The invention discloses a traditional Chinese medicine composition for painlessly removing gall stone and a taking method. A decoction is prepared from lysimachia christinae hance, sculellaria barbata, dandelion, S.yunnanensis, spicate clerodendranthus herb, vicia sativa, Cynanchum amplexicaule (Sieb. et Zucc.) Hemsl., oriental wormwood, pericarpium citri reticulatae viride, semen plantaginis, corn stigma, honeysuckle stem, radix gentianae, sensitive plant, silybum marianum, lawn pennywort herb and astragalus membranaceus; powdered medicine is prepared from bryozoatum, talc, natural caffeine, amber, scutellaria baicalensis, costusroot, membrane of goose gizzard, lygodium japonicum, polygonum cuspidatum, coix lacryma-jobi roots, curcuma aromatica, cape jasmine, turtle shells and rheum officinale. Under the experience guidance of the traditional Chinese medicine theory and application to clinical practice in lots of cases, through the combination of secret prescription handed down from ancestors and folk remedies, authentic medicine and formulas are selected; the functions of clearing heat and promoting diuresis, tonifying kidneys and qi, and cracking toughness and removing urinary calculus are achieved; the composition is good in curative effect, free of pain, rapid in effect, free of side effects, and simple in preparation method; the formula is prepared from the decoction and the powdered medicine, and raw medicine is decocted into the decoction in the use process; one dosage is divided into two parts everyday, the powered medicine is added to the warm decoction to be mixed and then taken after breakfast and dinner, a user drinks a large volume of warm boiled water after taking the medicine, urinary calculus removal is facilitated by enhancing the activity, and one treatment course includes ten days.