The invention provides a composition for preventing and controlling local harmful vines. The composition is prepared from
picloram, 2,4-dichlorphenoxyacetic acid, bentazone and sulfometuron, wherein the
mass ratio of the
picloram to the 2,4-dichlorphenoxyacetic acid to the bentazone to the sulfometuron is (20-30) to (2-5) to (0.5-2) to (0.5-1), and the
mass percent after combination is 24-30% of the total
mass of the composition. The composition is further prepared from a cosolvent, the cosolvent is prepared from alkylbenzene
sulfonate, a dispersing agent and a
thickening agent, the mass ratioof which is 1 to 1 to (2-1) to 1 to 4, the mass percent after combination is 2-6% of the total mass of the composition. According to the composition, various raw materials have complementary advantages and synergistic effects, the effectiveness of killing the local harmful vines is remarkable, the dosage is low during use, the
phytotoxicity caused to trees and shrubs is small, the
pollution to soil is small, and the
ecological safety is high. The invention further provides application of the composition for preventing and controlling the local harmful vines.