6 results about "Mosapride citrate" patented technology

The present application belongs to the technical field of oral solid preparation, and particularly relates to a mosapride citrate orally disintegrating tablet and a preparation method thereof. Raw and auxiliary materials comprise mosapride citrate, a filling agent, a disintegrating agent, a glidant, a lubricant and a flavoring agent. The present application screens and optimizes the auxiliary material formula, adopts dry granulation, optimizes the preparation process, improves the compressibility and fluidity of the material, saves energy, improves the production quality and stability, makes the prepared orally disintegrating tablet disintegrate rapidly, has excellent taste, greatly improves the medication compliance of patients, simultaneously improves the drug dissolution and improves the bioavailability. In addition, compared with other types of solid oral preparations of the product, the mosapride citrate orally disintegrating tablet is particularly suitable for the elderly and patients with difficulty in swallowing, and provides convenience in special and urgent situations such as lack of drinking water for taking medicine.

The present application relates to a kind of syrup containing mosapride citrate, belong to the field of pharmaceutical preparations, the syrup of the present application contains mosapride citrate, flavouring agent, β-cyclodextrin, stabilizer, aromatic agent, bacteriostatic agent and purified water composition, preparation method is: first β-cyclodextrin is dissolved in water, stirring dissolves, then mosapride citrate is added, stirring dissolves, obtains solution I, standby;Stabilizer, bacteriostatic agent, aromatic agent are dissolved in water, then flavouring agent is added, obtains solution II standby;Solution I, solution II are mixed, obtain immediately.The syrup prepared in the present application, stability is improved, child is convenient, safe characteristics of taking.For industrial production, it is convenient for market promotion that preparation process is simple.

The present application provides a novel mosapride citrate composition, which is prepared by a specially optimized fluidized bed granulation process, has good content uniformity, and can keep the dissolution of the finished product from decreasing and the related substances from increasing for a long time, so that the drug effectiveness and safety of the mosapride citrate composition after long-term storage are more guaranteed.

The application provides a mosapride citrate stomach floating preparation, a preparation method thereof and application thereof. The mosapride citrate stomach floating preparation comprises first immediate-release particles, second immediate-release particles and sustained-release particles with a mass ratio of (1-2):(1-2):(1-2). The application uses the first immediate-release particles, the second immediate-release particles and the sustained-release particles in combination, and introduces mosapride citrate co-grinding materials into the second immediate-release particles and the sustained-release particles, so that the obtained preparation has a sustained-release effect. In addition, the application introduces a gas production layer coating and a retardation layer coating into the second immediate-release particles and the sustained-release particles in sequence, so that the mosapride citrate is prepared into a stomach floating preparation, the absorption of the mosapride citrate in the stomach and the upper part of the small intestine is prolonged, the blood drug concentration is stabilized, and the frequency of taking medicine is reduced. According to tests, the mosapride citrate stomach floating preparation provided by the application can be released smoothly within 2-12 hours, and has no burst release effect.

The invention discloses a traditional Chinese medicine composition for treating gastrointestinal motility disorder. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 2-8 parts of radix aucklandiae, 5-15 parts of pericarpium arecae, 2-8 parts of rhizoma cyperi, 3-7 parts of pericarpium citri reticulatae viride, 3-7 parts of fructus amomi, 5-15 parts of fructus aurantii immaturus, 2-8 parts of pericarpium citri reticulatae, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of rhizoma atractylodis, 3-7 parts of radix et rhizoma rhei, 10-20 parts of fingered citron and 10-20 parts of semen raphani. The traditional Chinese medicine composition disclosed by the invention is simple in medication, is used for treating distention and fullness, can effectively relieve stomach fullness, distention or swelling pain discomfort, is quick in effect taking, good in safety and free from relapse after drug withdrawal, has the effect superior to that of mosapride citrate which is commonly used clinically at present, remarkably relieves the pain of a patient, and has practical popularization and application values.

The application provides a mosapride citrate sustained-release preparation, a preparation method thereof and application thereof. The mosapride citrate sustained-release preparation comprises first immediate-release granules, second immediate-release granules and sustained-release granules with a mass ratio of (1-2):(1-2):(1-2). The application can make the obtained preparation have a sustained-release effect by using the first immediate-release granules, the second immediate-release granules and the sustained-release granules in combination, and introducing mosapride citrate co-grinding materials into the second immediate-release granules. The test shows that the mosapride citrate sustained-release preparation provided by the application can be released smoothly within 2-12 hours without burst release effect. Meanwhile, the preparation process of the mosapride citrate sustained-release preparation provided by the application is simple, easy to realize, high in production efficiency, good in stability, and suitable for large-scale industrialized or industrialized production.