Traditional Chinese medicine composition for treating gastrointestinal motility disorder

Abstract

The invention discloses a traditional Chinese medicine composition for treating gastrointestinal motility disorder. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 2-8 parts of radix aucklandiae, 5-15 parts of pericarpium arecae, 2-8 parts of rhizoma cyperi, 3-7 parts of pericarpium citri reticulatae viride, 3-7 parts of fructus amomi, 5-15 parts of fructus aurantii immaturus, 2-8 parts of pericarpium citri reticulatae, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of rhizoma atractylodis, 3-7 parts of radix et rhizoma rhei, 10-20 parts of fingered citron and 10-20 parts of semen raphani. The traditional Chinese medicine composition disclosed by the invention is simple in medication, is used for treating distention and fullness, can effectively relieve stomach fullness, distention or swelling pain discomfort, is quick in effect taking, good in safety and free from relapse after drug withdrawal, has the effect superior to that of mosapride citrate which is commonly used clinically at present, remarkably relieves the pain of a patient, and has practical popularization and application values.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating gastrointestinal motility disorder. BACKGROUND

[0002] Pi-man disease is a TCM disease name, mainly referring to a kind of disease syndrome that patients feel stuffy and uncomfortable in the heart (stomach), soft and painless when touched, and no pain when pressed, or severe pain when pressed, but no hard swelling. It is one of the common symptoms of spleen and stomach diseases, which is caused by disorders of spleen and stomach function, qi stagnation, and phlegm and dampness. The symptoms of Pi-man disease are the same as functional dyspepsia and functional abdominal distension in western medicine, so traditional Chinese medicine classifies functional dyspepsia as 'Pi-man','stomach pain' and 'accumulation and stagnation'. One of the main pathophysiological bases of them is gastrointestinal motility disorder.

[0003] At present, the treatment drugs for functional dyspepsia and functional abdominal distension caused by gastrointestinal motility disorder include pro-gastrointestinal motility drugs such as mosapride citrate and domperidone, and acid suppressants such as famotidine and omeprazole. These drugs all have typical side effects, and patients cannot use them for a long time. There are also many traditional Chinese medicine prescriptions for treating Pi-man disease. For example, CN110613812A discloses a traditional Chinese medicine composition with the effects of eliminating accumulation, promoting defecation and detoxification, which can treat food stagnation in the stomach and intestines, heat accumulation in the stomach and intestines, constipation, abdominal distension, and picky eating. However, these traditional Chinese medicine prescriptions have the problems of complex drug composition, high use cost, easy recurrence of symptoms after use, and limited benefits for patients. SUMMARY

[0004] To solve the above problems, the present application provides a traditional Chinese medicine composition for treating gastrointestinal motility disorder, which is prepared from the following raw materials by weight:

[0005] Radix Aucklandiae 2-8 parts, Cortex Alpiniae Oxophyllae 5-15 parts, Rhizoma Cyperi 2-8 parts, Pericarpium Citri Reticulatae Viride 3-7 parts, Fructus Amomi Rotundus 3-7 parts, Fructus Aurantii 5-15 parts, Pericarpium Citri Reticulatae 2-8 parts, Magnolia officinalis 10-20 parts, Atractylodes 10-20 parts, Radix et Rhizoma Rhei 3-7 parts, Citrus medica 10-20 parts, Semen Raphani 10-20 parts.

[0006] Further, it is prepared from the following raw materials by weight:

[0007] Radix Aucklandiae 6 parts, Cortex Alpiniae Oxophyllae 10 parts, Rhizoma Cyperi 6 parts, Pericarpium Citri Reticulatae Viride 5 parts, Fructus Amomi Rotundus 5 parts, Fructus Aurantii 10 parts, Pericarpium Citri Reticulatae 6 parts, Magnolia officinalis 15 parts, Atractylodes 10 parts, Radix et Rhizoma Rhei 5 parts, Citrus medica 15 parts, Semen Raphani 15 parts.

[0008] Further, the Rhizoma Cyperi is vinegar Rhizoma Cyperi; the Pericarpium Citri Reticulatae Viride is bran-fried Pericarpium Citri Reticulatae Viride; the Fructus Aurantii is bran-fried Fructus Aurantii; the Magnolia officinalis is ginger Magnolia officinalis; the Atractylodes is bran-fried Atractylodes; the Radix et Rhizoma Rhei is cooked Radix et Rhizoma Rhei; and the Semen Raphani is fried Semen Raphani.

[0009] Further, it is a preparation prepared from the powder of the crude drug, or the water or organic solvent extract of the crude drug as the active ingredient, plus pharmaceutically acceptable excipients.

[0010] Further, the preparation is an oral preparation; the oral preparation includes solutions, pills, granules, tablets, powders or pastes.

[0011] The present application also provides a preparation method of the aforementioned traditional Chinese medicine composition, which comprises the following steps:

[0012] (1) The crude drug is weighed according to the aforementioned ratio;

[0013] (2) The crude drug is ground into powder, or the water or organic solvent extract of the crude drug is added with commonly used excipients or auxiliary ingredients in the pharmaceutical industry, and then the mixture is obtained.

[0014] The present application also provides the use of the aforementioned traditional Chinese medicine composition in the preparation of a medicament for treating gastrointestinal motility disorders.

[0015] Further, the medicament is a medicament for treating the disease of fullness, preferably a medicament for treating the disease of fullness of the liver stagnation type.

[0016] Further, the medicament is a medicament for treating the disease of fullness, preferably a medicament for treating the disease of fullness of the liver stagnation type.

[0017] Traditional Chinese medicine emphasizes "adapt to local conditions", that is, according to the differences in geographical location, the constitution and health status of people, and the different strategies for disease treatment. The traditional Chinese medicine composition in the present application pays attention to the fact that the humidity in the Sichuan-Chongqing region is relatively heavy, the residents like to eat spicy and greasy food, the humidity is generated from the middle, the qi is blocked, and then the liver, which is the main body of the qi, is affected, resulting in liver qi not being smooth, liver stagnation, invading the stomach, and being prone to the disease of fullness of the liver stagnation type. The traditional Chinese medicine signs are fullness in the chest and abdomen, distension in the lateral ribs, depression, poor appetite, tongue pale red, thin white tongue fur, and stringy pulse. According to the analysis of the pathological mechanism of traditional Chinese medicine and the combination of clinical exploration, a unique treatment method for the disease of fullness of the liver stagnation type is formed: Xiangfu, Zhishi, and Ruhuang are used as the monarch drugs to soothe the liver and promote qi and dredge the bowels, Ruhuang and Laiqiezi are used as the ministerial drugs to assist Zhishi in promoting qi and dredging the bowels, Muxiang, Dafupi, Qingpi, and Foshou are used as the assistant drugs to assist Xiangfu in soothing the liver and stomach, promoting qi and removing distension, and Chenpi, Sharen, Huhou, and Cangzhu are used as the auxiliary drugs to dry dampness and promote qi. The whole prescription has the functions of promoting qi and removing distension, dredging the bowels, and has a definite effect on the gastrointestinal motility disorders of people with heavy humidity and qi stagnation.

[0018] Clinical application statistics prove that the traditional Chinese medicine composition has the advantages of simple medication, effective relief of stomach fullness, distension or distending pain, fast effect, good safety, no recurrence after drug withdrawal, and better effect than Mosapride Citrate which is commonly used in the clinic, and significantly reduces the pain of patients, and has practical popularization and application value.

[0019] Obviously, according to the above content of the present application, according to the ordinary technical knowledge and conventional means in the art, other various forms of modifications, substitutions or changes can be made without departing from the above basic technical idea of the present application.

[0020] The above content of the present application will be further described in detail through the specific embodiments below. However, it should not be understood that the scope of the above subject matter of the present application is limited to the following examples. Any technology realized based on the above content of the present application belongs to the scope of the present application. DETAILED DESCRIPTION

[0021] The raw materials and equipment used in the specific embodiments of the present application are known products, which are obtained by purchasing commercially available products. The preparation process of the modern Chinese medicine preparation made of the traditional Chinese medicine composition of the present application is mature, and the preparation can be made by referring to the conventional method of the prior art.

[0022] Example 1, preparation of the drug of the present application

[0023] Formula: 6g of costus root, 10g of pericarpium citri reticulatae viride, 6g of rhizoma zedoariae, 5g of pericarpium citri reticulatae praeparatum, 5g of amomum villosum, 10g of fructus aurantii immaturus praeparatus, 6g of pericarpium citri reticulatae, 15g of radix aucklandiae, 10g of atractylodis rhizoma praeparatum, 5g of radix et rhizoma rhei praeparatum, 15g of fructus citri medicae, 15g of semen raphani praeparatum;

[0024] Preparation method: the above raw medicinal materials are weighed according to the proportion, 300ml of water is added for decoction for 20-30min, and then filtered. The filtrate is concentrated into a daily dose of medicinal liquid.

[0025] Example 2, preparation of the drug of the present application

[0026] Formula: 6g of costus root, 10g of pericarpium citri reticulatae viride, 6g of rhizoma zedoariae, 5g of pericarpium citri reticulatae praeparatum, 5g of amomum villosum, 10g of fructus aurantii immaturus praeparatus, 6g of pericarpium citri reticulatae, 15g of radix aucklandiae, 10g of atractylodis rhizoma praeparatum, 5g of radix et rhizoma rhei praeparatum, 15g of fructus citri medicae, 15g of semen raphani praeparatum;

[0027] Preparation method and use method: the above raw medicinal materials are weighed according to the proportion, 450ml of water is added for decoction for 20-30min, and then filtered. The filtrate is concentrated into a daily dose of medicinal liquid.

[0028] Example 3, preparation of the drug of the present application

[0029] Ingredients: Radix Aucklandiae 2g, Pericarpium Citri Reticulatae Viride 5g, Radix Cyathulae Officinalis 2g, Pericarpium Citri Reticulatae Viride 3g, Fructus Amomi Rotundus 3g, Fructus Aurantii Immaturus 5g, Pericarpium Citri Reticulatae 2g, Rhizoma Zingiberis Recens 10g, Rhizoma Atractylodis 10g, Radix et Rhizoma Rhei 3g, Fructus Citri Medica 10g, Semen Raphani 10g;

[0030] Preparation method and use method: the above raw medicinal materials are weighed according to the proportion, 300ml of water is added and decocted for 20-30min, filtered, the filtrate is concentrated into thick paste under reduced pressure, and the commonly used auxiliary materials for drugs are added to prepare a daily dose of tablets.

[0031] Example 4, preparation of the drug of the present application

[0032] Ingredients: Radix Aucklandiae 8g, Pericarpium Citri Reticulatae Viride 15g, Radix Cyathulae Officinalis 8g, Pericarpium Citri Reticulatae Viride 7g, Fructus Amomi Rotundus 7g, Fructus Aurantii Immaturus 15g, Pericarpium Citri Reticulatae 8g, Rhizoma Zingiberis Recens 20g, Rhizoma Atractylodis 20g, Radix et Rhizoma Rhei 7g, Fructus Citri Medica 20g, Semen Raphani 20g;

[0033] Preparation method and use method: the above raw medicinal materials are weighed according to the proportion, 450ml of water is added and decocted for 20-30min, filtered, the filtrate is concentrated into thick paste under reduced pressure, and the commonly used auxiliary materials for drugs are added to prepare a daily dose of granules.

[0034] The beneficial effects of the present application are illustrated by the following test examples.

[0035] Test Example 1 Pharmacodynamic study based on clinical practice

[0036] 1. Clinical data

[0037] Patients with fullness disease (including functional indigestion and functional abdominal distension in Western medicine) were selected from the outpatient department of the Spleen and Stomach Disease Department of the Integrated Traditional Chinese and Western Medicine Hospital of Dazhou from January 2022 to December 2024, and the TCM syndrome was diagnosed as liver stagnation. According to the order of admission, they were randomly divided into test group 1, test group 2 and control group, 51 patients in each group, test group 1 including 27 males and 24 females; age 32-65 years, average (49.93±8.26) years; disease course 1-7 years, average (3.03±0.91) years. Test group 2 includes 25 males and 26 females; age 31-65 years, average (49.88±8.24) years; disease course 1-8 years, average (3.12±0.89) years; the control group includes 26 males and 25 females; age 31-64 years, average (50.09±7.58) years; disease course 1-8 years, average (3.14±0.99) years. There was no significant difference in gender, age and disease course among the three groups (P>0.05), which was comparable.

[0038] 2. Diagnosis standard refers to the "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine" formulated and issued by the Ministry of Health of the People's Republic of China

[0039] 2.1 Diagnosis criteria of TCM

[0040] (1) Subjective feeling of stomach fullness, distension or distending pain;

[0041] (2) Repeated attacks for more than 2 months.

[0042] 2.2 TCM syndrome differentiation

[0043] Refer to the diagnosis criteria of liver stagnation qi stagnation syndrome in the TCM disease part of the TCM Internal Medicine Common Disease Diagnosis and Treatment Guidelines published by the Chinese Association of Traditional Chinese Medicine: chest and stomach fullness, distension in lateral chest and ribs, sullenness or irritability, sometimes sighing, belching, poor appetite, pale red tongue, thin white tongue coating, and wiry pulse.

[0044] 2.3 Severity grading criteria

[0045] +: Occasional stomach fullness after eating, lasting less than half an hour, no stomach tenderness, normal food intake and taste, belching less than 3 times a day.

[0046] ++: Stomach fullness after eating, lasting 1 / 2-1 hour, no stomach tenderness, food intake not reduced but tasteless, belching 4-6 times a day, slightly hard stool but no increase in frequency.

[0047] +++: Stomach distension after eating, lasting 1-3 hours, mild stomach tenderness, food intake reduced by more than 1 / 3, belching 7-9 times a day, 1 stool every 2-3 days.

[0048] ++++: Stomach distension, even distending pain, regardless of eating or not, with obvious stomach tenderness, food intake reduced by more than 1 / 2, belching more than 10 times a day, 1 stool every 3 days.

[0049] 2.4 Western medicine diagnosis criteria

[0050] The western diseases involved in this TCM syndrome are implemented according to the diagnosis criteria of functional dyspepsia and functional abdominal distension in Rome IV Functional Gastrointestinal Disorders Intestinal-Brain Interaction Abnormality.

[0051] 3. Treatment method

[0052] The control group was given Mosapride Citrate Dispersible Tablets (Xinluo Sodium, approval number: GMP H20031110), with a dosage of 5 mg / time, 3 times / d, taken orally after meals, and the treatment course was 4 weeks.

[0053] The test group 1 was given Xiangzhi Daizhi Tongfu Decoction, i.e. the medicinal liquid prepared according to Example 1, taken warm after breakfast, lunch and dinner, 3 times / d, and the treatment course was 4 weeks.

[0054] The test group 2 is given the Xiangzhi Daozhi Tongfu Decoction, that is, the Xiangzhi Daozhi Tongfu Decoction reduces the dosage of cooked rhubarb to 2g and increases the dosage of dried tangerine peel to 9g, and the specific prescription composition is: 6g of costus root, 10g of big belly skin, 6g of vinegar radix cyperi, 5g of pericarpium citri reticulatae, 5g of amomum villosum, 10g of fried fructus aurantii, 9g of dried tangerine peel, 15g of ginger and magnolia officinalis, 10g of fried atractylodes, 2g of cooked rhubarb, 15g of bergamot, and 15g of fried semen raphani. The medicine liquid is prepared according to the method in Example 1, and is taken after breakfast, lunch and dinner, 3 times / d, and the treatment course is 4 weeks.

[0055] 4. Therapeutic effect standard

[0056] (1) Clinical cure: The symptoms of fullness disappear, and other related examinations basically reach normal.

[0057] (2) Marked effect: The symptoms of fullness are reduced by ++ (such as from + + to +), and other related examinations are obviously improved.

[0058] (3) Effectiveness: The symptoms of fullness are reduced by + (such as from ++ to +), and other related examinations are improved.

[0059] (4) Ineffectiveness: The symptoms of fullness are reduced by not more than +, and other related examinations are not improved.

[0060] Note: Symptoms of fullness: self-consciousness of stomach distension, fullness or distending pain discomfort; related examination: gastrointestinal electrogastrography examination.

[0061] 5. Results

[0062] 5.1 Comparison of clinical effects as shown in Table 1

[0063] The effects of the three groups are observed and compared after 4 weeks of treatment, and the difference is statistically significant (P<0.05).

[0064] Table 1 Comparison of therapeutic effects of traditional Chinese medicine in two groups [n (%)]

[0065]

[0066]

[0067] The statistical results show that the traditional Chinese medicine composition has a significant effect on treating the TCM disease of fullness and the indigestion and abdominal distension caused by gastrointestinal motility disorder in western medicine, and the curative effect is better than that of the commonly used mosapride citrate.

[0068] In the process of forming the traditional Chinese medicine composition, based on the pathogenesis characteristics of patients with fullness disease in Sichuan and Chongqing, the traditional Chinese medicine flavors are added or subtracted according to the pathogenesis details of dampness and qi stagnation. Since rhubarb is cold and easy to hurt stomach qi, and pericarpium citri reticulatae is bitter and warm and can dry dampness and invigorate the spleen and regulate qi, the amount of rhubarb is reduced and the proportion of pericarpium citri reticulatae is increased in the prescription in order to obtain better therapeutic effect. However, it is found through clinical verification that the adjustment according to the thinking of traditional Chinese medicine theory cannot obtain the expected curative effect suitable for the complex pathogenesis of fullness disease. The Xiangzhi Daozhi Tongfu Decoction obtained by the present application is an ideal choice for treating fullness disease.

[0069] 5.2 Comparison of incidence of adverse reactions

[0070] In this study, there were no obvious abnormalities in the safety indicators of the three groups, and there were no obvious abnormalities in the blood routine, ECG and abdominal color Doppler ultrasound before and after treatment. Rhubarb as a ministerial drug in the Xiangzhi Daozhi Tongfu Decoction plays a major therapeutic role. However, rhubarb is bitter and cold, and long-term use may cause spleen deficiency, diarrhea, loss of appetite and other side effects. Therefore, during the 4-week medication process, special attention was paid to the patients' diarrhea and loss of appetite, but follow-up confirmed that the patients did not have diarrhea and loss of appetite. There were no serious adverse reactions or adverse events during the treatment of the three groups, and the drug safety was good.

[0071] Since fullness disease is a frequently-occurring disease in the department of spleen and stomach, it can occur alone or as a manifestation of other diseases, and its characteristic is that it can recur with varying degrees of severity. Therefore, after 1 month of clinical cure, the patients in the three groups were followed up by telephone, the recurrence rate of the experimental group 1 was 10%, the recurrence rate of the experimental group 2 was 18%, and the recurrence rate of the control group was the highest, reaching 31%. The Xiangzhi Daozhi Tongfu Decoction of the present application can effectively prevent the recurrence of stomach discomfort.

[0072] Test Example 2 Typical Case

[0073] Case 1: Liu, female, 49 years old, came to our hospital, Sichuan Province, Department of Integrative Medicine, Spleen and Stomach Disease, on July 15, 2022. She complained of recurrent epigastric distension for 4 years, which worsened 1 month ago. The epigastric distension was more obvious after meals, and the epigastric pain was more obvious when hungry. There was no dry mouth at night, no bitter taste, no hiccup, no acid reflux, no nausea, no vomiting, no epigastric burning sensation, and occasional unformed stools. Sleep was normal. The tongue was dark red, the fur was thin and white, and the pulse was stringy. The gastroscopy in our hospital in March showed chronic atrophic gastritis C1, HP (-). Western medical diagnosis: functional dyspepsia. Traditional Chinese medicine diagnosis: fullness and liver stagnation. After 1 week of treatment with the drug of the present application, the patient's condition improved, and after 2 weeks, the patient's condition improved, and after 1 month, the patient recovered. One month after recovery, the patient was followed up by telephone, and the patient's condition was stable and did not recur.

[0074] Case 2: Zhu, female, 53 years old, came to the Spleen and Stomach Disease Department of the Integrative Medicine Hospital of our hospital on July 3, 2023. The main complaint is abdominal obstruction for half a year, intermittent hiccups, belching, no dry mouth, no bitter taste, no acid reflux, no nausea, vomiting, no burning sensation in the upper abdomen, normal stool, poor sleep, and nightmares. Dark red tongue, thin white fur, and pulse is deep and wiry. One month ago, gastroscopy showed chronic non-atrophic gastritis. Western medical diagnosis: functional dyspepsia. Chinese medical diagnosis: fullness and liver stagnation. After 1 week of treatment with the drug of the present application, the symptoms were relieved, and after 3 weeks of consolidation treatment, the patient was cured 1 month later.

[0075] Case 3: Pu, female, 28 years old, came to the Spleen and Stomach Disease Department of the Integrative Medicine Hospital of our hospital on March 10, 2024. The main complaint is abdominal distension, chest tightness, and hiccups for 1 year, bitter taste, no acid reflux, nausea, vomiting, no burning sensation in the upper abdomen, normal stool, and sleep. The last menstrual period was on March 1. Pale red tongue, thin white and slightly greasy fur, and wiry pulse. Gastroscopy in October 2023 showed chronic atrophic gastritis, and colonoscopy showed no abnormalities in the colon. Western medical diagnosis: functional abdominal distension. Chinese medical diagnosis: fullness and liver stagnation. After 1 week of treatment with the drug of the present application, the symptoms were relieved, and after 2 weeks of treatment, the patient was cured 1 month later.

[0076] In summary, the traditional Chinese medicine composition of the present application is simple and effective in treating fullness and liver stagnation, effectively relieving gastric fullness, distension, or distending pain, with fast-acting, good safety, no recurrence after stopping medication, and better effect than the currently widely used mosapride citrate, significantly reducing patient pain, and having practical application value.

Claims

1. A traditional Chinese medicine composition for treating gastrointestinal motility disorders, characterized in that: It is prepared from the following parts by weight of active pharmaceutical ingredient: Costus root 2-8 parts, Areca peel 5-15 parts, Cyperus rhizome 2-8 parts, Citrus reticulata peel 3-7 parts, Amomum villosum 3-7 parts, Citrus aurantium 5-15 parts, Citrus reticulata peel 2-8 parts, Magnolia officinalis 10-20 parts, Atractylodes lancea 10-20 parts, Rheum palmatum 3-7 parts, Citrus medica 10-20 parts, Radish seed 10-20 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that: It is prepared from the following parts by weight of active pharmaceutical ingredient: 6 parts of costus root, 10 parts of areca peel, 6 parts of cyperus rhizome, 5 parts of green tangerine peel, 5 parts of amomum villosum, 10 parts of immature bitter orange, 6 parts of dried tangerine peel, 15 parts of magnolia bark, 10 parts of atractylodes rhizome, 5 parts of rhubarb, 15 parts of citron, and 15 parts of radish seed.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that: The Cyperus rotundus is vinegar-processed Cyperus rotundus; the Citrus reticulata peel is bran-fried Citrus reticulata peel; the Citrus aurantium is bran-fried Citrus aurantium; the Magnolia officinalis is ginger-processed Magnolia officinalis; the Atractylodes lancea is bran-fried Atractylodes lancea; the Rheum palmatum is processed Rheum palmatum; and the Radish seed is stir-fried Radish seed.

4. The traditional Chinese medicine composition according to claim 1, characterized in that: It is a formulation prepared by adding pharmaceutically acceptable excipients to a powdered active pharmaceutical ingredient or an aqueous or organic solvent extract of the active pharmaceutical ingredient.

5. The traditional Chinese medicine composition according to claim 4, characterized in that: The preparation is an oral preparation.

6. The traditional Chinese medicine composition according to claim 5, characterized in that: The oral preparations include solutions, pills, granules, tablets, powders, or ointments.

7. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 6, characterized in that: It includes the following steps: (1) Weigh the raw materials according to the proportions described in claim 1; (2) The active pharmaceutical ingredient is ground into powder, or the active pharmaceutical ingredient is extracted with water or organic solvent, and then excipients or auxiliary ingredients commonly used in pharmaceuticals are added to obtain the product.

8. Use of the traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicament for treating gastrointestinal motility disorders.

9. The use according to claim 8, characterized in that: The drug is for treating epigastric fullness, and preferably a drug for treating epigastric fullness due to liver qi stagnation.

10. The use according to claim 8 or 9, characterized in that: The medication is for treating stomach fullness, bloating, and / or bloating pain.

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