8 results about "Bacterial enteritis" patented technology

The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to application of nitrothiazole derivatives and hydrochloride and sulfate thereof in preparation of medicines for treating intestinal infection of poultry and livestock. The nitrothiazole derivatives synthesized by the present application have high biological activity at the cell level, and have good biological activity on bacterial enteritis of poultry and livestock, especially chicken, pig, sheep and deer, and have high application value.

The invention discloses a traditional Chinese medicine composition for preventing and treating fish enteritis. The traditional Chinese medicine composition is prepared from 10-50 parts of rheum officinale, 10-30 parts of origanum vulgare, 10-30 parts of herba andrographitis, 10-30 parts of humifuse euphorbia herb, 5-20 parts of radix aucklandiae and 5-20 parts of rhizoma smilacis glabrae. The corresponding preparation method comprises the following steps: stir-frying the rheum officinale with yellow wine, and stir-frying half of the radix aucklandiae with bran; all the components are weighed according to the formula and smashed to obtain traditional Chinese medicine composition powder, or all the components are weighed according to the formula, extracted and concentrated to be prepared into traditional Chinese medicine composition oral liquid, granules, extract powder or tablets. The invention relates to application in preparation of medicine-containing feed or medicine for preventing and treating fish enteritis. The traditional Chinese medicine composition has a good prevention and treatment effect on bacterial enteritis of fishes, can improve the immune function and disease resistance of the fishes, relieve inflammatory response caused by pathogenic infection, delay the morbidity process of fish enteritis caused by pathogenic bacteria and reduce the death rate of the fishes, and also can improve the feed intake of the fishes, reduce the feed coefficient and effectively improve the production performance.

The invention discloses a preparation method of eugenol-loaded quercetin-zinc nano-enzyme for treating enteritis of livestock. The nano-enzyme is constructed by forming nano-enzyme particles by virtue of coordination of quercetin and zinc ions and loading eugenol by virtue of metal-hydroxyl interaction, the nano-enzyme has the high-efficiency antioxidant activity of quercetin-zinc nano-enzyme and the anti-inflammatory and antibacterial functions of eugenol, and can synergistically inhibit pathogenic bacteria in intestinal tracts, remove excessive reactive oxygen species (ROS) at intestinal inflammation parts and promote the recovery of the intestinal tracts. The nano-enzyme is good in biocompatibility and high in stability, can slowly release active ingredients in an intestinal environment, is lasting in effect, can effectively relieve symptoms of bacterial enteritis and promote intestinal tissue repair, provides a novel efficient treatment strategy for treatment of bacterial enteritis, and has important clinical application value.

The application discloses application of fullerene in preparation of products for relieving bacterial enteritis of piglets, and belongs to the technical field of livestock and poultry breeding and feed preparation. It is found by experiment verification that the fullerene can relieve the bacterial enteritis of piglets: E. coli attack can significantly inhibit the growth performance of piglets after weaning and aggravate diarrhea, the addition of C60 in the daily ration can relieve the growth inhibition induced by K88 after weaning to a certain extent, and significantly reduce the post-weaning diarrhea rate and diarrhea index of piglets; the E. coli attack significantly up-regulates the mRNA expression amount of proinflammatory factors IL-1beta and IL-6 in the colon, and the daily ration added with C60 significantly inhibits the abnormal expression of the two proinflammatory factors; the E. coli attack leads to the significant increase of the contents of serum proinflammatory factors TNF-alpha and IL-6, and the addition of C60 in the daily ration significantly reduces the concentrations of TNF-alpha and IL-6 in the serum. It can be seen that the application provides a new solution for the bacterial enteritis of piglets.

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of Chinese tamarisk twigs in preparation of a medicine for treating chicken bacterial enteritis. And side effects and potential problems caused by long-term use of antibiotics for treatment are effectively solved. A preparation method of the Chinese tamarisk twig extract comprises the following steps: taking a Chinese tamarisk twig medicinal material, adding 50% ethanol which is 10 times of the Chinese tamarisk twig medicinal material to soak for 1 hour, then performing ultrasonic extraction for 1 hour at 50 DEG C, and collecting an extracting solution; then 50% ethanol with the amount 8 times that of the medicinal materials is continuously added into the medicinal materials, ultrasonic extraction is conducted for 1 hour at the temperature of 50 DEG C, and an extracting solution is collected; combining the two extracting solutions, carrying out vacuum suction filtration, carrying out 50 DEG C rotary steam concentration to obtain a concentrated solution, and freeze-drying the concentrated solution to obtain a powdery Chinese tamarisk twig extract; the effective dose of the Chinese tamarisk twig extract is 1g / kg; the Chinese tamarisk twig extract is added into chicken feed as a feed additive. The invention is helpful for reducing the dependence on chemical synthetic drugs and the long-term sustainable development of animal breeding industry.

This invention relates to the fields of molecular biology and biomedicine, specifically to a method and application of recombinant methods for the grass carp IL-21 optimized gene, its recombinant protein, and plasmids. The recombinant protein of this invention is a mature grass carp IL-21 peptide. The pET-28a-IL-21 recombinant expression plasmid was constructed by optimizing the IL-21 base codons, transformed into an *E. coli* (DE3) expression system, and soluble grass carp IL-21 recombinant protein was obtained by IPTG induction. Furthermore, this invention also found that the optimized gene, its recombinant protein, and plasmids can enhance the intestinal barrier integrity of grass carp, inhibit the load of pathogenic bacteria in the intestine, and repair intestinal damage caused by bacterial infection. This indicates that the grass carp IL-21 recombinant protein has a significant effect on protecting intestinal homeostasis, highlighting its promising application prospects in the research and development of prevention and treatment of bacterial enteritis in aquatic animals.

The application discloses a kind of over rumen aureomycin premix for sheep digestive tract infection and preparation method, including capsule material and aureomycin premix, wherein, capsule material mass percentage is 45%-55%, and aureomycin premix mass accounts for 45%-55% of total mass.The premix of the application can avoid the degradation of aureomycin in sheep rumen, ensure sufficient active drug to reach intestinal lesions, and has excellent antibacterial and antidiarrheal effects on lamb dysentery, growing sheep stress bacterial enteritis and adult sheep digestive tract secondary bacterial infection, while reducing the dosage and reducing the risk of drug residues.

This invention discloses the application of β,β-dimethylacrylshikonin in the prevention and control of nonbacterial enteritis in carnivorous fish. Through experiments, the applicant discovered that, under the condition of replacing 50% of fishmeal protein in the feed with soybean meal protein, the addition of shikonin compounds, shikonin alcohol extract, or shikonin ultrafine powder can effectively improve the symptoms of enteritis in pearl grouper, increase the average weight gain rate of pearl grouper, improve the antioxidant capacity of pearl grouper, improve intestinal tissue structure, reduce the transcription levels of pro-inflammatory factors IL1β and IL8 in the intestine, and simultaneously upregulate the transcription level of anti-inflammatory factor IL10. Therefore, shikonin compounds, shikonin alcohol extract, or shikonin ultrafine powder have significant effects on soybean meal-induced enteritis in fish and can be used to prepare drugs or feed additives for the treatment or prevention of soybean meal-induced enteritis in fish.