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Medical adhesive and preparation method thereof

An adhesive, allyl technology, applied in pharmaceutical formulations, surgical adhesives, applications, etc., can solve problems such as side effects, affecting the effect of medical adhesives and application promotion, and achieve low biological toxicity and tissue adhesion. Good, good antibacterial effect

Inactive Publication Date: 2019-11-08
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the storage and use of cyanoacrylate medical adhesives, the production of formaldehyde has side effects on biological tissues, and the damage to organisms increases with the increase of formaldehyde concentration, which seriously affects the effect and application of medical adhesives.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A medical adhesive is characterized in that it is made of the following raw materials in parts by weight: ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxy 35 parts of stilbene glucoside / N-acryloyloxysuccinimide copolymer, 30 parts of cyanovinyl modified quaternized chitosan, 3 parts of Chinese herbal medicine concentrate, 0.3 part of pectin acid, N, 20 parts of N-dimethylformamide, 1 part of benzoyl peroxide.

[0036] The ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxystilbene glucoside / N-acryloyloxysuccinimide copolymer The preparation method comprises the following steps: 100 g of ethyl cyanoacrylate, 100 g of S-allyl-D-cysteine, 30 g of 2,3,5,4-tetrahydroxystilbene glucoside, N-acryloyl Add 40 g of oxysuccinimide and 2 g of azobisisobutyronitrile into 1000 g of N,N-dimethylformamide, stir and react at 70°C for 3 hours in a nitrogen atmosphere, and remove the solvent by rotary evaporation after the reaction is completed. Obtain ethyl cyanoacry...

Embodiment 2

[0045] A medical adhesive is characterized in that it is made of the following raw materials in parts by weight: ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxy 37 parts of stilbene glucoside / N-acryloyloxysuccinimide copolymer, 35 parts of cyanovinyl modified quaternized chitosan, 4 parts of Chinese herbal medicine concentrate, 0.5 part of pectin acid, N- 23 parts of methylpyrrolidone, 1.5 parts of tert-butyl peroxybenzoate.

[0046] The ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxystilbene glucoside / N-acryloyloxysuccinimide copolymer The preparation method comprises the following steps: 100 g of ethyl cyanoacrylate, 100 g of S-allyl-D-cysteine, 40 g of 2,3,5,4-tetrahydroxystilbene glucoside, N-acryloyl 40g of oxysuccinimide and 2.5g of azobisisobutyronitrile were added to 1100g of N-methylpyrrolidone, stirred and reacted at 73°C for 3.5 hours in a helium atmosphere, and after the reaction was completed, the solvent was removed by rotary evaporation ...

Embodiment 3

[0055] A medical adhesive is characterized in that it is made of the following raw materials in parts by weight: ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxy 39 parts of stilbene glucoside / N-acryloyloxysuccinimide copolymer, 40 parts of cyanovinyl modified quaternized chitosan, 4.5 parts of Chinese herbal medicine concentrate, 0.6 part of pectin acid, 25 parts of glycerin Parts, 2 parts of methyl ethyl ketone peroxide.

[0056] The ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxystilbene glucoside / N-acryloyloxysuccinimide copolymer The preparation method comprises the following steps: 100 g of ethyl cyanoacrylate, 100 g of S-allyl-D-cysteine, 45 g of 2,3,5,4-tetrahydroxystilbene glucoside, N-acryloyl Add 40g of oxysuccinimide and 3g of azobisisobutyronitrile into 1300g of dimethyl sulfoxide, and stir and react at 75°C for 4 hours in a neon atmosphere. After the reaction, the solvent is removed by rotary evaporation to obtain cyanoacrylic acid Ethyl ...

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PUM

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Abstract

The invention provides a medical adhesive, and further discloses a preparation and using method of the medical adhesive. The medical adhesive is characterized by being prepared from the following rawmaterials in parts by weight: 35-45 parts of copolymers of ethyl cyanoacrylate / S-allyl-D-cysteine / 2,3,5,4-tetrahydroxy stilbene glucoside / N-acryloxysuccinimide, 30-50 parts of cyanovinyl modified quaternized chitosan, 3-6 parts of Chinese herbal medicine concentrate, 0.3-1 part of pectic acid, 20-30 parts of an organic solvent, and 1-3 parts of an initiator. The medical adhesive has excellent comprehensive performance, a good adhesive tissue effect, high adhesive strength, low biological toxicity, excellent adhesion durability and a good antibacterial effect, and can effectively inhibit formaldehyde production.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a medical adhesive and a preparation method thereof. Background technique [0002] In recent years, with the improvement of the level of science and technology and the progress of medicine, the clinical requirements for the effect of surgical techniques and auxiliary materials are getting higher and higher, especially for medical adhesives, which are one of the important surgical auxiliary materials. Medical adhesive is a branch of medical polymer. It takes biological tissue as the bonding object. Most of the tissues and organs of the human body can be replaced by adhesive technology during the treatment process, without anesthesia; wound healing Then it will fall off automatically. Compared with traditional methods, the use of medical adhesives can effectively shorten the operation time and reduce the patient's pain. [0003] "Medical adhesives" in a broad sense mean...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/06A61L24/00
CPCA61L24/0005A61L24/001A61L24/0015A61L24/06A61L24/08A61L2300/236A61L2300/30A61L2300/404A61L2300/412A61L2400/04C08L5/08C08L5/06C08L33/18C08L39/00
Inventor 朱水寿姜宇
Owner 湖南博隽生物医药有限公司
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