67results about How to "Avoid hemolysis" patented technology

The present invention provides a blood cell separation membrane for separating blood into serum or plasma and blood cells while preventing hemolysis of the blood cells. Such a blood cell separation membrane can be obtained by impregnating a porous membrane for separating blood cells from blood supplied thereto with a solution containing a hydrophobic aminocarboxylic acid, a protein derived from silk, Tris, TES, ε-aminohexanoic acid, tranexamic acid, or heparin and then drying the membrane.

The invention discloses a pharmaceutical composition of oryzanol, which comprises the oryzanol, phospholipid, bile acid and/or salt of bile acid. The pharmaceutical composition effectively improves the water solubility and the stability of the oryzanol and has better grain diameter and stability than the prior product, and further, the invention provides injectio and freeze-dried powder of the pharmaceutical composition, and preparation methods thereof.

The invention discloses umbilical cord blood mesenchymal stem cell separation liquid and an umbilical cord blood mesenchymal stem cell separation flow. The separation liquid is prepared by mixing saccharosan of which the concentration is 9 percent and meglumine diatrizoate of which the concentration is 33.9 percent in the ratio of 26.88:10, wherein the concentration of the separation liquid is 1.073+/-0.01g/L. A two-step method for separating umbilical cord blood mesenchymal stem cells comprises the following steps of: 1, precipitating red cells by a hydroxyethyl starch; and 2, separating the mesenchymal stem cells by the separation liquid of which the concentration is1.073g/L. The mesenchymal stem cell with the highest proportion in umbilical cord blood can be obtained by the separation liquid and the separation flow, the proportions of lymphocytes and mononuclear cells are very low, and the obtained cells are good in state and high in activity. The used materials and reagents are medical products, are non-toxic, do not have heat sources, can be industrially produced and are convenient to store. The used method is an optimized flow, is high in stability and repeatability, can be also used for separating human marrow and peripheral blood mesenchymal stem cells, is the best method for separating and extracting the mesenchymal stem cells in the current density gradient centrifugation and is better than other products and methods.

A counter typing reagent of ABO blood type is prepared as improving buffer system to change single citrate buffer system to be citrate-phosphate double-buffer system, adding adenine as nutrition composition, applying no any chemical anticorrosive in anticorrosion system and adding EDTA for preventing red blood cell of blood type from hemolysis.

The invention discloses a flexible ventricle assist device which comprises an elastic shell attached to the outer wall of the heart and at least two sets of pneumatic muscles embedded in the elastic shell and corresponding to the left ventricle and the right ventricle of the heart respectively. An air passage for communicating the air bags in all the pneumatic muscles is arranged in the elastic shell, and is led out through an air inlet and an air outlet in the elastic shell to be connected with an external air source; and a strain limiting layer is arranged on the outer side air bag wall, away from the heart, of the pneumatic muscle. The heart pump blood function of a heart failure patient can be assisted; the whole device is simple in structure, and the elastic shell can be designed to be lighter and thinner; the load of the implantation device on the body of the patient is reduced; the whole elastic structure can better adapt to different biological characteristics adapting to hearts of different patients, is wider in adaptability, can act on the heart to conduct adaptive deformation on torsion of the heart in the heart process, reduces damage to cardiac myocardium of the heart,and enables the heart of the heart failure patient to reach the normal blood pumping level through heart pacing signal feedback control.

The invention provides a device used for filtering a liquid. The device includes a flow channel and a filtering film. The flow channel is provided with an inlet and an outlet. The filtering film is provided with a plurality of holes. The flow channel is arranged on the filtering film in an overlapping manner. And when the liquid flows through the flow channel, the liquid contact with the filtering film. The device in the invention has a structure satisfying cross flow filtering principle. Thus, parallel shear stress can be generated by the liquid in the flow channel, thereby avoiding impurity accumulation in the holes of the filtering film.

The invention provides skin-building toilet water rich in sodium copper chlorophyllin and a preparation method thereof. The skin-building toilet water uses sodium copper chlorophyllin as one of effective components and comprises main raw materials such as sodium copper chlorophyllin, wild chrysanthemum flower volatile oil, Artemisia leaf volatile oil, coconut oil acylamide propyl lycine, lemon extract, ethanol and water, and the steps comprise weighing, dissolution, emulsification, total mixing, uniform emulsification, filling, code spraying, packaging, and the like. The skin-building toilet water has simple preparation method and equipment and easy production and popularization. The skin-building toilet water rich in sodium copper chlorophyllin has the effects of mosquito expelling, prickly heat prevention, itching relieving, sterilization, detoxification, air freshening, toxin resistance, ulcer resistance, hemolysis resistance, white ascending, liver protection and yellow elimination, and can promote the concrescence of ulcer surfaces, prevent cold, cephalitis and skin pruritus, maintain the functions of the brain, the heart and the lung and improve the immunity. The skin-building toilet water rich in sodium copper chlorophyllin is especially suitable for infants and children.

The invention discloses an officinal product of oryzanol and a preparation method thereof. The product is a kit which contains two unit preparations, wherein the first unit preparation is a composition of oryzanol, phospholipid, bile acid and/or salt of bile acid; and the second unit preparation is a solvent of the first unit preparation. The officinal product of oryzanol solves the problem of poor water solubility of the oryzanol and has simple use and easy storage.

The invention discloses a preparation method of quality control serum for ischemia-modified albumin; the preparation method comprises the following steps of: (1) adopting the blood serum of a healthy person, and adjusting a pH value to be 7.0-7.5; (2) adding 0.1-100mm of metal ionic salt with a variable valence center or a metal organic composite with molecule planarity to the blood serum, and then adding 0.1-100mm of hydrogen peroxide; (3) reacting for 10-30min under the 35-40 DEG C illumination; (4) dialyzing a solution obtained through the reaction in the step (3) in 0.1-1000mm of a dialysis buffer solution with pH of 7.5-8.0 under the 20-25 DEG C temperature for 12-24h; and (5) adding a preservative according to a conventional technology, subpackaging and determining after mixing uniformly. The preparation method has the advantages of adequate the source of raw materials, easily obtaining of the raw materials, simple preparation technology, few amount of additives, low production cost, small non-specificity interference, no needing for composite dissolving, good homogeneity and small difference between bottles.

The emulsified injection is prepared with zedoary oil, middle chain oil for injection, long chain oil for injection, emulsifier, isoosmotic regulator, antioxidant, pH regulator and water for injection. The preparation process include adding emulsifier into the middle chain oil and the long chain oil, heating and stirring to dissolve emulsifier, adding zedoary oil, heating and stirring to dissolve and mix, and adding tocopherol via stirring to obtain oil phase; adding isoosmotic regulator into water for injection, and heating and stirring to dissolve to obtain water phase; mixing the oil phase and the water phase, emulsifying, regulating pH value and adding water for injection to required amount. The preparation has great medicine carrying amount, no toxic side effect, stable property, convenient use and fast and simple preparation, and is suitable for mass production.

The invention relates to a biological power duplex valve device and a charging and discharging method. Dilated cardiomyopathy and ischemic cardiomyopathy are the principal diseases causing congestive heart failure, and have the common pathophysiologic characteristics of atrioventricular valve ring, left ventricular enlargement, atrioventricular valve regurgitation and reduction of ventricular ejection fraction. The biological power duplex valve device comprises a power fluid balloon (1), an in-vitro pump controller (2) and a catheter (3), wherein the power fluid balloon is connected with the catheter, the catheter is connected with a valve ring (4) and a group of holder legs (8), the valve ring is connected with a valve leaflet (5), the valve leaflet is connected with a valve fluid balloon (6), the valve ring is connected with the power fluid balloon, and signals sent by the in-vitro pump controller are received by a magnet of the power fluid balloon. The biological power duplex valve device is applied as a medical appliance.

The invention discloses a blood collection tube blending device which comprises a blending box and a storage module, and the blending box and the storage module are each provided with an expansion strip and an expansion groove; a button is arranged on the blending box and connected with an internal uniform mixing mechanism, an opening is formed in the top of the blending box, a test tube rack is arranged at the opening, the two ends of the test tube rack are connected with the inner wall of the blending box and the uniform mixing mechanism through first rotating shafts, through holes for placing a blood collection tube are formed in the test tube rack, and the inner walls of the through holes are made of a rubber material; a plurality of storage holes for storing blood collection tubes are formed in the storage module. The shaking frequency can be adjusted according to the condition of the blood collection tubes or the test tubes, so that the uniform mixing quality of blood and a reagent in the blood collection tubes is ensured, and the accuracy of subsequent experimental data is ensured.

An immunochromatographic method comprising: (1) preparing a sample derived from whole blood by hemolysis of the whole blood and a treatment for enabling chromatographic development, (2) developing the resulting sample on an immunochromatographic developing membrane, and (3) developing a washing liquid on the immunochromatographic developing membrane to thereby remove an erythrocyte-derived red pigment from the immunochromatographic developing membrane, is disclosed. According to the method, a whole blood sample can be analyzed rapidly, conveniently, and at a low cost.

The invention provides a traditional Chinese medicine preparation for treating kidney calculi and a preparation method thereof, and relates to the field of traditional Chinese medicine. The traditional Chinese medicine preparation is prepared from honeysuckle flowers, fructus forsythiae, cortex phellodendri, herba lysimachiae, pyrrosia leaves, spora lygodii, heartleaf houttuynia herbs, endothelium corneum gigeriae galli, akebia stems, pink herbs, herba polygoni avicularis, turmeric root-tuber, fructus aurantii, talc and licorice roots; the medicines are extracted through baijiu and mature vinegar respectively, the effective components of the medicines are fully dissolved out, concentration is conducted to obtain a solution with the relative density ranging from 1.05 to 1.20, and the solution is mixed with the edible mature vinegar. The preparation has the effects of promoting blood circulation to remove blood stasis, clearing heat, promoting urination, expelling calculi and dispersing accumulation, the curative effect on kidney calculi expelling is significant, good treatment effect on urologic obstruction and infection with the symptoms of lumbago, hematuresis, frequent urination, urgent urination, painful urination and the like caused by the calculi is achieved, the kidney function is recovered through blood cooling, stasis breaking, hemostasis and tissue regeneration, safety is achieved, toxic and side effects do not exist, the preparation serves as medicine for external application, absorption of the effective components is much, the course of treatment is short, the curative effect is obvious, great clinical significance on treatment of the clinical significance is achieved, and the traditional Chinese medicine preparation for treating the kidney calculi is worthy of wide application and promotion.

The invention discloses a sending mechanism and a sample tube sending device and aims at solving the problem that hemolysis is prone to occurring in the sending process of an existing sample tube. The sending mechanism comprises a guiding body and an accelerating device. The guiding body is provided with a guiding channel so as to enable the sample tube to move in the guiding channel in a direction of the guiding channel, the acceleration device is used for providing an incremental transmission acceleration for the sample tube in the direction of the guiding channel, and the sending mechanism where the guiding body and the acceleration device are located is arranged in the sample tube sending device and used for sending the sample tube in the sample tube sending device. The sending mechanism and the sample tube sending device have the advantages that the sample tube is flexibly sent, so that the influence of the inertia effect of the sample tube and a blood sample self in the sample tube is weakened, the collision strength between the blood sample and the sample tube is weakened, and the hemolysis condition of the blood sample is avoided.

The invention discloses levosimendan sodium represented by a formula I and a crystal form of the levosimendan sodium, and the levosimendan sodium and the levosimendan sodium crystal form A has good solubility in water and is beneficial to production of a preparation.