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Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation and preparing method thereof

A technology of tyvanectin and enteric-coated preparations, which is applied in the field of veterinary antibiotic preparations, can solve problems such as easy flying and falling palatability, decreased drug efficacy, and poor feed intake, so as to improve the therapeutic effect, save production costs, and ensure local effect of concentration

Active Publication Date: 2018-07-10
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the common tivalamectin in the market is a common premix and soluble powder. Due to the simple preparation process, the bioavailability is low, and at the same time, it is easily affected by gastric acid, and the drug itself has a serious impact on the gastrointestinal tract. Ordinary preparations have a strong smell and bitter taste and are easy to scatter, resulting in poor palatability. The feed intake decreases, the curative effect of the drug decreases, and the desired effect cannot be achieved; , to reduce the efficacy of the

Method used

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  • Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation and preparing method thereof
  • Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A tyvanin tartrate inclusion enteric preparation, and its preparation method is as follows:

[0034] (1) Add 0.5 kg of tartaric acid and 3 kg of polyvinylpyrrolidone PVP-K30 to 50 kg of water, heat to 50°C to dissolve, and prepare solution A;

[0035] (2) Add 50 kg of tyvanin tartrate into solution A, keep the temperature at 50°C, and stir for 15 minutes to prepare a tyvanin tartrate solution;

[0036] (3) Dissolve 50kg of hydroxypropyl-β-cyclodextrin in 100kg of water to prepare solution B;

[0037] (4) Add the tyvans tartrate solution to solution B, stir and mix for 30 min, to obtain the tyvans tartrate inclusion compound solution.

[0038] (5) Add 20 kg of maltodextrin to the tyvanin tartrate inclusion compound solution in step (4), and stir to dissolve the drug-containing binder.

[0039] (6) Put 75kg glucose in the fluidized bed coating machine, the inlet air temperature is 80℃, the fan frequency is 35Hz, the spray frequency is 85Hz, and spray the drug-containing adhesive obt...

Embodiment 2

[0043] A tyvanin tartrate inclusion enteric preparation, and its preparation method is as follows:

[0044] (1) Add 0.5 kg of tartaric acid and 3 kg of polyvinylpyrrolidone PVP-K30 to 50 kg of water, heat to 50°C to dissolve, and prepare solution A;

[0045] (2) Add 50 kg of tyvanin tartrate into solution A, keep the temperature at 50°C, and stir for 15 minutes to prepare a tyvanin tartrate solution;

[0046] (3) Dissolve 40kg of hydroxypropyl-β-cyclodextrin in 100kg of water to prepare solution B;

[0047] (4) Add the tyvans tartrate solution to solution B, stir and mix for 30 min, to obtain the tyvans tartrate inclusion compound solution.

[0048] (5) Add 20 kg of maltodextrin to the tyvanin tartrate inclusion compound solution in step (4), and stir to dissolve the drug-containing binder.

[0049] (6) Put 50kg glucose in the fluidized bed coating machine, the inlet air temperature is 80℃, the fan frequency is 35Hz, the spray frequency is 85Hz, spray into the medicine-containing adhesiv...

Embodiment 3

[0054] A tyvanin tartrate inclusion enteric preparation, and its preparation method is as follows:

[0055] (1) Add 0.5 kg of tartaric acid and 3 kg of polyvinylpyrrolidone PVP-K30 to 50 kg of water, heat to 50°C to dissolve, and prepare solution A;

[0056] (2) Add 50 kg of tyvanin tartrate into solution A, keep the temperature at 50°C, and stir for 15 minutes to prepare a tyvanin tartrate solution;

[0057] (3) Dissolve 50kg of hydroxypropyl-β-cyclodextrin in 100kg of water to prepare solution B;

[0058] (4) Add the tyvans tartrate solution to solution B, stir and mix for 30 min, to obtain the tyvans tartrate inclusion compound solution.

[0059] (5) Add 20 kg of maltodextrin to the tyvanin tartrate inclusion compound solution in step (4), and stir to dissolve the drug-containing binder.

[0060] (6) Put 50kg glucose in the fluidized bed coating machine, the inlet air temperature is 80℃, the fan frequency is 35Hz, the spray frequency is 85Hz, spray into the medicine-containing adhesiv...

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Abstract

The invention provides a preparing method of an Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation. The preparing method comprises the steps of clathration of Acetylisovaleryl Tylosin Tartrate in hydroxypropyl-beta-cyclodextrin, Acetylisovaleryl Tylosin Tartrat is directly used for being manufactured into a medicine carrying inner core, and then the medicine carrying inner core is covered with an isolating layer and a coating layer separately to prepare the Acetylisovaleryl Tylosin Tartrate clathration enteric-coated preparation. Compared with the prior art, the coating and pelletizing technology of Acetylisovaleryl Tylosin Tartrate is implemented at a time, the operation is simple, and the production cost is saved. Meanwhile, the influence generated by gastric acid is avoided, the preparation can be targetedly released in the intestinal part, and the clinical treatment effect is better.

Description

Technical field [0001] The invention relates to the technical field of veterinary antibiotic preparations, in particular to a tyvanin tartrate inclusion enteric preparation and a preparation method thereof, and is suitable for veterinary antibiotic drugs. Background technique [0002] The chemical name of tylosin tartrate is AcetylisovalerylTylosin Tartrate, which is a derivative of tylosin A through chemical modification, which mainly acts on gram-positive bacteria and mycoplasma, and has some effects on some Gram-negative bacteria have obvious inhibitory effects. It mainly acts on gram-positive bacteria and mycoplasma, and has obvious inhibitory effect on some gram-negative bacteria. It is mainly used for the treatment of proliferative enteritis, dysentery, mycoplasmal pneumonia (swine asthma) in pigs, mycoplasma in chickens, Bacillus perfringens, and ornithosis rhinotrachea. It is an ideal medicine for mycoplasma in poultry and livestock. [0003] At present, the common tyvans...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/7048A61K47/61A61K47/38A61P31/04
CPCA61K9/5026A61K9/5042A61K9/5089A61K31/7048
Inventor 张卫元李子彬张可荣刘志滨杨飞高经纬
Owner 武汉回盛生物科技股份有限公司
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