343 results about "Sulfamic acid" patented technology

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The invention discloses a preparation method of salt-resistant sodium carboxymethyl cellulose, and relates to the technical field of petroleum fracturing materials. The preparation method comprises the following steps: reacting stearic acid with ethylenediamine to obtain a monosubstituted intermediate, reacting the monosubstituted intermediate with cocoyl chloride to obtain an intermediate 1, reacting the intermediate 1 with epoxypropane to obtain an intermediate 2, and reacting the intermediate 2 with paratoluensulfonyl chloride to obtain a hydrophobic intermediate; reacting a sodium carboxymethyl cellulose solution with the hydrophobic intermediate to obtain modified sodium carboxymethyl cellulose, and sulfonating the modified sodium carboxymethyl cellulose with sulfamic acid to obtain crude salt-tolerant sodium carboxymethyl cellulose; and reacting the crude product salt-resistant sodium carboxymethyl cellulose with borax to obtain the salt-resistant sodium carboxymethyl cellulose. The salt-resistant sodium carboxymethyl cellulose prepared by adopting a step-by-step synthesis strategy has excellent salt resistance, temperature resistance, shearing resistance and dissolution rate, and is suitable for thickening and sand carrying of high-temperature and high-salt oil and gas field fracturing fluid.

The invention discloses an electrolytic solution of a platinum-rhodium alloy, a preparation method and a preparation method of a plating layer of the platinum-rhodium alloy, and belongs to the technical field of precise electroplating. The electrolytic solution comprises a platinum salt, a rhodium salt, a first additive, a second additive, a first complexing agent, a second complexing agent, a first stabilizer and a second stabilizer, the first additive is a sulfamic acid compound containing 3-4 hydroxyalkyl groups, the second additive is sulfamic acid salt containing 3-4 hydroxyalkyl groups, and the first complexing agent and the second complexing agent are a platinum salt and a rhodium salt. The first complexing agent is a mixture of dicarboxylic acid and dicarboxylic acid containing amino or hydroxyl, the second complexing agent is a salt corresponding to the dicarboxylic acid, and the first stabilizer is a mixture of alkyl sulfonic acid and alkyl sulfonate. Through the synergistic effect of the additive, the complexing agent and the stabilizer, the additive, the complexing agent and the stabilizer form a five-membered to seven-membered heterocyclic coupling structure with platinum ions and rhodium ions, and the stability of the electrolytic solution is remarkably improved. And the obtained platinum-rhodium alloy coating is compact and uniform, and has excellent nitric acid steam and mixed gas corrosion resistance.

The invention discloses a bacteriostatic food packaging bag and a preparation method thereof, and relates to the technical field of food packaging, the bacteriostatic food packaging bag comprises the following components by weight: 12-22 parts of bamboo fiber; 55 to 80 parts of TPS (Thermoplastic Polystyrene); 15-20 parts of a modified ethylene composite copolymer; 15 to 20 parts of modified chitosan; wherein the modified ethylene composite copolymer is obtained by polymerizing active group-containing ethylene and one of vinyl acetate, butene, hexene or octylene according to a molar ratio of 10: (3-6); the active group is at least one of amino and sulfonic acid group; the modified chitosan is sulfo-grafted chitosan, and the mass grafting rate is greater than 0.1 wt%. The preparation method has the advantages that the compatibility of a composition formula is improved through the modified ethylene composite copolymer and the modified chitosan, a uniform net structure is formed in a cross-linking reaction to serve as a supporting framework, the overall mechanical structure performance is enhanced through the bamboo fibers which are synergistically and uniformly distributed in the composition formula, and the degradable and non-toxic effects are achieved through the cooperation of the bamboo fibers and the TPS.

The invention relates to a high-performance reactive asphalt cold patch mixture and a preparation process thereof. The mixture comprises a sulfonated fatty acid diluent, a graded aggregate, an atomic layer deposition (ALD) modified basalt aggregate and a solid waste-based composite curing agent. The sulfonated fatty acid diluent is prepared by sulfonating oleic acid, linoleic acid and palmitic acid through sulfamic acid, the sulfonation degree is 15-20%, and the sulfonated fatty acid diluent contains an epoxy three-membered ring structure; the 3-5mm aggregate is used as a transition layer to block the caking path of the fine aggregate; the basalt aggregate is subjected to TDMAT and TMA alternate deposition to form a Ti < x > Al < gamma > O < 2 > nano film; the curing agent comprises calcium strontium sulphoaluminate minerals, a titanium gypsum-carbide slag compound and magnesium-loaded lithium slag. During preparation, the modified aggregate, the sulfonated diluent and the curing agent are mixed at normal temperature. The problems that a traditional cold repairing material is poor in low-temperature fluidity and weak in interface bonding are solved, the viscosity at-20 DEG C is smaller than or equal to 450 mPa.s, the 7-day strength is larger than or equal to 5.2 kN, and the cold repairing material is suitable for low-temperature emergency repairing.

The invention belongs to the technical field of CT imaging, and relates to a bismuth-based imaging contrast agent and a preparation method thereof. The bismuth-based imaging contrast agent is formed by chelating diethylenetriamine pentaacetic acid (DTPA) modified by sulfamic acid with bismuth ions and then connecting an antibody to the surface. The preparation method comprises the following steps: carrying out first reaction on DTPA and sulfamic acid in the presence of an activating agent to obtain sulfamic acid modified DTPA; carrying out a second reaction with an inorganic bismuth salt in a second solvent, then adjusting the pH value to be neutral, and drying to obtain aminosulfonic acid modified DTPA chelated bismuth ions; and carrying out third reaction on the DTPA chelated bismuth ions modified by sulfamic acid and an antibody, and drying to obtain the product. The CT imaging contrast agent has excellent CT imaging capability, high safety and tumor cell killing capability.

The invention discloses a method for extracting copper fine powder by flotation of copper-containing ore, which belongs to the technical field of mineral processing, and comprises the following steps: after copper-containing raw ore is crushed, ground and classified by a cyclone, overflow enters flotation, and settled sand is returned for regrinding; sodium carbonate is added into graded overflow to adjust the pH, a sodium hexametaphosphate-polyacrylamide composite dispersant is added, and copper sulfate is added and stirred after low-temperature microwave heating; gradient flotation is conducted, specifically, copper sulfide is roughly selected, the pH is adjusted, an amino-sulfonic acid group synergistic modified layered double metal hydroxide / cobalt ferrite composite collecting agent is added, and rough concentrate 1 is obtained through high-frequency pulse air inflation flotation; copper oxide roughing is conducted, clear water is supplemented to adjust the pH, and a collecting agent is supplemented to obtain rough concentrate 2; scavenging is performed for three times, a collecting agent is added for flotation, and concentrate returns to the previous stage; the rough concentrates are combined, and magnetic impurities are removed through high-gradient magnetic separation to obtain magnetic concentrates; and carrying out microbiological leaching on tailings to recover copper. The composite collecting agent is prepared through layered double hydroxide carrier synthesis, amino modification, sulfonic acid group grafting and cobalt ferrite anchoring.

The invention discloses a preparation method of high-purity bis (fluorosulfonyl) imide alkali metal salt. The method comprises the following steps: (1) synthesizing bis (chlorosulfonic acid) imide by taking sulfamic acid, chlorosulfonic acid, thionyl chloride and chlorosulfonic acid isocyanate as raw materials; (2) fluorinating the bis (chlorosulfonic acid) imide by ammonium fluoride to obtain bis (fluorosulfonyl) imide ammonium salt; (3) treating the imidodisulfuryl fluoride ammonium salt solution with a strong acid ion exchange column and concentrating under reduced pressure to obtain imidodisulfuryl fluoride; (4) reacting the alkali metal salt with bis (fluorosulfonyl) imide to obtain bis (fluorosulfonyl) imide alkali metal salt; and (5) carrying out a series of purification processes on the bis (fluorosulfonyl) imide alkali metal salt to obtain the high-purity bis (fluorosulfonyl) imide alkali metal salt. The preparation method has the advantages of mild reaction conditions, low danger coefficient in the technological process, easiness in control, no use and generation of corrosive acid, greenness and environmental protection, and high yield and high purity of the bis (fluorosulfonyl) imide alkali metal salt, and is suitable for large-scale industrial application.

The present invention relates to a solid hard surface cleaning composition comprising: a. a biocidal quaternary ammonium compound; b. an anionic surfactant comprising alkyl sulfate; and c. an effervescence base comprising a carbonate salt and an acid; wherein, • the weight ratio of biocidal quaternary ammonium compound to anionic surfactant is from 1.5:1 to 7:1; • at least 50 wt% of the total amount of acid present in the cleaning composition is sulfamic acid calculated on total amount of acid present in the cleaning composition; • the cleaning composition comprises from 0 to 1 wt% water; and • 25 grams of the cleaning composition dissolved in 1.5 litres of water of 20° Celsius provides an aqueous solution with a pH of 1.5 to 4.5. The invention further relates to a method of cleaning the inside surface of a toilet bowl using the composition of the present invention.

The invention belongs to the technical field of oil exploitation, and relates to a drag reducer for fracturing and a preparation method thereof. The preparation method comprises the following steps: adding 1, 5-hexadiene-3, 4-diol and a catalyst into a high-pressure reactor, raising the temperature, introducing ethylene oxide, raising the temperature, carrying out a heat preservation reaction, stopping heating, and cooling to 50 DEG C or below; adjusting the pH value to 2-3 by using phosphoric acid, adding sulfamic acid, heating, preserving heat and reacting, and cooling to below 40 DEG C; the preparation method comprises the following steps: adding deionized water, 2-(trifluoromethyl) acrylic acid and methacryloylethyl sulphobetaine, stirring and dissolving, adjusting the pH value to 7-8, adding an initiator, heating and carrying out a heat preservation reaction to obtain a viscous liquid; and settling, centrifuging, cleaning and drying to obtain the product drag reducer. The drag reducer has the characteristics of high viscosity and high drag reduction rate.

The present disclosure provides anionic citrate-based composition for use in regenerative applications. The disclosed composition may take the form of a scaffold and generally includes (i) a citrate component, (ii) a diol, and (iii) an anionic moiety. The anionic moiety may include one or more of a sulfate, sulfonate, phosphate, phosphonate, sulfamate, or carboxylic acid, The sulfate and / or sulfonate containing moiety may be conjugated via an amidation reaction, esterification, and / or substitution reaction with a sulfur trioxide complex. A peptide may be conjugated to a surface of the composition.

The present invention discloses aramid insulation paper, a preparation method, and applications, relating to the technical field of aramid paper. The present invention utilizes cellulose treated with a treatment agent A and aminosulfonic acid in combination with meta-aramid chopped fibers treated with the treatment agent A to produce aramid insulation paper with excellent mechanical properties and resistance to high-frequency partial discharge and high temperatures.

The invention provides a rubidium and cesium adsorbent and a preparation method and application thereof. The preparation method comprises the following steps: providing a doped and modified Prussian blue analogue, wherein the Prussian blue analogue comprises a Prussian blue matrix material and a transition metal doping element doped in the Prussian blue matrix material; granulating a mixed material containing the doped and modified prussian blue analogue and a granulating agent to obtain a rubidium and cesium adsorbent precursor; a mixed reaction system containing the rubidium and cesium adsorbent precursor and a surface modifier are subjected to a reaction, the surface modifier contains one or more functional structures of an amino group, a sulfonic group, a carboxyl group, a sulfydryl group, an acryloyloxy group, an epoxy group, a crown ether structure and a calixarene structure, and therefore the rubidium and cesium adsorbent is obtained. Through a multi-aspect synergistic strategy of transition metal doping, granulation and surface modification, the prepared rubidium and cesium adsorbent has good stability and high adsorption capacity, and has strong selectivity to Cs < + > / Rb < + >.

The invention discloses a ceramic filter plate cleaning agent and a preparation method thereof, the ceramic filter plate cleaning agent comprises 10%-20% of citric acid, 10%-20% of sulfamic acid, 10%-20% of HEDP, 10%-20% of EDTA, 10%-20% of a corrosion inhibitor, 10%-20% of AEO-9, 10%-20% of JFC and the balance of ultrapure deionized water. 2%-4% of sulfamic acid; 2%-5% of HEDP; 0.5%-2.5% of EDTA (Ethylene Diamine 0.1%-0.5% of a corrosion inhibitor; 1%-3% of AEO-9; 1%-3% of JFC; the AEO-9 is a nonionic surfactant, the sulfamic acid is inorganic solid acid formed by replacing hydroxyl of sulfuric acid with amino, the HEDP is an organic phosphonic acid scale and corrosion inhibitor, the EDTA is a powerful chelating agent, the corrosion inhibitor is benzotriazole, and the JFC is a penetrant auxiliary agent. The cleaning agent can effectively remove various dirt and impurities including organic pollutants, metal oxides, mineral particles and the like on the surface of the ceramic filter plate, does not corrode the ceramic filter plate, has good environmental protection performance, does not generate harmful gas, and is simple and feasible in cleaning process.

The invention provides a preparation method of ethylene carbonate and ethylene sulfate, which comprises the following steps: 1) by taking vinylethylene carbonate as a raw material, carrying out oxidation reaction with an oxidant to obtain epoxy ethylene carbonate as shown in a formula I; and 2) carrying out heating reaction on the epoxy ethylene carbonate as shown in the formula I obtained in the step 1) and sulfamic acid in an acidic solvent to obtain ethylene carbonate disulfate as shown in a formula II. The method avoids the problem of poor reaction selectivity caused by using butantetraol as a raw material in the prior art; according to the method disclosed by the invention, an intermediate butantetraol carbonate is not generated, so that the problem that the intermediate further reacts to generate a byproduct 2, 4, 7-trioxa-3-oxy-bicyclo [3.3. 0] octane does not exist; in addition, when the final product sulfate is synthesized, mild and non-irritant sulfamic acid is used, and the method has the advantages of being clean, green and environmentally friendly.

The invention belongs to the technical field of preparation of sulfamic acid, and particularly relates to high-purity sulfamic acid production equipment and a sulfamic acid synthesis process. Comprising a sulfonation kettle, a feeding pipe is fixedly connected to one side of the sulfonation kettle, an exhaust pipe is fixedly connected to the other side of the sulfonation kettle, a discharging pipe is fixedly connected to the bottom end of the sulfonation kettle, a motor is fixedly installed on one side of the top of the sulfonation kettle, and a first rotating shaft is rotationally connected to the center of the top of the sulfonation kettle; the first rotating shaft is in transmission connection with the output end of the motor through a belt, an annular partition plate is arranged in an inner cavity of the sulfonation kettle, and a plurality of supporting legs are arranged at the bottom end of the annular partition plate. The space in the sulfonation kettle can be divided into the inner side and the outer side through the annular heat conduction plate arranged in the sulfonation kettle, and the jacket heating unit arranged in the sulfonation kettle shell is matched, so that it is effectively ensured that heat is evenly transmitted to a reaction medium, and the local overheating or supercooling phenomenon is reduced.

The invention relates to the technical field of all-vanadium redox flow batteries, and particularly discloses a composition for promoting continuous production of a vanadium electrolyte and application of the composition. The invention discloses a composition for promoting continuous production of a vanadium electrolyte, which is characterized by specifically comprising the following components in parts by weight: 32-42 parts of concentrated sulfuric acid, 0.8-1.2 parts of a sulfonic acid compound, 0.05-0.15 part of sodium sulfate and 60-66 parts of water, the sulfonic acid compound is selected from any one or more of methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, sulfamic acid and p-toluenesulfonic acid. When the composition provided by the invention is used in continuous production of the vanadium electrolyte, the use amount of concentrated sulfuric acid is reduced, vanadium pentoxide can be effectively activated, and the reaction rate is increased; and the produced vanadium electrolyte has excellent electrochemical performance.

Provided in the present application is a method for treating a heavy bis(fluorosulfonyl)imide residue, comprising the following step: causing a starting material system comprising the heavy bis(fluorosulfonyl)imide residue and an acidic aqueous solution to react to obtain a fluorine-containing acid solution and a crude sulfamic acid product, wherein the fluorine-containing acid solution can be used as a by-product acid, thereby saving treatment costs; and the crude sulfamic acid product can also be directly sold as a product, thereby reducing treatment costs, bringing economic benefits, and achieving resource recycling of the heavy bis(fluorosulfonyl)imide residue.

The invention discloses a rare earth element doping modification process of an optical module electroplated layer, which belongs to the technical field of optical module manufacturing, and comprises the following steps: sequentially carrying out oil removal, acid pickling and activation treatment on an optical module matrix to form a clean active surface; the preparation method comprises the following steps: taking nickel aminosulfonate or potassium gold cyanide as main salt, adding 0.5-5g / L of rare earth salt which is at least one of cerium chloride, lanthanum nitrate or yttrium sulfate, and adding 5-15g / L of sodium citrate complexing agent and lauryl sodium sulfate surfactant; under the conditions that the pH is 3.5-4.5 and the temperature is 45-55 DEG C, pulse current with the density being 2-5 A / dm < 2 > is adopted for electroplating, the pulse frequency is 100-500 Hz, and the duty ratio is 30-50%; when electroplating deposition is carried out, hydrogen bubbles on the outer side of the optical module are removed through a hydrogen removal device, the hydrogen bubbles are prevented from being attached to the surface of a cathode, and the uniformity of codeposition of rare earth and metal is ensured; and after electroplating is completed, deionized water cleaning and vacuum drying are carried out on the optical module. The high temperature resistance of the surface of the optical module obtained through the technology is improved.

The invention belongs to the technical field of fabric treatment, and particularly relates to a fabric hydrophilic finishing agent as well as a preparation method and application thereof. The fabric hydrophilic finishing agent comprises water and the following preparation raw materials in percentage by mass: 6%-7% of hexamethylene diisocyanate tripolymer, 4%-5% of polyether polyol, 6%-8% of polyethylene glycol monomethyl ether, 0.5%-1% of sulfamic acid, 1%-2% of an emulsifier, 0.5%-1% of polyether amino silicon oil and 0.1%-0.3% of acetic acid. The prepared finishing agent has good hydrophilicity, washing resistance, yellowing resistance and the like, and is suitable for after-finishing of fabrics, especially chinlon and chinlon-containing blended fabrics.

To achieve an efficacy equivalent to or superior to that of traditional organic biocides through the combination of low-cost components.SOLUTION: A composition for slime prevention according to the present invention comprises a chlorine-based oxidizing agent, a sulfamic acid compound, an anionic polymer, an alkali metal salt, and an azole compound.SELECTED DRAWING: None

The present invention provides sulfamate derivative prodrugs of the dopamine agonist (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol, their use in treating conditions for which treatment with a dopamine agonist has therapeutic benefit, and pharmaceutical compositions comprising a compound of the present invention. The compounds according to the present invention have the formula (Id), wherein R1and R2are each independently selected from H and the substituent (iii) below, wherein * indicates the point of attachment to oxygen, wherein R3is selected from H and COR4, and wherein R4is selected from H and C1-C6alkyl, with the proviso that R1and R2cannot both be H, 15or a pharmaceutically acceptable salt thereof.

The present application relates to the technical field of pipeline drainage, and particularly relates to a composite hydrophobic material for inhibiting crystallization of a tunnel drainage pipeline and a preparation method thereof; the composite hydrophobic material comprises a hydrophobic inner layer and a scale inhibition outer layer attached to the outer surface of the hydrophobic inner layer; the hydrophobic inner layer comprises tetrahydrofuran, a solvent volatilizing agent, a surfactant, nano-silicon dioxide, a cross-linking agent and a curing agent; the scale inhibition outer layer comprises a scale inhibitor solution and a gum material, wherein the scale inhibitor solution comprises EDTA, hydrolyzed maleic anhydride and sulfamic acid; the preparation method comprises the following steps: S1, coating the hydrophobic inner layer material; S2, air-drying to obtain the hydrophobic inner layer; S3, coating the scale inhibition outer layer material on the surface of the hydrophobic inner layer to obtain the composite material; the composite material prepared by the present application still has excellent hydrophobic performance after being left for 24 hours and can be maintained for a long time; the scale inhibition outer layer protects the hydrophobic inner layer and simultaneously plays a scale inhibition role, thereby improving the functionality of the material.

The application belongs to the technical field of tertiary oil recovery, and relates to a heavy oil viscosity reducer and a preparation method and application thereof.The preparation method is as follows: p-nonyl phenol, 1-(4-fluorophenyl)piperazine, 40wt% formaldehyde and water are added into a reactor, stirring is carried out, temperature is increased to reflux, and temperature is kept;temperature is reduced to below 40 DEG C, extraction is carried out, the obtained product is placed in a high-pressure reactor, sodium hydroxide solid is added, nitrogen is introduced, vacuum is drawn, temperature is increased, vacuum drawing is stopped, ethylene oxide is slowly introduced, temperature is increased, and temperature is kept;viscous liquid is obtained through reduced pressure distillation, the obtained product is placed in a high-pressure reactor, pH is adjusted to 3-4, aminosulfonic acid powder is added, stirring and heating are carried out, temperature is kept, and the obtained product is cooled to below 40 DEG C;ethanolamine is added, pH is adjusted to 7-8, and the heavy oil viscosity reducer is obtained.The viscosity reducer has the advantages of low surface tension, low interfacial tension, low critical micelle concentration and good viscosity reduction effect.

A sulfamic acid refined product washing system comprises a cleaning water buffer tank, the bottom of the cleaning water buffer tank is connected with a scraper lower discharging centrifugal machine through a cleaning water conveying pipe, a cleaning liquid outlet of the scraper lower discharging centrifugal machine is connected with a horizontal centrifugal machine through a cleaning liquid conveying pipe, and the horizontal centrifugal machine is connected with an electrolytic bath through a clear liquid pipe. The electrolytic cell is connected with a top liquid inlet pipe of the cleaning water buffer tank through a clean water pipe. By the adoption of the structure, the washing efficiency is improved through improved water circulation and treatment processes, and it is ensured that washed products meet strict quality standards.

The invention provides a method for treating bis (fluorosulfonyl) imide heavy slag, which comprises the following steps: reacting a raw material system comprising bis (fluorosulfonyl) imide heavy slag and an acidic aqueous solution to obtain a fluorine-containing acid solution and a sulfamic acid crude product; wherein the fluorine-containing acid liquid can be used as a byproduct acid, so that the treatment cost is saved; and the sulfamic acid crude product can also be directly sold as a product, so that the treatment cost is reduced, economic benefits are brought, and resource recycling of the bis (fluorosulfonyl) imide heavy slag is realized.

The invention discloses an electrochemical polishing solution for laser additive manufacturing of a tantalum material and a preparation method and process, and relates to the technical field of surface treatment of metal workpieces. According to the electrochemical polishing solution, an alcohol-salt system is adopted for electropolishing treatment, and compared with a traditional electropolishing solution, the electrochemical polishing solution has the advantages of electrochemical and chemical stability, relatively high conductivity, relatively high controllability, relatively low toxicity, low volatility, environment friendliness and the like; the electropolishing solution has the characteristics of no volatilization, no odor, low toxicity to a human body and the like by adding the inorganic solid acid formed by replacing sulfamic acid sulfuric acid hydroxyl with amino, and not only has the oxidation capacity of sulfuric acid, but also can promote dissolution and improve the material removal rate by the amino; the electrochemical polishing solution is mild in process parameter, insensitive to temperature, capable of implementing polishing at room temperature, small in corrosion to electrolysis equipment and capable of being used for a long time.

The invention discloses a humic acid-based soil alkalinity adjusting agent and a preparation method thereof, and belongs to the field of soil amendments, the humic acid-based soil alkalinity adjusting agent comprises the following raw materials by weight: 30-50 parts of a modified humic acid carrier; 8-15 parts of carbonate; 3-5 parts of a microbial agent; wherein the modified humic acid carrier is prepared from the following raw materials: acylating chlorinated nano humic acid, sulfamic acid and acidified chitosan in a mass ratio of 1: (0.1-0.4): (0.1-0.3). The density of acidic functional groups is improved by modifying nano humic acid through sulfamic acid, a three-dimensional network structure is constructed by the nano humic acid and acidified chitosan, and meanwhile, carbonate, a microbial agent and hydroxyapatite are compounded, so that high efficiency and durability of an alkali adjusting effect are realized. Compared with a traditional inorganic acid modifier, the modifier can prevent local pH sudden change from burning crop root systems, the three-dimensional network structure can delay carbonate release, the alkali adjusting effect is continuous, and the problems that a traditional modifier acts transiently, and soil is prone to being damaged are effectively solved.

The present disclosure provides methods, pharmaceutical compositions, and kits for treating cancer in patients in need thereof. The methods comprise administering to a patient in need a small ubiquitin-like modifier (SUMO) activating enzyme (SAE) inhibitor, such as [(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxy-cyclopentyl]methyl sulfamate (Compound I-263a) or a pharmaceutically acceptable salt, in combination with one or more anti-CD19 antibodies. Also provided are medicaments for use in treating cancer.

The embodiment of the invention discloses a dispersing agent for a geopolymer cementing material as well as a preparation method and application of the dispersing agent. The method comprises the following steps: mixing lignosulfonate, sulfamic acid, heteropoly acid and ethylene glycol, and carrying out degradation and sulfonation reaction to obtain modified lignosulfonate; carrying out esterification reaction on the modified lignosulfonate in the presence of methacrylic acid, a catalyst and a polymerization inhibitor to obtain a modified polymeric monomer; and carrying out polymerization reaction on the modified polymeric monomer and a polyether monomer under the action of an initiator to obtain the polymer. The dispersant disclosed by the invention can play roles in reducing the mixing water consumption and improving the water reducing effect of the dispersant in a geopolymer cementing material system, so that the curing performance defect of a geopolymer cementing material mixture is better solved, application of geopolymers is promoted, meanwhile, a large amount of cement is saved, carbon emission is reduced, and the dispersant has a wide application prospect.