176results about How to "Inhibition of adhesion" patented technology

The invention relates to medical equipment, particularly a medical scaffold with an inner coating film, and a preparation method for the medical scaffold, and belongs to the field of medical equipment. In the medical scaffold with the inner coating film, a non-woven inner coating film of which fibers are distributed on the axial direction of the medical scaffold is prepared on the inner surface of an inner film by an electrospinning method by taking a coating film scaffold as a basis, wherein the coating film scaffold consists of a netlike scaffold which is formed by weaving medical alloy wires, an electrospinning non-woven inner film and an electrospinning non-woven outer film; and the thickness of the inner coating film is 2 to 6 mu m. During preparation of the medical scaffold with the inner coating film, the inner coating film, the inner film and the outer film are prepared sequentially, and the inner coating film in the medical scaffold improves the biocompatibility with tract tissues of a human body, facilitates adhesion, migration and reproduction of endothelial cells at two ends of the medical scaffold, promotes quick endothelialization of the medical scaffold, and prevents the medical scaffold from becoming narrow again. The preparation method for the medical scaffold is simple, convenient to operate, and low in cost, and suitable for preparation of medical scaffolds with different diameters and lengths.

The invention specifically relates to an improved preparation method for a zinc / copper acrylate resin, which belongs to the technical field of marine anti-fouling paints. The preparation method comprises the following steps: with a mixed system of water and an organic solvent as a disperse medium, reacting a metal salt solution with aqueous alkali to produce zinc / copper hydroxide, fully dispersing the zinc / copper hydroxide in a dispersant and then carrying out filtering and drying so as to obtain high-dispersibility zinc / copper hydroxide; subjecting soft and hard monomers of acrylic acid to free radical polymerization under the action of an initiator at a constant temperature so as to produce an acrylic prepolymer containing a carboxyl group; and reacting the acrylic prepolymer obtained in the previous step with the dispersed zinc / copper hydroxide under the action of an organic acid at a constant temperature so as to prepare the zinc / copper acrylate resin with hydrolysis characteristics. According to the invention, the zinc / copper hydroxide prepared in the invention has good dispersibility and no agglomeration and needs short reaction time during reaction with the acrylic prepolymer, so cost is low, and original equipment does not need to be improved.

The invention provides a nuisanceless traditional Chinese medicine pesticide which has good insecticidal effects, does not cause resistance to a pesticide, has long action time and can promote crop growth. The traditional Chinese medicine pesticide comprises, by weight, 10-60 parts of melia root bark extract, 10-60 parts of Celastrus angulatus velamen or bark extract, 10-60 parts of derris velamen extract, 10-40 parts of extract of root of Stellera chamaejasme, 10-50 parts of extract of root of Caulis Spatholobi, 10-50 parts of root or leaf extract of Tripterygium wilfordii Hook. f., 20-50 parts of castor bean extract, 20-50 parts of yellowish sophora root extract, 20-50 parts of croton seed extract, 20-50 parts of extract of seed case of Chinese prickly ash, 20-50 parts of tea seed bran extract, 20-50 parts of fructus cnidii extract and 20-50 parts of radix stemonae extract. The above extract products are organic solutions obtained through an ethanol extraction method.

The invention relates to an external composition, and a preparation and an application thereof and belongs to the field of medicines. The external composition provided by the invention is a medicine composition which contains chlorhexidine or officinal salt thereof, or benzalkonium bromide or officinal salt thereof and a recombinant human epidermal growth factor or a recombinant cattle alkali fibroblast growth factor. According to the invention, the medicine composition is also further prepared into gel, liniment, ointment or paste, and the gel further comprises chitosan or officinal salt thereof and hyaluronic acid or officinal salt thereof. When being used for treating vagina inflammation, the external composition disclosed by the invention can improve a vagina microenvironment, promote growth of granulation tissue and repair vagina micro damage; and when being used for skin wound atraumatic restorative treatment, the external composition also can speed up restoration and regeneration of a wound tissue, promote healing and reduce scar formation, so that the external composition has a wide medical application prospect.

The invention relates to the technical field of health-care food, in particular to a probiotic composition as well as application and a product thereof. The probiotic composition comprises the following components in parts by weight: 2-6 parts of lactobacillus rhamnosus Rosell-11, 2-5 parts of lactobacillus helveticus Lafti L10 and 1-3 parts of lactobacillus salivarius HA-118. The acting principleof the probiotic composition is achieved by adjusting the dynamic balance of bacterial florae in an oral cavity; through a mechanism of competing with oral pathogenic bacteria, growth and adhesion ofthe pathogenic bacteria are inhibited, so that periodontitis and bad breath are alleviated; researches show that through cooperative use of the lactobacillus rhamnosus Rosell-11, the lactobacillus helveticus Lafti L10 and the lactobacillus salivarius HA-118, the probiotic composition has a significant synergetic effect.

The invention relates to a method for modifying a polyamide composite thin film, relates to a method for improving pollution resistance of a forward osmosis polyamide composite film through post-treatment modification, and is used for solving the problems that because a conventional polyamide TFC film easily gets biological pollution, the film effluent flux is decreased, the film cleaning frequency is increased, the energy consumption is increased, the film life cycle is shortened, then the process treatment efficiency is reduced and the operation cost is increased. The method comprises the steps: one, coupling dopamine and an initiator; two, introducing the initiator to the surface of a film; three, grafting a zwitterionic polymer on the surface of the film; four, adsorbing silver ions; and five, producing nano silver in situ. The obtained modified TFC film has anti-adhesion and bacteriostasis effects, and can effectively control the biological pollution of the film. The atom transfer radical polymerization reaction is adopted for grafting of the zwitterionic polymer, large controllability is achieved, the graft length and density of the organic polymer can be controlled by adjusting and controlling parameters, and the properties of pollution resistance and mass transfer of the film are further optimized.

The invention discloses a porous biological ceramic coating with antibiosis and bone promoting functions as well as a preparation method and application thereof, and belongs to the technical field ofbiomedical ceramic materials. The porous biological ceramic coating is a titanium dioxide coating doped with copper, magnesium, fluorine, calcium and phosphorus elements, the doped biological ceramiccoating is tightly combined with titanium and a titanium alloy substrate, and the doped biological ceramic coating is not prone to peel during implantation and use, can be combined with the substrateto form human body hard tissue repair with good mechanical and biological properties, and has the good antibiosis and bone promoting activity. According to the method, a prepared electrolyte for micro-arc oxidation treatment is simple in component, easy to control, free of components prone to decompose and stable in process, and large-scale batch production of the coating is promoted. The preparation method has no special requirements on the shape of a substrate material, can be suitable for the substrate with the complex shape, and thus the application range of the coating is effectively expanded.

The invention provides a poly(ether-ether-ketone) / nano hydroxyapatite dental implant which consists of a neck part and a root part, wherein the matrix material of the dental implant is a poly(ether-ether-ketone) / nano hydroxyapatite composite material; fibronectin or basic fibroblast growth factors are grafted to the neck part; a sub-surface layer of the root part has a micron porous-nano bulge multistage microstructure; and the surface layers of the neck part and the root part are nano hydroxyapatite layers containing Ag<+> and Zn<2+>. The manufacturing method comprises the following steps: (1) preparing a blank; (2) grafting the fibronectin or basic fibroblast growth factors on the surface of the neck part of the blank; (3) soaking the root part of the blank into a decafluoro-naphthalene solution to etch for 0.5-1 hour, and then putting the blank into nano hydroxyapatite powder to adhere a layer of nano hydroxyapatite particles; and (4) soaking the root of the blank in nano hydroxyapatite slurry doped with Ag<+> or Zn<2+> for 1-3 hours. The poly(ether-ether-ketone) / nano hydroxyapatite dental implant provided by the invention ensures that the elastic modulus of the dental implant is matched with human bone tissues, and the dental implant has high bioactivity and continuous antibacterial ability and can improve the long-term success rate of implantation.

The invention relates to a device and a method for preparing titanium tetrachloride in a manner of vibrating-type inner circulation fluidization, and belongs to the technical field of preparation of the titanium tetrachloride. The device mainly comprises an outer circulating fluidized bed, an inner circulating fluidized bed, a vibration distribution plate, a vibrator, a cyclone separator, a gas buffer tank, a gas distribution plate and the like. The method comprises the following steps: carrying out a chlorination reaction, cooling and gas-solid separation in the device by taking low-grade high titanium slags with a high calcium and magnesium content and coke as solid raw materials as well as taking chlorine gas, oxygen and nitrogen as gas raw materials, thereby preparing the titanium tetrachloride. The device has the characteristics of being compact in structure, easy to operate and overhaul, good in granule anti-bonding effect, high in titanium tetrachloride quality, favorable for continuous, stable and long-term operations, suitable for large-scale industrial production and the like. The method has the characteristics of being high in material heat utilization rate, uniform in reaction temperature distribution, convenient to control, high in titanium conversion rate and the like. Thus, the method and the device which are provided by the invention are particularly suitable for preparing the titanium tetrachloride from the low-grade high titanium slags with the high calcium and magnesium content.

The invention discloses probiotics compound cranberry female reproduction health nutrition supplementary. The nutrition supplementary is prepared from the following raw materials of active probiotics micro capsules, cranberry fruit powder, collagen, fructo-oligose, herba lophatheri, soy isoflavone, grape fruit powder and vitamin C, wherein the probiotics micro capsules are 9-11 billion colony forming unit (CFU), the cranberry fruit powder is 3-7 weight parts, the collagen is 1-10 weight parts, the fructo-oligose is 8-15 weight parts, the herba lophtheri is 1-10 weight parts, the soy isoflavone is 9-25 weight parts, the grape fruit powder is 1-20 weight parts, and the vitamin C is 0.01-0.05 weight part. When the cranberry fruit powder and the active probiotics micro capsules are combined and used according to a reasonable proportion, flora balance is effectively maintained, and an antibacterial effect is improved by one time. Compared with the prior art, the probiotics compound cranberry female reproduction health nutrition supplementary has the advantages of effectively improving female reproduction health and being convenient to take ,little in side effect and the like.

The invention discloses an intestine-moistening and bowel-relaxing composition. The intestine-moistening and bowel-relaxing composition comprises a probiotic compound and a prebiotic compound, whereinthe probiotic compound comprises the following components in parts by weight: 1-5 parts of lactobacillus acidophilus, 0.5-2 parts of bifidobacterium lactis, 0.5-4 parts of pediococcus acidilactici, 0.5-4 parts of bifidobacterium longum and 0.5-2 parts of lactobacillus plantarum; and the prebiotic compound comprises the following components in parts by weight: 3 to 40 parts of fructo-oligosaccharide, 2 to 30 parts of galacto-oligosaccharide, 0 to 30 parts of resistant dextrin, 0 to 20 parts of xylooligosaccharide, 0 to 30 parts of isomalto-oligosaccharide, 1 to 15 parts of inulin and 1 to 8 parts of stachyose. The invention also discloses an application of the composition and an intestine-moistening and bowel-relaxing solid beverage containing the composition. According to the composition,probiotics and prebiotics are combined, so that adhesion of pathogenic bacteria can be relieved, intestinal flora can be adjusted, and the incidence rate of irritable bowel comprehensive symptoms canbe remarkably reduced; and crowd food tasting experiments show that the composition has the effects of promoting defecation and relieving abdominal pain, abdominal distension and diarrhea symptoms.

The invention discloses a medicine composition and gel for treating colpitis and applications thereof. The medicine composition for treating colpitis contains soybean peptide and barbaloin in mass ratio of (0.1-1): (0.05-2). Through adopting the manner, the medicine composition has the advantages of being capable of improving the microenvironment of female vaginas, stopping the adhesion and breeding of germs by repairing the micro-damage of the vaginas, fundamentally blocking the inflammation course for treating the colpitis and also avoiding the defects such as drug tolerance caused by taking antibiotics, double infection and anaphylactic reaction as well as toxic and side effects on organisms.

Disclosed is an absorbent tissue paper with softness and smoothness equal to or higher than conventional moisturized tissue papers but with less stickiness during use. Also disclosed is a tissue paper that is not easily torn even after the paper sucks water. A two-ply tissue paper has surfaces to which chemical solution is applied such that the amount of chemicals contained in both the surfaces is 1.4 to 4.5 g / m2 and such that the amount of chemicals contained in one of two sheets that constitute the two-ply paper is 0.67 to 1.5 times the amount of chemicals contained in the other sheet. The content of oil components contained in the chemicals is less than 7.0 percent by mass, and the content of silicones is less than 0.1 percent by mass.

The invention discloses a cryopreservation protective agent for vitrification cryopreservation of marrow mesenchymal stem cells and belongs to the field of protective agents. The cryopreservation protective agent for vitrification cryopreservation of the marrow mesenchymal stem cells is prepared from 8.2%-8.6% of permeable protection fluid, 0.8%-1% of monosaccharide, 20% of human serum albumin, 2.1%-2.3% of Rho inhibitor and normal saline. The cryopreservation protective agent for vitrification cryopreservation of the marrow mesenchymal stem cells has the advantages of low cytotoxicity to the marrow mesenchymal stem cells, low cytotoxicity damage and low permeability damage in the vitrification cryopreservation process and increasing of the recovery rate of cryopreservation cells.

The invention discloses a self-cleaning type aluminum-plastic composite panel and a manufacturing method thereof. The self-cleaning type aluminum-plastic composite panel is composed of aluminum panel base layers (2) and a PE plastic core layer (4), wherein polymeric membrane bonding layers (3) are installed between the aluminum panel base layers (2) and the PE plastic core layer (4), an anti-pollution oil paint layer (1) and an anti-pollution transparent nanometer paint layer are installed on the outer surface of each aluminum panel base layer (2), the oil paint layers (1) are made of fluorocarbon baking varnish material, and an aluminum-plastic panel substrate is formed by the aluminum panel base layers (2), the polymeric membrane bonding layers (3) and the PE plastic core layer (4) in a composite mode. Dust and other pollutant are effectively prevented from being adhered to the surface of the aluminum-plastic composite panel. After being installed on a building wall, the self-cleaning type aluminum-plastic composite panel is washed by rainwater in the nature and can achieve the self-cleaning effect. Therefore, specialized cleaning and maintenance does not need to be performed on baking varnish on the surface of the aluminum-plastic composite panel at regular intervals, and the bright and clean effects can be kept enduringly.

The invention discloses a flow sensor. The flow sensor comprises a substrate; a heating element, formed on the substrate; at least one temperature-sensing element, wherein the temperature-sensing element is formed on the substrate, and a preset distance is formed between the temperature-sensing element and the heating element, so the flow of fluid flowing through the flow sensor is obtained by measuring the temperature change of the temperature-sensing element; and a hydrophillic layer, wherein the outer surface of the whole flow sensor is covered by the hydrophillic layer, so bubbles in the fluid are inhibited from being adhered to the outer surface of the flow sensor. The flow sensor disclosed by the invention is provided with the hydrophillic layer, the outer surface of the whole flow sensor is covered by the hydrophillic layer, and the installed hydrophillic layer has strong attraction to liquid in the fluid, so the bubbles in the fluid can be inhibited from being adhered to the surface of the flow sensor, the bubbles cannot affect the measurement of the flow sensor 100 to the flow velocity, and furthermore the accuracy of the flow sensor in measuring the flow of the fluid canbe improved.

The invention belongs to the field of health-care foods, and in particular relates to a food for treating urethritis of pets. The food for treating urethritis of pets comprises the following raw materials in parts by weight: 10-50 parts of poultry meat, 20-40 parts of rice, 2-10 parts of Cranberry, 2-8 parts of dietary fiber, 1-3 parts of bone meal, 0.5-1 part of animal fat, 1-2 parts of vegetable oil, 1-5 parts of salt, 1-5 parts of sugar, 1-6 parts of vitamin C, 2-6 parts of an additive and 30-80 parts of water. The food contains a certain proportion of Cranberry in the raw materials and the food processed by a specific method to treat urethritis of pets can be used for preventing and treating urethritis, has the effects of clearing heat and removing toxicity, diminishing inflammation and sterilizing, can be used for treat pets at home instead of treatment in pet hospitals, and saves troubles because the urethritis can be treated after the food is taken.

The invention discloses a biological aerated filter system with alkaline leaching excess sludge as filler, an operating method of the biological aerated filter system and a preparing method of the filler, and belongs to the technical field of sewage disposal. The biological aerated filter system comprises a water inlet and a water outlet, and further comprises a filter layer, the filler, a microporous aeration device and a backwash device. The biological aerated filter system is provided with the filter layer, the microporous aeration device and the backwash device in sequence from top to bottom, the space between the filter layer and the microporous aeration device in the biological aerated filter system is filled with the filler, the water inlet is located in the top of the biological aerated filter system, the water outlet is located in the bottom of the biological aerated filter system, the space between an inner column layer and an outer column layer of the biological aerated filter system is sealed to be vacuum, and the outer surface of the inner column layer is closely wrapped with a heat insulation glass wool layer. Due to the heat insulation arrangement, the biological aerated filter system still has high ammonia nitrogen and phosphorus removing efficiency in cold winter. By the adoption of the up-to-bottom water inlet mode, the problem that filler is likely to cause blockage is relieved; meanwhile, the purpose of recycling the industrial waste alkaline leaching excess sludge is achieved.

The invention discloses a method for cryopreserving mesenchymal stem cells with low cryo-damage, and belongs to the field of stem cell cryopreservation. The method comprises the following four steps: extracting bone marrow, and purifying and separating single karyocytes; inoculating and culturing primary cells for 48 hours, and culturing for 8 days at 37 DEG C in a culture solution comprising 10 mmol / L of dexamethasone, 2.16g / L of beta-glycerol phosphate sodium and 37.5mg / L of ascorbic acid-2-phosphate in an incubator having 5% CO2; conducting first generation with a culture solution consisting of 0.25 percent of trypsin and 0.02 percent of EDTA; inoculating with a cell density of 1.3*10<4> / cm<2>, culturing to P2 generation and the like. The method has the characteristics of low toxic injury and low protectant osmotic injury on cryopreserved cells in the freezing process, and can be used for preventing mechanical injury caused by ice crystal and improving the thawing rate of cryopreserved cells.

The invention belongs to the field of pharmacy, and discloses the application of rusogenin fucopyranoside C in the pharmacy. The invention also provides the application of the rusogenin fucopyranoside C in the preparation of the medicine for resisting tumor metastasis, and more particularly relates to the application in the preparation of the medicine for generating tumour new blood vessels and inhibition of relative tumor metastasis. Being proved by the study of the invention, the rusogenin fucopyranoside C can effectively inhibit the growth, migration and adhesive ability, can inhibit lung metastasis of melanoma B16, and provides new selection in the application of preparing the medicine for resisting tumor metastasis.

The invention discloses a water conservancy gate. The water conservancy gate structurally comprises a driver, an outer frame, a gate body, a water permeable opening and a mud removing mechanism, wherein the driver is connected with the gate body through the outer frame; the gate body is in clearance fit with the inner wall of the outer frame; the water permeable opening and the mud removing mechanism are of an integrated structure; and the mud removing mechanism is embedded and fixed to the bottom of the gate body. When the gate body ascends to be opened, water flow in a water storage tank canimpact a linkage plate on a removing roller, accordingly, the water flow can continuously flush away sludge and stone attached to the removing roller, and the situation that the sludge and the stoneare likely to be attached to the bottom of the mud removing mechanism is avoided. Through thrust generated by the water flow to a rolling column on the opening and closing plate, the rolling column can slide downwards along a sliding groove, accordingly, a scraper on the rolling column can scrape away the sludge left on the upper surface of a bottom plate, and the situation that a small part of sludge high in viscosity is not likely to be thoroughly flushed away and continues to be attached to the bottom plate is avoided.

The invention discloses a method for cryopreserving umbilical cord blood stem cells with low cryo-damage, and belongs to the field of stem cell cryoprservation. The method comprises the following four steps: extracting bone marrow, and purifying and separating single karyocytes; inoculating and culturing primary cells for 48 hours, and culturing for 8 days at 37 DEG C in a culture solution comprising 8mmol / L of dexamethasone, 2.16g / L of beta-glycerol phosphate sodium and 37.5mg / L of ascorbic acid-2-phosphate in an incubator having 5% CO2; conducting first generation with a culture solution consisting of 0.25 percent of trypsin and 0.02 percent of EDTA; inoculating with a cell density of 1.3*10<4> / cm<2>, culturing to P2 generation and the like. The method has the characteristics of low toxic injury and low protectant osmotic injury on cryopreserved cells in the freezing process, and can be used for preventing mechanical injury caused by ice crystal and improving the thawing rate of cryopreserved cells.

The invention relates to a novel imidazole diphosphonie acid compound and a pharmaceutically-acceptable salt thereof. The diphosphonie acid compound disclosed by the invention, farnesylpyrophosphate synthetase is treated, and lipotropy is enhanced. The type of compound can be used for treating diseases including osteoporosis, hypercalcinemia and the like, and can be applied to cancer chemotherapy, immunotherapy and the like.

The invention discloses a high-flux antibacterial anti-pollution polymer separation membrane and a preparation method thereof, and belongs to the technical field of membrane separation. The method comprises the following steps: firstly the surface of a polymer separation membrane is activated, nano silicon dioxide particles are deposited in situ on the surface of the surface-activated polymer separation membrane to enhance water permeability of the membrane, then a quaternary ammonium salt is used as a bactericide, and the quaternary ammonium salt is grafted onto the polymer separation membrane on which the nano silicon dioxide particles are deposited by adopting an electron transfer regeneration catalyst atom transfer free radical polymerization method. The method provided by the invention is simple to operate, the surface of the modified polymer separation membrane prepared by adopting the method can effectively inhibit growth and adhesion of bacteria and microorganisms, and the membrane has high water permeability and sustained and stable antibacterial and anti-pollution effects.

The invention discloses an underwater high-adhesion organosilicone marine antifouling paint and a cured coating and a preparation method thereof. The coating subjected to ultraviolet curing shows an excellent hydrophobic effect on a seawater contact interface, and the hydrophobic effect is kept for a long time; the coating can be firmly bonded on a base material or epoxy intermediate paint contact interface by virtue of Van der Waals force and hydrogen bonds between thiourea groups and ether groups, and meanwhile, the synergistic effect of hydrophobic interaction and weak hydrogen bonds can ensure that the coating keeps a good bonding effect in a long-term underwater environment; and the coating can be widely applied to ocean ships, offshore oil drilling platforms, deep sea detection equipment, underwater long-term use equipment and the like, and is particularly suitable for facilities immersed in a seawater environment for a long time.

The invention discloses a pharmaceutical composition and food for preventing or treating oral diseases. Both the composition and food comprise lactobacillus paracasei L9 and staphylococcus salivariusLD11. Studies show that the L9 and the LD11 can significantly alleviate the occurrence degree of E-level dental caries of an occlusal surface, after the composition and food containing the L9 and LD11are taken, the structures of oral floras change significantly, especially actinomycetes are significantly increased, and klebsiella, aerococcus, Gemella, corynebacterium and pseudomonas aeruginosa are significantly reduced in the category classification level. Taking of the L9 and LD11 can significantly reduce saliva species richness, the relative abundances of bacteria related to the oral diseases such as staphylococcus salivarius, actinomycetaceae and peptostreptococcus are significantly reduced, and periodontitis diseases may be alleviated; the species diversity of a dental plaque flora issignificantly reduced, the relative abundances of leptotrichia, fusobacterium and flavobacterium are all significantly reduced, and the oral diseases such as periodontal diseases, ozostomia and dental caries may be alleviated.

The invention discloses a modifier, which comprises a structural unit represented by a general formula (I), wherein R1 represents a direct bond or C1-C5 alkylidene or substituted alkylidene, R2 represents a direct bond or C1-C5 alkyl or substituted alkyl, R3 is a direct bond or C1-C5 alkyl or substituted alkyl, R4 is a direct bond, C1-C5 alkylidene or substituted alkylidene or C1-C5 acyloxy, R5 isa zwitterionic group, and the molecular weight of the modifier is 10-180 KDa. The invention also discloses a preparation method and a use method of the modifier, and a medical material.

The invention discloses drainage equipment with an anti-blocking function, which structurally comprises a fixing plate, a blocking cover and a lower drainage pipe, the fixing plate is embedded into the blocking cover, the lower drainage pipe is mounted at the bottom of the blocking cover, and the anti-blocking mechanism can rotate along a connecting block due to the impact force generated by wastewater entering through the fixing plate on the anti-blocking mechanism, so that the anti-blocking function is realized. The cutting knife can cut hair entering the lower discharge pipe into multiple small-size hair sections, so that the small-size hair can be discharged downwards into a sewer line, part of waste water can be discharged between a stress plate and a bottom plate through holes in thestress plate, and then the waste water can be discharged into the sewer line through impact force generated by the waste water on the stress plate. According to the hair washing device, the stress plate can shrink inwards, so that the deformation piece can shrink and deform downwards, the extrusion plate can quickly extrude moisture in the middle outwards, and the extruded moisture can wash awayhair on the stress plate.

The invention discloses an anticoagulant and metal-organic framework compound dual-modified in-vitro blood circulation pipeline coating and a preparation method thereof. The anticoagulant of the coating is selected from heparin, hirudin, citric acid or argatroban, and the metal-organic framework compound in the coating is MOF-Ag or MOF-Cu; the coating is obtained by fixing the metal-organic framework compound on the inner wall of an in-vitro blood circulation pipeline through dopamine and then fixing the anticoagulant on a dopamine layer with the metal-organic framework compound in a chemical grafting mode. The coating is high in stability, can improve blood compatibility and has excellent anticoagulation and antibacterial effects; and the in-vitro blood circulation pipeline with the coating can be applied to conventional hemodialysis, blood adsorption and continuous blood purification treatment.