Traditional Chinese medicine composition for treating chronic renal failure and application thereof

By combining the traditional Chinese medicine ingredients of Qixiandanhuang Decoction, the problems of complex formulation and unclear mechanism in the treatment of chronic renal failure with traditional Chinese medicine have been solved. It has achieved the effects of significantly reducing blood urea nitrogen, serum creatinine and proteinuria, relieving micro-inflammation and protecting renal function.

CN122272733AActive Publication Date: 2026-06-26AFFILIATED HOSPITAL OF JIANGXI UNIV OF TCM
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Patent Information

Application Number
CN202610705930.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-21
Publication Date
2026-06-26
Estimated Expiration
2046-05-21

AI Technical Summary

Technical Problem

Current TCM treatments for chronic renal failure suffer from problems such as complex formulations, unclear mechanisms, and insufficient formulation stability, while Western medicine treatments are expensive, have many complications, and suffer from a shortage of kidney donors.

Method used

The formula uses the Qixiandanhuang Decoction, a traditional Chinese medicine combination. Based on the theory of traditional Chinese medicine, it addresses the root cause of "spleen and kidney deficiency" and the symptoms of "dampness and blood stasis". It is combined with Astragalus membranaceus, Epimedium, Salvia miltiorrhiza and other drugs to treat chronic renal failure by strengthening the spleen and kidney, removing blood stasis and unblocking the meridians, and eliminating turbidity and detoxifying.

Benefits of technology

It significantly reduces blood urea nitrogen, serum creatinine and urinary protein levels, alleviates microinflammatory state, and protects renal function, demonstrating good medical application value and safety.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic renal failure and application thereof. The composition is prepared from astragalus membranaceus, herba epimedii, salvia miltiorrhiza, raw rhubarb, clerodendranthus spicatus, radix ranunculi ternati, centella asiatica, pyrola, rhizoma smilacis glabrae, euonymus alatus and seaweed according to a specific weight. The composition can significantly reduce the content of creatinine, urea nitrogen and 24-hour urine protein in serum of chronic renal failure model rats and effectively improve pathological injury of kidneys, and the action mechanism of the composition may be related to multi-target effects such as regulation of kidney local inflammatory factors and the like. Through reasonable compatibility, the composition gives full play to the synergistic effect of all the components, and has the advantages of definite curative effect, small side effect and the like.
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