123results about How to "Mask bad taste" patented technology

The invention discloses application of an inclusion technology in preparing animal medicines, and an animal medicine inclusion compound. The animal medicine inclusion compound can increase the dissolution velocity and the solubility of indissolvable medicines, improve the stability of the medicines which are changeable in the presence of lights or moistures and the like, and facilitate the storage of medicines. The invention also provides a method for preparing the animal medicine inclusion compound, and the method is simple in operation, can reduce the use of organic solvent, lower the cost, reduce the poisonous side effects of the medicines, and can be applied to the preparation of animal medicines.

The invention provides a health-care food capsule, which consists of a content and a gelatine skin, wherein the content is a mixture which is prepared from raw materials according to the following part by weight: 12-22 of maca powder, 5-15 of wolfberry extract, 5-15 of Chinese angelica extract, 2-8 of acanthopanax extract, 2-8 of epimedium extract, 1-5 of ginseng extract, 15-25 of corn oil and 35-50 of tea seed oil. The gelatine skin is prepared from edible gelatine, glycerin and purified water according to the weight ratio of 1/1/0.5. The content is obtained through crushing, burdening, mixing, grinding and degassing the raw materials. The gelatine skin takes the edible gelatine, the glycerin and the purified water as gelatine skin raw materials, the gelatine liquor is obtained after mixing, gelating and heating the gelatine skin raw materials,, then the content and the gelatine liquor in the capsule are produced through the pelleting of an automated machine, and a product has a reasonable and practicable processing method. The health-care food capsule has the effects of alleviating climacteric syndrome, increasing the sexual capacity and relieving physical fatigue, is easy to beabsorbed by the human body, has no toxic and side effects, and can be orally taken for a long time.

The present invention provides a solid preparation comprising a crystal of [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid (Compound A), especially a crystal of Compound A having a particle size of not larger than 100 mum at the cumulative weight distribution value of 50%, and not larger than 200 mum at the cumulative weight distribution value of 95%, preferably a solid preparation having the excellent stability and the content uniformity of Compound A, which is prepared by preparing granules of the crystal of Compound A with fillers, disintegrants and binders, and then followed by mixing said granules with external excipients.

The invention relates to a preparation having the functions of promoting blood circulation, enlivening spleen and tonifying kidney, the process for preparation and quality control method, wherein the preparation is produced mainly from astragalus root, Chinese ephedra, Chinese angelica root, herba ecliptae, atractylodes rhizome, safflower, radix paeoniae rubrathe, peach kernels, achyranthes and cyathula root, Ligusticum wallichii, bitter orange and root of balloonflower. The preparation can be made into injections and various oral administration preparations including dripping pills, mini-pills and dispersible tablets. The invention also provides the method for determining and identifying contents of the preparation.

The invention relates to a particles used to shade bad taste of drug, wherein it is formed by corn element with active component and continuous polymer dress; the corn element is formed by active component and acrylic resin at 1:0.5-1:20 mass ratio; the dress is soluble gel slurry; and the drug is soluble in acid solution with bad taste. And the production comprises that: dissolving drug and soluble base material into solvent; using atomizing drier or rotation evaporator to obtain dry particles; then graining them at neutral condition via gel material; forming dress that separates drug and taste bud on the surface of particles; preparing oral agent via general method. The invention can avoid releasing bad taste in mouth but release drug in stomach.

The polypeptide fruit jelly producing process includes the following steps: mixing fruit jelly powder in 0.6-1.2 weight portions and sweetener in 0.03-15 weight portions, adding water in 59.9-67.03 weight portions via stirring for 3-10 min until complete water absorbing swelling of fruit jelly powder, heating at the boiling temperature 85-90 deg.c for 3-10 min, immediately filtering, adding preservative at 80 deg.c to the boiling point, adding essence at 75-80 deg.c, adding acidity regulating agent at 70-75 deg.c, adding polypeptide solution at 65-70, pouring, sealing, sterilizing, cooling and inspection. The present invention has good taste and health care effect, and may be used as the excellent nutrient source for athlete, valetudinarian and other special people.

The invention provides a medicine composition. The medicine composition is a soft capsule that can effectively treat cold and comprises active drug components, a solvent and a co-solvent. The soft capsule can not only solve the problems of leakage and crystallization existing in existing preparation and remarkably improve the beneficial effects of the medicine composition. Compared with products sold in the market, the medicine composition provided by the invention has more remarkable stability and better treat result.

The invention belongs to the technical field of drugs and relates to an oral ulcer treatment patch film and a preparation method thereof. The oral ulcer treatment patch film mainly comprises oleanolic acid, polysaccharide sulfate, vitamin B6, chitosan, a film forming agent, glucoside, tributyl citrate and distilled water. The oral ulcer treatment patch film has a reasonable and scientific formula. Components of the oral ulcer treatment patch film interact with each other and have effects of inhibiting bacteria, diminishing inflammation and easing pain so that the oral ulcer treatment patch film can effectively relieve oral ulcer and shorten cure time. The oral ulcer treatment patch film has the advantages of good adhesion, fast dissolving speed and good uncovered film integrity, guarantees drug effects and is an ideal oral ulcer patch film.

The invention discloses a film agent containing alkannin and resisting oral ulcer inflammation, and preparation and application thereof. The film agent is prepared from the following materials in parts by weight: 0.01--0.05 part of alkannin, 1-3 parts of gamma-cyclodextrin, 0.25-15 parts of chitosan quaternary ammonium salt, 0.5-5 parts of polyvinylpyrrolidone K90, 5-30 parts of bletilla hyacinthine gum, 0.5-2 parts of gelatin, 3-10 parts of ethyl cellulose, 90-97 parts of alcohol and 20-50 parts of distilled water. The film forming agent is prepared according to a certain method and comprises two layers, namely a complete drug-loaded film and a blank film, one side of the drug-loaded film is stuck to the affected part, the blank film can stop drug from dissolving out in an oral cavity, so that the effect of one-way drug release is achieved, simultaneously bad taste of main medicines is covered, the drug is gathered to the affected part, the treating effect is improved, further the pain of patients is greatly relieved and the action time of the medicines is prolonged; and the effective-component alkannin in the medicine film has the anti-inflammation and bacteriostatic effects, namely inflammation diminishing, astringency and antipyresis. Simultaneously, the film agent is convenient to store and carry and can be easily industrialized.

The invention relates to an oral anti-tumor drug capecitabine granule and a preparation method thereof. The capecitabine granule exists in the form of a cyclodextrin inclusion compound and is prepared from capecitabine serving as a raw material drug and auxiliary materials comprising cyclodextrin, a diluting agent, a disintegrating agent, an adhesive and a flavoring agent by wet granulation. The capecitabine granule disclosed by the invention not only covers the bitterness of a capecitabine drug and enhances the drug compliance of a cancerous person, but also enhances the stability of the capecitabine in gastrointestinal tracts and accelerates the digestion velocity, thereby preventing the peak valley phenomenon of the blood concentration of a drug, outstandingly reducing the adverse reactions of the drug, such as irritation and toxic side effect, on the gastrointestinal tracts due to the stable release of capecitabine in the gastrointestinal tracts, enhancing the drug safety and better taking the anti-tumor effect.

The invention relates to a medicine sustained release preparation, and particularly relates to a topiramate sustained release preparation and a preparation method thereof. The topiramate sustained release preparation is prepared by sustained release particles and pharmaceutical auxiliary materials, wherein the sustained release particles comprise 15-30% of topiramate, 30-60% of an ion-exchange resin, 12-25% of an impregnant and 5-15% of a sustained release coating material. The topiramate sustained release preparation has stable and effective plasma concentration which is lower than the peak concentration of a quick release preparation, reduces incidence rate of side reactions, and can control epileptic seizures well. The topiramate sustained release preparation is taken once every day, and employs the ion ion-exchange resin, so that unpleasant taste of topiramate can be covered; and adaptability for patients is increased. The topiramate sustained release preparation can be well-received by doctors and patients.

The invention belongs to the technical field of pharmaceutical preparations and discloses a pharmaceutical preparation of a tebipenem pivoxil composition and a preparation method of the pharmaceutical preparation. The pharmaceutical preparation of the tebipenem pivoxil composition comprises the following components in parts by weight: 10-100 parts of tebipenem pivoxil, 10-100 parts of a resin material, 200-1000 parts of a substrate material, 200-1000 parts of a filler, 1-10 parts of a defoamer, 1-10 parts of a surfactant, 10-100 parts of a lubricant and 20-100 parts of a binder. The pharmaceutical preparation of the tebipenem pivoxil composition has good dissolution rate and stability and also covers the bad taste of tebipenem pivoxil, and has a good taste. The preparation method provided by the invention further improve the dissolution rate of medicines, and the bitterness caused by tebipenem pivoxil is effectively covered, the effectiveness and safety of the preparation are guaranteed and the medicament compliance of the patient is improved.

The invention relates to a novel compound propolis preparation and a preparation method thereof. The compound propolis product is prepared form the following ingredients: supercritical propolis, supercritical perilla frutescens seed oil, supercritical glossy ganoderma spore oil and ethanol extracted supercritical propolis residue. A main technical method has the following steps: removing impurities from raw materials; pulverizing raw materials; carrying out CO2 supercritical extraction; preparing microcapsule emulsion; carrying out vacuum freeze drying; carrying out pulverization; stirring and mixing all ingredients; and carrying out sterilization, capsule filling and package. The product of the invention belongs to the health care food with higher nutritional value, and has various health care effects of blood pressure reduction, blood fat reduction, antioxidation, immunity improvement and the like.

The present invention provides a clarithromycin dispersible tablet preparation method, which comprises: carrying out ultrafine crushing on clarithromycin and part of lactose into micro-powder with the diameter of less than 10 [mu]m to obtain mixed powder A; taking the remaining filler and part of a disintegrant, and mixing to form mixed powder B; mixing an adhesive and purified water to prepare an aqueous solution with the mass fraction of 1-10%; mixing the mixed powder B with the mixed powder A in an equal increase manner, placing into a three-dimensional mixer to mix for 30-40 min, adding to the adhesive aqueous solution to prepare a soft material, and screening with a 16-24 mesh sieve; drying at a temperature of 50-70 DEG C, and screening the whole particle with a 16-24 mesh sieve; externally adding the remaining disintegrant, a lubricant and a sweetener to the particles to obtain a material C; and tableting the material C to obtain the clarithromycin dispersible tablets. According to the invention, the clarithromycin and part of the lactose are subjected to ultrafine crushing, such that the particle size is small, the specific surface area is increased, the adsorption property and the solubility are correspondingly increased, the bitterness of the product can be reduced, and the patient compliance can be improved; and with the process, the clarithromycin dispersible tablet with characteristics of stable quality, rapid drug dissolution and no bad odor can be prepared.

The invention provides a medicinal composition for treating gastrointestinal disorders, and the medicinal composition is prepared from the following main components in parts by weight: 0.5 to 10 parts of sodium azulene sulfonate and 20 to 300 parts of sodium bicarbonate. The invention also provides a preparation method and application of the medicinal composition. The medicinal composition can achieve the medical effect of synergy by compatibly using the sodium azulene sulfonate and the sodium bicarbonate, has stable quality and strong controllability, has the functions of light protection, damp prevention and the like, and can cover defect taste of the medicament, so that decomposition of the medicament can be prevented or retarded, and the medicament stability is improved to ensure the curative effect of the medicament is exerted better. The medicinal composition is easily disintegrated and quickly absorbed, is convenient for clinical application, and provides a novel option for clinical treatment.

The invention discloses a beverage capable of lowering blood sugar. Each 1kg of the beverage capable of lowering the blood sugar is composed of following raw materials according to mass: 250g-350g of bitter gourds, 6g-10g of tartary buckwheat, 0.5g-1.0g of pectin, 10g-20g of isomaltulose, 0.2g-0.4g of sodium isoascorbate, 0.2g-0.3g of sodium copper chlorophyllin, 0.05g-0.15g of stevioside, 0.8g-1.4g of edible essence and the balance of pure water. The beverage capable of lowering the blood sugar takes the bitter gourds as a main raw material and the tartary buckwheat is added; the bitter gourds and the tartary buckwheat are natural vegetables or plants so that medicine components are safely and greatly reduced; the beverage is a health-care product beverage, and the side effects and the toxicity of the medicine are reduced and the blood sugar lowering effect is very good; meanwhile, the beverage capable of lowering the blood sugar also has the effects of lowering blood pressure, lowering blood lipids, promoting a digestion function, and losing weight and beautifying.

The invention discloses a composition conducive to lowering of cholesterol, and a preparation method, a preparation and an application of the composition. The composition conducive to lowering of cholesterol is prepared from the following raw materials in parts by weight: 100-600 parts of horseradish tree leaves, 100-350 parts of hawthorns and 50-300 parts of orange peel by pretreatment, extraction and post-treatment. The horseradish tree leaves in the composition are capable of providing essential nutrient substances in human bodies and improving body health, have the efficacies of lowering cholesterol and reducing blood fat; and the hawthorn has the efficacies of promoting digestion, invigorating the stomach, promoting the circulation of qi, dissipating blood stasis and the like, is rich in abundant hesperetin and hesperidin, is capable of inhibiting the activity of reductase and cholesterol enzyme in plasma and liver, increasing emission of cholesterol, and has the functions of lowering cholesterol, reducing blood fat, resisting atherosclerosis and reducing cardiovascular diseases.

The invention discloses a clindamycin phosphate oral pharmaceutical preparation, which is mainly prepared from raw materials in the following weight ratio: (1) a buccal tablet which comprises 1 to 100 portions of clindamycin phosphate counted on clindamycin, 0 to 100 portions of disintegrant, and 5 to 500 portions of filler; (2) a filmogen which comprises 1 to 100 portions of the clindamycin phosphate counted on the clindamycin, and 5 to 500 portions of film-forming material; and (3) an oral patch which comprises 1 to 100 portions of the clindamycin phosphate counted on the clindamycin, 5 to 500 portions of the filler, and 1 to 100 portions of adhesive material. The clindamycin phosphate oral pharmaceutical preparation is directly applied to a local infection and has high local drug concentration and fast effect, and the dose is low and adverse reactions are few.

The invention discloses a method for preparing Xinnaokang capsules, which comprises the following steps of: crushing nine medicinal materials, namely Sichuan lovage rhizome, red flower, rhizoma alismatis, root of bidentate achyranthes, curcumae, polygala root, irkutsk anemone rhizome, spina date seed and liquorice, screening by using a 100-mesh screen and uniformly mixing; combining six medicinalmaterials of salvia miltiorrhiza, root of common peony, prepared tuber of multiflower knotweed, fruit of Chinese wolfberry, root of kudzu vine and earthworm and adding water and decocting for three times; combining the decoction, filtering, concentrating the filtrate into thick paste with the relative density of 1.35 at the temperature of 50 DEG C, adding the screened medicinal materials into thethick paste, uniformly mixing, drying, crushing and screening by using the 100-mesh screen; and adding deer heart powder, uniformly mixing and filling into capsules and obtaining the Xinnaokang capsules. The technology is simple, and the prepared Xinnaokang capsules mask the bitter taste of the medicaments, improve the medicinal stability and bioavailability, and are beautiful in appearance, convenient to take, carry and store, and accurate in dosage.

The present invention relates to a levofloxacin hydrochloride micropill capsule and its preparation method. It is composed of capsule external shell and micropill, the micropill is formed from levofloxacin hydrochloride, blank pill core and adhesive, every pill contains (by wt%) 10%-80% of levofloxacin hydrochloride, 15%-60% of medicine micropill pill core and 5%-30% of adhesive. Besides, said invention also provides the concrete steps of its preparation method.