Modifier, preparation method and use method thereof, and medical material

A technology of modifiers and substrates, applied in the field of medical materials and modifiers, can solve the problems of weak binding between polymers and substrates, limited application range of substrates, unfavorable long-term use, etc., and achieve good cell compatibility, Good for grooming and avoiding pollution effects

Active Publication Date: 2020-01-10
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface grafting method is that the polymer is connected with the groups on the surface of the substrate through chemical bonds, but the requirements for the substrate are relatively high, the surface of the substrate needs to be activated and modified, and the reaction conditions must be strictly controlled. The process is cumbersome and the preparation cycle is relatively short. long
The physical immobilization method is to immobilize the polymer on the surface of the substrate through the effect of physical non-covalent bond through van der Waals force, hydrogen bond or electric charge. The modification of charges or active groups limits the scope of application of the substrate, and the binding force between the polymer and the substrate is weak, and the polymer is easy to fall off from the substrate, which is not conducive to long-term use

Method used

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  • Modifier, preparation method and use method thereof, and medical material
  • Modifier, preparation method and use method thereof, and medical material
  • Modifier, preparation method and use method thereof, and medical material

Examples

Experimental program
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Effect test

preparation example Construction

[0066] The embodiment of the present invention also provides a method for preparing a modifier, comprising:

[0067] The dopamine derivative modified with an active alkenyl group and the zwitterionic compound with an active alkenyl group or the zwitterionic derivative compound modified with an active alkenyl group undergo a free radical-initiated carbon-carbon addition reaction under the action of an initiator.

[0068] The modifying agent in the embodiment of the present invention is formed by polymerizing the dopamine derivative modified with an active alkenyl group and the zwitterionic compound through a carbon-carbon double bond free radical polymerization reaction. The zwitterionic compound itself may carry a reactive alkenyl group, or the alkenyl group may be modified by additional steps. The synthesis route of the modifier is short, the conditions are mild, and the functional groups of dopamine and zwitterionic compounds are not destroyed, the production of by-products ...

Embodiment 1

[0106] (1) Add 18g of sodium pyroborate and 8g of sodium bicarbonate into 200ml of deionized water and stir to dissolve, then filter out the insoluble matter, pass nitrogen into the aqueous solution to remove dissolved oxygen, then put 10g of dopamine hydrochloride into the aqueous solution and stir to dissolve it , appropriately add 0.2mol / L NaOH solution to adjust the pH to above 8, and then pass nitrogen gas for treatment for ten minutes.

[0107] (2) Add 9.4ml of methacrylic anhydride into 50ml of THF and stir evenly, then add dropwise into the solution obtained in step (1), then maintain nitrogen atmosphere, and stir overnight at room temperature.

[0108] (3) Adjust the pH of the solution obtained in step (2) to below 2 with 0.2 mol / L hydrochloric acid solution, and wash off the oily drop-like substance in the upper layer with a small amount of ethyl acetate. The solution was extracted and separated three times with 200 ml of ethyl acetate, and the ethyl acetate phase (t...

experiment example 1

[0113] Experimental example 1 antibacterial test

[0114] The unirritated saliva of healthy blood donors was collected, the supernatant was collected after centrifugation, and pasteurized at 60°C for 30 minutes. Add sterilized PBS to the sterilized saliva at a ratio of 1:1 to obtain a nutrient solution. Soak the medical material with the nutrient solution overnight at 37°C.

[0115] Streptococcus mutans UA-159 was used for antibacterial test. The strain was first incubated at 37 °C in CO 2 After culturing in the incubator for 48 hours, take a single strain and inoculate it in BHI (brain heart infusion) culture solution, and then incubate at 37°C, CO 2 conditions overnight. Place the medical materials treated with nutrient solution in a 12-well plate, inoculate 2mL of BHI culture solution and 40μL of Streptococcus mutans suspension in each well, and inoculate at 37°C in CO 2 cultured in an incubator. After culturing for 15 hours, the morphology and distribution of bacteri...

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Abstract

The invention discloses a modifier, which comprises a structural unit represented by a general formula (I), wherein R1 represents a direct bond or C1-C5 alkylidene or substituted alkylidene, R2 represents a direct bond or C1-C5 alkyl or substituted alkyl, R3 is a direct bond or C1-C5 alkyl or substituted alkyl, R4 is a direct bond, C1-C5 alkylidene or substituted alkylidene or C1-C5 acyloxy, R5 isa zwitterionic group, and the molecular weight of the modifier is 10-180 KDa. The invention also discloses a preparation method and a use method of the modifier, and a medical material.

Description

technical field [0001] The invention relates to the field of functional materials, in particular to a modifier, its preparation method and use method, and medical materials. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace damaged tissues and organs of living organisms or enhance their functions. It is the basis for the study of artificial organs and medical devices, and has become an important branch of contemporary materials science. Especially with the vigorous development and major breakthroughs of biotechnology, biomedical materials have become a hot spot for scientists from all over the world to research and develop. [0003] When using biomedical materials to treat organisms, since they are in close contact with the blood or tissues of the organisms, there are special requirements for biomedical materials, such as requiring biomedical materials to have lubricity and antibacterial properties. Therefore, it is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/36C08F230/02C08F220/38
CPCC08F220/36C08F220/38C08F230/02
Inventor 张洪玉刘思哲韩英张晓威
Owner TSINGHUA UNIV
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