5 results about "Chronic kidney failure" patented technology

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic renal failure, which is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix bupleuri, 9-18 parts of radix scutellariae, 6-12 parts of ginger processed pinellia, 9-18 parts of radix pseudostellariae, 3-9 parts of honey-fried licorice root, 3-9 parts of leech, 3-9 parts of fructus amomi, 9-18 parts of perilla leaf and 9-18 parts of common fenugreek seed. The traditional Chinese medicine composition aims at symptoms and pathogenesis of the chronic renal failure, adopts treatment principles of tonifying qi, warming yang, dispersing blood stasis and draining turbidity, is cheap in raw materials, simple and convenient to prepare, convenient to use and small in side effect, can be taken for a long time, and has a better curative effect and a good application prospect on the chronic renal failure through observation and analysis.

The present application relates to the field of pharmaceutical chemistry, and particularly relates to application of apigenin and derivatives thereof or pharmaceutically acceptable salts thereof in preparation of drugs for treating or preventing kidney diseases, for example, chronic renal failure diseases. The research results of the present application show that apigenin can obviously improve symptoms of kidney diseases, especially chronic renal failure diseases.

The present invention relates to a new process for the preparation of heterocyclic derivative compounds of Formula I; to new intermediate compounds used in said process for the preparation; to compositions for the treatment or prevention of hyperuricemia, gout disease, nephritis, chronic renal failure, kidney stones, uremia, urinary stones or uric acid-related diseases, said compositions comprising a compound of Formula I at a dosage of administration of more than 2 mg to 10 mg below, administered orally once a day; and to new hydrochloride 1.5 hydrate salts of compounds of Formula I.

To provide an ATP production promoter useful for preventing or treating diseases associated with decreased ATP production, particularly renal impairment. [Solution] The present invention comprises an ATP production promoter containing a component having URAT1 inhibitory activity. Preferably, the component having URAT1 inhibitory activity is at least one selected from the group consisting of benzbromarone, probenecid, dotinurad, recinurad, and berinurad. The present invention is expected to be useful as a preventive and therapeutic agent for diseases of decreased ATP production, and is particularly useful as a therapeutic and / or preventive agent for nephrotic syndrome, chronic glomerulonephritis, chronic tubulointerstitial nephritis, chronic pyelonephritis, amyloid kidney, familial juvenile hyperuricemia nephropathy, autosomal dominant tubulointerstitial kidney disease, nephronoplasia, renovascular hypertension, renal vein thrombosis, renal arteriovenous fistula, renal tubular acidosis, Gitelman syndrome, Bartter syndrome, Fanconi syndrome, Lowe syndrome, Alport syndrome, kidney and ureteral stones, and chronic renal failure.

This invention discloses a traditional Chinese medicine composition for treating chronic renal failure and its application. The composition is made from Astragalus membranaceus, Epimedium, Salvia miltiorrhiza, Rheum palmatum, Orthosiphon aristatus, Uncaria rhynchophylla, Centella asiatica, Pyrola rotundifolia, Smilax glabra, Euonymus alatus, and Sargassum fusiforme in specific weights. The composition significantly reduces serum creatinine, blood urea nitrogen, and 24-hour urinary protein levels in rats with a chronic renal failure model, effectively improving renal pathological damage. Its mechanism of action may be related to multi-target effects such as regulating local renal inflammatory factors. Through rational formulation, this composition fully utilizes the synergistic effects of its components, exhibiting advantages such as definite efficacy and minimal side effects.