Delivery systems and methods for diagnosing and treating cardiovascular diseases

A vascular, therapeutic agent technology, applied in the field of biological systems, can solve problems such as susceptibility to erosion and rupture

Inactive Publication Date: 2008-05-28
MEDSTAR HEATH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the inflammatory cells present in the plaque are activated, they can produce proteo

Method used

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Embodiment Construction

[0026] The present invention broadly relates to atherosclerosis and / or cardiovascular disease associated with atherosclerosis. Aspects of the invention provide delivery systems and methods for the treatment, prevention, and diagnosis of atherosclerosis and cardiovascular diseases associated with atherosclerosis.

[0027] In certain embodiments, the present invention provides biodelivery for the delivery of therapeutic or imaging agents to atherosclerotic lesions (stable atherosclerotic lesions or vulnerable atherosclerotic lesions) in blood vessels of an individual system. In one embodiment, the biological system comprises (a) a therapeutic agent and (b) a molecule that interacts with a target molecule present in an atherosclerotic lesion (e.g., a chemokine ligand, a chemokine receptor, or an adhesion molecule) A vector of at least one targeting structure interacting, wherein the biological system delivers a therapeutic agent to an atherosclerotic lesion in a blood vessel. I...

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Abstract

The invention relates to medicine mixtures containing phosphorylcholine conjugate or antibody preparing product (such as monoclonal antibody) specific to phosphorylcholine conjugate and roles of the mixtures in treatment and prevention of atherosclerosis (such as the roles in treatment, prevention and depression of further development of atherosclerosis). And the invention further relates to usage of phosphorylcholine conjugate or antibody preparing product (such as monoclonal antibody) in production of any medicine mixtures with adjuvants. In addition, the invention relates to diagnose to judge whether antibodies such as IgM or IgG antibody exist or not, the antibodies is relevant with increase and decrease of risk for occurring of ischemic cardiovascular disease.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application No. 60 / 664,300, filed March 22,2005. The entire teaching and specification of the referenced application is hereby incorporated by reference. Background technique [0003] Atherosclerosis is an inflammatory disease that eventually leads to the accumulation of lipids within the walls of arteries. Damage to the vascular endothelium due to hypercholesterolemia, hypertension, high levels of homocysteine, infection, and / or other conditions appears to be the initiating event of atherosclerosis. This causes arterial endothelial cells to express adhesion molecules that bind to different types of leukocytes, including monocytes and T lymphocytes. Once adhered to the endothelium, chemokines (such as MCP-1) expressed by the damaged arterial wall stimulate the migration of leukocytes to the intima of the vessel, and thus an inflammatory process that eventually leads to the development o...

Claims

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Application Information

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IPC IPC(8): C12N15/63A61K47/48A61K9/127A61P9/10A61K51/08A61K49/22A61K49/08A61K49/14
CPCA61K47/48561A61K47/48415A61K47/48238A61K49/221A61K47/484A61K49/14A61K51/088A61K49/085A61K47/62A61K47/6807A61K47/6811A61K47/6849A61P9/10
Inventor 史蒂芬·E·爱泼斯坦玛丽·苏珊·比尔内特马丁·A·马林斯
Owner MEDSTAR HEATH INC
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