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Anti-irritation composition, and preparation method and application thereof

A composition and anti-irritant technology, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as skin irritation, achieve simple material composition, improve the inhibition rate of red blood cell hemolysis, and reduce the chicken embryo chorioallantoic. The effect of membrane stimulation

Active Publication Date: 2021-06-29
BEIJING DONGFANG MIAOSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it only addresses skin irritation caused by surfactants in cosmetics

Method used

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  • Anti-irritation composition, and preparation method and application thereof
  • Anti-irritation composition, and preparation method and application thereof
  • Anti-irritation composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Peach gum 3g, cactus 1g, centella asiatica 1g, psyllium 0.1g, according to the total raw material: water = 1:40 (m / m), add water 204g, extraction temperature 80 ℃, extract for 2h, filter, concentrate 1 times ;Based on the weight of the concentrate, compounded with 24% glycerin, 9% trehalose, 9% hydroxypropyl-β-cyclodextrin, 1% hexanediol, 2% pentylene glycol, 0.2% disodium EDTA, 0.05% Xanthan gum was sterilized at 90° C. for 40 minutes to obtain the anti-irritant composition of Example 1.

Embodiment 2

[0061] Peach gum 10g, cactus 5g, centella asiatica 5g, psyllium 1g, according to the total raw materials: water = 1:30 (m / m), add 630g of water, extract at 70°C, extract for 3h, filter, concentrate 2 times; Based on the weight of the concentrated solution, compound 20% glycerin, 8% trehalose, 5% β-cyclodextrin, 1.5% hexanediol, 1.5% pentanediol, 0.5% disodium EDTA, 0.1% xanthan gum, 100 C. Sterilize for 30 minutes to obtain the anti-irritant composition of Example 2.

Embodiment 3

[0063] 15g of peach gum, 7g of cactus, 5g of centella asiatica, 3g of psyllium, according to the total raw material: water = 1:50 (m / m), add 1500g of water, extract at 50°C, extract for 5h, filter, and concentrate 3 times; Based on the weight of the concentrate, compound 10% glycerin, 20% trehalose, 20% hydroxypropyl-β-cyclodextrin, 1% hexanediol, 2% pentanediol, 0.5% disodium EDTA, 0.1% yellow Raw gum was sterilized at 100° C. for 30 minutes to obtain the anti-irritant composition of Example 3.

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Abstract

The invention discloses an anti-irritation composition, and a preparation method and application thereof. The anti-irritation composition comprises peach gum, cactus, centella asiatica and semen plantaginis; the material composition is simple; the preparation process is simple; all the components interact; and skin irritation caused by cosmetic raw materials can be effectively resisted. Effect evaluation experiments prove that the anti-irritation composition in the invention can antagonize lactic acid stimulation, improve the inhibition rate of red blood cell hemolysis caused by sodium dodecyl sulfate (SDS), reduce chick chorioallantoic membrane irritation caused by SDS and antagonize various irritation sources in cosmetics. When the composition is applied to cosmetics, the composition is expected to have an anti-irritation effect and can antagonize skin irritation caused by various irritation sources such as acidic substances, surfactants, flavours and fragrances, preservatives and the like in cosmetic raw materials.

Description

technical field [0001] The invention relates to an anti-irritant composition and its preparation method and application. Background technique [0002] With the continuous improvement of living standards, people's pursuit of beauty and skin care is also getting higher and higher. In recent years, the production and consumption of cosmetics in my country have increased sharply, and the resulting skin adverse reactions are increasing day by day, which has aroused widespread concern. Adverse skin reactions to cosmetics have become a common disease in dermatology. In my country, a total of 13,534 patients with cosmetic adverse reactions were reported from 2005 to 2014, of which women accounted for 95.40%, young and middle-aged patients (20-44 years old) accounted for 80.85%, and 5,446 confirmed cases. The type of disease was cosmetic adverse reaction contact dermatitis. Mainly (94.66%), there were 132 other lesion types not included in the diagnostic criteria, and a total of 14,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61Q19/10
CPCA61K8/9789A61Q19/00A61Q19/10A61K2800/75A61K2800/5922
Inventor 刘有停苏牧楠吕永博
Owner BEIJING DONGFANG MIAOSEN BIOTECH CO LTD
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