Bioglass granular material and preparation technique thereof

Abstract

The invention discloses a bioglass granular material and a preparation technique thereof. The bioglass granular material comprises the following components in percentage by weight (represented in the form of oxides): 20-35% of CaO, 20-38% of SiO2, 0.4-1.8% of P2O5, 12-18% of B2O3, 0.1-0.8% of CuO, 0-0.7% of ZnO, 8.5-18.0% of K2O and 0.2-4.0% of Na2O. The preparation method comprises the following steps: preparing a gel, drying and calcining to obtain the bioglass granular material. The bioglass granular material can induce remineralization and total closing of dentinal tubules; the granular surface layer can be quickly degraded under the action of saliva in the oral cavity and can release multiple physiologically necessary inorganic metals and acid ions for the human body; and the inorganic ion composition can quickly inhibit the activity of harmful bacteria of the oral cavity and relieve the allergy of the dental pulp sensitive nerves to the external stimulation, thereby having great popularization and practical values.

Description

technical field [0001] The invention relates to a biologically active inorganic ultrafine particle material for alleviating human tooth sensitivity and sealing dentin tubules, and belongs to the technical field of biological materials. Background technique [0002] In 1969, Professor Larry L. Hench of the University of Florida in the United States first discovered a compound composed of CaO and SiO 2 ,P 2 o 5 and Na 2 The glass powder fired from the compound of the O component induces the deposition of bone-like apatite in the body fluid or simulated body fluid, and can form a bone chemical bond with the living bone tissue, and develop into a bone repair material for clinical application (trade name: 45S5 ). The discovery and application of this material has given people a new understanding of the connotation of bioactivity and the design of bioactive materials. So far, people have found many calcium-silicon (CaO-SiO 2 )-based amorphous glass and glass-ceramic materi...

AI Technical Summary

Problems solved by technology

It can be seen that the particle size, particle shape and early degradation and dissolution ion composition characteristics of bioactive glass are the key factors to determine the desensitization efficiency and long-term effect, but they have been widely ignored for a long time

Careful analysis shows that the particle size of powders such as 45S5 bioglass and strontium-strengthened bioactive glass-ceramics prepared by high-temperature melting are controlled by the intensity and time of high-energy ball milling, but the particle size distribution range of ball-milled powders is wide, and there are often significantly larger than Particles with a diameter of dentin tubules (generally less than 3 microns), such coarse particles are difficult to enter the exposed dentin tubule channels during the process of treating the tooth surface with the carrier, and the residual rate of particles on the dentin surface and saliva is extremely limited during the mouthwash process , affecting its clinical desensitization efficiency

Secondly, the high-temperature molten bioglass or glass-ceramic ultrafine particles prepared by ball milling are extremely irregular in shape, especially when a large number of particles with sharp edges and corners are produced during the contact friction process of the tooth surface, the sharp and small edges and corners are easy to scratch dentin and dentine. Enamel, increasing the risk of insurmountable damage to healthy tooth surfaces

Thirdly, the fine particles of 45S5 bioglass, strontium-enhanced bioactive glass and glass ceramics contact saliva to release inorganic ions, and the resulting saliva is weakly alkaline. This intermittent increase in the pH value of oral saliva cannot effectively kill The activity of harmful microorganisms in active dental plaque, so it is difficult to achieve the desired effect in inhibiting dental plaque and dental caries; in addition, the anti-gingival bleeding effect of these conventional inorganic ion compositions also lacks basic theoretical basis

[0008] Throughout the clinical application in recent years, although a large number of special-effect desensitizing toothpastes have had positive effects on desensitization, none of them can solve clinical problems including multiple dental lesions and compound oral problems, and patients with dentin sensitivity are accompanied by dental caries and gingival bleeding. Therefore, based on the conventional bioglass that releases calcium and phosphorus ions to alleviate the problem of tooth sensitivity, it cannot fundamentally solve the accompanying oral problems.

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