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Antioxidation active researching method for positioning chitoglycansulfate

A technology of polysaccharide sulfate and anti-oxidation activity, which is applied in the direction of color/spectral characteristic measurement, testing of pharmaceutical preparations, material inspection products, etc., can solve the problem of reducing ability and anti-oxidation ability that have not been reported, chitosan sulfate anti-oxidation There are not many active studies, etc.

Inactive Publication Date: 2006-03-01
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many studies on the antioxidant activity of chitosan sulfate. It has been reported in the literature that chitosan sulfate derivatives have 2 o 2 It has obvious antioxidant activity, but for other antioxidant aspects such as scavenging superoxide anion free radicals (O 2 ·- ), hydroxyl radicals (·OH), inhibition of organic free radicals (DPPH), erythrocyte hemolysis, liver homogenate lipid peroxidation, metal chelating ability of chitosan sulfate, their reducing ability and overall antioxidant None of the abilities have been reported

Method used

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  • Antioxidation active researching method for positioning chitoglycansulfate
  • Antioxidation active researching method for positioning chitoglycansulfate
  • Antioxidation active researching method for positioning chitoglycansulfate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0093] Compared with the control group: * P** P*** P<0.001

[0094] Concentration (mg / ml)

A 520

HCTS

TSCTS

SCTS

TCTS

Control

0.446±0.003

1.241±0.001

Reference

0.073±0.001

0.178±0.002

0.1

0.074±0.004 *

0.102±0.003 *

0.089±0.004 *

0.293±0.002 *

0.2

0.077±0.003 **

0.131±0.004 ***

0.105±0.003 ***

0.515±0.003 ***

0.4

0.092±0.005 **

0.183±0.002 ***

0.170±0.002 ***

0.766±0.002 ***

[0095] 0.8

0.126±0.001 ***

0.255±0.001 ***

0.297＝0.001 ***

0.946±0.002 ***

1.6

0.212±0.001 ***

0.403±0.002 ***

0.485±0.001 ***

1.025±0.001 ***

3.2

0.372±0.002 ***

0.571±0.001 ***

0.610±0.002 ***

1.158±0.001 ***

clearance rate(%)

0.1

0.20

5.79

3.19

10.82

...

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PUM

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Abstract

The present invention discloses a method for researching oxidation-resisting activity of localized chitosan sulfate. Said invention researches the oxidation-resisting activity of chitosan sulfates (HCTS,TSCTS,SCTS and TCTS) substituted in different position points, and finds that said four kinds of sulfate derivatives have the obvious action for inhibiting superoxide radical and hydroxyl radical, and have strong reducing power. Said four kinds of derivatives also have the strong action for inhibiting hemolysis induced by H2O2. Said invention can be used as basis for developing medicine for resisting senility.

Description

Technical field [0001] The invention relates to the research and development of marine medicines, in particular to a research method for locating the antioxidant activity of chitosan sulfate, which can be used as a basis for anti-aging medicines, and belongs to the field of marine biological technology. Background technique [0002] Reactive oxygen free radicals have a huge damaging effect on the body, such as protein damage, enzyme inactivation, membrane peroxidation, leading to aging, tumors, atherosclerosis and many other diseases. Therefore, it is of great significance to screen safe and efficient active oxygen scavengers for the human body. [0003] It has good antioxidant activity for synthetic dibutyl hydroxytoluene (BHT), butyl hydroxymethoxy (BHA), propylene glycol (PG), etc., but long-term consumption has harmful effects on the human body, so in recent years , The antioxidant effect of marine bioactive polysaccharides has received extensive attention. Studies have shown...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15G01N21/31
Inventor 李鹏程邢荣娥刘松于华华郭占勇王丕波李翠萍
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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