The invention relates to a golden pompano immune promoting compound feed and a preparation method thereof. The feed comprises fish meal, flour, shrimp pulp, bean meal, corn protein powder, fish oil, meat meal, a plurality of vitamins, a plurality of mineral substances, immunopotentiator, bilineurine and dibastic sodium phosphate; and the preparation method comprises the following steps: batching, primary cleaning, primary mixing, iron removing, crushing, secondary mixing, conditioning, puffing, drying, grease spraying, cooling and packaging. The formula of the feed is scientific and reasonable, and the high-efficiency pollution-free immunopotentiator is added into the feed, which causes the feed to have high-quality crushing particle size, mixing uniformity, feed formability, water resistance, etc.; furthermore, the compound feed has the advantages of improving the absorption and utilization rates, satisfying the nutrition requirements of the golden pompano, improving disease resistance of the fish, and promoting the quick and sound growth of the fish; thus greatly shortening the breeding cycle, reducing the breeding cost and reducing the pollution to water body; and the preparation method is scientific and reasonable and has obvious economic benefit and environmental benefit.