Film agent containing alkannin and resisting oral ulcer inflammation and preparation and application thereof
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A technology for oral ulcers and shikonin, which is used in medical preparations containing active ingredients, anti-inflammatory agents, and medical preparations without active ingredients, etc., to achieve the effects of improving curative effect, relieving pain, and prolonging action time.
Inactive Publication Date: 2017-08-18
南京紫源康医药科技有限公司
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[0006] Purpose of the invention: In order to overcome the problems in the prior art that the film preparations for oral ulcers have good antibacterial and anti-inflammatory effects on wounds, but it is difficult to avoid drug resistance and allergic reactions, the present invention proposes a film-forming, waterproof It can prevent wound infection and promote wound healing without causing allergic reactions and drug resistance in patients, and it is convenient to carry the anti-oral ulcer inflammation film containing shikonin and its preparation method and application
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Embodiment 1
[0021] An anti-oral ulcer inflammatory film containing shikonin, comprising the following preparation raw materials by weight: 0.04 parts of shikonin, 2 parts of gamma-cyclodextrin, 5 parts of chitosan quaternary ammonium salt, polyvinylpyrrolidone K90 3 10 parts of bletilla striata gum, 1.2 parts of gelatin, 8 parts of ethyl cellulose, 92 parts of ethanol, and 45 parts of distilled water.
[0022] Wherein, the purity of the ethanol is 95%.
[0023] The above-mentioned preparation method of an anti-oral ulcer inflammation film containing shikonin comprises the following steps:
[0024] (1) Firstly weigh each preparation raw material according to the required amount for subsequent use;
[0025] (2) Dissolve 0.04g of shikonin and 1.2g of γ-cyclodextrin in 1-2mL of ethyl acetate, stir well, transfer to a distillation flask, then add 1-2mL of ethyl acetate and 0.8g of The γ-cyclodextrin transfers the remaining shikonin to the distillation flask, and rotary evaporates until there...
Embodiment 2
[0030] An anti-oral ulcer inflammatory film containing shikonin, comprising the following preparation materials by weight: 0.02 parts of shikonin, 2 parts of gamma-cyclodextrin, 3 parts of chitosan quaternary ammonium salt, polyvinylpyrrolidone K90 2 parts 8 parts of bletilla striata gum, 0.8 parts of gelatin, 10 parts of ethyl cellulose, 100 parts of ethanol, and 35 parts of distilled water.
[0031] Wherein, the purity of the ethanol is 95%.
[0032] The above-mentioned preparation method of an anti-oral ulcer inflammation film containing shikonin comprises the following steps:
[0033] (1) Firstly weigh each preparation raw material according to the required amount for subsequent use;
[0034] (2) Dissolve 0.02g of shikonin and 1.2g of γ-cyclodextrin in 1-2mL of ethyl acetate, stir well, transfer to a distillation flask, then add 1-2mL of ethyl acetate and 0.8g of The γ-cyclodextrin transfers the remaining shikonin to the distillation flask, and rotary evaporates until th...
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Abstract
The invention discloses a film agent containing alkannin and resisting oral ulcer inflammation, and preparation and application thereof. The film agent is prepared from the following materials in parts by weight: 0.01--0.05 part of alkannin, 1-3 parts of gamma-cyclodextrin, 0.25-15 parts of chitosan quaternary ammonium salt, 0.5-5 parts of polyvinylpyrrolidone K90, 5-30 parts of bletilla hyacinthine gum, 0.5-2 parts of gelatin, 3-10 parts of ethyl cellulose, 90-97 parts of alcohol and 20-50 parts of distilled water. The film forming agent is prepared according to a certain method and comprises two layers, namely a complete drug-loaded film and a blank film, one side of the drug-loaded film is stuck to the affected part, the blank film can stop drug from dissolving out in an oral cavity, so that the effect of one-way drug release is achieved, simultaneously bad taste of main medicines is covered, the drug is gathered to the affected part, the treating effect is improved, further the pain of patients is greatly relieved and the action time of the medicines is prolonged; and the effective-component alkannin in the medicine film has the anti-inflammation and bacteriostatic effects, namely inflammation diminishing, astringency and antipyresis. Simultaneously, the film agent is convenient to store and carry and can be easily industrialized.
Description
technical field [0001] The invention relates to the field of medical medicaments, in particular to an anti-oral ulcer inflammation film containing shikonin, a preparation method and application thereof. Background technique [0002] Oral ulcers, also known as recurrent aphthous ulcers, are the most common oral mucosal diseases with a high incidence rate and very easy to relapse. Clinically, it mainly manifests as round or oval small erosions scattered in the oral cavity, surrounded by congestion and edema, and patients often feel pain, which affects daily life activities such as eating and speaking. At present, it is believed that the main pathogenic factors of oral ulcers are related to the decline of the body's immune function. In addition, endocrine factors and mental factors will also affect the onset. Diabetes and those with low immune function will delay the healing time of ulcers. But so far, there is no medicine or method in the world that can completely cure oral u...
Claims
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Application Information
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