115 results about "Aminopyralid" patented technology

An herbicidal composition containing (a) aminopyralid and (b) 2,4-D provides synergistic control of selected broadleaf weeds.

An herbicidal composition containing (a) aminopyralid and 2,4-D and (b) atrazine provides synergistic control of selected weeds in corn, sorghum, sugar cane and range and pasture.

The invention discloses a substituted 2-aminopyridine inhibitor for protein kinase, and concretely relates to 2-aminopyridine derivatives with protein kinase inhibition activity, a preparation method thereof, and pharmaceutical compositions thereof, and the invention also discloses application of the compounds and the pharmaceutical compositions thereof to treat diseases related to protein kinase.

An herbicidal composition containing (a) propyzamide and (b) aminopyralid provides synergistic control of selected weeds in oilseed rape and in broadleaf, grass and perennial crops.

A process for synthesizing the unsymmetrical dipyridinyl substituted urea derivative features the reaction between aminopyridine derivative, nitropyridine derivative, Se or SeO2 as catalyst, and triethylamine as cocatalyst in organic solvent at 50-200 deg.C in a sealed high-pressure reactor for 2-20 hr. Its advantages are simple process and high output rate.

The invention relates to a herbicide composition for a wheat field. The herbicide composition contains effective components including florasulam, aminopyralid (or salt compounds of aminopyralid) and a phenoxy carboxylic acid herbicide, wherein the phenoxy carboxylic acid herbicide is one selected from 2-methyl-4-chlorophenoxyacetic acid, 2-methyl-4-chlorophenoxyacetic acid sodium salt, 2-methyl-4-chlorophenoxyacetic acid-isooctyl, 2,4-D, 2,4-D butyl ester and 2,4-D isooctyl ester. The herbicide composition disclosed by the invention has a synergistic effect and is remarkably better than each independently-used agent in effect on preventing and removing annual weeds in the wheat field; and by using the herbicide composition, the herbicide controlling spectrum is widened, meanwhile, the dosage is reduced, the generation of herbicide resistance of the weeds is delayed, and the environment pollution is relieved.

The invention provides a synthesis method of 2-amino pyridine compounds, belonging to the technical field of organic synthesis. The existing synthesis method has the disadvantages of difficult acquisition of raw materials, high catalyst cost, complicated reaction steps, harsh reaction conditions, serious environmental pollution, low yield, few substituent groups, specific substituent positions and atomic diseconomy. The synthesis method provided by the invention is characterized by comprising the following steps of: adding a 2,4-pentadiene nitrile compound and an amine compound in a molar ratio of 1.0:(1.0-2.5) to a solvent to form a reaction mixture; adding a base the amount of which is 0-250mol% of a substrate while stirring the reaction mixture; and then stirring at the temperature from room temperature to 150 DEG C for 3-24 hours to obtain a product namely the 2-amino pyridine compound. The synthesis method provided by the invention lowers the catalyst cost, relieves the pollution, simplifies the synthesis processes, has the advantages of mild reaction conditions, easy acquisition of raw materials, light side reaction, many substituent groups and wide application range, and has the yield of 58-81% depending on different reactions.

The invention provides synergistic weeding composition containing pinoxaden and mesosulfuron-methyl. The synergistic weeding composition is characterized by comprising active components A and B, wherein the active component A contains pinoxaden and mesosulfuron-methyl; the active component B contains one or combination of more than one of carfentrazone-ethyl, flufenacet, pyraflufen-ethyl, bromoxynil octanoate, fenoxaprop-P-ethyl, aminopyralid, flurochloridone and flupoxam; the synergistic weeding composition further contains auxiliaries capable of being used in pesticide preparation processing, conventional pesticide preparations are prepared, and the weeding composition is applied to control for unnecessary plants.

The invention relates to a preparation method of fluoropyridine compounds. Aminopyridine compounds are brominated and fluorinated by an improved Blaz-Schiemann, or nitropyridine compounds are brominated, denitrified and fluorinated to obtain the fluoropyridine compounds. The invention overcomes the defects of harsh reaction conditions and multiple side reactions in most fluorination processes, has the advantages of scientific design of synthetic technique and simple and reliable execution route, and is suitable for suitable for industrialization. The technical route of the five related compounds is novel in design, and the reactions are mostly carried out at normal temperature, so the reaction energy consumption is lower; and the reaction steps are subjected to optimized solvent selection and condition control, so that the yield is higher than the traditional reaction route, and the invention is very suitable for large-scale mass production.

The invention relates to a method for preparing a poly-substituted 1, 5-naphthyridine compound. The method comprises the steps of: mixing 3-aminopyridines compound shown in constitutional formula (II), (III) or (IV) with 2-alkenyl aldehyde or 2-alkenyl ketone; adding green vitriol as a catalyst; carrying out heating reflux reaction in sulphuric acid for 2 to 20 hours; cooling a reaction system till the temperature of the reaction system reaches room temperature and then regulating pH value to be neutral; filtering the reactants and extracting, concentrating, separating and refining the filtrate to obtain the poly-substituted 1, 5-naphthyridine compound shown in constitutional formula (I). The method can be applied to various substrates and materials are highly available; poly-substituted 1, 5-naphthyridine compound banks with diverse structures can be synthesized by optimizing and regulating substrates involved in the reaction, and the compounds can be widely applied to the fields such as pharmacochemistry, biomedicine, materials science and the like.

The invention discloses a method for preparing flupirtine maleate by a one-pot method. The method is characterized in that 2-amino-3-nitro-6-pyridine and 4-fluorobenzylamine serve as starting materials, and condensation, raney nickel reduction, ethyl chloroformate acylation and maleic acid salification are accomplished in a reactor without intermediate separation. The total yield of flupirtine maleate is increased from below 40% of a step-by-step method to above 70%, and the purity of a crude product is greater than 99%. According to the method, the technical flow is shortened, equipment is decreased, and the problem of high oxidation stain possibility of aminopyridine intermediates in a separation process is effectively solved. The feasibility and controllability of the one-pot method is proven by small-scale and pilot-scale studies, and the method is a handleable and environment-friendly manner to prepare flupirtine maleate, and is suitable for industrial production.

The invention discloses a microbial pesticide and a preparing method thereof. The microbial pesticide is prepared from, by weight, 40-50 parts of aphid killing powder, 1-5 parts of garlic oil, 20-40 parts of quinclorac, 8-12 parts of hirsutella thompsonii fisher powder, 4-8 parts of thiopyran diketone, 6-10 parts of verticillium powder, 5-9 parts of acetochlor, 2-6 parts of sophocarpidine, 1-5 parts of thiencarbazone-methyl, 1-5 parts of rhizoma cyrtomii, 1-6 parts of radix sophorae flavescentis, 1-5 parts of aminopyralid, 15-25 parts of microzyme, 4-8 parts of herba houttuyniae and 1-5 parts of octylphenol polyoxyethylene ether sulfonate. According to the microbial pesticide and the preparing method thereof, microorganism powder and plant raw materials serve as main materials, the raw materials are easy to obtain, the price is low, the adopted raw material ratio is simple, environment friendliness is achieved, the cost is low, the pesticide is excellent in effect, safe, efficient and good in degrading effect, and few residues are generated.

The invention discloses a preparation method of an imidazo-[1,2-a] pyridine compound. The preparation method comprises the following steps of: (1) adding 2-aminopyridine compound, a propiophenone compound and a condensation catalyst to an organic solvent, and heating for condensation reaction, wherein an imine intermediate is obtained after complete reaction; (2) adding a copper catalyst, an oxidizing agent, alkali the imine intermediate obtained from the step (1) to the organic solvent, heating for ring closing reaction, and carrying out post processing to obtain the imidazo-[1,2-a] pyridine compound after the complete reaction. The preparation method disclosed by the invention has the advantages of wide source, cheapness and easiness for obtaining of used raw materials, namely the 2-aminopyridine compound and the propiophenone compound, is easy to operate without a complex post processing process and is suitable for the large-scale preparation of the compound.

The invention discloses a preparation method for a silver extraction material. The preparation method comprises the following two steps: selecting specific fibers, using an organic alcohol type compound as a solvent, adding a balanced amount of aminopyridine reagent, and generating a reaction at a certain temperature; separating the fibers after reaction, cleaning the fibers by using a balanced amount of distilled water, and drying the fibers in an extraction manner; taking the dried fibers, utilizing a chlorinated alkane type reagent as a solvent, adding a balanced amount of hydroxylamine type reagent, and enabling reaction at a certain temperature; separating the fibers after the reaction, cleaning the fibers by using the distilled water, treating the fibers by using HCl, cleaning the fibers again by using the distilled water, and then drying in the extraction manner. According to the preparation method for the silver extraction material, an acrylonitrile polymer is taken as a framework, and an alcohol type reagent is taken as a solvent, so that amino modification is performed; and then the chlorinated alkane type reagent is utilized as a solvent, thereby hydroxylamine modification is performed; therefore, high-efficiency ion exchange fiber materials are prepared. The preparation method provided by the invention is simple to operate and low in cost, and can effectively solve silver recycle and utilization problems.

The invention discloses a corn field weeding composition. Effective components comprise halosulfuron-methyl, aminopyralid (salt compounds thereof) and thiencarbazone-methyl, wherein the weight percent of halosulfuron-methyl in the composition is 0.1%-10%, the weight percent of aminopyralid (salt compounds thereof) in the composition is 0.1%-40%, and the weight percent of thiencarbazone-methyl in the composition is 0.1%-10%. The weeding composition has a remarkable synergistic interaction effect; the effect of preventing and removing annual weeds in a corn field is obviously better than the effect of a single dosage, and the use amount of the effective components of the composition is obviously reduced when being compared with the effect of using the single component; and the weeding spectrum is expanded, the production of weed drug resistance is delayed and the pollution to the environment is alleviated.

The invention provides a synergetic weeding composition containing thiencarbazone-methyl. The synergetic weeding composition is characterized by comprising active components A and B, wherein the component A is thiencarbazone-methyl; the component B is selected from one or combination of one or more of pinoxaden, bicyclopyrone, flucetosulfuron, aminopyralid, metamifop, glufosinate-p, aminocyclopyrachlor and tiafenacil. The synergetic weeding composition also comprises additives used for processing pesticide preparations. The synergetic weeding composition can be prepared into a conventional pesticide preparation and can be used for controlling unwanted plants.

The invention provides a quantitative determination method of aminopyridine carcinogenic substances in meat products. The quantitative determination method comprises a step of meat product pretreatment, and a step of UHPLC-MS / MS quantitative determination. The meat product pretreatment step mainly comprises following steps: a trichloroacetic acid aqueous solution is added, and homogenizing is carried out; ultrasonic extraction and centrifugation are carried out, and a supernate is collected; pH value of the supernate is adjusted, and the supernate is delivered through an activated MCX small column; a hydrochloric acid solution, a methanol solution, and ammonium hydroxide-methanol are used for elution successively; and acetonitrile is added for redissolving, and a caffeine methanol solution is added. In the step of UHPLC-MS / MS quantitative determination, UHPLC-MS / MS detection is carried out, retention time of a standard substance and retention time in a sample spectrum are compared, and the content of the aminopyridine carcinogenic substances in barbecue is obtained via calculation. Compared with the prior art, the quantitative determination method possesses following advantages: accuracy rate is increased, adding standard recovery rate is increased, the pretreatment steps are simplified, detection cost is reduced, detection limit is low, accuracy is high, repeatability is high, and the quantitative determination method can be used for quantitative determination of aminopyridine compounds in a plurality of commercially available meat products.

The invention relates to a cornfield weeding composite. The cornfield weeding composite comprises the effective components including thiencarbazone-methyl, aminopyralid (or a salt compound) and mesotrione. The cornfield weeding composite has a synergistic interaction function, annual weed prevention and removal effect in the cornfield achieved by using the weeding composite is obviously superior to that achieved by separately using single dosage; moreover, the herbicide controlling spectrum is enlarged; meanwhile, the pesticide using amount is reduced, the production of weed pesticide-resistant property is delayed, and the pollution to the environment is reduced.

The invention relates to the daily chemical field and the medical industry, and particularly relates to aminopyridine type acetyl synanthrin and a preparation method thereof. The structural formula of the aminopyridine type acetyl synanthrin is as shown in formula (1) in the specification. The preparation method comprises the following steps: firstly, reacting synanthrin with chloroacetyl chloride, then reacting with aminopyridine, and purifying to finally obtain the aminopyridine type acetyl synanthrin as shown in the formula (1), wherein the molar weight of chloroacetyl chloride is 1-2 times that of the synanthrin; the molar weight ratio of the aminopyridine to acetyl synanthrin is (2-3):1. According to the aminopyridine type acetyl synanthrin and the preparation method provided by the invention, the reaction is simple and convenient, high efficiency is realized, promotion is easy to implement, and required equipment and raw materials are easy to get. A research shows that the derivative has good water solubility and remarkable antioxidant activity, improves the biological activity of the synanthrin, widens the application range of the synanthrin, and can be widely applied to the daily chemical and medical fields.

The invention relates to a medicinal plant weeding composition, which is characterized in that clopyralid, picloram or aminopyralid and benazolin are used as main active components; and weight ratio of clopyralid to picloram or aminopyralid to benazolin is 1-50:1-50:1-50. The weeding composition is used for treatment of postemergence stem leaf in oilseed rape fields and / or medicinal plant fields, is applied in prevention and removal of field weeds, and has a remarkable synergistic effect.

The invention provides a hydroxamic acid fragment-containing aminopyridine derivative as shown in a formula V, pharmaceutically acceptable salt thereof as well as application of the aminopyridine derivative to anti-tumor aspect (the formula is shown in the description). The compound has high protein kinase inhibition activity and histone deacetylase inhibition activity, has high inhibition activity on various human tumor cells, has weak inhibition effect on normal cells, has low toxicity and is suitable for being applied to development of anti-tumor medicines.

The invention discloses a composite herbicide and a preparation method thereof. The composite herbicide comprises raw materials in parts by weight as follows: 40-50 parts of quinclorac, 10-20 parts of cyclohexanedione, 10-15 parts of thiopyrandione, 6-10 parts of acetochlor, 8-12 part of chloroacetamide, 5-9 parts of thiencarbazone-methyl, 4-8 parts of aminopyralid, 1-5 part of sodium dibutylnaphthalenesulfonate, 13-17 parts of a surfactant and 20-40 parts of an assistant. The composite herbicide and the preparation method thereof have the advantages that the weed removal effect is very good, and the herbicide is safe and efficient and has good degradation effect and few residues.

The invention relates to a method for synthesizing a compound represented by a formula (1) or a formula (2) or a formula (3) shown in the description. The method specifically comprises the steps of putting an o-amino nitrogen heterocyclic compound, a 2-oxo acetophenone derivative and a transition-metal salt catalyst into an organic solvent, carrying out a heated reaction in an oxygen-containing atmosphere, and subjecting the reaction solution to aftertreatment after the reaction ends, thereby obtaining the compound represented by the formula (1) or formula (2) or formula (3). 2-amino heterocyclic compounds are 2-aminopyridine compounds or 2-aminobenzo[d]thiazole compounds or 1-amino isoquinoline. According to the method disclosed by the invention, the operation is simple, the reaction conditions are mild, the byproduct is restricted to water, the reaction yield is high and reaches 97% to the maximum, and two kinds of heterocyclic compounds synthesized have pharmacological properties and can serve as important precursors of medicines.

The invention discloses a mixed herbicide containing aminopyralid and quinclorac, which belongs to the technical field of pesticide. The herbicide uses aminopyralid and quinclorac as main effective components, wherein the mass ratio of aminopyralid to quinclorac is 0.1-80: 0.1-80. The mixed herbicide provided by the invention is applied to non-cultivated land, orchards, woodland, paddy fields and wheat paddocks for post-emergence weeding and has the advantages of a wide weed control spectrum, fast action, high efficiency, low toxicity, safety, environment friendliness and the like.

The invention relates to a wheat field composite herbicide containing quinmerac and tribenuron-methyl. The herbicide is characterized in that the herbicide comprises main effective components A, B and C, wherein A is quinmerac, B is tribenuron-methyl, C is any one of clopyralid, aminopyralid, chipton, and carfentrazone-ethyl; the weight ratio of A:B:C is 1-150:1-20:0.1-50, the herbicide is used for wheat field post-emergence stem leaf treatment, and is used for control of broad-leaf weeds with substantial synergistic effects, such as Galium aparine, Veronica didyma, Shepherdspurse, Stellaria media, Stellaria uliginosa, and the like.

The invention discloses pyridine weeding composition containing brassinolide compounds. The composition comprises active components and synergistic safeners, wherein the active components comprise aminopyralid and florpyrauxifen-benzyl; the synergistic safeners comprise the brassinolide compounds, sodium alginate and dimethachlon. According to the composition, aminopyralid and florpyrauxifen-benzyl with different herbicidal spectra and complementary advantages and disadvantages are selected and form a mixture for use, so that the weed control spectrum is expanded, the weeding effect is obviously improved, the possibility of phytotoxicity to crops in season and residual toxicity to subsequent crops is also avoided, and occurrence and development of single-dose resistance are effectively delayed.

The invention provides a sugarcane herbicide. The sugarcane herbicide is prepared from components in parts by weight as follows: 100 parts of water, 5-15 parts of permethrin, 8-12 parts of aminopyralid, 2-10 parts of methothrin, 6-10 parts of cyhalothrin, 1-5 parts of allethrin, 7-9 parts of acetochlor, 2-4 parts of penoxsulam, 1-3 parts of ethoxysulfuron, 6-8 parts of fentrazamide, 40-50 parts of glycerin and 4-6 parts of tetrabutylammonium bromide. The formula is reasonable, the sugarcane herbicide has excellent weeding effect on various weeds affecting yield and quality of sugarcane and is high in weeding time effectiveness, safe and efficient, the chemical degrading effect is good, and few residues are produced.

The invention discloses a mixed herbicide containing aminopyralid and clopyralid, belonging to the technical field of pesticides. The herbicide takes aminopyralid and clopyralid as main active ingredients, wherein the mass ratio of aminopyralid to clopyralid is (0.1-80) to (0.1-80). The mixed herbicide has the advantages of quickness in effect taking, wide weeding spectrum, long lasting period, thoroughness in weeding, low residues, low toxicity, safety, environment friendliness, and the like when being applied to post-emergence weeding on non-cultivated lands, forest lands, pastures and lawns and in orchards and wheat fields, and is a high-quality chemical herbicide applied to the non-cultivated lands, orchards, forest lands, pastures, lawns and wheat fields.

Disclosed herein are herbicidal compositions comprising a synergistically herbicidal effective amount of (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) aminopyralid, or an agriculturally acceptable salt or ester thereof. Also disclosed herein are methods of controlling undesirable vegetation, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) aminopyralid, or an agriculturally acceptable salt or ester thereof, wherein (a) and (b) are each added in an amount sufficient to produce a synergistic herbicidal effect.