Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Levofloxacin hydrochloride micro-pill capsule and its preparing method

A technology of levofloxacin hydrochloride and micropill capsules, which is applied in the field of levofloxacin hydrochloride micropill capsules and its preparation, can solve the problems of uneven size of micropills and easy adhesion of micropills, so as to avoid excessive drug concentration, good fluidity and local less irritating effect

Inactive Publication Date: 2006-08-09
范敏华
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Another purpose of the present invention is to solve the uneven size of the micropills in the preparation of the existing levofloxacin micropills, and the problem of easy adhesion of the micropills, to provide a prepared micropill with uniform size, narrow particle size distribution, rounded shape, no Adhesion, the raw and auxiliary materials are not lost, which is beneficial to the preparation method of improving the operating environment and reducing production costs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of levofloxacin hydrochloride pellet capsule of the present invention:

[0035] Levofloxacin hydrochloride (calculated as levofloxacin) 100g

[0036] Povidone 9.2g

[0037] Medicinal pellet core 76.7g

[0038] Makes 1000 capsules

[0039] 1. Preparation of drug-containing pellets:

[0040] Get the povidone of 9.2 grams, dissolve with 320ml ethanol, make povidone ethanol solution as adhesive. Add the prescribed amount of levofloxacin hydrochloride to the above binder, and keep stirring to make it a uniform suspension;

[0041] Weigh the prescribed amount of medicinal pellets and place them in the side spray of the fluidized bed. After 5 minutes of preheating, the side spray is loaded with medicine. The speed is 7rpm. Until the uniform suspension is completely loaded; sieve 30-mesh pellets, place them in a fluidized bed top spray, and dry at 50°C for 1 hour.

[0042] 2. Preparation of pellets and capsules

[0043] Th...

Embodiment 2

[0045] The preparation of levofloxacin hydrochloride pellet capsule of the present invention:

[0046] Levofloxacin hydrochloride (calculated as levofloxacin) 200g

[0047] Povidone 18.4g

[0048] Medicinal pellet core 153.4g

[0049] Makes 1000 capsules

[0050] 1. Preparation of drug-containing pellets:

[0051] Get the povidone of 18.4 grams, dissolve with 640ml ethanol, make povidone ethanol solution as binding agent. Add the prescribed amount of levofloxacin hydrochloride to the above binder, and keep stirring to make it a uniform suspension;

[0052] Weigh the prescribed amount of medicinal pellet cores and place them in the side spray of the fluidized bed. After preheating for 5 minutes, load the drug on the side spray. The rate is 30rpm. Until the uniform suspension is completely loaded; sieve 16-mesh pellets, place them in a fluidized bed top spray, and dry at 50°C for 1 hour.

[0053]2. Preparation of pellets and capsules

[0054] Fill...

Embodiment 3

[0056] The preparation of levofloxacin hydrochloride pellet capsule of the present invention:

[0057] Levofloxacin hydrochloride (calculated as levofloxacin) 50g

[0058] Hydroxypropyl Methyl Cellulose 10g

[0059] Medicinal pellet core 40g

[0060] Makes 1000 capsules

[0061] 1. Preparation of drug-containing pellets:

[0062] Get the hydroxypropyl methylcellulose of 10 grams, dissolve with 350ml ethanol, make the hydroxypropyl methylcellulose ethanol solution as binder. Add the prescribed amount of levofloxacin hydrochloride to the above binder, and keep stirring to make it a uniform suspension;

[0063] Weigh the prescribed amount of medicinal pellet cores and place them in the side spray of the fluidized bed. After 5 minutes of preheating, the side spray is loaded with medicine. The rate is 20rpm. Until the uniform suspension is completely loaded; sieve 30-mesh pellets, place them in a fluidized bed top spray, and dry at 50°C for 1 h...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a levofloxacin hydrochloride micropill capsule and its preparation method. It is composed of capsule external shell and micropill, the micropill is formed from levofloxacin hydrochloride, blank pill core and adhesive, every pill contains (by wt%) 10%-80% of levofloxacin hydrochloride, 15%-60% of medicine micropill pill core and 5%-30% of adhesive. Besides, said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a levofloxacin hydrochloride pellet capsule and a preparation method thereof. Background technique [0002] Levofloxacin hydrochloride, chemical name (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H -Pyridine-[1,2,3,-de]-[1,4]benzoxazine-6-carboxylate hydrochloride - crystalline hydrate. It is the L-isomer of ofloxacin S configuration, white or yellowish crystalline powder, odorless, bitter, and gradually changes color when exposed to light. It is a third-generation quinolone broad-spectrum antibacterial synthetic drug. For Staphylococcus, Streptococcus, Streptococcus pneumoniae, Neisseria gonorrhoeae, Escherichia coli, Citrobacter, Shigella, Klebsiella pneumoniae, Enterobacter, Haemophilus influenzae, Acinetobacter, Helicobacter, etc. Good antibacterial effect. It has certain antibacterial activity against Pseudomonas aeruginosa, Chlamydia trachomatis and Mycobacterium tub...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5383A61K9/48A61P31/04A61P11/04A61P13/02A61P17/02A61P1/16A61P27/16
Inventor 范敏华
Owner 范敏华
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com