The invention discloses
sodium valproate-containing sustained-release
transdermal patch as well as a preparation method and application thereof. The sustained-release
transdermal patch comprises a back lining layer, a
medicine-containing layer and a protective layer, wherein the
medicine-containing layer comprises
sodium valproate, a complexing agent, an
adhesive, a transdermal improver, a
bacteriostatic agent and a hot-melt pressure-sensitive
adhesive. The preparation method comprises the following steps: heating and melting the hot-melt pressure-sensitive
adhesive, adding the
sodium valproate, the transdermal improver, the adhesive, the complexing agent and the
bacteriostatic agent into the hot-melt pressure-sensitive adhesive to dissolve, mixing uniformly, performing ultrasonic degassing,
coating the surface of the protective layer with the mixture to form the
medicine-containing layer, and covering the surface of the dried medicine-containing layer with the back lining layer;
cutting and packaging. The sodium valproate-containing sustained-release
transdermal patch can serve as a medicine for treating
pediatric epilepsy. The sodium valproate-containing sustained-release transdermal patch has medicine release uniformity and mild and durable effect, can effectively reduce the administration times, is convenient in
dosage adjustment, is convenient to carry, has high patient adaptability, and solves the problem that infantile administration is difficult.