The invention provides a brewing method of a nutritional and healthy blueberry wine with a short brewage time, belonging to a field of wine brewage. The method comprises selecting fresh and high-quality blueberry, washing, air drying, putting into a crusher to crush into blueberry slurry, adding 15-45 ml / 480 kg of pectin methyl esters hydrolase and pectic acid enzyme into the blueberry slurry for biological enzymatic hydrolysis, with an enzymatic hydrolysis temperature being controlled between 50-60 DEG C and an enzymatic hydrolysis time being controlled between 30-90 DEG C, using an ultrahigh pressure enzyme inactivation method to inactive the enzyme under 100 Mpa, cooling the blueberry slurry to a normal temperature after the enzyme inactivation, putting in a cool and dry place for 8-20 days to form an immersing liquid with a alcohol volume content of 10-11 %, adding 3-5 % of jujube, 2-3 % of matrimony vine, 4-6 % of longan and 1-4 % of honey into the immersing liquid by weight ratio, immersing for 100-140 days to obtain a new wine, adding 0.15-0.25 % by weight ratio of a clarificant to clarify and filter the new wine, blending the new wine with a rice wine so that an alcohol concentration reaches 10-11 DEG, and then filtering to obtain the finish product. The method has advantages of short brewage time, high clarification degree and high nutrition value.