2 results about "Mosapride citrate" patented technology

The application provides a mosapride citrate stomach floating preparation, a preparation method thereof and application thereof. The mosapride citrate stomach floating preparation comprises first immediate-release particles, second immediate-release particles and sustained-release particles with a mass ratio of (1-2):(1-2):(1-2). The application uses the first immediate-release particles, the second immediate-release particles and the sustained-release particles in combination, and introduces mosapride citrate co-grinding materials into the second immediate-release particles and the sustained-release particles, so that the obtained preparation has a sustained-release effect. In addition, the application introduces a gas production layer coating and a retardation layer coating into the second immediate-release particles and the sustained-release particles in sequence, so that the mosapride citrate is prepared into a stomach floating preparation, the absorption of the mosapride citrate in the stomach and the upper part of the small intestine is prolonged, the blood drug concentration is stabilized, and the frequency of taking medicine is reduced. According to tests, the mosapride citrate stomach floating preparation provided by the application can be released smoothly within 2-12 hours, and has no burst release effect.

The application provides a mosapride citrate sustained-release preparation, a preparation method thereof and application thereof. The mosapride citrate sustained-release preparation comprises first immediate-release granules, second immediate-release granules and sustained-release granules with a mass ratio of (1-2):(1-2):(1-2). The application can make the obtained preparation have a sustained-release effect by using the first immediate-release granules, the second immediate-release granules and the sustained-release granules in combination, and introducing mosapride citrate co-grinding materials into the second immediate-release granules. The test shows that the mosapride citrate sustained-release preparation provided by the application can be released smoothly within 2-12 hours without burst release effect. Meanwhile, the preparation process of the mosapride citrate sustained-release preparation provided by the application is simple, easy to realize, high in production efficiency, good in stability, and suitable for large-scale industrialized or industrialized production.