3 results about "Targeted liposomes" patented technology

This invention relates to the fields of pharmaceuticals and nanomedicine, specifically disclosing the preparation of a dual-targeting liposome drug delivery system and its application in stroke. The dual-targeting liposome drug delivery system comprises neutrophils, artemisinin, edaravone, and liposomes. The liposomes co-load artemisinin and edaravone, and their surfaces are modified with sialic acid derivatives and phosphatidylserine to form liposome nanomedicines. The neutrophils act as carriers, transporting the drug across the brain border (BBB) ​​and targeting it to the ischemic brain region. This dual-targeting strategy achieves precise two-stage drug delivery to the ischemic brain region. This delivery system can inhibit NLRP3 inflammasome activation, reduce pyroptosis, and promote microglial polarization towards the M2 anti-inflammatory phenotype, thereby effectively treating cerebral ischemia-reperfusion injury or ischemic stroke.

The application provides a kind of targeting drug-loaded liposome combined functional hydrogel and its preparation method and application, including active targeting liposome and functional gelatin hydrogel, make the active targeting liposome disperse in functional gelatin hydrogel, under the photo initiator, ultraviolet crosslinking solidification obtains the targeting drug-loaded liposome combined functional hydrogel;The functional gelatin hydrogel includes methacrylic anhydride grafting gelatin hydrogel and gallic acid grafting gelatin hydrogel, and the active targeting liposome is RGD peptide modified drug-loaded liposome.The application overcomes the defects of poor targeting, large systemic toxic side effects and insufficient regulation of joint immune microenvironment in the existing methotrexate single drug therapy for rheumatoid arthritis.

The application belongs to the field of biological medicine, and relates to a pH-sensitive cationic liposome for targeted delivery of siRNA and paclitaxel to lung cancer cells and a preparation method and application thereof. 2000 DEPE-PEG is obtained by covalently connecting -Mal through a Michael addition reaction 2000 -YSA and DSPE-PEG 2000 -SS31, the initial liposome is prepared through a film dispersion method, and the liposome loaded with PTX is formed through rotation evaporation, hydration, whole-grain, column filtration, and then the siCXCR2 is compressed through electrostatic combination to obtain the liposome loaded with siCXCR2. The targeted liposome constructed in the application can not only effectively improve the sensitivity of cells to PTX, but also effectively protect siRNA from being degraded, thereby realizing the inhibition of the expression of the cancer-related gene CXCR2, reducing the drug resistance of patients to PTX, and achieving the purpose of enhancing the curative effect.