Medicine composition and gel for treating colpitis and applications thereof

A composition and technology of vaginitis, applied in the field of pharmaceutical preparations, can solve problems such as vaginal bacterial flora imbalance and repeated inflammation, achieve the effect of restoring pH value, repairing vaginal inflammation, and remarkable curative effect

Active Publication Date: 2013-07-10
JIANGSU DIWO BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the technical defects of the existing gynecological diseases such as vaginitis treatment process of antibiotics and bactericides that lead to vaginal flora imbalance and repeated inflammation, the present invention provides a new type of antimicrobial agent that uses polypeptide mixtures and anthraquinone compounds as Active ingredients to treat vaginitis pharmaceutical composition, the technology of the present invention can not only improve the female vaginal microenvironment, prevent the adhesion and reproduction of bacteria by repairing vaginal micro-damages, and treat vaginitis fundamentally with the goal of blocking the inflammation process, It also avoids the disadvantages of drug resistance caused by the use of antibiotics, superinfection, allergic reactions, and toxic and side effects on the body.

Method used

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  • Medicine composition and gel for treating colpitis and applications thereof
  • Medicine composition and gel for treating colpitis and applications thereof
  • Medicine composition and gel for treating colpitis and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Example 1: A gel for treating vaginitis, based on 1 kg of the gel, add 1 g of water-soluble chitosan and 80 g of sodium hyaluronate to 960 ml of purified water, and fully dissolve it with a high-speed disperser to obtain solution 1; Fully disperse 1g of soybean peptide and 20g of aloin in 5ml of propylene glycol to obtain solution 2; then mix solution 1 and solution 2 and stir evenly, adjust the pH of the solution to 6.0, and filter with a 0.22um microporous membrane after stirring , to obtain the gel finished product 1000g.

Embodiment 2

[0037] Example 2: A gel for treating vaginitis, the main components include the following components by mass percentage: 3% chitosan, 0.3% sodium hyaluronate, 0.1% soybean peptide, and 1.5% aloin. Taking 1 kg of the gel described in this embodiment as an example, the preparation method is as follows: 30 g of water-soluble chitosan and 3 g of sodium hyaluronate are added to 960 ml of purified water, and they are fully dissolved with a high-speed disperser to obtain a solution. ; Fully disperse 1g of soybean peptide and 15g of aloin in 5ml of propylene glycol to obtain solution 2; mix solution 1 with solution 2 and stir evenly, adjust the pH of the solution to 5.0, stir evenly to obtain a gel-like mixture, use 0.22um Filter through a microporous membrane to obtain 1000 g of the finished gel.

Embodiment 3

[0038] Example 3: A suppository for treating vaginitis, based on 1000 suppositories, 10g of soybean peptide, 10g of aloin, 800g of polyethylene glycol, 0.1g of ethylparaben, and 180ml of 50% ethanol. Dissolve soybean peptide, aloin and ethylparaben in ethanol, slowly add to heated and melted polypropylene glycol, keep warm at 60°C, and fill the mold. 1 gram per plug.

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Abstract

The invention discloses a medicine composition and gel for treating colpitis and applications thereof. The medicine composition for treating colpitis contains soybean peptide and barbaloin in mass ratio of (0.1-1): (0.05-2). Through adopting the manner, the medicine composition has the advantages of being capable of improving the microenvironment of female vaginas, stopping the adhesion and breeding of germs by repairing the micro-damage of the vaginas, fundamentally blocking the inflammation course for treating the colpitis and also avoiding the defects such as drug tolerance caused by taking antibiotics, double infection and anaphylactic reaction as well as toxic and side effects on organisms.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating vaginitis, a gel and a preparation method thereof. Background technique [0002] Vaginitis is a common and frequently-occurring disease in gynecological clinics. Its incidence is mostly related to the imbalance of vaginal microecology, and the treatment effect is poor and the recurrence rate is high. The main pathological change of vaginitis is the imbalance of flora in the vagina, that is, the imbalance of the microecological balance (flora) that normally parasitizes in the vagina, the beneficial bacteria such as Lactobacillus in the vagina decrease, and other bacteria multiply in large numbers, and anaerobic bacteria multiply at the same time. Amines, alkalinize the vagina, increase the vaginal discharge and have a bad smell. Therefore, adjusting the normal balance of vaginal flora in patients is the key to the prevention and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61P15/02A61P15/00A61K31/351A61K31/352
Inventor 贾峻峰
Owner JIANGSU DIWO BIOLOGICAL PROD
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