6 results about "Erythrocyte hemolysis" patented technology

This invention discloses crystals of nitrogen-containing spiro compounds, methods for producing the same, and uses thereof. This invention provides a type I crystal of a nitrogen-containing spiro compound represented by formula A, in which the powder X-ray diffraction pattern displayed at a 2θ angle using Cu-Kα rays has diffraction peaks at positions 5.67±0.20°, 11.37±0.20°, 16.69±0.20°, 17.32±0.20°, and 19.73±0.20°. This invention also provides a type II crystal of a nitrogen-containing spiro compound represented by formula A, in which the powder X-ray diffraction pattern displayed at a 2θ angle using Cu-Kα rays has diffraction peaks at positions 11.32±0.20°, 11.70±0.20°, 11.93±0.20°, 18.03±0.20°, 18.81±0.20°, and 19.17±0.20°. The nitrogen-containing spiro compound crystals of the present invention exhibit good stability and complement factor D inhibitory activity, good inhibitory effect against rabbit erythrocyte hemolysis, high in vivo exposure levels, and high oral bioavailability. JPEG2026513298000037.jpg5469

The invention discloses an image processing method and device for judging suspension red blood cell hemolysis. The method comprises the following steps: acquiring a blood image set; the blood image set comprises a plurality of blood images and corresponding label information; acquiring a blood parameter information set; the blood parameter information set comprises a plurality of blood parameters and corresponding label information; the blood parameters comprise hemoglobin concentration, reticulocyte concentration, indirect bilirubin concentration, lactic dehydrogenase concentration and globin concentration; utilizing the blood image set and the blood parameter information set to construct a blood hemolysis composite detection model; based on the blood hemolysis composite detection model, processing the collected blood image and blood parameters to obtain hemolysis detection result information; the hemolysis detection result information is used for representing erythrocyte hemolysis information of the blood corresponding to the collected blood image and blood parameters.

The invention discloses an antibacterial peptide and application thereof as a medicine and a feed additive. The antibacterial peptide is obtained by modifying an amino acid sequence as shown in SEQ ID No: 1. A potential antibacterial peptide sequence is excavated from channel catfish proteome, and a novel antibacterial peptide which has broad-spectrum antibacterial activity and particularly has a remarkable inhibition effect on APEC is obtained through structural modification and optimization. The antibacterial peptide can effectively inhibit the growth of various drug-resistant APEC strains in vitro, shows good safety in cytotoxicity and red blood cell hemolysis experiments, and can be used as a powerful supplement for traditional antibiotic and vaccine prevention and control.

This invention discloses a method for preparing an aqueous extract of Artemisia argyi and its application, particularly in the preparation of drugs for treating allergic contact dermatitis. The preparation method includes step 1: naturally air-drying harvested Artemisia argyi leaves, followed by mechanical pulverization to obtain Artemisia floss raw material; step 2: mixing the Artemisia floss raw material with pure water, soaking at room temperature, extracting with ultrasound assistance, combining the extracts, decocting in a water bath, concentrating under reduced pressure, and freeze-drying to obtain the Artemisia argyi aqueous extract. This invention provides an Artemisia argyi aqueous extract, its preparation method, and its application. This Artemisia argyi aqueous extract has significant anti-allergic and anti-irritant effects, effectively inhibiting hyaluronidase activity, reducing erythrocyte hemolysis rate, and exhibiting good therapeutic effects on 2,4-dinitrofluorobenzene-induced allergic contact dermatitis. It also has high bioavailability and good safety. This invention lays an important foundation for developing efficient and safe natural anti-allergic products.

The application discloses an image processing method and device for judging hemolysis of suspended red blood cells, and the method comprises the following steps: acquiring a blood image set; the blood image set comprises a plurality of blood images and corresponding label information; acquiring a blood parameter information set; the blood parameter information set comprises a plurality of blood parameters and corresponding label information; the blood parameters comprise hemoglobin concentration, reticulocyte concentration, indirect bilirubin concentration, lactate dehydrogenase concentration and globin concentration; a blood hemolysis composite detection model is constructed by using the blood image set and the blood parameter information set; the collected blood image and blood parameter are processed based on the blood hemolysis composite detection model, and hemolysis detection result information is obtained; the hemolysis detection result information is used for representing the red blood cell hemolysis information of the corresponding blood of the collected blood image and blood parameter.

The application discloses a peony endophyte, a method for producing exopolysaccharide by the peony endophyte and application of the exopolysaccharide, and the peony endophyte is obtained by culturing root, stem and leaf parts of peony, and the peony endophyte strain with high exopolysaccharide yield is screened out through color reaction and exopolysaccharide content determination; the strain is identified as Kosakonia cowanii LYH-L3, and the exopolysaccharide yield of the strain is 1.176 mg / mL. Safety determination experiments such as red blood cell hemolysis experiment and zebra fish acute toxicity experiment show that the exopolysaccharide of the application has no irritation and acute toxicity; and through zebra fish model experiment, in-vitro water absorption and water loss rate determination and human body test, it is shown that the exopolysaccharide produced by the peony endophyte strain has a moisturizing effect and a skin barrier repair function, and the application provides a theoretical basis for application of the exopolysaccharide produced by the peony endophyte in preparation of natural moisturizing and repairing cosmetics, skin care products, medicines and other related products, and provides a new target and a new direction for development and utilization of plant resources with Chinese characteristics.