22 results about "Copper gluconate" patented technology

The invention relates to the technical field of medical dressings, in particular to a liquid adhesive bandage and a preparation method thereof.The preparation method comprises the following steps that according to the formula amount, sodium chloride and sodium citrate are added into water, and a mixture A is obtained; adding copper gluconate into the mixture A to form a mixture B; mixing Tween 20 with glycerin, adding L-menthol, and stirring to form a mixture C; adding the mixture C into the mixture B to form a mixture D; the preparation method comprises the following steps: adding acetic acid into water, uniformly mixing, adding chitosan, and dissolving to obtain a chitosan-acetic acid solution; adding a chitosan-acetic acid solution into the mixture D, and dissolving to form a mixture E; adjusting the pH value of the mixture E to 4.5-6.5, filtering, filling and sterilizing to obtain the liquid adhesive bandage. The prepared liquid adhesive bandage can quickly form a layer of protective film on the surface of a wound, effectively inhibits growth of bacteria and promotes wound healing, and meanwhile, the liquid adhesive bandage has good flexibility and comfort and small irritation.

The present invention provides a carbomer copper gluconate complex hydrogel, a preparation method, and applications thereof. The carbomer copper gluconate complex hydrogel is prepared in 100 ml or 100 g portions. The raw materials, calculated by mass percentage, include: 0.01% to 0.1% carbomer copper gluconate complex (calculated as copper ion addition); 1% to 2% propylene glycol; 0.1% to 0.2% sodium hyaluronate; 2% to 6% dimethicone; and the balance is an acidity regulator and water. The carbomer copper gluconate complex hydrogel not only effectively kills sperm and common pathogens, but also protects the vaginal mucosa while providing contraception, avoiding the irritation and side effects of chemical spermicides.

The invention relates to the technical field of wound disinfection, in particular to antibacterial wound flushing fluid and a preparation method thereof.The preparation method comprises the following steps that according to the formula amount, vitamin E and glycerin are mixed at 40-50 DEG C, and a mixture A is formed; adding poloxamer into water according to the formula ratio, stirring until the poloxamer is dissolved, and adding the poloxamer into the mixture A to form a mixture B; adding sodium citrate, sodium chloride and L-menthol into water according to the formula ratio to form a mixture C; adding copper gluconate into the mixture C according to the formula ratio to form a mixture D; dropwise adding the mixture B into the mixture D to form a mixture E; adjusting the pH value of the mixture E to 4.5-6.5, filtering, filling and sterilizing to obtain the antibacterial wound flushing fluid. The preparation process is optimized, so that the prepared antibacterial wound flushing fluid has excellent stability; through the coordination effect of all the components, the prepared flushing fluid has a remarkable antibacterial effect.

The invention provides medical application of copper salt with medical value in preparation of a medicine for relieving photolysis of tigecycline. A minimum inhibitory concentration detection test, a sterilization curve detection, a cell protection test and a mouse staphylococcus aureus skin infection treatment effect experiment prove that the copper salt represented by copper gluconate significantly enhances the treatment effect of tigecycline as an external medicine. The photolysis effect of tigecycline is reduced by adding the copper salt, so that the antibacterial effect of tigecycline under any illumination condition is enhanced. The concentration of the used copper salt is far lower than the antibacterial effect of the copper salt. Therefore, the copper salt represented by the copper gluconate can be used for new drug development. The discovery of the application has very important clinical application value, can greatly promote the medication spectrum and indications of tigecycline as an externally applied drug, can solve the problem that no externally applied antibacterial drug is available for skin or soft tissue infection of various complex drug-resistant bacteria clinically, and can generate great economic benefits at the same time.

The invention relates to a mineral buffer salt stabilizing system and application thereof, and belongs to the technical field of formula milk powder processing. In order to further improve the stability of protein in milk powder and improve the reconstituability of the milk powder under the existing mature preparation process condition of formula milk powder, the invention provides a mineral buffer salt stabilizing system. The compound fertilizer comprises the following components in parts by weight: 5.0 to 50 parts of sodium citrate, 5.0 to 55 parts of potassium chloride, 0.10 to 40 parts of calcium hydrogen phosphate, 0.10 to 30 parts of magnesium sulfate, 0.1 to 25 parts of ferrous gluconate, 0.1 to 25 parts of zinc gluconate and 0.1 to 25 parts of copper gluconate. The components of the mineral buffer salt stabilizing system are healthier and safer, and mineral ions and protein micelles in a subsequent hot processing solution are kept relatively stable by adjusting the ion composition and pH range of the solution, so that the protein denaturation degree is reduced, nutrient substances are reserved to the greatest extent, and the brewing characteristic is improved.

The invention belongs to the technical field of pesticides, and particularly relates to a pesticide composition for preventing and treating strawberry bacterial wilt. The invention relates to a sterilization pesticide composition. The effective components of the sterilization pesticide composition are compounded by copper gluconate and aureonucleomycin or benziothiazolinone. The copper gluconate is compounded with the existing bactericide aureonucleomycin or benziothiazolinone according to a certain mass ratio, the effect of the compounded combination on strawberry bacterial wilt is measured through an indoor turbidity method, and the result shows that the co-toxicity coefficient of the compounded combination on strawberry bacterial wilt bacteria is larger than 120; therefore, the pesticide composition disclosed by the invention has a synergistic effect on strawberry bacterial wilt.

The invention relates to the technical field of catalysts, in particular to a reverse water gas shift reaction catalyst and a preparation method and application thereof. The preparation method of the reverse water gas shift reaction catalyst provided by the invention comprises the following steps: dissolving a Cu salt and a Co salt in water, adding a TS-1 molecular sieve, stirring, heating in a water bath until water is evaporated to dryness, drying and calcining the evaporated sample, and finally performing reduction treatment to obtain the reverse water gas shift reaction catalyst, wherein the Cu salt is selected from one or more of copper acetate, ethylenediamine tetraacetic acid copper diammonium or copper gluconate, and the Co salt is selected from one or more of cobalt acetate, cobalt acetylacetonate or cobalt disalicylaldehyde ethylenediamine. According to the method, the organic metal salt is uniformly loaded on the TS-1 molecular sieve through a wet impregnation method, and the organic metal salt and the TS-1 molecular sieve interact to form a stable active center with high dispersity, so that efficient conversion of carbon dioxide is realized.

The application belongs to the field of pharmaceutical preparations, and provides a liposome of eribulin mesylate, a preparation method and application thereof.The liposome of eribulin mesylate comprises the following raw materials: eribulin mesylate, a lipid material, an inner water phase buffer and an outer water phase buffer; the inner water phase buffer comprises the following raw materials: a mixture of copper gluconate triethanolamine and histidine or a mixture of copper gluconate triethanolamine and a Tris solution.The liposome of eribulin mesylate prepared by the application has high encapsulation efficiency, good stability and low impurity content.

The present invention relates to the recovery of divalent copper ions and cytarabine in the process of cytarabine daunorubicin liposomes for injection, and specifically to a method for recovering divalent copper ions and cytarabine. After passively encapsulating cytarabine, the cytarabine daunorubicin liposomes for injection use ultrafiltration to remove free cytarabine, copper gluconate and triethanolamine. Divalent copper ions belong to heavy metals, and cytarabine is an anti-tumor drug with certain genotoxicity. Direct discharge of waste liquid will seriously pollute the environment. The present invention uses alkaline solution to form precipitation with copper ions for removal, then neutralizes with acid, adsorbs through cation exchange resin, elutes with a certain concentration of ammonia water and ethanol, and concentrates under reduced pressure and recrystallizes to obtain a raw material drug that meets the requirements, thereby achieving the purpose of green manufacturing.

The invention belongs to the technical field of cosmetics, and discloses an anti-aging composition and application thereof and a skin care product, the anti-aging composition comprises royal jelly polypeptide, a dendrobium officinale stem extract solution, a ginsenoside solution and copper gluconate; the mass ratio of the royal jelly polypeptide to the dendrobium officinale stem extract solution to the ginsenoside solution to the copper gluconate is (3-5): (18-22): (18-22): (4-6), and through cooperation of the royal jelly polypeptide, the dendrobium officinale stem extract solution, the ginsenoside solution and the copper gluconate, on one hand, the expression quantity of collagen is remarkably improved; on the other hand, the synergistic matching of the raw materials can also reduce the generation of MDA of oxidative damage cells so as to provide good oxidation resistance.

The invention provides a compound dietary nutrient for tonifying qi and blood and a preparation method thereof, and relates to the field of health food. The invention relates to a compound dietary nutrient for tonifying qi and blood and a preparation method thereof. The compound dietary nutrient capable of tonifying qi and blood is prepared from the following raw materials in percentage by mass: 23.9% of plant extract, 22.334% of maltodextrin, 10% of vitamin C, 8% of ferrous glycinate, 6% of fish collagen peptide, 3% of sodium hyaluronate, 1.8% of zinc glycinate, 1% of heme iron, 0.06% of copper gluconate, 0.6% of 2-oxoglutaric acid, 0.2% of vitamin B2, 0.006% of vitamin B12, 0.2% of vitamin B6, 1.4% of vitamin E and the balance of water. 0.3% of pyrroloquinoline quinone disodium salt, 1.2% of silicon dioxide and 20% of gelatin capsules. Through mutual cooperation of the components, the nutrient elements can promote qi and blood of a human body.

The application belongs to the technical field of cosmetics and discloses an anti-aging composition and purposes, skin care products, which comprise royal jelly polypeptide, Dendrobium candidum stem extract solution, ginsenoside solution and copper gluconate; the mass ratio of the royal jelly polypeptide, the Dendrobium candidum stem extract solution, the ginsenoside solution and the copper gluconate is 3-5:18-22:18-22:4-6; the application provides a significant improvement in the expression amount of collagen through the cooperation between the royal jelly polypeptide, the Dendrobium candidum stem extract solution, the ginsenoside solution and the copper gluconate, and then the content of elastin is improved; on the other hand, the synergistic arrangement between the above raw materials can reduce the generation of MDA of oxidative damage cells and provide good antioxidant capacity.

A liquid oral composition containing component (a): copper gluconate, component (b): zinc chloride, and component (c): sodium L-aspartate.

The invention relates to the field of sodium ion battery negative electrode materials, and discloses phenolic resin hard carbon microspheres as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: by using copper gluconate as an active site, inducing resorcinol and a formaldehyde solution to polymerize on the surface of the copper gluconate, so as to obtain phenolic resin rich in copper components, and after high-temperature carbonization, obtaining the phenolic resin hard carbon microspheres with rich ultra-micropores and a small amount of small-size mesopores by using escape of ultra-small copper particles. The preparation process route is simple, raw materials are cheap and easy to obtain, and industrial production is easy. The prepared phenolic resin-based hard carbon negative electrode material has the advantages of low cost, high reversible capacity, high initial coulombic efficiency, excellent cycle performance and the like.

The invention discloses a food capable of balancing blood sugar and a preparation method, and relates to the technical field of health foods. The food is prepared from the following raw materials: sorbitol, taurine, L-tyrosine, microcrystalline cellulose, Arabic gum, a compound coloring agent, copper gluconate, multivitamins, magnesium stearate, mogroside, a plant extract, puffed cereal powder, corn dietary fiber powder, cranberry powder, glycine and inulin. According to the food capable of balancing blood sugar and the preparation method, the food is prepared from sorbitol, taurine, L-tyrosine, microcrystalline cellulose, Arabic gum, a compound coloring agent, copper gluconate, multivitamins, magnesium stearate, mogroside, a plant extract, puffed cereal powder, corn dietary fiber powder, cranberry powder, glycine and inulin; after being eaten, the food can assist in reducing blood sugar and balancing the blood sugar of an eater, and the satiety of the eater is improved through the puffed cereal powder and the corn dietary fiber powder.

The disclosure relates to antimicrobial compositions comprising at least 80% water by weight, a copper component selected from copper (II) carbonate basic or sodium copper chlorophyllin, a zinc component selected from zinc oxide or zinc acetyl-acetonate, and at least one processing aid such as sulfamic acid, lactic acid, maleic acid, fumaric acid, 2-furoic acid, succinic acid, sulfosuccinic acid, 2,5-furandicarboxylic acid, glycolic acid, α-ketoglutaric acid, malic acid, acexamic acid, or gluconic acid. The copper-to-zinc molar ratio ranges from about 1:6 to about 6:1. The composition demonstrates enhanced antimicrobial activity against bacteria, fungi, and sclerotia, and is effective at lower copper concentrations than conventional agents. Principal uses include agricultural pathogen control via foliar spray or soil treatment. The composition provides broad-spectrum, persistent, and cost-effective antimicrobial action with improved environmental safety and resistance management.

The invention discloses a nutritious food and a preparation method thereof, and relates to the technical field of health foods. The food is prepared from the following raw materials: sorbitol, taurine, L-tyrosine, microcrystalline cellulose, Arabic gum, a compound coloring agent, copper gluconate, calcium, magnesium stearate, titanium dioxide, sunset yellow aluminum lake, multivitamins, carotene, a sun element extract, a plant extract, glycine, inulin, fish meal and chicken meal. According to the nutritious food and the preparation method, the vitamin B2, the vitamin C, the carotene and the sun-dried element extract are beneficial nutrient elements, and the body immune function can be improved due to the increase of animal protein supplement.

This invention relates to the field of wound disinfection technology, and more particularly to an antibacterial wound irrigation solution and its preparation method. The preparation method includes the following steps: Vitamin E and glycerin are mixed at 40-50°C according to the prescribed amounts to form mixture A; poloxamer is added to water and stirred until dissolved, then added to mixture A to form mixture B; sodium citrate, sodium chloride, and L-menthol are added to water according to the prescribed amounts to form mixture C; copper gluconate is added to mixture C according to the prescribed amounts to form mixture D; mixture B is added dropwise to mixture D to form mixture E; the pH of mixture E is adjusted to 4.5-6.5, filtered, filled, and sterilized to obtain the antibacterial wound irrigation solution. This invention optimizes the preparation process, resulting in an antibacterial wound irrigation solution with excellent stability; and through the synergistic effect of the components, the prepared irrigation solution exhibits significant antibacterial efficacy.

This invention relates to the field of medical dressing technology, and more particularly to a liquid wound dressing and its preparation method. The preparation method includes the following steps: Sodium chloride and sodium citrate are added to water according to the formula to obtain mixture A; copper gluconate is added to mixture A to form mixture B; Tween 20 and glycerin are mixed, L-menthol is added, and the mixture is stirred to form mixture C; mixture C is added to mixture B to form mixture D; acetic acid is added to water, mixed, and then chitosan is added and dissolved to obtain a chitosan-acetic acid solution; the chitosan-acetic acid solution is added to mixture D and dissolved to form mixture E; the pH of mixture E is adjusted to 4.5-6.5, filtered, filled, and sterilized to obtain the liquid wound dressing. The liquid wound dressing prepared by this invention can quickly form a protective film on the wound surface, effectively inhibiting bacterial growth, promoting wound healing, and also has good flexibility and comfort with low irritation.

The present application provides a kind of pet wound care compound hydrogel and its preparation method, raw materials include: lignin-copper gluconate complex, sodium hyaluronate, propylene glycol, aloe extract, wherein, in mass percent, copper ion in lignin-copper gluconate complex is added 0.01% to 0.1%.The compound hydrogel is alcohol-free, preservative-free, non-toxic and harmless, edible, more easily accepted by pets and combined with wound care, low sensitivity and mild, no irritation to pet skin.

The invention provides a traditional Chinese medicine composition for treating malignant tumors as well as a preparation method and application thereof, and is characterized in that the traditional Chinese medicine composition comprises verdigris and Chinese gall leaven in a mass ratio of 1: 10; or the traditional Chinese medicine composition comprises copper gluconate and Chinese gall leaven according to the mass ratio of 1: 5. According to the traditional Chinese medicine composition provided by the invention, the Chinese gall leaven has an active component which forms a complex with copper ions, so that the Chinese gall leaven is compatible with the verdigris or the copper gluconate, and the active component of the Chinese gall leaven can chelate the copper ions contained in the verdigris or the copper gluconate, so that the copper ions contained in the verdigris or the copper gluconate can be removed; and carrying out a coordination chemical reaction to form the copper complex with an anti-tumor effect.

The invention relates to the technical field of cosmetics, and particularly discloses a toning lotion with rapid moisturizing, firming and soothing effects and a preparation method thereof.The toning lotion takes embryo extract in a specific proportion as a core and cooperates with glycerin and propylene glycol to construct a rapid moisture absorption-water locking network, panthenol and copper gluconate are matched to enhance the firming and anti-wrinkle effects, and the toning lotion has the advantages of being good in moisturizing, firming and soothing effects and good in moisturizing, firming and soothing effects. Plant extracts such as chrysanthellum indicum are combined, so that the soothing effect is achieved; the embryo extract is subjected to enzymolysis purification to obtain small-molecule active peptide and amino acid, the moisturizing timeliness and transdermal efficiency are remarkably improved, a step-by-step low-temperature mixing process is adopted in the preparation process, the stability of active ingredients is reserved to the maximum extent, and the product overcomes the technical defects that traditional toning lotion is short in moisturizing time and single in effect.