text The high-performance liquid chromatography method for the content determination of acteoside and acteosin glucoside of this product was established

Method used

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  • Six-flavor hematinic capsule, its quality control method and application thereof
  • Six-flavor hematinic capsule, its quality control method and application thereof
  • Six-flavor hematinic capsule, its quality control method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0052] (1) Weigh 680g of comfrey, 560g of white peony, 760g of angelica, 880g of rehmannia glutinosa, 420g of chuanxiong, 350g of astragalus, 5g of magnesium stearate, 48g of pregelatinized starch, 33g of microcrystalline cellulose, 10g of mannitol, and talcum powder 19g, silicon dioxide 5g, spare.

[0053] (2) Soak Angelica and Rhizoma Chuanxiong with 6 times the amount of water at 30°C for 1 hour, distill and extract the volatile oil for 6 hours, collect the volatile oil extract, store the distilled aqueous solution in another container for future use, and leave the residue for later use;

[0054] (3) Mix the medicinal dregs after extracting the volatile oil with Radix Paeoniae Alba, Comfrey, Radix Astragali, and Rehmannia glutinosa, add 10 times the amount of water to decoct twice, each time for 2 hours, filter in stages, combine the filtrate and the distilled aqueous solution and Concentrate to a clear paste with a relative density of 1.10 (45°C), stir and add 98% ethanol ...

Embodiment 2

[0060] (1) Weigh 680g of comfrey, 560g of white peony, 760g of angelica, 880g of rehmannia glutinosa, 420g of chuanxiong, 350g of astragalus, 5g of magnesium stearate, 48g of pregelatinized starch, 33g of microcrystalline cellulose, 10g of mannitol, and talcum powder 19g, silicon dioxide 5g, spare.

[0061] (2) Soak Angelica and Rhizoma Chuanxiong with 7 times the amount of water at 40°C for 1 hour, distill and extract the volatile oil for 5 hours, collect the volatile oil extract, store the distilled aqueous solution in another container for future use, and leave the residue for later use;

[0062] (3) Mix the medicinal dregs after extracting the volatile oil with Radix Paeoniae Alba, Comfrey, Radix Astragali, and Rehmannia glutinosa, add 11 times the amount of water to decoct twice, each time for 2 hours, filter in stages, combine the filtrate and the distilled aqueous solution and Concentrate to a clear paste with a relative density of 1.12 (50°C), stir when cooled to room ...

Embodiment 3

[0068] (1) Weigh 680g of comfrey, 560g of white peony, 760g of angelica, 880g of rehmannia glutinosa, 420g of chuanxiong, 350g of astragalus, 5g of magnesium stearate, 48g of pregelatinized starch, 33g of microcrystalline cellulose, 10g of mannitol, and talcum powder 19g, silicon dioxide 5g, spare.

[0069] (2) Soak Angelica and Rhizoma Chuanxiong with 8 times the amount of water at 50° C. for 1 hour, distill and extract the volatile oil for 4 hours, collect the volatile oil extract, store the distilled aqueous solution in another container for future use, and leave the residue for later use;

[0070](3) Mix the medicinal dregs after extracting the volatile oil with Radix Paeoniae Alba, Comfrey, Radix Astragali, and Rehmannia glutinosa, add 12 times the amount of water to decoct twice, each time for 2 hours, filter in stages, combine the filtrate and the distilled aqueous solution and Concentrate to a clear paste with a relative density of 1.15 (55°C), stir when cooled to room...

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Abstract

The invention discloses a six-flavor hematinic capsule, its quality control method and an application thereof. The six-flavor hematinic capsule is prepared by adding auxiliary materials into raw materials consisting of Chinese angelica, Ligusticum wallichii, Radix Astragali, prepared rehmannia root, lithospermum and white peony root. According to the quality control method of the six-flavor hematinic preparation, whether the six-flavor hematinic capsule contains white peony root, Chinese angelica, Radix Astragali, prepared rehmannia root, lithospermum, Ligusticum wallichii and components is identified by thin layer chromatography; by high-performance liquid chromatography, in vitro dissolution behavior of the six-flavor hematinic capsule is determined, and effective component groups are identified by fingerprint; verbascoside and calycosin glucoside are used as reference substances to simultaneously determine contents in the six-flavor hematinic capsule; and the content of a volatile component ligustilide in the six-flavor hematinic capsule is determined by a gas chromatographic method. The method provided by the invention is simple to operate, is accurate and advanced, has good linear relation, reappearance, precision, stability and recovery rate, can be adopted to effectively control product quality and guarantee curative effect of the product. The invention also provides an application in the preparation of a medicine for treating eye damage and blurred vision.

Description

field of invention [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Liuwei Buxue capsule and a quality control method and application thereof. Background technique [0002] Liuwei Buxue Capsules are composed of angelica, white peony root, rehmannia glutinosa, astragalus, comfrey, chuanxiong and other medicinal materials. It has the function of nourishing qi and blood. It is used for the deficiency of both qi and blood. . Angelica has the effects of nourishing blood, promoting blood circulation, regulating menstruation and relieving pain, moistening dryness and smoothing intestines, and is often used for blood deficiency syndromes, irregular menstruation, etc. Pain in chest and abdomen, fever due to yin deficiency, etc. Rehmannia glutinosa has the effect of nourishing blood, nourishing essence and filling marrow. Astragalus has the effects of invigorating qi, generating yang, promoting body fluid and nourishing blood, and is oft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/48A61K47/40G01N30/90G01N30/02A61P27/02A61P27/12
Inventor 张凯谢隆谢雁鸣郭彧伍彪陈腊梅艾风
Owner GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD
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