167 results about "Increasing risk" patented technology

A system for continuously monitoring a user's motion and for continuously providing realtime visual physical performance information to the user while the user is moving to enable the user to detect physical performance constructs that expose the user to increased risk of injury or that reduce the user's physical performance. The system includes multiple passive controllers 100A-F for measuring the user's motion, a computing device 102 for communicating with wearable display glasses 120 and the passive controllers 100A-F to provide realtime physical performance feedback to the user. The computing device 102 also transmits physical performance constructs to the wearable display glasses 120 to enable the user to determine if his or her movement can cause injury or reduce physical performance.

A solid-state storage system is described with a method for adjusting the frequency of data retention operations. The data retention operation frequency can be increased or decreased according to a variety of environmental factors such as error code frequency, system temperature, altitude, and other operating conditions. These factors can indicate an increased or decreased risk of failure and accordingly provide increased or decreased rates of data retention operations.

The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat anemia (e.g., anemia associated with chemotherapy) including persons on a treatment regimen with a drug or chemotherapy and / or radiation for cancer (e.g., head and neck cancer) that is associated with increased risk of anemia.

This invention is based on the observed oxidative stress and increased risk on cardiovascular diseases in subjects with increased lipid peroxidation, in particular with women using oral contraceptives and in hormone replacement therapies. The invention provides compositions and combinations, particularly useful in preventing and or reducing the increased lipid peroxidation in subjects in need thereof. These compositions are based on the synergistic combination of zinc and / or a hydroxyl radical scavenger in reducing lipid peroxidation.

Apparatus is provided, including a sensor configured to sense motion of a subject and generate a motion signal in response thereto. The apparatus includes an output unit and a control unit. The control unit is configured to: (a) analyze the motion signal, (b) at a first time, determine that the motion signal is indicative that the subject is likely sleeping, (c) at a second time following the first time, determine that the motion signal is indicative that the subject is likely no longer sleeping, and (d) in response thereto, drive the output unit to alert a clinician if the subject is at an increased risk for falling out of a bed. Other applications are also described.

The present invention relates to compounds for treatment that protects the endothelium, prevents pathologic thrombus formation in the microcirculation and preserves platelet number and function and thus may be related to treatment or prevention of ischemic events in patients with cardiovascular disease. The present invention is particularly useful for patients having or being at increased risk of development of an ischemic event such as an acute myocardial infarction and / or no-reflow phenomena and / or ischemia-reperfusion injury by administration of agent(s) modulating and / or preserving endothelial integrity. The compounds may be administered in combination with standard treatment of acute cardiovascular ischemic events such as Platelet inhibitors such as aspirin (ASA), Thienopyridins, GPIIb / IIIa inhibitors), Parenteral anticoagulants such as unfractioned heparin (UFH), bivalirudin, enoxaparin, and fondaparinux, Verapamil, Adenosine, Sodium nitroprusside, Nitroglycerin, Epinephrine, Beta-blockers and surgical methods such as percutaneous coronary intervention (PCI), PCI with thrombus aspiration, PCI with stents.

The invention discloses an operation risk evaluation method comprising a wind-power plant electric system. With view to affection on the electric system from a wind-power plant, the operation risk evaluation method traces back to nodes and includes that real-time importance degree weights of the nodes are introduced into risk indexes, affection of a network topology and real-time tide state information is comprehensively reflected, real-time risk variation of the electric system under the action of the wind-power plant can be truly reflected, updating of various state parameters and risk level sequence is completed in real time in a short calculation period of system running risk evaluation, the problem that operating monitoring of power plants or substation busses high in importance degree is ignored is avoided, value-at-risk is converted into a dimensionless utility value by evaluating a function through consequence severity of exponential risk-preferred utility function, the risk-at-value is increased at different degrees so as to increase risk level difference identification degree and differentiation degree under same low-loss-load probability and scientifically compare different risk levels.

The present invention is directed to methods of treating or preventing a metabolic disease or disorder and cardiovascular complications and other complications thereof by administering agents that inhibit the NOTCH signaling pathway. In addition, the invention encompasses methods for determining whether a patient is at increased risk for developing these conditions by determining the amount, function, or activity of NOTCH pathway components in biological samples derived from the patient or in imaging analyses.

The invention provides compositions and methods for determining the increased risks for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprising determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

A surgical tool handle and separate disposable orthopedic tool head assembly is disclosed. The surgical tool handle has a reinforcing member extending from it. The reinforcing member is receivable in an internal bore of the disposable orthopedic tool head and provides structural reinforcement for the tool head. This reinforcement allows the use of disposable materials in the construction of the tool head that otherwise could not be use (e.g., plastic and resin materials) because of an increased risk of breakage or failure relative to metallic tool heads.

A system and method is disclosed for assessing a probability of failure of operation of a semiconductor wafer. The method includes inputting risk factor data into a memory and inputting a plurality of wafers into a semiconductor fabrication manufacturing process. A subset of wafers is selected to obtain a sample population and at least one region of each wafer of the sample population is inspected. Circuit design data associated with each wafer of the sample population is obtained and one or more defects that present an increased risk to the operation of a particular wafer are identified. The identification is a function of the risk factor data, the inspecting step and the circuit design data. A probability of semiconductor wafer failure is calculated.

To deal with user network communication activity which cannot easily and clearly be determined as problematic behavior, a behavior analysis apparatus 14 monitors communication between each user PC 16 in a domain 10 and Internet 20 via a gateway apparatus 12. For example, when there is a monitored item related to information leakage of the user in the detected communication, a weight value corresponding to the monitored item is added to a score concerning a possibility of the user leaking information. Subsequently, the scores are totaled and recorded for each unit of time. The behavior analysis apparatus 14 inputs data of time-series transition of the total value to a neural network which has performed learning for prediction processing, and predicts the possibility of the user's information leak at a time in the near future. When an increasing risk of leakage is predicted, the behavior analysis apparatus 14 communicates an alarm to a security manager.

A wearable device including a sensor system for Manual Wheelchair Users (MWCUs) to provide an alert to the MWCUs when there is an increased risk of injury is provided. The wearable device includes sensors measuring the physical activity of the MWCU and transmitting it as user data to a user motion dynamics analysis system on a user device. When the user motion dynamics analysis system determines that there is a risk of injury, it transmits an alert to the wearable device for display to the user.

There is provided a fall detection system for use in detecting falls by a user, the fall detection system comprising a processing unit configured to determine context information about the user and / or the environment in which the user is located, and to increase the sensitivity of a fall detection algorithm used to detect falls by a user in the event that the determined context information indicates that the user is or may be at an increased risk of falling, the increase in sensitivity occurring while the increased risk of falling is indicated by the determined context information.

In a P-channel transistor comprising a high-k metal gate electrode structure, a superior dopant profile may be obtained, at least in the threshold adjusting semiconductor material, such as a silicon / germanium material, by incorporating a diffusion blocking species, such as fluorine, prior to forming the threshold adjusting semiconductor material. Consequently, the drain and source extension regions may be provided with a high dopant concentration as required for obtaining the target Miller capacitance without inducing undue dopant diffusion below the threshold adjusting semiconductor material, which may otherwise result in increased leakage currents and increased risk of punch through events.

Methods for calculating a maximum safe over-rated power demand for a wind turbine operating in non-standard conditions include the steps of determining a value indicative of a risk of exceeding an ultimate design load during operation in a standard operating condition, and establishing a maximum over-rated power demand corresponding to a maximum power that the turbine may produce under the non-standard operating condition without incurring an increased risk of exceeding the ultimate design load, with respect to operation in the standard condition. A method of over-rating a wind turbine, a wind turbine controller, a wind turbine and a wind power plant are also claimed.

A computer-implemented method and a computer-based system for detecting, profiling and benchmarking Intellectual Property (IP) law professional liability risks and professional liability insurance risks and value associated with IP prosecution and maintenance processes for IP business entities, including IP law firms and independent IP professionals. The invention allows further an insurance firm to accurately quantify professional liability risk of a new or existing IP business client and to mitigate such risks. The present method involves accessing and collecting transaction data indicative of risk-reducing and risk-increasing behavior of an IP business entity from a National IP Office in a chosen jurisdiction and sending the transaction data to a back-end computer system for processing and analysis. In the preferred embodiment of the invention, the transaction data is collected from the USPTO PAIR system.

The inventive IR camera is used to identify areas of a surface in which there is an increased risk of condensation, by imaging the surface determining, from humidity and temperature values, a condensation temperature at which there is a risk of condensation on the surface, comparing the temperature in at least one image point registered by the camera to the condensation temperature colouring any image points having a temperature lower than the condensation temperature in a particular colour, or grey tone, selected to indicate an increased risk of condensation.

Methods, systems, and apparatuses for detecting seizure events are disclosed, including a system for identification of an increased risk of a severe neurological event. The system may include an electroencephalogram (“EEG”) monitoring unit configured to collect EEG data from the patient during at least a postictal phase of one or more seizures and a processing unit configured to receive the EEG data from the EEG monitoring unit. The processing unit is configured to detect postictal EEG suppression from the EEG data and to identify the increased risk of the severe neurological event based on the detected postictal EEG suppression. Other embodiments are described and claimed.

Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.

A method of diagnosing ovarian cancer in a subject is described that includes identifying the expression level of at least one diagnostic miRNA in a biological sample from the subject, comparing the expression level of the at least one diagnostic miRNA to control expression levels, and diagnosing the subject as having or being at an increased risk of having ovarian cancer if the subject has a changed expression level of the one or more diagnostic miRNA. The method also includes a method of providing a prognosis for a subject having ovarian cancer, and kits for carrying out a diagnosis or prognosis of ovarian cancer using miRNA.

The disclosure includes assays and methods for screening for risk of Down syndrome and / or trisomy 21 in a fetus. The assays and methods comprise determining the level of at least one biomarker selected from mucin 13 (MUC13), bile salt-activated lipase (CEL), dipeptidyl peptidase 4 (DPP4), carboxypeptidase A1 (CPA1), amyloid precursor protein (APP) and tenascin-C (TNC-C) polypeptides in a test biological sample from a pregnant subject, wherein a decreased level of MUC13, CEL, DPP4, and / or CPA1 polypeptide and / or an increased level of APP and / or TNC-C polypeptide in the test biological sample compared to a corresponding reference biomarker polypeptide level indicates an increased risk of Down syndrome or trisomy 21 in the fetus. The disclosure also includes assays, compositions, immunoassays, and kits for performing the methods disclosed herein.

The invention relates to the field of milling and discloses a ball mill. The ball mill comprises a barrel (10) capable of rotating and a feeding hole (11) and a discharging hole (12) formed in the barrel (10). The ball mill is characterized by further comprising a steel ball adding device which comprises a steel ball adding pipeline (21) and a supporting frame (22), wherein the steel ball adding pipeline (21) extends into the barrel (10) from the discharging hole (12) and the supporting frame (22) is used for supporting and fixing the steel ball adding pipeline (21). When steel balls are added, the ball mill provided by the invention does not need to stop running and a manhole does not need to be opened, so that the problem of increasing risk in work high above the ground caused by frequently detaching the manhole is solved. That is to say, the steel balls can be added into the barrel of the ball mill in the running state of the ball mill, the operation is easy and convenient and the ball mill is safe and practical.

The invention relates to a pharmaceutical composition containing mosapride citrate. The pharmaceutical composition contains lactose and other pharmaceutically acceptable accessory materials. Through strict control of a mass ratio of lactose to water in the pharmaceutical composition, mosapride citrate long-term storage stability is greatly improved and related substance generation and increasing risk is reduced. The pharmaceutical composition provides guarantee for clinical drug safety and effectiveness.

The invention relates to medicine mixtures containing phosphorylcholine conjugate or antibody preparing product (such as monoclonal antibody) specific to phosphorylcholine conjugate and roles of the mixtures in treatment and prevention of atherosclerosis (such as the roles in treatment, prevention and depression of further development of atherosclerosis). And the invention further relates to usage of phosphorylcholine conjugate or antibody preparing product (such as monoclonal antibody) in production of any medicine mixtures with adjuvants. In addition, the invention relates to diagnose to judge whether antibodies such as IgM or IgG antibody exist or not, the antibodies is relevant with increase and decrease of risk for occurring of ischemic cardiovascular disease.

A method is for identifying risks as a result of stray currents which flow to ground from a rail which returns a traction current in a track with a DC power supply. In accordance with a first embodiment, in which the voltage between the rail and ground is measured and an increased risk as a result of stray currents is indicated if there is a discrepancy from a voltage reference value, provision is made for the voltage to be measured at a plurality of measurement points along the track and for the measurements to be evaluated in an evaluation center. In accordance with a second embodiment, provision is made for activating a short-circuiter to connect a parallel path to the rail for returning the traction current. The current level in the parallel path is then measured and an increased risk as a result of stray currents is indicated if there is a discrepancy from a current-level reference value. Further, the method includes joint evaluation of a plurality of measurements which have been ascertained along the track.