Clarithromycin dispersible tablet preparation method
A technology for clarithromycin and dispersible tablets, which is applied in the field of preparation of clarithromycin dispersible tablets, can solve the problems of difficult quality standard control, high quality requirements, increased production processes, etc., so as to avoid excessive drug concentration and increase the ratio of Surface area, the effect of reducing irritation of the gastrointestinal tract
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Embodiment 1
[0031] The plain tablet formula of clarithromycin dispersible tablet is as follows:
[0032]
[0033] The preparation method of above-mentioned clarithromycin dispersible tablet is as follows:
[0034] 1. Superfinely pulverize clarithromycin and 200 mg of lactose into micropowders with a diameter of less than 10 μm to obtain mixed powder A, and set aside, and pass the rest of the auxiliary materials through an 80-mesh sieve for set aside;
[0035] 2. Weigh the remaining lactose, starch and sodium starch glycolate 5 mg and mix evenly to obtain mixed powder B;
[0036] 3. Make hydroxypropyl cellulose into a 5.5% aqueous solution for subsequent use;
[0037] 4. Mix powder A and powder B evenly to get powder C
[0038] 5. Add the aqueous solution prepared in 3 to the mixed powder C to prepare soft materials, pass through a 20-mesh nylon sieve, dry at 50-70°C, and granulate with a 20-mesh stainless steel sieve;
[0039] 6. Add the remaining sodium starch glycolate, talcum pow...
Embodiment 2
[0044]
[0045]
[0046] 1. Superfinely pulverize clarithromycin and 200 mg of lactose into micropowders with a diameter of less than 10 μm to obtain mixed powder A, and set aside, and pass the rest of the auxiliary materials through an 80-mesh sieve for set aside;
[0047] 2. Weigh the remaining lactose and mix with microcrystalline cellulose and sodium starch glycolate 5 mg evenly to obtain mixed powder B;
[0048] 3. Make hydroxypropyl cellulose into a 5.5% aqueous solution for subsequent use;
[0049] 4. Mix powder A and powder B evenly to obtain powder C;
[0050] 5. Add the aqueous solution prepared in 3 to the mixed powder C to prepare soft materials, pass through a 20-mesh nylon sieve, dry at 50-70°C, and granulate with a 20-mesh stainless steel sieve;
[0051] 6. Add the remaining sodium starch glycolate, talcum powder, magnesium stearate and sodium saccharin into the above granules, and mix well. Detect the content of semi-finished products, determine the tab...
Embodiment 3
[0054]
[0055] 1. Superfinely pulverize clarithromycin and 200 mg of lactose into micropowders with a diameter of less than 10 μm to obtain mixed powder A, and set aside, and pass the rest of the auxiliary materials through an 80-mesh sieve for set aside;
[0056] 2. Weigh the rest of the lactose, microcrystalline cellulose, and 5 mg of cross-linked polyvinylpyrrolidone and mix evenly to obtain the mixed powder B;
[0057] 3. Make hypromellose into a 5.5% aqueous solution for subsequent use;
[0058] 4. Mix powder A and powder B evenly to obtain powder C;
[0059] 5. Add the aqueous solution prepared in 3 to the mixed powder C to prepare soft materials, pass through a 20-mesh nylon sieve, dry at 50-70°C, and granulate with a 20-mesh stainless steel sieve;
[0060] 6. Add the remaining cross-linked polyvinylpyrrolidone, silicon dioxide, magnesium stearate and aspartame into the above granules, and mix well. Detect the content of semi-finished products, determine the table...
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