32 results about "Pediatric epilepsy" patented technology

The present invention relates to therapeutic and/or prophylactic uses of pyridazine compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disorder characterized by conduction disturbances, electroconvulsions and/or seizures, in particular epilepsy, more particularly pediatric epilepsy. In an aspect of the invention, the pyridnsine compound has the Formula (Ia) or (Ib) wherein R¹, R², R³, R⁴, R⁵, R⁶ and R⁷ are as defined in the description.

The invention relates to a traditional Chinese medicinal preparation for treating pediatric epilepsy, and belongs to the technical field of preparation of traditional Chinese medicines. Traditional Chinese medicine holds that the pediatric epilepsy starts from frightening in the worm or fetal deficiency first and acquired malnutrition, external contraction of wind evil and internal injury diet later, to result in visceral qi disorder, and the pediatric epilepsy is caused by endogenous phlegm, qi-movement disturbance, wind yang agitation and obnubilation. Effective ingredients of the traditional Chinese medicinal preparation include the following raw materials: liquorice, bamboo shavings, polygala tenuifolia, rhizoma gastrodiae, ligusticum wallichii, angelica, peach kernels, safflower, musk, old onion stalks, fresh ginger and red jujube. The traditional Chinese medicinal preparation disclosed by the invention is prepared from pure natural traditional Chinese medicine raw materials; clinical tests for many years verify that the traditional Chinese medicinal preparation has excellent functions of stabilizing wind and calming, activating blood circulation and dissolving blood stasis, reducing phlegm and unblocking meridians, promoting qi circulation and relieving depression. and has a good effect on treating the pediatric epilepsy; the traditional Chinese medicinal preparation has the advantages of being concrete in pharmaceutical effect, short in treatment course, rapid to become effective, free from toxic and side effects, not easy to recur after healing and the like.

The invention relates to traditional Chinese medicine radix curcumae-tangerine peel powder for treating anorexia. The traditional Chinese medicine radix curcumae-tangerine peel powder is mainly used for solving the problem that the current drugs for treating pediatric epilepsy are poor in treatment effect and have side effects. The traditional Chinese medicine radix curcumae-tangerine peel powder is prepared through the steps of weighing 5 parts of tangerine peel, 5 parts of nutagrass flatsedge rhizome, 5 parts of fried fructus aurantii, 5 parts of yam, 5 parts of radix curcumae, 5 parts of parched hawthorn fruit, 3 parts of chicken gizzard membrane and 3 parts of licorice root, and co-grinding into fine powder. The usage and dosage are as follows: the powder is orally taken once in the morning and evening of a day, the dosage for children of 1-3 years old is 5g, and the dosage for children of 4-6 years old is 8g; a treatment course lasts one month. The traditional Chinese medicine radix curcumae-tangerine peel powder has the aims and advantages that the total effective rate for anorexia treatment is over 95%, and the cure rate is over 80%. The traditional Chinese medicine radix curcumae-tangerine peel powder is free from toxic and side effects.

The invention discloses a traditional Chinese medicine preparation for treating pediatric epilepsy. The traditional Chinese medicine preparation consists of the following raw materials in parts by weight: 3-9 parts of radix ligustici sinensis, 15-30 parts of elaeagnus angustifolia, 3-6 parts of ferula asafetida, 9-15 parts of rhizoma polygonati, 1.5-9 parts of liquorice, 9-27 parts of radix acanthopanacis semticosi, 6-15 parts of semen nelumbinis, 6-20 parts of mulberries, 6-15 parts of Chinese dates, 9-12 parts of hawthorns, 1-3 pats of stigma croci, 6-12 parts of lilium brownii and 5-10 parts of bombyx batryticatus. The invention further discloses a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation for treating pediatric epilepsy is a pure traditional Chinese medicine preparation which is remarkable in curative effect and free of obvious toxic and side effects, can be used for overcoming the problems of relatively high cost due to clinic application of drugs such as carbamazepine and zonisamide tablets at present and relatively large side effects to infant patients due to long-term application, and has the advantages of being quick in effect, definite in curative effect, wide in drug resource and low in cost.

The invention provides a traditional Chinese medicine preparation for treating pediatric epilepsy and a preparation method thereof. The traditional Chinese medicine preparation comprises the following raw medicines: tangerine peel, ground beeltle, selfheal, lignum dalbergiae odoriferae, mongolian gazelle horn, jujube, heterophylly falsestarwort root, lumbricus, natural indigo, pubescent angelica root, nacre mother, Chinese dodder seed, pork heart, Chinese yam and forsythia. The traditional Chinese medicine preparation provided by the invention has the advantages of fast effect, exact drug efficacy, low toxic and side effects and capability of being safely taken by sick children for a long term and has the beneficial effects that the damage to brain nervous function can be reduced, the drug tolerance has small possibility of producing and the drug dependence is alleviated.

The invention relates to a traditional Chinese medicine cinnabar-ginseng pill for treating pediatric epilepsy. The traditional Chinese medicine cinnabar-ginseng pill is mainly used for solving the problem that the current drugs for treating pediatric epilepsy are poor in treatment effect and have side effects. The traditional Chinese medicine cinnabar-ginseng pill is prepared through the steps of weighing 3-5 parts of ginseng, 3-5 parts of cinnabar and 3-5 parts of clam powder, baking, co-grinding into fine powder, and pilling in the size of parasol tree seeds with pig heart blood. The usage and dosage are as follows: the pill is orally taken 2-3 times every day by 1.5-2.5g every time, and the dosage for children is halved; the pill can be orally taken continuously. The traditional Chinese medicine cinnabar-ginseng pill has the aims and advantages that the total effective rate for pediatric epilepsy treatment is over 95%, and the cure rate is over 80%. The traditional Chinese medicine cinnabar-ginseng pill is free from toxic and side effects.

The invention discloses a traditional Chinese medicine composition for treating pediatric epilepsy. The traditional Chinese medicine composition for treating the pediatric epilepsy is prepared from the following raw materials in parts by weight: 3-9 parts of polygonum multiflorum, 6-9 parts of semen cuscutae, 6-12 parts of schisandra chinensis, 4-10 parts of mulberry leaf, 9-16 parts of blackend swallowwort root, 6-15 parts of tangerine leaf, 5-12 parts of rehmannia root, 8-16 parts of radix paeoniae alba, 9-12 parts of medicinal cyathula root, 4-8 parts of centella, 8-12 parts of dried tangerine or orange peel, 5-9 parts of radix ophiopogonis, 8-12 parts of crude fossil fragment, 25-45 parts of raw oyster shell, 6-15 parts of gardenia fructus, 3-6 parts of lysimachia longipes, 6-12 parts of bamboo shavings, 5-15 parts of fried fructus aurantii, 3-6 parts of raw liquorice and 3-6 parts of irkutsk anemone rhizome. The traditional Chinese medicine composition for treating the pediatric epilepsy has an obvious therapeutic effect on the pediatric epilepsy and has the effects of stabilizing wind, tranquilizing mind, promoting blood circulation, removing blood stasis, reducing phlegm, inducing resuscitation, promoting qi circulation and relieving depression. The traditional Chinese medicine composition for treating the pediatric epilepsy has the advantages that local common medicinal materials are chosen mainly, the cost is low and financial burden of a patient is reduced.

The invention provides a traditional Chinese medicine composition for treating pediatric epilepsy. The traditional Chinese medicine composition is prepared from the following bulk drugs in parts by weight: 5 to 7 parts of ocher, 1 to 3 parts of magnetitum, 2 to 4 parts of Chinese angelica, 1 to 3 parts of natural cinnabaris, 1 to 3 parts of succinum, 1 to 3 parts of arisaema cum bile, 5 to 7 parts of ramulus uncariae cum uncis, 4 to 6 parts of scolopendra, 5 to 7 parts of scorpion, 1 to 3 parts of cornu saigae tataricae, 4 to 6 parts of bombyx batryticatus, 5 to 7 parts of liquorice root and 2 to 4 parts of altai anemone root. The traditional Chinese medicine composition for treating the pediatric epilepsy, provided by the invention, has good curative effect on the pediatric epilepsy.

The invention discloses a traditional Chinese medicine preparation for treating pediatric epilepsy as well as a preparation method and an application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10-16 parts of smallfruit fig aerial roots, 5-12 parts of liquidambar formosana hance and 22-30 parts of leatherleaf mahonia. The method comprises the following steps: cleaning, airing and frying the smallfruit fig aerial roots, and grinding into powder to obtain smallfruit fig aerial root powder; crushing liquidambar formosana hance and leatherleaf mahonia, sieving, adding water to decoct twice, mixing decoctions, concentrating, adding ethanol, standing and filtering to obtain an ethanol mixed solution; adding the smallfruit fig aerial root powder to the ethanol mixed solution, heating, stirring and then adding water; and heating, stirring, concentrating, drying and pelletizing the mixed solution to obtain the traditional Chinese medicine preparation for treating the pediatric epilepsy. The traditional Chinese medicine preparation is used for treating the pediatric epilepsy, and has the advantages of being fast in acting, accurate in medicine effect and free of toxic or side effect; the damage to the brain nervous function can be reduced; the traditional Chinese medicine preparation is wide in material source, low in cost, simple to prepare, good in long-term curative effect and not easy to recur; and the drug resistance is not easy to generate.

The invention discloses a decoction medicament for treating pediatric epilepsy and a preparation method of the decoction medicament. The decoction medicament comprises the following components in parts by mass: 1-3 parts of rhizome of manyleaf paris, 1-3 parts of white silkworm, 1-3 parts of grass leaf sweelflag rhizome, 1-3 parts of gambir plant, 1-3 parts of prepared arisaema with bile and 1-3 parts of turmeric root-tuber. The preparation method of the medicament comprises the following steps: selecting high-quality clean first-class rhizome of manyleaf paris, white silkworm, grass leaf sweelflag rhizome, gambir plant, prepared arisaema with bile and turmeric root-tuber in parts by mass, and removing impurities and dust respectively for later use; and putting the medicaments into a cloth bag, tying the cloth bag, then soaking in cooled boiled water for about half an hour, then putting the well soaked medicaments and the clear liquor for soaking the medicaments into a domestic medicine decoction machine according to a degree of penetrating medicament structures, injecting cooled boiled water until the cooled boiled water is 38mm higher than the medicament level, performing decoction for the first time for 30 minutes, filtering the liquid medicine, injecting warm boiled water until the warm boiled water is 30mm higher than the medicament level, performing decoction for the second time for 25 minutes, mixing the liquid medicines and concentrating into 900ml of 50% traditional Chinese medicine liquid, bagging and sealing.

The invention belongs to the technical field of medicines, in particular to a liposome micro-capsule for preventing and treating pediatric epilepsy and a method for preparing the liposome micro-capsule. The liposome micro-capsule comprises compatible components from plant traditional Chinese medicine raw materials and animal raw materials including cornu cervi pantotrichum, hippocampus, placenta hominis, pig spinal marrow and sea cucumber, and is prepared by specially manufactured pressure-resistant containers and the corresponding method by the aid of combined processes of smashing, anoxic extraction, medicine yeast fermentation, compound enzymatic hydrolysis, fine filtration, gel mist spray, freeze drying and the like. The liposome micro-capsule and the method have the advantages that the liposome micro-capsule comprises the unique components, is free of toxic and side effects and stable in quality, can be permeated through blood brain barriers and can be conveniently administered bychildren, the processes are innovative, and obvious curative effects can be realized.

The invention discloses a traditional Chinese medicinal preparation for treating pediatric epilepsy in the attack stage. Pediatric epilepsy is called as 'epilepsy' in traditional Chinese medical literature and attacks brain, heart, liver, spleen and kidney, the pathogenesis characteristics are evil excess and healthy energy deficiency, and phlegm is the key of pathology. The pediatric epilepsy in the attack stage is caused by phlegm due to spleen deficiency and anemophlegmatic orifice accumulation. The traditional Chinese medicinal preparation is prepared from the following traditional Chinese medicinal materials with effects of eliminating phlegm for resuscitation, clearing heat and arresting epilepsy: hyacinth dolichos stem, calamus, fructus gleditsiae, lycianthes biflora, lespedeza formosa root, ajuga decumbens thunb, ternate grape fern herb, white quartz, cladonia fallax abbayes and gigantism rhodobryum herb. Clinical tests on 55 affected infants indicate that the total effective rate of the traditional Chinese medicinal preparation is 98.2 percent, and the traditional Chinese medicinal preparation has a remarkable curative effect and low treatment cost. The preparation method is simple and convenient.

The invention discloses a traditional Chinese medicinal composition for treating pediatric epilepsy during an attack period. The pediatric epilepsy is induced by craniocerebral trauma, birth injury or collateral damage, and is represented as stagnation of blood stasis and obstruction in collaterals, therefore the symptom may result in sudden faint. For the reason, the traditional Chinese medicinal composition is a traditional Chinese medicinal preparation prepared from the following traditional Chinese medicines: campsis grandiflora, laxflower pottsia root, euphorbia humifusa, wilson passion flower, white-flowered agapetes, winter jasmine, red rhodobryum, yichang meadow rue, Japanese peristrophe herb and vittaria flexuosa which function as promoting blood circulation and dissolving stasis, relieving convulsion and treating epilepsy. A clinical test in the hospital shows that the traditional Chinese medicinal composition is significant in curative effect and achieves a total effective rate of 95.8%, so that the traditional Chinese medicinal composition is worthy of clinical popularization and application.

The invention relates to traditional Chinese medicine cinnabar-saltpeter powder for treating pediatric epilepsy. The traditional Chinese medicine cinnabar-saltpeter powder is mainly used for solving the problem that the current drugs for treating pediatric epilepsy are poor in treatment effect and have side effects. The traditional Chinese medicine cinnabar-saltpeter powder is prepared through the steps of weighing 15-18 parts of raw white alum, 15-18 parts of cinnabar, 15-18 parts of red halloysite and 15-18 parts of saltpeter, baking, co-grinding into fine powder, and grinding garlic paste, so as to pill in the size of mung beans. The pill is orally taken by 2g once every day for the adult, and the dosage for children is halved; the pill can be orally taken continuously. The traditional Chinese medicine cinnabar-saltpeter powder has the aims and advantages that the total effective rate for pediatric epilepsy treatment is over 95%, and the cure rate is over 80%. The traditional Chinese medicine cinnabar-saltpeter powder is free from toxic and side effects.

The invention discloses a traditional Chinese medicine composition for mainly treating pediatric epilepsy. The traditional Chinese medicine composition is mainly prepared from, by mass, 10-15 parts of caulis bambusae in taeniam, 8-16 parts of rhodobryum roseum, 9-13 parts of fraxinus malacophylla, 6-12 parts of pennycress seeds, 7-14 parts of dichotomy forked fern frond, 10-16 parts of corn stigma, 7-15 parts of autumn zephyrlily herb, 8-13 parts of ophiopogon roots, 6-15 parts of sorghum roots, 7-13 parts of rheum acuminatum, 9-14 parts of dutch bract flowers, 7-12 parts of radix gentianae, 10-14 parts of potentilla chinensis and 8-12 parts of rhizome of fokien angiopteris. The traditional Chinese medicine composition is good in treatment effect, prevents relapse, produces few adverse effects, is suitable for epilepsy children, completely meets traditional Chinese medicine rules, has the effects of reducing phlegm, eliminating evil, invigorating the circulation of blood, opening orifices and the like, is prepared from Chinese medicinal herb materials which are low in cost and easy to obtain, is low in cost and produces no obvious toxic or side effect if being taken for a long time.

The invention discloses a traditional Chinese medicine preparation for treating attack-stage convulsive pediatric epilepsy. The disease is internally caused by congenital defect and fetal disease. Attack-stage convulsive pediatric epilepsy is often caused by fetal frightening or frightening at infancy. The traditional Chinese medicine preparation is prepared from the following medicinal materials having the effects of relieving convulsion, soothing the nerves, dispelling the wind and treating epilepsy: plagiopus oederi limpr, medical angiopteris rhizome, madagascar periwinkle herb, sensitive plant, marigold, alpine swertia, sowthistle tasselflower herb, tansy, nerved elecampane root and root of procumbent Indian mallow. As proved by clinical test, the Chinese medicinal preparation is remarkable in curative effect, up to 94.3 percent in total effective rate, and worthy of clinical popularization and application.

The invention discloses a traditional Chinese medicine formula for treating pediatric epilepsy. The traditional Chinese medicine formula is prepared from the following traditional Chinese medicines in parts by weight of cinnabar, red tangerine peel, alum, rhizoma pinelliae, bighead atractylodes rhizome, hawksbill shell, honey-fried licorice root, dragon bone, tabasheer, caulis bambusae in taenian, rhizoma arisaematis, arisaema cum bile, stiff silkworm, lumbricus, rhizoma typhonii, radix pseudostellariae, scorpion, centipede strip and iron chippings. Pure traditional Chinese medicine formula is adopted, therefore, the whole body is more beneficial to digestion and absorption of a human body, no obvious side effect exists, and the chronic disease can be expected through long-term taking.

The invention relates to a traditional Chinese medicine cinnabar-realgar pill for treating pediatric epilepsy. The traditional Chinese medicine cinnabar-realgar pill is mainly used for solving the problem that the current drugs for treating pediatric epilepsy are poor in treatment effect and have side effects. The traditional Chinese medicine cinnabar-realgar pill is prepared through the steps of weighing 3-5 parts of chlorite schist, 9-11 parts of cinnabar, 3-5 parts of realgar, 3-5 parts of toad, 7-9 parts of iron powder and 6-8 parts of pyrite nodule, baking, co-grinding into fine powder, immersing with water, steaming to form cakes, and pilling in the size of parasol tree seeds. The usage and dosage are as follows: the pill is orally taken 2-3 times every day by 0.05-0.1g every time, the dosage for children is halved, and peppermint soup is decocted to dissolve the cinnabar-realgar pill; the pill can be orally taken continuously. The traditional Chinese medicine cinnabar-realgar pill has the aims and advantages that the total effective rate for pediatric epilepsy treatment is over 95%, and the cure rate is over 80%. The traditional Chinese medicine cinnabar-realgar pill is free from toxic and side effects.

The invention discloses a preparation for treating pediatric epilepsy. The preparation is prepared from the following raw materials in parts by weight: 7 to 12 parts of radix ophiopogonis, 9 to 14 parts of fraxinus malacophylla, 6 to 15 parts of sorghum roots, 8 to 14 parts of radix gentianae, 7 to 15 parts of bergamot roots, 6 to 12 parts of semen thlaspi, 9 to 13 part of crocus sativus, 10 to 14 parts of autumn zephyrlily herbs, 8 to 13 parts of wisteria roots, 11 to 15 parts of corn stigma, 8 to 12 parts of calceolaria crenatiflora, 9 to 15 parts of all grass of Buchnera cruciata Ham, 11 to 16 parts of lily and 7 to 16 parts of herba adenostemmatis. The preparation has good effects that medicines complement each other and have the effects of stabilizing wind, calming nerves, promoting blood circulation to remove blood stasis, dissipating phlegm for resuscitation, promoting qi circulation and relieving depression, and the preparation has an obvious effect of treating the pediatric epilepsy.

The invention discloses sodium valproate-containing sustained-release transdermal patch as well as a preparation method and application thereof. The sustained-release transdermal patch comprises a back lining layer, a medicine-containing layer and a protective layer, wherein the medicine-containing layer comprises sodium valproate, a complexing agent, an adhesive, a transdermal improver, a bacteriostatic agent and a hot-melt pressure-sensitive adhesive. The preparation method comprises the following steps: heating and melting the hot-melt pressure-sensitive adhesive, adding the sodium valproate, the transdermal improver, the adhesive, the complexing agent and the bacteriostatic agent into the hot-melt pressure-sensitive adhesive to dissolve, mixing uniformly, performing ultrasonic degassing, coating the surface of the protective layer with the mixture to form the medicine-containing layer, and covering the surface of the dried medicine-containing layer with the back lining layer; cutting and packaging. The sodium valproate-containing sustained-release transdermal patch can serve as a medicine for treating pediatric epilepsy. The sodium valproate-containing sustained-release transdermal patch has medicine release uniformity and mild and durable effect, can effectively reduce the administration times, is convenient in dosage adjustment, is convenient to carry, has high patient adaptability, and solves the problem that infantile administration is difficult.