Oral ulcer treatment patch film and preparation method thereof

A technology for oral ulcers and film application in the field of medicine, which can solve problems such as side effects, restrictions on drug promotion and application, and drug dependence, and achieve the effects of prolonging the shelf life, accelerating swelling and healing, and promoting contraction

Active Publication Date: 2016-11-02
宁波市诚德医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the main drugs of oral patch currently used are hormonal drugs such as dexamethasone and dexamethasone acetate. Long-term use will produce drug dependence and serious side effects, which greatly limits the promotion and application of this drug.

Method used

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  • Oral ulcer treatment patch film and preparation method thereof
  • Oral ulcer treatment patch film and preparation method thereof
  • Oral ulcer treatment patch film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, a kind of oral ulcer patch

[0034] The oral ulcer patch consists of the following components and parts by weight thereof:

[0035] 5 parts of oleanolic acid, 8 parts of sodium alginate, vitamin B 6 2 parts, 3 parts of chitosan, 40 parts of film-forming agent, 10 parts of lauryl glucoside, 16 parts of tributyl citrate and 400 parts of distilled water; The composition of element and citric acid is 4:4:1.2 by weight.

[0036] Preparation:

[0037]S1 Take half of the amount of distilled water and heat it to 75°C, add half of the amount of film-forming agent and stir until it is completely dissolved, filter while it is hot, take the filtrate, add tributyl citrate to the filtrate, and stir evenly to obtain a glue solution;

[0038] S2 Cool the mucilage solution obtained in step S1 to 35°C and add oleanolic acid, sodium alginate diester, vitamin B 6 , stir evenly, then add chitosan and glucoside, mix evenly, remove air bubbles, spread the film, and dry at 62...

Embodiment 2

[0041] Embodiment 2, a kind of oral ulcer patch

[0042] The oral ulcer patch consists of the following components and parts by weight thereof:

[0043] 8 parts of oleanolic acid, 14 parts of sodium alginate diester, vitamin B 6 3 parts, 6 parts of chitosan, 56 parts of film-forming agent, 15 parts of lauryl glucoside, 24 parts of tributyl citrate and 480 parts of distilled water; The composition of element and citric acid is 5:3:0.8 by weight.

[0044] Preparation:

[0045] S1 Take half of the amount of distilled water and heat it to 80°C, add half of the amount of film-forming agent and stir until it is completely dissolved, filter while it is hot, take the filtrate, add tributyl citrate to the filtrate, and stir evenly to obtain a glue solution;

[0046] S2 Cool the mucilage solution obtained in step S1 to 40°C and add oleanolic acid, sodium alginate diester, and vitamin B 6 , stir evenly, then add chitosan and glucoside, mix evenly, remove air bubbles, lay a film, and ...

Embodiment 3

[0049] Embodiment 3, a kind of oral ulcer patch

[0050] The oral ulcer patch consists of the following components and parts by weight thereof:

[0051] 10 parts of oleanolic acid, 18 parts of sodium alginate diester, vitamin B 6 4 parts, 8 parts of chitosan, 60 parts of film-forming agent, 18 parts of lauryl glucoside, 30 parts of tributyl citrate and 500 parts of distilled water; Described film-forming agent is made of sodium alginate, hydroxypropyl cellulose Vegetarian and citric acid are composed of 6:2:0.5 by weight.

[0052] Preparation:

[0053] S1 Take half of the amount of distilled water and heat it to 85°C, add half of the amount of film-forming agent and stir until it is completely dissolved, filter while it is hot, take the filtrate, add tributyl citrate to the filtrate, and stir evenly to obtain a glue solution;

[0054] S2 Cool the mucilage solution obtained in step S1 to 45°C and add oleanolic acid, sodium alginate diester, and vitamin B 6 , stir evenly, th...

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Abstract

The invention belongs to the technical field of drugs and relates to an oral ulcer treatment patch film and a preparation method thereof. The oral ulcer treatment patch film mainly comprises oleanolic acid, polysaccharide sulfate, vitamin B6, chitosan, a film forming agent, glucoside, tributyl citrate and distilled water. The oral ulcer treatment patch film has a reasonable and scientific formula. Components of the oral ulcer treatment patch film interact with each other and have effects of inhibiting bacteria, diminishing inflammation and easing pain so that the oral ulcer treatment patch film can effectively relieve oral ulcer and shorten cure time. The oral ulcer treatment patch film has the advantages of good adhesion, fast dissolving speed and good uncovered film integrity, guarantees drug effects and is an ideal oral ulcer patch film.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral ulcer patch and a preparation method thereof. Background technique [0002] Oral ulcer is a kind of common oral disease, and wherein recurrent oral ulcer is the modal ulcer property damage in oral mucosal disease. Clinically, according to the size, quantity and duration of ulcers, they are divided into three types: mild, heavy and herpetic. Mild to moderate oral ulcers bring discomfort to people's daily life, and severe oral ulcers can affect people's eating. At the same time, oral ulcers have the characteristics of high incidence and easy recurrence after healing, seriously affecting people's normal life. [0003] The medicine for the treatment of oral ulcer at present mainly contains: immunostimulator and hormonal medicine. This kind of medicine is widely used in foreign countries. It can effectively treat some deep and long-term ulcers, and can effective...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K47/12A61K47/36A61K47/38A61K9/70A61P1/02A61P31/02A61P29/00A61K31/4415A61K31/56A61K31/722
CPCA61K9/006A61K9/7007A61K31/4415A61K31/56A61K31/722A61K31/737A61K47/12A61K47/36A61K47/38A61K2300/00
Inventor 胡波
Owner 宁波市诚德医疗科技有限公司
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