116results about How to "High inhibitory effect" patented technology

The invention provides a method for manufacturing a metal surface self-cleaning high-protection film. The method comprises two steps of molybdate solution soaking treatment and plant corrosion inhibitor-low-surface-energy material collaborative modification treatment. According to the molybdate solution soaking treatment step, a composite film which is of a specific micro/nano coarse structure, has the good protection effect and is composed of metallic oxides, molybdenum oxide and metal molybdate can be formed on a metal surface, and therefore according to the plant corrosion inhibitor-low-surface-energy material collaborative modification treatment step, efficient green plant corrosion inhibitors can be introduced into the film, and the protection effect can be obviously improved. Due to the hydrophobization effect of the low-surface-energy material on the film, the film has the self-cleaning function, the pollution can be avoided, the probability of direct contact of metal materials and corrosive media can be reduced, and the protection effect of the film can be further improved. The method has the advantages of being environmentally friendly, simple in process, convenient to operate, capable of being easily and industrially produced in a large-scale mode and the like.

The invention belongs to the technical filed of medicines, and concretely relates to optically pure benzyl-4-chlorophenyl C-glucoside derivatives represented by formula (II) and formula (III), a method for preparing the above compounds and intermediates thereof, a medicinal preparation and a medicinal composition containing the compounds, and an application of the optically pure benzyl-4-chlorophenyl C-glucoside derivatives in the preparation of medicines for treating and/or preventing insulin-dependent diabetes, non-insulin dependent diabetes, insulin resistance diseases or obesity, various diabetes and relevant diseases as a sodium-glucose cotransporter (SGLT) inhibitor.

The invention relates to hair washing and caring products, and in particular relates to a hair-nourishing hair-loss-preventing dandruff-removing stock shampoo and a preparation method thereof. The method comprises the following steps: adding sodium lauryl polyoxyethylene ether sulfate, glycine betaine and soapberry extract under a stirring situation to obtain a shampoo substrate; regulating the pH to be neutral by using citric acid; sequentially adding Chinese honeylocust fruit extract, cacumen biotae extract, eclipta, rhodiola-polygonum multiflorum-ginseng combined extract, Chinese angelica extract, ginger extract, gingko leaf extract, dandelion extract, honeysuckle extract and mulberry leaf extract; finally adding plant preservative to obtain the finished product. The shampoo prepared by adopting the technical scheme is prepared according to a natural plant formula. Tests indicate that the shampoo can be used for cleaning the scalp and well inhibiting scalp fungi, has remarkable effects of nourishing scalp, removing dandruff relieving itching, reducing hair loss and caring hair, and is mild, non-irritative, safe and healthy. Sewage residue of the shampoo can be easily decomposed after the shampoo is used.

The invention relates to a green environment-friendly polyether carboxylic acid ester corrosion inhibition and scale inhibitor (APEL) and preparation method thereof. The corrosion and scale inhibitor is a phosphorus-free, nitrogen-free and biodegradable water treatment agent, which is applicable to industrial recirculated cooling water and is used for water quality corrosion inhibition and scale inhibition treatment. The corrosion inhibition scale inhibitor of the present invention is obtained by free radical copolymerization of polyether carboxylic acid ester reactive monomers and vinyl unsaturated double bond monomers, which comprise the following structural general formula: wherein A is monomer copolymerized constitutional repeating unit containing vinyl unsaturated double bond; R is Hor C1 to C5 low carbon alkyl; the degree of polymerization of x is 1 to 5000; the degree of polymerization of y is 1 to 5000; repeating unit amount of m is 1 to 100. The carboxylic acid ester corrosion inhibition and scale inhibitor has good compatibleness, can be used alone or in combination with other water treatment agents, like organic phosphate, zinc salt corrosion inhibitor.

The present invention features that the polynary copolymer is prepared with itaconic acid, sulfonate and acrylate and through water phase polymeriztion in the presence of initiator system. Relates to itaconic acid, the amount of sulfonate is 0-50 wt%, the acrylate 5-200 wt% and the initiator 0-30 wt%. The preparation process includes mixing itaconic acid and sulfonate to prepare water solution, and adding initiator solution and acrylate homogeneously for copolymerization reaction at 30-100 deg.c. The prepared polynary copolymer solution may be used as anti-sludging agent, scale remover, dispersant, detergent aid, etc. The production process is simple and has no 'three-waste' exhaust.

The invention discloses a bacteriophage depolymerase capable of degrading Klebsiella pneumoniae capsular polysaccharides and biofilms. By prokaryotic expression and purification of a 32nd open readingframe in a genome of Klebsiella pneumoniae bacteriophage GH-K3, a brand-new depolymerase depo32 with high activity is obtained. The depolymerase has high-efficiency degradation effect on the capsularpolysaccharides and biofilms formed by Klebsiella pneumoniae.

The invention relates to polyitaconic acid and a preparation method thereof, in particular to the polyitaconic acid and a method for preparing the polyitaconic acid quickly and effectively. The polyitaconic acid comprises an itaconic acid monocarboxylate monomer unit and an itaconic acid dicarboxylate monomer unit, the molecular weight range of the polyitaconic acid, which is determined by a gel permeation chromatograph through standard polyethylene oxide (PEO) is 1000-10000, and a polymer is light yellow or dark red liquid which belongs to an environment-friendly product. The polyitaconic acid takes itaconic acid monomers which are partially neutralized as raw materials and is polymerized in water phase through the radical polymerization method. The method has simple process, few residues of the monomers, high conversion rate, high polymerization time, low energy consumption, and no emission of three wastes. The polyitaconic acid salt has a high-efficient inhibition role for formation and adhesion of calcium carbonate scale in seawater. The polyitaconic acid can be used as a scale inhibitor, a dispersing agent and a corrosion inhibitor in a seawater utilization (seawater circulating cooling, seawater desalting and the like) system, as well as a detergent additive, a chelating agent and the like.

An environment-friendly polyethyleneglycol multifunctional water treatment agent (namely PEGY) is prepared through free radical copolymerization of polyethyleneglycol carboxylic acid reaction monomers and monomers containing vinyl unsaturated double bonds. The structural formula of the environment-friendly polyethyleneglycol multifunctional water treatment agent figured as follows, wherein A represents a constitutional repeating unit formed after the polymerization of the monomers containing the vinyl unsaturated double bonds, the polymerization degree x is 1-5,000, the polymerization degree y is 1-5,000, the polymerization degree z is 1-5,000, the polymerization degree z is 1-5,000, and the number m of repeating units is 3-1000.

The invention provides a beta hairpin antibacterial peptide with tryptophan and arginine cross-chain interaction and a preparation method of the beta hairpin antibacterial peptide. The sequence of theantibacterial peptide WRLPG is shown as SEQ ID No. 1. The preparation method comprises the following step: designing an antibacterial peptide template XWYRYPGXWYRY-NH2 containing tryptophan and arginine cross-chain interaction and a PG corner unit on the basis of beta-hairpin amphiphilic peptide arrangement, wherein X= R, and Y= L. The invention also provides application of the antibacterial peptide in preparation of medicines for treating infectious diseases caused by gram-positive bacteria or/and gram-negative bacteria. The antibacterial peptide forms a stable beta-hairpin structure under the condition that a disulfide bond formed by cysteine pairs is not contained, the length of an amino acid sequence is only 12, the antibacterial peptide has excellent biosecurity on the basis of maintaining high antibacterial activity, and the treatment index reaches 90.78. The antibacterial peptide has high development potential of replacing antibiotics.

The invention discloses a strain of antagonistic bacteria for preventing and controlling poplar colletotrichumgloeosporioides and application thereof. The antagonistic bacteria are bacillus atrophaeus XW2, and the microbial collection number is CGMCC NO. 7689. The bacillus atrophaeus XW2 is obtained through plate face-to-face culturing and screening of poplar endophytes via a flat plate, has an obvious antagonistic effect on the poplar colletotrichumgloeosporioides, can be used for effectively inhibiting the growth of poplar colletotrichumgloeosporioides hypha and germination of spores and preventing and controlling plant diseases caused by the poplar colletotrichumgloeosporioides, is a biological prevention and control potential strain with high protection effect and good environmental safety and has good development and application prospect.

The invention discloses a fluorescent tracing green environmental-friendly polyglycol type water treatment agent (namely PEGEYYG) which is prepared by carrying out free radical copolymerization on a polyethylene glycol carboxylic acid reaction monomer, a monomer containing vinyl unsaturated double-bond and a fluorescent monomer containing unsaturated double-bond. According to the structural general formula of the water treatment agent, A is a repeating structure unit after the polymerization of the monomer containing the vinyl unsaturated double-bond, B is a repeating structure unit after the polymerization of the fluorescent monomer containing the unsaturated double-bond, the polymerization degrees x, y, z, p, q and g are respectively 1-5000, and the repeating unit m is 3-1000.

The invention provides enterococcus faecium G12. The enterococcus faecium G12 is isolated from hepato-pancreas of shellfish, is safe and has probiotic characteristics. A strain enterococcus faecium isnamed the enterococcus faecium G12, and is deposited in the China General Microbiological Culture Collection Center, the deposit number is CGMCC NO.15230, and the date of deposit is January 17, 2018.The enterococcus faecium G12 has high heat resistance, high resistance to stress and remarkable probiotic properties, has an obvious inhibitory effect on a common aquatic pathogenic bacterium aeromonas veronii, is sensitive to most broad-spectrum antibiotics, can tolerate a small intestine high-bile-salt environment and is colonized in the intestine, and is suitable for being used as a feed additive to be widely applied to aquaculture, thereby being capable of greatly reducing the pollution to the environmental and the adverse effects on human health caused by the addition of traditional antibiotics in the aquaculture, and achieving sustainable development of the aquaculture.

The invention discloses a bioglass granular material and a preparation technique thereof. The bioglass granular material comprises the following components in percentage by weight (represented in the form of oxides): 20-35% of CaO, 20-38% of SiO2, 0.4-1.8% of P2O5, 12-18% of B2O3, 0.1-0.8% of CuO, 0-0.7% of ZnO, 8.5-18.0% of K2O and 0.2-4.0% of Na2O. The preparation method comprises the following steps: preparing a gel, drying and calcining to obtain the bioglass granular material. The bioglass granular material can induce remineralization and total closing of dentinal tubules; the granular surface layer can be quickly degraded under the action of saliva in the oral cavity and can release multiple physiologically necessary inorganic metals and acid ions for the human body; and the inorganic ion composition can quickly inhibit the activity of harmful bacteria of the oral cavity and relieve the allergy of the dental pulp sensitive nerves to the external stimulation, thereby having great popularization and practical values.

The invention discloses a plant extract-based sterilization composition. The plant extract-based sterilization composition is prepared from the following components in percentage by weight: 1.0 to 3.0percent of grapefruit extract, 3.0 to 10.0 percent of cortex magnoliae officinalis extract, 3.0 to 8.0 percent of ginger root extract, 3.0 to 8.0 percent of pericarpium zanthoxyli extract and 71 to 90 percent of polyol. The plant extract-based sterilization composition is prominent in lasting antibacterial property; the plant extract-based sterilization composition is prepared from the grapefruitextract, the cortex magnoliae officinalis extract, the ginger root extract, the pericarpium zanthoxyli extract and the polyol, so that the plant extract-based sterilization composition is capable ofeffectively controlling plenty of bacteria and mould, which are difficult to control, in cosmetics, and the plant extract-based sterilization composition is gentle in property, has no irritation and no hotness and is very safe. The plant extract-based sterilization composition is capable of effectively killing the bacteria, the mould and saccharomycetes in the cosmetics, and the components of thecomposition are not included in an accepted preservative list specified by Cosmetic Safety Technological Specification, and can meet the requirement of a 'no preservative' concept of a product.

The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

The invention discloses application of epigallocatechingallate (EGCG) in improving dental resin adhesive material restoration performance. The application of the EGCG prepared into a 400 micrograms/ml ECCG ethanol solution used as a pretreating agent in the coronal dentin adhering aspect and the application of the EGCG prepared into the 400 micrograms/ml ECCG ethanol solution used as the pretreating agent in root canal dentin adhering aspect are involved. By means of the characteristic of the EGCG for restraining matrix metalloproteinase activity and inoxidizability, the EGCG is prepared into the pretreating agent to be applied to coronal dentin and root canal dentin adhering, and the long-term restoration effect of a clinic resin adhesive restoration body and the long-term restoration effect on devital teeth with deficiency of a large amount of tooth tissue are effectively improved.

The invention provides a preparation method of a kiwifruit preservative based on plant essential oil. The preparation method includes following steps: (1) dissolving cinnamon essential oil, thyme essential oil and clove essential oil into ethanol respectively; (2) preparing beta-cyclodextrin into saturated water solution, stirring and slowly adding the cinnamon essential oil, thyme oil and clove essential oil obtained in the step (1), and controlling the quality ratio of beta-cyclodextrin, cinnamon essential oil to thyme oil to clove essential oil at 120-130:1-3:0.5-1.5:5-10; (3) after material adding is completed at the step (2), uniformly stirring and freezing for 12 to 36 hours; (4) adding products of the step (3) into sodium alginate, making sodium alginate account for 0.6% of the total weight of the mixture. The invention also provides a preparation method of the kiwifruit preservative. The kiwifruit preservative is great in antibacterial effect, long in action time and convenient to use.

The invention discloses an environment-friendly water treatment agent capable of realizing fluorescence tracing. The environment-friendly water treatment agent capable of realizing fluorescence tracing is obtained via water phase free radical copolymerization of an isopentenyl alcohol ester monmer and a monomer containing vinyl unsaturated double bonds with a fluorescent monomer capable of realizing fluorescence tracing. The general structural formula is disclosed in the invention, wherein A is used for representing structural repeat units obtained via copolymerization of the monomer containing vinyl unsaturated double bonds, B is used for representing structural repeat units obtained via polymerization of the fluorescent monomer containing unsaturated double bonds, polymerization degreesx and y range from 1 to 5000, the numbers of the repeat units m and n range from 1 to 100. The environment-friendly water treatment agent is excellent in compatibleness, can be used alone, and also can be combined with water treatment agents such as organic phosphates, and zinc corrosion inhibitors.

The invention discloses a circulating water phosphorus-free corrosion and scale inhibitor and a preparation method thereof, and belongs to the technical field of water treatment agent preparation. Thecorrosion and scale inhibitor comprises the following components in parts by weight: 10-20 parts of polyepoxysuccinic acid or polyaspartic acid, 10-35 parts of sodium gluconate, 10-20 parts of acrylic acid-2-acrylamide-2-methyl propane sulfonic acid copolymer, 5-10 parts of zinc salt, 3-15 parts of molybdate, 1-3 parts of a copper corrosion inhibitor, 1-2 parts of a fluorescent tracer, 1-2 partsof a pH regulator, 5-10 parts of isothiazolinone and the balance of water. The phosphorus-free corrosion and scale inhibitor has the advantages of high corrosion inhibition rate, high scale inhibitionrate, low cost, no phosphorus, wide scale inhibition spectrum, wide pH application range, sterilization and slime stripping effects, low toxicity, chloride resistance, simple operation, controllablecirculating water agent concentration, safety and high efficiency, and belongs to an environment-friendly corrosion and scale inhibitor.

The invention provides an antimicrobial peptide derived from scorpion venom as well as a preparation method and application of the antimicrobial peptide. The antimicrobial peptide RLL has a sequence shown as SEQ ID No.1. A peptide RSN is obtained by intercepting 14 amino acids in the middle of the scorpion toxin, negatively charged aspartic acid in the peptide RSN is replaced with positively charged arginine, and serine, glycine and asparagine in a peptide chain are replaced with leucine to obtain the antimicrobial peptide RLL; and the antimicrobial peptide RLL has very low hemolytic activityand eukaryotic cytotoxicity, the antimicrobial peptide cannot cause 10% erythrocyte hemolysis at a concentration of 128 [mu]mol/L, the survival rate of mouse macrophages RAW 264.7 reaches 80% or more,and the antimicrobial peptide has the development potential of becoming an antibiotic substitute.

The invention discloses an isolated streptomyces and biocontrol and growth promoting application thereof, and belongs to the field of biotechnology. The Streptomyces sp. DL70 of the invention is deposited in China Center for Type Culture Collection (CCTCC), the deposit number is CCTCC NO.M 2019475, and the deposit date is June20, 2019. The streptomyces is isolated from the deep rhizosphere soil ofhealthy plants along the coastal beach in Dalian, has low nutritional requirements and rapid cell growth, and can achieve an effective number of viable bacteria of not less than 1010 cfu/mL in 48 hours of liquid fermentation. According to the present invention, the Streptomyces DL70 and the fermentation products of the Streptomyces DL70 have highly effective antagonistic effects on a variety of plant pathogenic fungi, significantly promote the rapid growth of plants at the same time, and have obvious advantages of biocontrol and growth promoting application and industrial production potential.