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2 results about "Azulene" patented technology
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Azulene is an organic compound and an isomer of naphthalene. Whereas naphthalene is colourless, azulene is dark blue. Two terpenoids, vetivazulene (4,8-dimethyl-2-isopropylazulene) and guaiazulene (1,4-dimethyl-7-isopropylazulene), that feature the azulene skeleton are found in nature as constituents of pigments in mushrooms, guaiac wood oil, and some marine invertebrates.
Preparation process of sodium azulene sulfonate
This invention relates to the field of pharmaceutical formulation technology, specifically disclosing a preparation process for sodium azulene sulfonate. The preparation process includes: adding sodium azulene sulfonate and a modified polysaccharide derivative to a solvent and stirring until completely dissolved to form a homogeneous organic phase solution; adding the organic phase solution dropwise to deionized water under stirring to form a nano-micelle dispersion; dialyzing the nano-micelle dispersion to obtain a nano-micelle solution; adding a lyophilization protectant to the nano-micelle solution and freeze-drying to obtain a lyophilized powder injection loaded with sodium azulene sulfonate. This invention solves the technical problem of low encapsulation efficiency and easy leakage of water-soluble drugs in conventional liposomes by forming a strong electrostatic complex between the amino groups in chitosan modified with uric acid and the sulfonate groups of sodium azulene sulfonate, supplemented by the hydrophobic self-assembly of uric acid, thus achieving effective encapsulation of highly water-soluble sodium azulene sulfonate. The preparation process of this invention is simple, using natural, inexpensive, and biocompatible raw materials, making it easy to scale up industrial production.
Owner:SHANDONG HUASU PHARM CO LTD
Particles containing sodium azulene sulfonate, oral preparation, and method for producing sodium azulene sulfonate particles
To provide sodium azulene sulfonate-containing particles, an oral formulation, and a method for producing sodium azulene sulfonate-containing particles, which exhibit excellent stability and high productivity. [Solution] A particle containing sodium azulene sulfonate, comprising (A) component: sodium azulene sulfonate, (B) component: antacid, and (C) component: binder, wherein component (A) exists in an amorphous state and substantially does not contain sugar alcohols.
Owner:LION CORP