5results about How to "Avoid hemolysis" patented technology

The invention discloses a degradable polycarbonate cationic carrier and application thereof, and belongs to the technical field of drugs, the degradable polycarbonate cationic carrier is a nano-micelle formed by self-assembly of diblock polymers, the diblock polymers are represented as A-B, the A block is mPEG, and the B block is PAMA, PDMA or PDEA; the molecular weight of the block A is 2000 to 5000, and the polymerization degree of the block B is 50 to 150. The degradable polycarbonate cation carrier has an mRNA delivery function, and is combined with mRNA through a positive and negative electricity interaction principle, so that the problem of gene waste caused by mRNA loading through a microfluidic method can be solved, and efficient delivery of antigen presenting cells (APC) is realized.

The utility model provides a kind of blood specimen transmission cylinder, including main body cylinder, first buffer sleeve and cylinder cover;Wherein main body cylinder has accommodating cavity;First buffer sleeve is installed in accommodating cavity, blood collection tube can be inserted into first buffer sleeve;Cylinder cover can be connected with main body cylinder cover, after cover connection, the inner top wall of cylinder cover and the tube cap of blood collection tube abut.In transmission blood specimen, blood collection tube with blood specimen is placed in first buffer sleeve, then cylinder cover is connected with main body cylinder cover and fixed blood collection tube.The blood specimen transmission cylinder of the utility model can effectively avoid specimen spilling and hemolysis problem in transmission process, specifically, blood collection tube is placed in first buffer sleeve, the impact of transport vibration on blood collection tube is reduced using the buffer effect of sleeve, and the stability of tube body is enhanced, so as to prevent hemolysis;In addition, cylinder cover and main body cylinder are reliably fixed by clamping structure, and the pre-tightening pressure exerted on blood collection tube cap by cylinder cover inner wall can prevent tube cap from loosening and avoid spilling.

The invention discloses a blood identification puncture needle, and relates to the technical field of blood identification sampling, the blood identification puncture needle comprises a needle tube and a needle head used for assisting blood sampling identification puncture, the front end of the needle tube is fixedly provided with a mounting cylinder, and the end part of the needle head is fixedly provided with a first connecting cylinder used for being in threaded connection with the outer side of the mounting cylinder in a communicating manner; the pressure extraction assembly is arranged on the needle tube and is used for assisting in sampling and pressure extraction. When the blood identification puncture needle is used for blood puncture sampling, through mutual cooperation of the resistance assembly, the limiting assembly, the liquid outlet assembly and other components, resistance with certain elastic force can be generated on pulling of the piston plate, and through the resistance effect, the situation that in the liquid pumping and sampling process, pumping and pulling are too violent is avoided; the hemolysis phenomenon caused by erythrocyte rupture of the blood after liquid extraction and sampling is further avoided, more accurate detection operation after sampling is facilitated, and closing and liquid outlet operation of the blood after sampling can be effectively controlled.

The application relates to a microfluidic device, a support and a plasma separation method for whole blood filtration, comprising a body, a filtration mechanism arranged in the body and a collection tank in communication with the filtration mechanism, the filtration mechanism is used for filtering red blood cells, and the collection tank is used for collecting plasma; the application further comprises a driving mechanism used for driving a sample in the body to move from a side where the filtration mechanism is located to a side where the collection tank is located. The driving mechanism can improve the flow speed of the sample, thereby improving the whole blood filtration speed, shortening the whole blood separation time and reducing the possibility of hemolysis. The microfluidic device provided by the embodiment can obtain plasma without a centrifuge, has a small device volume and is easy to operate.

The present invention discloses an anti-hemolysis blood sample collection device for a physical examination center, which belongs to the field of blood collection. The device comprises a blood storage tube, the upper end of which is provided with a plastic cap, a guide block is provided inside the blood storage tube, the guide block is in an umbrella shape, and the cutouts of the plurality of vertical grooves are all in an arc shape. The blood enters the blood storage tube through a needle and flows into the cavity on the shunt block. The blood is allowed to flow out evenly through the plurality of shunt ports and shunt holes on the shunt block. The blood flows dispersedly to the surface of the guide block through the plurality of shunt ports and shunt holes. The blood flows outward toward the tube wall of the blood storage tube through the inclined surface of the guide block. The blood is guided to flow slowly into the blood storage tube for storage through the plurality of vertical grooves, and the blood is evenly flowed, the impact force on the blood during the flow process is reduced, and the hemolysis caused by the rupture of red blood cells due to excessive pressure is avoided. At the same time, the flow along the plurality of vertical grooves also helps to reduce the direct contact between the blood and the air, and reduces the risk of oxidative hemolysis.