Method of producing electrically conductive polymers and removing protein-bound substances

Pending Publication Date: 2021-03-25
MING CHI UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0006]In the present invention, MWCNT/PEDOT:PSS nanofiber mats has been developed as BEI-based HD devices for effective ES to reduce the percentage of protein binding with protein-bound substances, such as protein-bound uremic toxins (PBUTs) while preserving the retention of bovine serum albumin (BSA), thereby improving overall dialysis performance for the removal of protein-bound substances, such as PBUTs. These MWCNT/PEDOT:PSS nanofiber mats, prepared using electrospinning and thermal cross-linking, exhibited high water-resistance and strong adhesion to conventional polyethersulfone (PES) dialysis membranes. The present invention has used scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spe

Problems solved by technology

Symptoms of kidney failure result from the accumulation of uremic toxins in the blood.
When the kidneys no longer work effectively, the concentration of uremic toxins will increase, resulting in increasing risk of mortality.
Although the high frequency of HD treatment (4 h each time, three times a week) is inconvenient, it remains the most viable clinic

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  • Method of producing electrically conductive polymers and removing protein-bound substances
  • Method of producing electrically conductive polymers and removing protein-bound substances
  • Method of producing electrically conductive polymers and removing protein-bound substances

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Embodiment Construction

[0047]Reference will now be made in detail to the exemplary embodiments of the present invention, examples of which are illustrated in the accompanying drawings. Therefore, it is to be understood that the foregoing is illustrative of exemplary embodiments and is not to be construed as limited to the specific embodiments disclosed, and that modifications to the disclosed exemplary embodiments, as well as other exemplary embodiments, are intended to be included within the scope of the appended claims. These embodiments are provided so that this invention will be thorough and complete, and will fully convey the inventive concept to those skilled in the art.

[0048]For convenience, certain terms employed in the specification, examples and appended claims are collected here. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of the ordinary skill in the art to which this invention belongs.

[0049]Various embodiments wi...

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Abstract

The present invention provides an organic bioelectronic HD device system for the effective removal of protein-bound substances, comprising PEDOT:PSS, a multiwall carbon nanotube, polyethylene oxide (PEO), and (3-glycidyloxypropyl)trimethoxysilane (GOPS). The composite nanofiber platform exhibited (i) long-term water-resistance; (ii) high adhesion strength on the PES membrane; (iii) enhanced electrical properties; and (iv) good anticoagulant ability and negligible hemolysis of red blood cells, suggesting great suitability for use in developing next-generation bioelectronic medicines for HD.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Patent Application No. 62 / 903,954, filed on Sep. 23, 2019, the disclosure of which is incorporated herein in its entirety by reference.FIELD OF INVENTION[0002]The present invention relates to a method of producing an electrically conductive material for blood purification; in particular, the present invention relates to a method of producing an electrically conductive material for removing protein-bound substances.BACKGROUND OF THE INVENTION[0003]Kidneys are organs that can filter waste metabolites from whole blood, while also regulating blood pressure and electrolyte balance. Symptoms of kidney failure result from the accumulation of uremic toxins in the blood. The rate of chronic kidney failure, causing chronic kidney disease (CKD) as well as end-stage renal disease (ESRD), is increasing rapidly worldwide. When the kidneys no longer work effectively, the concentration of uremic toxi...

Claims

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Application Information

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IPC IPC(8): B01D71/68A61M1/16C08J3/21C08L65/00D01D1/02D01D5/00D01F1/09B01D61/24B01D61/30
CPCB01D71/68B01D2311/2626C08J3/212C08L65/00D01D1/02D01D5/003D01F1/09B01D61/243B01D61/30C08L2203/12C08L2203/20C08L2312/08D10B2509/00B01D2311/2684B01D2313/345A61M1/1621C08J5/2275A61M1/3679C08J2325/18C08J2465/00C08G61/126C08G2261/3223C08G2261/1424C08G2261/794C09D165/00C08K3/041D01F1/10D01F6/94C08K5/5435
Inventor HSIAO, YU-SHENGYEN, SHIH-CHIEHSU, CHIA-HUNG
Owner MING CHI UNIVERSITY OF TECHNOLOGY
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