The invention discloses a capsule for treating a chronic kidney failure syndrome, and belongs to the field of traditional Chinese medicines. The effective constituents of the capsule comprise the following raw materials in parts by weight: 50-65 parts of white paeony root, 45-60 parts of perilla leaf, 42-58 parts of astragalus mongholicus, 38-54 parts of raw rhubarb, 34-50 parts of fructus forsythia, 30-46 parts of acorus calamus, 28-44 parts of lophatherum gracile, 25-40 parts of radix aconiti lateralis preparata, 22-26 parts of oriental wormwood, 18-22 parts of Sichuan fritillary bulb, 15-28 parts of herba leonuri, 12-25 parts of melon seed, 10-22 parts of blackberry lily, 8-18 parts of akebiaquinata, 5-15 parts of radix cyathulae and 3-12 parts of mirabilite powder. According to the invention, the raw materials complement each other, and the capsule is prepared by scientifically mixing the Chinese herbal medicines with the effects of warming the kidney, benefiting the spleen, descending the turbid, regulating the middle warmer, dredging water passage, tonifying the spleen and kidney, dredging the organs, descending the turbid, and promoting diuresis to remove toxic materials, is specially used for treating kidney and spleen-yang deficiency, turbid accumulation, spleen and kidney-yang deficiency, and water retention and toxin predominance, has a very good treatment effect for various complications of the chronic kidney failure syndrome, and can effectively prolong the survival time of a uremia patient and improve the life quality of the patient.