26 results about "Growth stimulation" patented technology

The invention discloses an antibody for resisting protein of a growth stimulation expression gene 2 and application of the antibody, and relates to the field of antibodies. The anti-GST2 protein antibody disclosed by the invention comprises a heavy chain complementarity determining region and a light chain complementarity determining region, provides an important raw material source for detection of GST2 protein, and has good activity and sensitivity.

The invention discloses an antibody pair, a reagent and a method for detecting soluble growth stimulation expression gene 2 protein, and relates to the field of immunodiagnosis. The antibody pair for detecting the soluble growth stimulation expression gene 2 protein comprises the first antibody and the second antibody, and the reagent and the detection method based on the antibody pair can accurately detect the existence of the soluble growth stimulation expression gene 2 protein.

The invention provides application of a biomarker combination for early screening and diagnosis of transthyretin cardiac amyloidosis (ATTR-CA) high-risk groups in preparation of a product for early screening and diagnosis of the ATTR-CA high-risk groups. In general, one or more biomarkers, such as total prealbumin (total PA), transthyretin (TTR) tetramer, misfolded protein, protein misfolding rate, and soluble growth stimulus expression gene 2 protein (sST2). In ATTR-CA high-risk groups and non-high-risk groups, the biomarkers show significant difference, which prompts that the biomarkers are related to ATTR-CA. When a plurality of biomarkers are combined for use, the biomarkers have relatively high sensitivity and specificity in early screening and diagnosis of ATTR-CA high-risk groups, have relatively high diagnosis efficiency, and provide a new thought and strategy for early diagnosis and treatment of ATTR-CA.

A transport device for increasing biological activity within a patient includes a base including a first end, a second end, an upper surface located between the first end and the second end, and a lower surface located between the first end and the second end, a base anchor configured to statically couple the base to a first portion of a bone of a subject, a translatable anchor configured to engage a growth stimulator, a leadscrew dynamically coupling the base to the translatable anchor, wherein the leadscrew is configured to rotate about a leadscrew axis while substantially maintaining its longitudinal position along the leadscrew axis in relation to the base, such that the growth stimulator, when engaged with the translatable anchor, is capable of independent movement in relation to the base along a stimulation axis that includes at least some transverse displacement with respect to the bone when the base is coupled to the bone via the base anchor, and a screw drive rotatably coupled to the leadscrew and configured to couple to a rotatable mating tool that is configured to rotate the leadscrew via the screw drive.

The invention is suitable for the technical field of aquaculture, and provides an electric field control method, system and device and terminal device.The method comprises the steps that monitoring data of aquatic organisms in an aquaculture area are obtained, the monitoring data at least comprise growth stage data, and an electric field generation device is placed in the aquaculture area; and dynamically controlling an electric pulse applied to the electric field generation device based on the growth stage data so as to give growth stimulation to the aquatic organisms by utilizing an electrostatic field generated by the electric field generation device based on the electric pulse. According to the method, the electric pulse applied to the electric field generation device is dynamically controlled according to the growth stage requirements of different aquatic organisms, and then the electrostatic field generated based on the electric pulse is used for giving growth stimulation to the aquatic organisms, so that the aquaculture scheme of the aquatic organisms is enriched, the growth environment of the aquatic organisms is accurately and automatically adjusted, and the aquaculture efficiency is improved. And the growth rate of aquatic organisms is improved.

A transport device for increasing biological activity within a patient includes a base including a first end, a second end, an upper surface located between the first end and the second end, and a lower surface located between the first end and the second end, a base anchor configured to statically couple the base to a first portion of a bone of a subject, a translatable anchor configured to engage a growth stimulator, a leadscrew dynamically coupling the base to the translatable anchor, wherein the leadscrew is configured to rotate about a leadscrew axis while substantially maintaining its longitudinal position along the leadscrew axis in relation to the base, such that the growth stimulator, when engaged with the translatable anchor, is capable of independent movement in relation to the base along a stimulation axis that includes at least some transverse displacement with respect to the bone when the base is coupled to the bone via the base anchor, and a screw drive rotatably coupled to the leadscrew and configured to couple to a rotatable mating tool that is configured to rotate the leadscrew via the screw drive.

The present invention concerns the use of at least one plant extract capable of activating the GDF11 (Growth Differentiation Factor 11) growth factor and a cosmetic or pharmaceutical composition comprising at least one extract as an active ingredient for treating hair growth. The at least one extract is chosen from the following: • an extract rich in peptides and sugars derived from Scabiosa arvensis cell cultures; • an extract rich in peptides and sugars derived from Lotus japonicus cell cultures enriched in somatic embryos; • a hydroethanolic extract from artichoke flower heads belonging to the species Cynara scolymus; and / or a water-soluble extract derived from prickly pear pads in combination with a hydroethanolic extract derived from coffee beans.

The present disclosure relates to a kit for detecting a soluble growth stimulation expressed gene 2 protein. In particular, the present disclosure relates to a latex-enhanced turbidimetric immunoassay kit for detecting the concentration and / or content of the sST2 in human samples. The kit can be used in transmission immunoturbidimetry and scattering immunoturbidimetry. The kit comprises a buffer system, an anti-interference component, latex microspheres, an anti-sST2 antibody, etc. The latex-enhanced immunoturbidimetric agent of the present disclosure can detect sST2 proteins within a range of <400 ng / ml in a sample, with a sensitivity of up to 0.1 ng / ml and a high specificity, accuracy and precision. The kit is suitable for a fully automatic biochemical analyzer and a scattering analyzer, and has the advantages of convenient and fast use and low cost, and can be used clinically to detect the sST2 protein.

Provided is a method for shortening the induction phase in the proliferation of bacteria. A growth stimulation solution obtained by (1) a step that inoculates a culture solution with Staphylococcus to obtain a cultured culture solution and (2) a step that removes the Staphylococcus from the cultured culture solution, or a growth stimulation powder obtained by drying the growth stimulation solution is used.

An interspinous fusion device is described. It includes a first member with a column of teeth, and a second member with a column of recesses adapted to mate with the column of teeth of the first member. The first member and the second member have opposing windows on their walls, such that when the first member is mated with the second member an unobstructed passage is formed through the opposing windows. The first member and the second member lock together when the teeth and recesses are mated, said locking occurring without the aid of a set screw, pin or other mechanical component.

The invention provides the high-sensitivity and high-stability sST2 chemiluminescence detection kit, by optimizing a magnetic particle coating process and an acridinium ester labeling purification process, the wide linear detection range of 4-1024ng / mL and the excellent performance that the inter-batch CV is less than or equal to 10% are realized, and the kit is suitable for clinical large-scale screening and accurate diagnosis.

The invention provides a kit for quantitatively detecting soluble growth stimulation expression gene 2 protein and a preparation method of the kit. The kit comprises a labeling reagent R1 and a solid-phase reagent R2, wherein the labeling reagent R1 comprises a soluble growth stimulation expression gene 2 protein antibody 1 labeled by a tracing marker and an anti-soluble growth stimulation expression gene 2 protein-IL-33 conjugate antibody labeled by the tracing marker; and the solid-phase reagent R2 comprises a magnetic particle suspension coated with a soluble growth stimulation expression gene 2 protein antibody 2. The technical problems that in the prior art, a kit is complex in reagent component, the detection method is tedious, the detection time is obviously prolonged, and the emergency treatment rapid detection requirement cannot be met are solved.

The application provides a method for breeding golden pompano, which comprises the following steps: setting a net cage, selecting and releasing fry, bait enhancement and daily management, selecting a suitable sea area as the breeding environment of the net cage according to the living habit of the golden pompano, ensuring a healthy breeding environment, enhancing the bait according to three stages of the golden pompano with different ages, and adjusting the bait according to the growth of the fish body in each stage, so that the fish body reaches a micro-ecological balance in nutrition, immunity, growth stimulation and biological antagonism, and the reproduction of bacterial enteritis is inhibited; the fry is irradiated by visible light with a wavelength of 597-3400 nm while the net cage is cleaned, which can promote the release of cytokines on the surface of the fish body, prevent the infection of vibrio campbellii, tropical pseudomonas aeruginosa and gram-negative bacilli, and the survival rate of the method for breeding the golden pompano is 96.5-98.1%, the incidence of bacterial colitis is 0.3-1.2%, and the incidence of furuncle disease is 0.2-0.9%.

A transport device for increasing biological activity within a patient includes a base including a first end, a second end, an upper surface located between the first end and the second end, and a lower surface located between the first end and the second end, a base anchor configured to statically couple the base to a first portion of a bone of a subject, a translatable anchor configured to engage a growth stimulator, a leadscrew dynamically coupling the base to the translatable anchor, wherein the leadscrew is configured to rotate about a leadscrew axis while substantially maintaining its longitudinal position along the leadscrew axis in relation to the base, such that the growth stimulator, when engaged with the translatable anchor, is capable of independent movement in relation to the base along a stimulation axis that includes at least some transverse displacement with respect to the bone when the base is coupled to the bone via the base anchor, and a screw drive rotatably coupled to the leadscrew and configured to couple to a rotatable mating tool that is configured to rotate the leadscrew via the screw drive.

The present invention relates to the field of biomedicine technology, and provides soluble ST2 protein antibodies, detection kits, and applications thereof. The present invention provides soluble ST2 protein antibodies, intermediates, and detection kits containing the same, which can be used for the prediction and diagnosis of myocardial fibrosis, heart failure, and the like. The present invention obtains multiple antibodies with high sensitivity and good specificity by constructing recombinant soluble ST2 protein antigens, immunization, and cell line screening. Through appropriate reagent configuration, the good performance of the ST2 detection kit, especially the chemiluminescence detection kit, is achieved. The ST2 detection kit of the present invention has high accuracy, high sensitivity, a wide linear range, and a high degree of correlation; the reagents have high precision, good repeatability, and strong applicability.

The application provides a molybdenum-rhenium alloy bone plate system with a growth stimulating function, and belongs to the technical field of trauma surgery instruments. The bone growth stimulating mechanism is arranged on one side of the bone plate body facing the bone surface through the micro self-adaptive lifting mechanism, and the pressure value between the bone growth stimulating mechanism and the bone surface is automatically adjusted by the control module, so that the electrode unit of the bone growth stimulating mechanism can be stably attached to the trauma surface without affecting the blood supply, the trauma bone surface is continuously and stably stimulated by direct current, the activity of osteoblast proliferation is promoted, and bone healing is accelerated.

The present invention relates to a combination of a CNP agonist and at least one further biologically active moiety or drug for use in a method for the treatment or prevention of disorders that benefit from growth stimulation, pharmaceutical compositions comprising at least one CNP agonist, preferably a controlled-release CNP agonist, wherein the pharmaceutical composition comprises at least one further biologically active moiety or drug, to the use of these pharmaceutical compositions as medicaments, to their use in the treatment of disorders that benefit from growth stimulation and to methods of preventing or treating a patient having a disorder that benefits from growth stimulation.

A system for increasing biological activity within a patient includes a housing, a drive carried within the housing, an indexing contour carried by the housing and configured to substantially stabilize the housing in relation to a transport device base of a transport device configured to move a growth stimulator in relation to a bone of a subject, a locking portion configured to releasably lock the housing to the transport device base, a rotatable mating tool carried by the housing, wherein the drive is configured to cause the rotatable mating tool to rotate, and wherein the rotatable mating tool is configured to be rotationally coupled to a screw drive of a leadscrew of the transport device when the housing is stabilized with the transport device base via the indexing contour and is locked to the transport device base via the locking portion, and a control unit configured to output a control signal configured to direct the drive to rotate the rotatable mating tool.

The invention provides a soluble growth stimulation expression gene 2 protein determination kit, a preparation method and application, and belongs to the technical field of biochemical immunoassay. The latex enhanced immunoturbidimetry is adopted to detect the soluble growth stimulation expression gene 2 protein, key components of the reagent 1 and the reagent 2 are optimized and adjusted, preferred components and concentrations of polyanions, a surfactant, an accelerant, a biochemical cross-linking agent and the like are obtained, and the problems that sST2 related reagents are poor in stability and poor in stability are solved. In order to solve the technical problems that in the prior art, the detection accuracy of the high value of sST2 larger than 400 ng / mL cannot be met and the like, the detection accuracy of the high value can be remarkably improved by the optimized components and concentration in the linear range of 5 ng / mL to 432 ng / mL, particularly, the sensitivity, the anti-interference capability, the stability, the repeatability and the front zone of the correspondingly prepared sST2 latex reagent reach and are superior to those of a third-party reagent, and the detection accuracy of the high value of sST2 larger than 400 ng / mL can be remarkably improved by the optimized components and concentration in the linear range of 5 ng / mL to 432 ng / mL. And the requirements of clinical use can be well met.

The invention relates to the technical field of medical equipment, and discloses an electrical stimulation device for axon regeneration and a control method. The electrical stimulation device comprises a control assembly used for generating an electrical signal and transmitting the electrical signal to a stimulation electrode; the stimulation electrodes are connected with the control assembly and are used for being placed on the two sides of a nerve injury plane respectively, so that an electric field is formed in the axon growth direction based on the electric signals, and axons are stimulated to grow across the nerve injury plane; the axon growth stimulation method is simple, and the cost is controllable; and the direction of the electric field is matched with the growth direction of the axons, so that the problem of disorder of a nerve regeneration network caused by random growth of the axons possibly caused by a traditional treatment method can be avoided, and the axon growth effect is improved.

An interspinous fusion device is described. It includes a first member with a column of teeth, and a second member with a column of recesses adapted to mate with the column of teeth of the first member. The first member and the second member have opposing windows on their walls, such that when the first member is mated with the second member an unobstructed passage is formed through the opposing windows. The first member and the second member lock together when the teeth and recesses are mated, said locking occurring without the aid of a set screw, pin or other mechanical component.

A system for increasing biological activity within a patient includes a housing, a drive carried within the housing, an indexing contour carried by the housing and configured to substantially stabilize the housing in relation to a transport device base of a transport device configured to move a growth stimulator in relation to a bone of a subject, a locking portion configured to releasably lock the housing to the transport device base, a rotatable mating tool carried by the housing, wherein the drive is configured to cause the rotatable mating tool to rotate, and wherein the rotatable mating tool is configured to be rotationally coupled to a screw drive of a leadscrew of the transport device when the housing is stabilized with the transport device base via the indexing contour and is locked to the transport device base via the locking portion, and a control unit configured to output a control signal configured to direct the drive to rotate the rotatable mating tool.

In order to provide a new agent for actively controlling hair growth in subjects, the present invention suggests an active agent for use in hair growth regulation, particularly for use in the treatment of hair growth (stimulation or inhibition), wherein said active agent activates, enhances, inactivates, blocks or dampens the cellular response of the olfactory receptor OR10J1 or interferes with the expression of said receptor. Furthermore, the present invention is directed to compositions for use as a cosmetic or medicament or food supplement in the treatment of hair growth said composition comprising at least one of the aforementioned active agents and at least one auxiliary agent. In addition, a non-therapeutic method of hair growth regulation is disclosed, wherein an effective amount of at least one of the aforementioned active agents is administered to a subject.

In order to provide a new agent for actively controlling hair growth in subjects, the present invention suggests an active agent for use in hair growth regulation, particularly for use in the treatment of hair growth (stimulation or inhibition), wherein said active agent activates, enhances, inactivates, blocks or dampens the cellular response of the olfactory receptor OR10J1 or interferes with the expression of said receptor. Furthermore, the present invention is directed to compositions for use as a cosmetic or medicament or food supplement in the treatment of hair growth said composition comprising at least one of the aforementioned active agents and at least one auxiliary agent. In addition, a non-therapeutic method of hair growth regulation is disclosed, wherein an effective amount of at least one of the aforementioned active agents is administered to a subject.

The invention discloses a preparation method of a seedling substrate for preventing and treating continuous cropping obstacles, and relates to the technical field of seedling substrates. Comprising the following steps: 1, preparing artificial peat; step 2, crushing and granulating; 3, mixing and stirring; and 4, drying, crushing and forming. The invention further discloses application of the seedling substrate for preventing and treating the continuous cropping obstacles, and the seedling substrate is applied to seedling culture of vegetables, flowers and forestry and is also applied to relieving the continuous cropping obstacles of soil. According to the preparation method and application of the seedling culture substrate for preventing and treating continuous cropping obstacles, the biological agent formed by mixing ningnanmycin and bacillus subtilis is added into the seedling culture substrate, so that bacterial and fungal diseases generated in the early stage of seedling culture can be effectively controlled, and various amino acids, vitamins and trace elements contained in the biological agent can be used for preventing and treating continuous cropping obstacles. The plant growth regulator has obvious regulation and growth stimulation effects on crop growth, is beneficial to improvement of germination of crop seeds and growth of root systems, and improves the emergence rate and the strong seedling rate.

The present disclosure relates to a kit for detecting a soluble growth stimulation expressed gene 2 protein. In particular, the present disclosure relates to a latex-enhanced turbidimetric immunoassay kit for detecting the concentration and / or content of the sST2 in human samples. The kit can be used in transmission immunoturbidimetry and scattering immunoturbidimetry. The kit comprises a buffer system, an anti-interference component, latex microspheres, an anti-sST2 antibody, etc. The latex-enhanced immunoturbidimetric agent of the present disclosure can detect sST2 proteins within a range of <400 ng / ml in a sample, with a sensitivity of up to 0.1 ng / ml and a high specificity, accuracy and precision. The kit is suitable for a fully automatic biochemical analyzer and a scattering analyzer, and has the advantages of convenient and fast use and low cost, and can be used clinically to detect the sST2 protein.