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Levofloxacin hydrochloride micro-pill capsule and its preparing method

A technology of levofloxacin hydrochloride and micropill capsules, which is applied in the field of levofloxacin hydrochloride micropill capsules and its preparation, can solve the problems of uneven size of micropills and easy adhesion of micropills, so as to avoid excessive drug concentration, good fluidity and local less irritating effect

Inactive Publication Date: 2006-08-09
范敏华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Another purpose of the present invention is to solve the uneven size of the micropills in the preparation of the existing levofloxacin micropills, and the problem of easy adhesion of the micropills, to provide a prepared micropill with uniform size, narrow particle size distribution, rounded shape, no Adhesion, the raw and auxiliary materials are not lost, which is beneficial to the preparation method of improving the operating environment and reducing production costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of levofloxacin hydrochloride pellet capsule of the present invention:

[0035] Levofloxacin hydrochloride (calculated as levofloxacin) 100g

[0036] Povidone 9.2g

[0037] Medicinal pellet core 76.7g

[0038] Makes 1000 capsules

[0039] 1. Preparation of drug-containing pellets:

[0040] Get the povidone of 9.2 grams, dissolve with 320ml ethanol, make povidone ethanol solution as adhesive. Add the prescribed amount of levofloxacin hydrochloride to the above binder, and keep stirring to make it a uniform suspension;

[0041] Weigh the prescribed amount of medicinal pellets and place them in the side spray of the fluidized bed. After 5 minutes of preheating, the side spray is loaded with medicine. The speed is 7rpm. Until the uniform suspension is completely loaded; sieve 30-mesh pellets, place them in a fluidized bed top spray, and dry at 50°C for 1 hour.

[0042] 2. Preparation of pellets and capsules

[0043] Th...

Embodiment 2

[0045] The preparation of levofloxacin hydrochloride pellet capsule of the present invention:

[0046] Levofloxacin hydrochloride (calculated as levofloxacin) 200g

[0047] Povidone 18.4g

[0048] Medicinal pellet core 153.4g

[0049] Makes 1000 capsules

[0050] 1. Preparation of drug-containing pellets:

[0051] Get the povidone of 18.4 grams, dissolve with 640ml ethanol, make povidone ethanol solution as binding agent. Add the prescribed amount of levofloxacin hydrochloride to the above binder, and keep stirring to make it a uniform suspension;

[0052] Weigh the prescribed amount of medicinal pellet cores and place them in the side spray of the fluidized bed. After preheating for 5 minutes, load the drug on the side spray. The rate is 30rpm. Until the uniform suspension is completely loaded; sieve 16-mesh pellets, place them in a fluidized bed top spray, and dry at 50°C for 1 hour.

[0053]2. Preparation of pellets and capsules

[0054] Fill...

Embodiment 3

[0056] The preparation of levofloxacin hydrochloride pellet capsule of the present invention:

[0057] Levofloxacin hydrochloride (calculated as levofloxacin) 50g

[0058] Hydroxypropyl Methyl Cellulose 10g

[0059] Medicinal pellet core 40g

[0060] Makes 1000 capsules

[0061] 1. Preparation of drug-containing pellets:

[0062] Get the hydroxypropyl methylcellulose of 10 grams, dissolve with 350ml ethanol, make the hydroxypropyl methylcellulose ethanol solution as binder. Add the prescribed amount of levofloxacin hydrochloride to the above binder, and keep stirring to make it a uniform suspension;

[0063] Weigh the prescribed amount of medicinal pellet cores and place them in the side spray of the fluidized bed. After 5 minutes of preheating, the side spray is loaded with medicine. The rate is 20rpm. Until the uniform suspension is completely loaded; sieve 30-mesh pellets, place them in a fluidized bed top spray, and dry at 50°C for 1 h...

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PUM

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Abstract

The present invention relates to a levofloxacin hydrochloride micropill capsule and its preparation method. It is composed of capsule external shell and micropill, the micropill is formed from levofloxacin hydrochloride, blank pill core and adhesive, every pill contains (by wt%) 10%-80% of levofloxacin hydrochloride, 15%-60% of medicine micropill pill core and 5%-30% of adhesive. Besides, said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a levofloxacin hydrochloride pellet capsule and a preparation method thereof. Background technique [0002] Levofloxacin hydrochloride, chemical name (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H -Pyridine-[1,2,3,-de]-[1,4]benzoxazine-6-carboxylate hydrochloride - crystalline hydrate. It is the L-isomer of ofloxacin S configuration, white or yellowish crystalline powder, odorless, bitter, and gradually changes color when exposed to light. It is a third-generation quinolone broad-spectrum antibacterial synthetic drug. For Staphylococcus, Streptococcus, Streptococcus pneumoniae, Neisseria gonorrhoeae, Escherichia coli, Citrobacter, Shigella, Klebsiella pneumoniae, Enterobacter, Haemophilus influenzae, Acinetobacter, Helicobacter, etc. Good antibacterial effect. It has certain antibacterial activity against Pseudomonas aeruginosa, Chlamydia trachomatis and Mycobacterium tub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5383A61K9/48A61P31/04A61P11/04A61P13/02A61P17/02A61P1/16A61P27/16
Inventor 范敏华
Owner 范敏华
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