The present invention relates to a precisely patterned selective
adhesive tissue patch and a preparation method thereof, wherein the selective
adhesive tissue patch is a
composite structure, which is composed of an
adhesive layer hydrogel and a non-adhesive layer substrate; the adhesive layer is a hydrogel containing an adhesive group with a hollow pattern; the non-adhesive layer substrate is a substrate that does not contain an adhesive group; the preparation method is: in a flat-bottomed container, a non-adhesive layer substrate, a B mold, and a pouring adhesive layer hydrogel precursor solution are sequentially laid, and
ultraviolet light is irradiated to form an adhesive layer hydrogel to obtain a precisely patterned selective
adhesive tissue patch; the number of B molds is more than one, and it is vertically arranged on the non-adhesive layer substrate to prevent
ultraviolet light from irradiating a local area of the substrate. The selective
adhesive tissue patch of the present invention can accurately control the adhesion area, realize selective adhesion to the tissue, and does not adhere to other tissues or affect tissue regeneration; the preparation method of the present invention has a simple process and a wide range of applications.