67results about How to "Avoid hemolysis" patented technology

The present invention provides a blood cell separation membrane for separating blood into serum or plasma and blood cells while preventing hemolysis of the blood cells. Such a blood cell separation membrane can be obtained by impregnating a porous membrane for separating blood cells from blood supplied thereto with a solution containing a hydrophobic aminocarboxylic acid, a protein derived from silk, Tris, TES, ε-aminohexanoic acid, tranexamic acid, or heparin and then drying the membrane.

The invention relates to an embeddable two-stage axial flow blood pump rotor structure. The embeddable two-stage axial flow blood pump rotor structure comprises a rotor head part, a rotor tail part and an impeller part, wherein the impeller part which adopts a two-stage structure design comprises a front-stage impeller and a back-stage impeller; the front-stage impeller (2) in a spiral structure has three blades; the back-stage impeller (3) is in a traditional axial flow structure; an axial distance is arranged between the front-stage impeller and the back-stage impeller; the surface curve equation of the heat part of the rotor is as follows: Formula, wherein the x is an axial distance of a hub; the y is a radial distance of the hub; and the original point is an intersection point of the surface curve of the head part of the rotor and the axial line of the hub. The embeddable two-stage axial flow blood pump rotor structure can enable the blood pump rotor to satisfy with a lift requirement at a relatively low rotating speed under the precondition that the axial size is as small as possible, thereby decreasing formation of hemolysis and reducing power consumption efficiently, and can reduce irregular flow resulted from the more complex blood pump rotor structure as the transition between the front and back impellers is corrected.

The invention discloses a pharmaceutical composition of oryzanol, which comprises the oryzanol, phospholipid, bile acid and / or salt of bile acid. The pharmaceutical composition effectively improves the water solubility and the stability of the oryzanol and has better grain diameter and stability than the prior product, and further, the invention provides injectio and freeze-dried powder of the pharmaceutical composition, and preparation methods thereof.

The invention relates to a stable medical lipid composite; the drug molecules which are insoluble or slightly water-soluble under physiological conditions and the amphiphatic molecules of cholesterin derivant and phospholipid are caused to form the lipid composite and further prepare the drug preparation.

The invention relates to a centrifugal left ventricle assisting device which comprises a pump body and a blood flow inlet and a blood flow outlet in the pump body, wherein the pump body comprises a pump shell, an inner cavity formed on the pump shell, an outer cavity formed on the pump shell and positioned outside the inner cavity, a stator arranged in the outer cavity, a rotor capable of rotating around the axis thereof under the effect of the stator and multiple blades connected with the rotor and capable of rotating along with the rotation of the rotor; the blade has an inclination angle; the rotor and the blades are suspended in the inner cavity; and the blood flow inlet and the blood flow outlet are communicated with the inner cavity respectively. In the invention, through structural improvement, the centrifugal left ventricle assisting device has the advantages of high efficiency, small volume, prevention of hemolysis and thrombus and lasting patient support.

The invention discloses umbilical cord blood mesenchymal stem cell separation liquid and an umbilical cord blood mesenchymal stem cell separation flow. The separation liquid is prepared by mixing saccharosan of which the concentration is 9 percent and meglumine diatrizoate of which the concentration is 33.9 percent in the ratio of 26.88:10, wherein the concentration of the separation liquid is 1.073+ / -0.01g / L. A two-step method for separating umbilical cord blood mesenchymal stem cells comprises the following steps of: 1, precipitating red cells by a hydroxyethyl starch; and 2, separating the mesenchymal stem cells by the separation liquid of which the concentration is1.073g / L. The mesenchymal stem cell with the highest proportion in umbilical cord blood can be obtained by the separation liquid and the separation flow, the proportions of lymphocytes and mononuclear cells are very low, and the obtained cells are good in state and high in activity. The used materials and reagents are medical products, are non-toxic, do not have heat sources, can be industrially produced and are convenient to store. The used method is an optimized flow, is high in stability and repeatability, can be also used for separating human marrow and peripheral blood mesenchymal stem cells, is the best method for separating and extracting the mesenchymal stem cells in the current density gradient centrifugation and is better than other products and methods.

A counter typing reagent of ABO blood type is prepared as improving buffer system to change single citrate buffer system to be citrate-phosphate double-buffer system, adding adenine as nutrition composition, applying no any chemical anticorrosive in anticorrosion system and adding EDTA for preventing red blood cell of blood type from hemolysis.

The invention discloses a flexible ventricle assist device which comprises an elastic shell attached to the outer wall of the heart and at least two sets of pneumatic muscles embedded in the elastic shell and corresponding to the left ventricle and the right ventricle of the heart respectively. An air passage for communicating the air bags in all the pneumatic muscles is arranged in the elastic shell, and is led out through an air inlet and an air outlet in the elastic shell to be connected with an external air source; and a strain limiting layer is arranged on the outer side air bag wall, away from the heart, of the pneumatic muscle. The heart pump blood function of a heart failure patient can be assisted; the whole device is simple in structure, and the elastic shell can be designed to be lighter and thinner; the load of the implantation device on the body of the patient is reduced; the whole elastic structure can better adapt to different biological characteristics adapting to hearts of different patients, is wider in adaptability, can act on the heart to conduct adaptive deformation on torsion of the heart in the heart process, reduces damage to cardiac myocardium of the heart,and enables the heart of the heart failure patient to reach the normal blood pumping level through heart pacing signal feedback control.

The invention provides a device used for filtering a liquid. The device includes a flow channel and a filtering film. The flow channel is provided with an inlet and an outlet. The filtering film is provided with a plurality of holes. The flow channel is arranged on the filtering film in an overlapping manner. And when the liquid flows through the flow channel, the liquid contact with the filtering film. The device in the invention has a structure satisfying cross flow filtering principle. Thus, parallel shear stress can be generated by the liquid in the flow channel, thereby avoiding impurity accumulation in the holes of the filtering film.

The invention relates to a centrifugal left ventricle assisting device which comprises a pump body and a blood flow inlet and a blood flow outlet in the pump body, wherein the pump body comprises a pump shell, an inner cavity formed on the pump shell, an outer cavity formed on the pump shell and positioned outside the inner cavity, a stator arranged in the outer cavity, a rotor capable of rotating around the axis thereof under the effect of the stator and multiple blades connected with the rotor and capable of rotating along with the rotation of the rotor; the blade has an inclination angle; the rotor and the blades are suspended in the inner cavity; and the blood flow inlet and the blood flow outlet are communicated with the inner cavity respectively. In the invention, through structural improvement, the centrifugal left ventricle assisting device has the advantages of high efficiency, small volume, prevention of hemolysis and thrombus and lasting patient support.

The invention relates to a composite pig blood anticoagulant and a use method thereof. The composite pig blood anticoagulant comprises sodium citrate, ethylene diamine tetraacetic acid, sodium acetate and sodium chloride at the weight ratio of 6:4:1:3. Before being used, the composite pig blood anticoagulant needs to be dissolved into water, and each 56g of the pig blood anticoagulant needs to be dissolved into 1L of water, and correspondingly the mixture is added into 12kg of pig whole blood. The composite pig blood anticoagulant provided by the invention can ensure that pig blood does not be subjected to obvious clotting phenomenon within four days at normal temperature. The composite pig blood anticoagulant is simple in formula and convenient in operation, is economical and applicable, and can be used for effectively preventing the pig blood from clotting with reduced environmental pollution.

The invention provides skin-building toilet water rich in sodium copper chlorophyllin and a preparation method thereof. The skin-building toilet water uses sodium copper chlorophyllin as one of effective components and comprises main raw materials such as sodium copper chlorophyllin, wild chrysanthemum flower volatile oil, Artemisia leaf volatile oil, coconut oil acylamide propyl lycine, lemon extract, ethanol and water, and the steps comprise weighing, dissolution, emulsification, total mixing, uniform emulsification, filling, code spraying, packaging, and the like. The skin-building toilet water has simple preparation method and equipment and easy production and popularization. The skin-building toilet water rich in sodium copper chlorophyllin has the effects of mosquito expelling, prickly heat prevention, itching relieving, sterilization, detoxification, air freshening, toxin resistance, ulcer resistance, hemolysis resistance, white ascending, liver protection and yellow elimination, and can promote the concrescence of ulcer surfaces, prevent cold, cephalitis and skin pruritus, maintain the functions of the brain, the heart and the lung and improve the immunity. The skin-building toilet water rich in sodium copper chlorophyllin is especially suitable for infants and children.

The invention discloses an officinal product of oryzanol and a preparation method thereof. The product is a kit which contains two unit preparations, wherein the first unit preparation is a composition of oryzanol, phospholipid, bile acid and / or salt of bile acid; and the second unit preparation is a solvent of the first unit preparation. The officinal product of oryzanol solves the problem of poor water solubility of the oryzanol and has simple use and easy storage.

A centrifugal pump (10) includes a housing (26), an impeller (28) that is rotatably disposed inside the housing (26), a shaft (62) that is provided at a center rotational axis of the impeller (28), and bearings (70) that pivotally support the shaft ends (66). At least one of the shaft ends (66) has surface roughness Ra equal to or less than 0.21 μm and / or surface roughness Ry equal to or less than 1.49 μm.

A method for monitoring conveyance of fluid in a device for extracorporeal blood treatment, whereby fluid is conveyed by a peristaltic pump in a fluid system from a low-pressure side to a high-pressure side in that an elastically deformable fluid line positioned between the low-pressure side and the high-pressure side is deformed between a support surface and at least two squeeze elements of a rotor rotating opposite the support surface in such a way that a conveyance volume section is formed between the squeeze elements, whereby a fluid pressure value in the fluid system is detected for the conveyance volume section that is specific to the conveyance volume section, and whereby the detected conveyance-volume-specific fluid pressure value of a conveyance cycle n is compared with the detected conveyance-volume-specific fluid pressure value of a previous conveyance cycle n-x.

A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic / metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.

The invention discloses a preparation method of quality control serum for ischemia-modified albumin; the preparation method comprises the following steps of: (1) adopting the blood serum of a healthy person, and adjusting a pH value to be 7.0-7.5; (2) adding 0.1-100mm of metal ionic salt with a variable valence center or a metal organic composite with molecule planarity to the blood serum, and then adding 0.1-100mm of hydrogen peroxide; (3) reacting for 10-30min under the 35-40 DEG C illumination; (4) dialyzing a solution obtained through the reaction in the step (3) in 0.1-1000mm of a dialysis buffer solution with pH of 7.5-8.0 under the 20-25 DEG C temperature for 12-24h; and (5) adding a preservative according to a conventional technology, subpackaging and determining after mixing uniformly. The preparation method has the advantages of adequate the source of raw materials, easily obtaining of the raw materials, simple preparation technology, few amount of additives, low production cost, small non-specificity interference, no needing for composite dissolving, good homogeneity and small difference between bottles.

The emulsified injection is prepared with zedoary oil, middle chain oil for injection, long chain oil for injection, emulsifier, isoosmotic regulator, antioxidant, pH regulator and water for injection. The preparation process include adding emulsifier into the middle chain oil and the long chain oil, heating and stirring to dissolve emulsifier, adding zedoary oil, heating and stirring to dissolve and mix, and adding tocopherol via stirring to obtain oil phase; adding isoosmotic regulator into water for injection, and heating and stirring to dissolve to obtain water phase; mixing the oil phase and the water phase, emulsifying, regulating pH value and adding water for injection to required amount. The preparation has great medicine carrying amount, no toxic side effect, stable property, convenient use and fast and simple preparation, and is suitable for mass production.

The invention relates to a biological power duplex valve device and a charging and discharging method. Dilated cardiomyopathy and ischemic cardiomyopathy are the principal diseases causing congestive heart failure, and have the common pathophysiologic characteristics of atrioventricular valve ring, left ventricular enlargement, atrioventricular valve regurgitation and reduction of ventricular ejection fraction. The biological power duplex valve device comprises a power fluid balloon (1), an in-vitro pump controller (2) and a catheter (3), wherein the power fluid balloon is connected with the catheter, the catheter is connected with a valve ring (4) and a group of holder legs (8), the valve ring is connected with a valve leaflet (5), the valve leaflet is connected with a valve fluid balloon (6), the valve ring is connected with the power fluid balloon, and signals sent by the in-vitro pump controller are received by a magnet of the power fluid balloon. The biological power duplex valve device is applied as a medical appliance.

A method for monitoring conveyance of fluid in a device for extracorporeal blood treatment, whereby fluid is conveyed by a peristaltic pump in a fluid system from a low-pressure side to a high-pressure side in that an elastically deformable fluid line positioned between the low-pressure side and the high-pressure side is deformed between a support surface and at least two squeeze elements of a rotor rotating opposite the support surface in such a way that a conveyance volume section is formed between the squeeze elements, whereby a fluid pressure value in the fluid system is detected for the conveyance volume section that is specific to the conveyance volume section, and whereby the detected conveyance-volume-specific fluid pressure value of a conveyance cycle n is compared with the detected conveyance-volume-specific fluid pressure value of a previous conveyance cycle n−x.

A method of conveying fluid in an apparatus for extracorporeal blood treatment is disclosed, wherein fluid is conveyed by a peristaltic pump from a low-pressure side to a high-pressure side, an elastically deformable fluid line arranged between the low-pressure side and the high-pressure side being deformed between a support surface and a rotor rotating with respect to the latter and having at least two pinch elements, wherein the pinch elements are repositioned at angles relative to each other during rotation of the rotor for causing pre-compression. A dialysis machine including a peristaltic pump conveying fluid from a low-pressure side to a high-pressure side, wherein the peristaltic pump is arranged to receive an elastically deformable fluid line between the low-pressure side and the high-pressure side and includes a support surface supporting the fluid line and a rotor is also disclosed, the rotor including at least two pinch elements each deforming the fluid line between itself and the support surface, wherein the pinch elements are formed to be repositioned at angles relative to each other in the direction of rotation.

The invention discloses a blood collection tube blending device which comprises a blending box and a storage module, and the blending box and the storage module are each provided with an expansion strip and an expansion groove; a button is arranged on the blending box and connected with an internal uniform mixing mechanism, an opening is formed in the top of the blending box, a test tube rack is arranged at the opening, the two ends of the test tube rack are connected with the inner wall of the blending box and the uniform mixing mechanism through first rotating shafts, through holes for placing a blood collection tube are formed in the test tube rack, and the inner walls of the through holes are made of a rubber material; a plurality of storage holes for storing blood collection tubes are formed in the storage module. The shaking frequency can be adjusted according to the condition of the blood collection tubes or the test tubes, so that the uniform mixing quality of blood and a reagent in the blood collection tubes is ensured, and the accuracy of subsequent experimental data is ensured.

The invention provides a method for controlling a blood pump, which comprises the following steps of: obtaining preset target aorta systolic pressure and target aorta systolic flow; on the basis of an iterative algorithm, obtaining the nth aorta systolic pressure and the nth aorta systolic flow detected during the nth iteration; determining an nth pressure difference value based on the target aorta systolic pressure and the nth aorta systolic pressure; determining an nth flow difference value based on the target aorta systolic flow and the nth aorta systolic flow; based on the nth pressure difference value and the nth flow difference value, determining the nth rotating speed of a motor during the nth iteration; determining the nth operation power of the motor matched with the nth rotation speed during the nth iteration, and controlling the motor to operate at the nth operation power; and if the mth aorta systolic pressure detected during the mth iteration and the target aorta systolic pressure meet a first iteration stopping condition and the detected mth aorta systolic flow and the target aorta systolic flow meet a second iteration stopping condition, stopping the iteration.

The invention provides a venous blood collecting needle. The venous blood collecting needle comprises a blood collecting needle tube, a blood collecting needle tube seat and a blood feeding needle tube, wherein an inner cavity of the blood feeding needle tube is communicated with an inner cavity of the blood collecting needle tube seat. The venous blood collecting needle is characterized in that aflexible sleeve is sleeved outside the blood collecting needle tube, the top end of the sleeve is coated with the tip of the blood collecting needle tube, the bottom end of the sleeve is connected with a sleeve seat, and the sleeve seat is sleeved outside the blood collecting needle tube; the sleeve seat is connected with a sleeve seat handle, and the sleeve seat handle is provided with a contactpart; an elastic part is arranged between the sleeve seat and the blood collecting needle tube seat; when an external force is applied to the sleeve seat through the sleeve seat handle to drive the sleeve seat to move toward a direction approaching the blood collecting needle tube seat and force the elastic part to deform, the tip of the blood collecting needle tube is exposed from the top end ofthe sleeve; the contact part of the sleeve seat handle is pressed and fixed to the surface of the blood collecting needle tube seat to ensure that the elastic part cannot be restored; and after the tip of the blood collecting needle tube enters a vein, reducing the pressing force of a finger on the sleeve seat handle can force the sleeve seat to move away from the blood collecting needle tube seat, and finally the top end of the sleeve is coated with tip of the blood collecting needle tube.

An immunochromatographic method comprising: (1) preparing a sample derived from whole blood by hemolysis of the whole blood and a treatment for enabling chromatographic development, (2) developing the resulting sample on an immunochromatographic developing membrane, and (3) developing a washing liquid on the immunochromatographic developing membrane to thereby remove an erythrocyte-derived red pigment from the immunochromatographic developing membrane, is disclosed. According to the method, a whole blood sample can be analyzed rapidly, conveniently, and at a low cost.

The invention provides a traditional Chinese medicine preparation for treating kidney calculi and a preparation method thereof, and relates to the field of traditional Chinese medicine. The traditional Chinese medicine preparation is prepared from honeysuckle flowers, fructus forsythiae, cortex phellodendri, herba lysimachiae, pyrrosia leaves, spora lygodii, heartleaf houttuynia herbs, endothelium corneum gigeriae galli, akebia stems, pink herbs, herba polygoni avicularis, turmeric root-tuber, fructus aurantii, talc and licorice roots; the medicines are extracted through baijiu and mature vinegar respectively, the effective components of the medicines are fully dissolved out, concentration is conducted to obtain a solution with the relative density ranging from 1.05 to 1.20, and the solution is mixed with the edible mature vinegar. The preparation has the effects of promoting blood circulation to remove blood stasis, clearing heat, promoting urination, expelling calculi and dispersing accumulation, the curative effect on kidney calculi expelling is significant, good treatment effect on urologic obstruction and infection with the symptoms of lumbago, hematuresis, frequent urination, urgent urination, painful urination and the like caused by the calculi is achieved, the kidney function is recovered through blood cooling, stasis breaking, hemostasis and tissue regeneration, safety is achieved, toxic and side effects do not exist, the preparation serves as medicine for external application, absorption of the effective components is much, the course of treatment is short, the curative effect is obvious, great clinical significance on treatment of the clinical significance is achieved, and the traditional Chinese medicine preparation for treating the kidney calculi is worthy of wide application and promotion.

The invention discloses a sending mechanism and a sample tube sending device and aims at solving the problem that hemolysis is prone to occurring in the sending process of an existing sample tube. The sending mechanism comprises a guiding body and an accelerating device. The guiding body is provided with a guiding channel so as to enable the sample tube to move in the guiding channel in a direction of the guiding channel, the acceleration device is used for providing an incremental transmission acceleration for the sample tube in the direction of the guiding channel, and the sending mechanism where the guiding body and the acceleration device are located is arranged in the sample tube sending device and used for sending the sample tube in the sample tube sending device. The sending mechanism and the sample tube sending device have the advantages that the sample tube is flexibly sent, so that the influence of the inertia effect of the sample tube and a blood sample self in the sample tube is weakened, the collision strength between the blood sample and the sample tube is weakened, and the hemolysis condition of the blood sample is avoided.

The invention discloses levosimendan sodium represented by a formula I and a crystal form of the levosimendan sodium, and the levosimendan sodium and the levosimendan sodium crystal form A has good solubility in water and is beneficial to production of a preparation.