54 results about "Atp production" patented technology

The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A):and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and / or oxidative stress and / or lipid peroxidation.

The present disclosure provides compounds of formula (I):compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and / or oxidative stress and / or lipid peroxidation.

The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially directly to a tumor, as well as methods for identifying compositions that selectively inhibitor ATP production for use in the invention.

Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and / or oxidative stress and / or lipid peroxidation.

The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially directly to a tumor, as well as methods for identifying compositions that selectively inhibitor ATP production for use in the invention.

The invention discloses a method for preparing adenosine triphosphate (ATP) with an immobilized enzyme method. The method comprises the following steps: (1) fixing an ATP production enzyme on an immobilized carrier to prepare an immobilized ATP production enzyme; (2) catalyzing by using the immobilized ATP production enzyme to prepare an adenosine triphosphate reaction solution; (3) separating the product adenosine triphosphate. According to the method disclosed by the invention, three types of novel ATP production enzymes including Ppk, Adk and Pap are adopted, and the ATP can be synthesized through only two steps of enzymatic reaction; a reaction process is simpler, a reaction is more easily controlled and the product quality is more stable; the ATP is prepared by adopting an immobilized enzyme catalysis method, and an immobilized enzyme can he continuously and repeatedly used for a plurality of times, so that the production cost is greatly reduced. Meanwhile, impurities including a lot of proteins, pigments and the like, which are introduced by utilizing yeasts, are avoided, and the product is more easily purified; an intermittent stirring reaction and enzyme reaction column continuous reaction system which is applicable to large-scale production of the ATP is established.

The subject invention relates to improved tocopheryl quinone derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorders, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.

The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and / or oxidative stress and / or lipid peroxidation.

The invention discloses a method for preparing triphosadenine by an enzymic method. The method comprises the following steps of (1) preparing ATP production enzymes: obtaining the ATP production enzymes in gene engineering transformation, fermentation, purification or direct extraction modes; (2) preparing ATP in reaction liquid; adding adenosine, the ATP production enzymes and polyphosphoric acid or salts of the polyphosphoric acid for ATP preparation; (3) separating products and ATP production enzymes; directly separating immobilized ATP production enzymes in a reaction tank, and separating free ATP production enzymes through an ultrafiltration membrane in a filtering device; (4) preparing a finished product: preparing the reaction liquid subjected to the enzyme separation into finished product ATP through the steps of ion-exchange column chromatography, concentration, crystallization; drying and the like. The method has the advantages that the novel ATP production enzymes are used; the production process is simple; the control is easy; the adenosine is used as a substrate; the cost is reduced; an APT production enzyme recovery system is built; the method is applicable to industrial production; the content of impurities such as impurity protein and pigment in the enzymic method preparation reaction liquid is low; the subsequent purification is easy.