Medicine for treating intestinal tract disease

A technology for gastrointestinal diseases and gastrointestinal diseases, applied in the field of medicine, can solve problems such as affecting the stability and efficacy of preparations, and achieve the effects of convenient clinical application, prevention of decomposition, and slowing of decomposition.

Inactive Publication Date: 2003-07-23
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The light test proves that after the sodium azulene sulfonate raw material is irradiated under strong light for 10 days, there will be an obvious decomposition product guaiazulene impurity peak after the main peak on the high performance liquid chromatography, thereby affecting the stability and stability of its preparation to a large extent. curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Take 2g of sodium azulene sulfonate, 80g of starch, and 15g of microcrystalline cellulose, dry the starch first, pass through a 120-mesh sieve, then mix evenly with sodium azulene sulfonate and microcrystalline fiber, pass through a 120-mesh sieve twice, and fill in hard In the capsule, make 1000 capsules of the present invention. Each hard capsule contains 2mg of active ingredient.

Embodiment 2

[0009] Take 2 g of sodium azulene sulfonate, measure 200 g of polyethylene glycol 400, first mix sodium azulene sulfonate with 1 / 5 amount of polyethylene glycol 400, pulverize it with a colloid mill, and then add the remaining amount of polyethylene glycol 400 for miscibility, Obtain medicinal liquid, add gelatin solution (gelatin: glycerol: water=10: 5.5: 12) for subsequent use, medicinal liquid and gelatin solution obtain 1000 soft capsules of the present invention with automatic rotary capsule rolling machine. Each capsule contains 2mg of active ingredient.

Embodiment 3

[0011] Take 6 g of sodium azulene sulfonate, 1 g of lactose, 1.5 g of polyvinylpyrrolidone, 80 g of hydroxypropyl methylcellulose, and 50 g of talcum powder. Mix hydroxypropyl methylcellulose and sodium azulene sulfonate, add lactose, make pellets with polyvinylpyrrolidone solution, fill capsules, and obtain 1000 long-acting sustained-release capsules of the present invention. Each capsule contains 6mg of active ingredient.

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Abstract

A medicine in the form of capsule for treating enterogastric diseases is disclosed, whose main active component is 1,4-dimethyl-7-isopropyl-3-sodium azulenylsulfonate. Its advantages are high curative effect, and easy desintegration and absorption.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine for treating gastrointestinal diseases. Background technique [0002] Sodium azulene sulfonate is often used in the treatment of gastric ulcer, duodenal ulcer, gastritis and bacterial enteritis, etc. It has definite curative effect and mild side effects. But there are only preparations such as tablets (containing buccal tablets), granules (containing compound granules) and eye drops at present. The active ingredient sodium azulene sulfonate has a certain decomposing property under heat and light irradiation, and usually has a certain hygroscopicity, and the latter is heavier, which accelerates the decomposition of sodium azulene sulfonate and destroys its molecular structure. , the decomposition products are mainly impurities such as guaiazulene. The light test proves that after the sodium azulene sulfonate raw material is irradiated under strong light for 10 days, there will be an obvi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/255A61P1/04
Inventor 冀广沁肖华邓聪左治国陈旭邹巧利
Owner SICHUAN GUOKANG PHARMA
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