Application of epigallocatechingallate (EGCG) in improving dental resin adhesive material restoration performance

A technology of epigallocatechin and gallate, applied in the field of application of epigallocatechin gallate in improving the restoration of dental resin bonding materials, can solve the problem of interfering with the polymerization reaction of resin bonding materials and affecting the adhesion In order to achieve the effect of improving long-term repair effect, high-efficiency anti-oxidation, and high-efficiency MMPs inhibition

Inactive Publication Date: 2016-02-24
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral microenvironment is complex and affected by many factors
The survey results of the National Dental Institute of the United States show that more than 50% of the existing resin restorations need to be replaced, and the clinical life of the resin bonding restoration is less than 6 years. The annual expenditure for replacing defective bonding restorations in the United States alone is as high as $5 billion
However, NaOCl will release oxygen and decomposition products, which can penetrate into the dentine tubules and interfere with the polymerization reaction of the resin bonding material, affecting its bonding effect

Method used

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  • Application of epigallocatechingallate (EGCG) in improving dental resin adhesive material restoration performance
  • Application of epigallocatechingallate (EGCG) in improving dental resin adhesive material restoration performance
  • Application of epigallocatechingallate (EGCG) in improving dental resin adhesive material restoration performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] EGCG pretreatment improves the bonding stability between coronal dentin and resin

[0041] The isolated human molars exposed the dentin in the middle of the crown, and the surface was polished with 600-mesh silicon carbide water sandpaper to prepare a standard smear layer. The dentin surface was acid-etched with 37% phosphoric acid gel for 15 seconds. After washing with running water, they were randomly divided into the following three groups. Treated differently:

[0042] Group 1, negative control group: Coat the dentin surface with deionized water cotton ball for 60 seconds;

[0043] Group 2, positive control group: Cotton balls coated with 0.2% chlorhexidine aqueous solution on the dentin surface for 60 seconds;

[0044] Group 3, EGCG experimental group: Cotton balls coated with 400 μg / mL EGCG ethanol solution on the dentin surface for 60 seconds.

[0045] The treated dentin surface of each group was coated with full-etching adhesive AdperSingleBond2 (3MESPE, USA) ...

Embodiment 2

[0047] EGCG treatment improves the retention strength of root canal fiber post

[0048] The isolated human single tooth was crowned at 1 mm above the enamel-dentin junction, and conventional root canal treatment was performed according to the ISO standard. After 7 days of root canal filling, the fiber post was used to prepare the post with a preparatory drill, and distilled water was continuously used during the preparation process. Rinse, then tip dry with absorbent paper. After the post preparation, they were randomly divided into three groups according to the treatment method of the root canal wall:

[0049] Group 2, NaOCl treatment group: 5.25% NaOCl solution rinsed the inner wall of the pile road for 2 minutes, then continued to rinse with deionized water for 2 minutes;

[0050] Group 3, NaOCl+EGCG treatment group: 5.25% NaOCl solution rinsed the inner wall of the post canal for 2 minutes, continued to rinse with deionized water for 2 minutes, dried the post with the tip...

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Abstract

The invention discloses application of epigallocatechingallate (EGCG) in improving dental resin adhesive material restoration performance. The application of the EGCG prepared into a 400 micrograms/ml ECCG ethanol solution used as a pretreating agent in the coronal dentin adhering aspect and the application of the EGCG prepared into the 400 micrograms/ml ECCG ethanol solution used as the pretreating agent in root canal dentin adhering aspect are involved. By means of the characteristic of the EGCG for restraining matrix metalloproteinase activity and inoxidizability, the EGCG is prepared into the pretreating agent to be applied to coronal dentin and root canal dentin adhering, and the long-term restoration effect of a clinic resin adhesive restoration body and the long-term restoration effect on devital teeth with deficiency of a large amount of tooth tissue are effectively improved.

Description

technical field [0001] The invention relates to the application of epigallocatechin gallate in improving the restoration of dental resin bonding materials. Background technique [0002] Compared with traditional amalgam and other restoration materials, composite resin has excellent biological, mechanical and aesthetic properties, and has become the most important way to repair various dental tissue defects. However, the oral microenvironment is complex and affected by many factors. The survey results of the National Dental Institute of the United States show that more than 50% of the existing resin restorations need to be replaced, and the clinical life of the resin bonding restoration is less than 6 years. The annual expenditure for replacing defective bonding restorations in the United States alone is as high as $5 billion. The formation of a firm and durable bond between the resin material and the tooth tissue is the decisive factor in determining the service life of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/00
CPCA61K6/30A61K6/50
Inventor 张凌陈吉华徐帅樊菁李芳陈宇江张少锋余昊翰
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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