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Porous biological ceramic coating with antibiosis and bone promoting functions as well as preparation method and application thereof

A bioceramic and bone-promoting technology, which is applied in the direction of coating, surface reaction electrolytic coating, electrolytic coating, etc., can solve the problems of anti-infection performance of few implants, achieve the purpose of inhibiting bacterial adhesion and growth, not easy to peel off, and promoting The effect of osteocyte osteogenesis

Inactive Publication Date: 2019-12-13
赵全明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the surface modification of implants has begun to be applied clinically, the surface modification of implants in the past was mainly aimed at the biocompatibility and biological activity of materials, especially the effect and influence of materials on cells, and rarely Shifting focus to anti-infective properties of implants

Method used

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  • Porous biological ceramic coating with antibiosis and bone promoting functions as well as preparation method and application thereof
  • Porous biological ceramic coating with antibiosis and bone promoting functions as well as preparation method and application thereof
  • Porous biological ceramic coating with antibiosis and bone promoting functions as well as preparation method and application thereof

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preparation example Construction

[0032]The preparation method of the porous bioceramic coating with both antibacterial and bone-promoting properties provided by the present invention comprises the following steps: dissolving copper source, magnesium source, fluorine source, calcium source and phosphorus source in deionized water to prepare electrolyte, to The medical titanium alloy sample is the anode, the stainless steel is the cathode, the pulse voltage is 100-500V, the frequency is 100-600Hz, the duty cycle is 10-80%, and the distance between the cathode and anode plates is 60-180mm. The sample is subjected to micro-arc oxidation treatment, the temperature of the electrolyte is kept below 30°C, and the treatment time is 5-30 minutes. After the reaction is completed, porous organisms doped with copper, magnesium, fluorine, calcium and phosphorus elements are formed on the surface of the titanium alloy. The active coating, that is, the porous bioceramic coating of the present invention that has both antibacte...

Embodiment 1

[0036] 1) Pretreatment.

[0037] Grind and polish the medical titanium alloy with 100#, 300#, 600#, 1500#, and 3000# sandpaper in sequence, and then use anhydrous acetone, anhydrous ethanol, and deionized water to ultrasonicate for 30 minutes each.

[0038] 2) Electrolyte preparation.

[0039] Dissolve calcium gluconate, magnesium gluconate, copper gluconate, sodium fluoride, sodium hexametaphosphate, and sodium hydroxide in deionized water, mix well, and prepare an electrolyte; the concentration of copper gluconate ions in the electrolyte is 0.005 mol / L, the concentration of magnesium gluconate ion is 0.01mol / L, the concentration of sodium fluoride ion is 0.01mol / L, the concentration of calcium gluconate ion is 0.01mol / L, the concentration of sodium hexametaphosphate is 0.01mol / L L, the concentration of sodium hydroxide is 0.005.

[0040] 3) Micro-arc oxidation.

[0041] With medical titanium alloy as the anode and stainless steel as the cathode, the unidirectional flow pu...

Embodiment 2

[0049] 1) Pretreatment.

[0050] Grind and polish the medical titanium alloy with 100#, 300#, 600#, 1500#, and 3000# sandpaper in sequence, and then use anhydrous acetone, anhydrous ethanol, and deionized water to ultrasonicate for 30 minutes each.

[0051] 2) Electrolyte preparation.

[0052] Dissolve calcium gluconate, magnesium gluconate, copper gluconate, sodium fluoride, sodium hexametaphosphate, and sodium hydroxide in deionized water, mix well, and prepare an electrolyte; the concentration of copper gluconate ions in the electrolyte is 0.005 mol / L, the concentration of magnesium gluconate ion is 0.01mol / L, the concentration of sodium fluoride ion is 0.02mol / L, the concentration of calcium gluconate ion is 0.01mol / L, the concentration of sodium hexametaphosphate is 0.005mol / L L, the concentration of sodium hydroxide is 0.005.

[0053] 3) Micro-arc oxidation.

[0054] With medical titanium alloy as the anode and stainless steel as the cathode, a unidirectional flow pul...

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Abstract

The invention discloses a porous biological ceramic coating with antibiosis and bone promoting functions as well as a preparation method and application thereof, and belongs to the technical field ofbiomedical ceramic materials. The porous biological ceramic coating is a titanium dioxide coating doped with copper, magnesium, fluorine, calcium and phosphorus elements, the doped biological ceramiccoating is tightly combined with titanium and a titanium alloy substrate, and the doped biological ceramic coating is not prone to peel during implantation and use, can be combined with the substrateto form human body hard tissue repair with good mechanical and biological properties, and has the good antibiosis and bone promoting activity. According to the method, a prepared electrolyte for micro-arc oxidation treatment is simple in component, easy to control, free of components prone to decompose and stable in process, and large-scale batch production of the coating is promoted. The preparation method has no special requirements on the shape of a substrate material, can be suitable for the substrate with the complex shape, and thus the application range of the coating is effectively expanded.

Description

technical field [0001] The invention belongs to the technical field of biomedical ceramic materials, and relates to a porous bioceramic coating, in particular to a porous bioceramic coating with both antibacterial and osteogenic properties, a preparation method and application thereof. Background technique [0002] Compared with traditional stainless steel and cobalt-chromium alloys, titanium is widely used in the field of hard tissue (such as bone and tooth) restoration and replacement due to its low density, low modulus, high strength, good biocompatibility and corrosion resistance. It has been widely used and is an ideal biomedical engineering material. However, titanium lacks biological activity and has no obvious promotion effect on the healing of body tissues. After being implanted in the body, it can only be mechanically combined with bone tissue, and it is difficult to form osseointegration with bone tissue. Associated infection. In addition, titanium will corrode ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/30A61L27/56A61L27/50
CPCA61L27/306A61L27/50A61L27/56A61L2420/02A61L2430/02A61L2430/12C25D11/024C25D11/026C25D11/26
Inventor 赵全明董健
Owner 赵全明
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