196 results about "Aleuritic acid" patented technology

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

An aqueous cosmetic composition containing uric acid in a stably solubilized state together with an acrylic polymer is disclosed. The composition is adjusted to pH equal to or higher than pK1 of uric acid, in particular, pH 7 or higher by an alkali to solubilize uric acid. A method for stably solubilizing uric acid in an aqueous cosmetic composition is also disclosed.

The invention discloses a preparation method of citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material, a hydrogen peroxide or uric acid detection method and applications. The preparation method comprises the following steps: 1) stirring alkali, water, oleic acid, C1-C3 alcohol, a manganese source, a ytterbium source a yttrium source, an erbium source and NaF, and then carrying out hydrothermal reaction and centrifugal separation to obtain OA-NaYF4:Yb,Er / Mn UCNPs; and 2) dispersing OA-NaYF4:Yb, Er / Mn UCNPs in alcohol, and then carrying out ligand exchange reaction with a trichloromethane and citrate solution to obtain the citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material. The citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material has the advantages of low detection limit, high sensitivity and good selectivity to hydrogen peroxide or uric acid detection, so that the material can be used for detecting uric acid in serum.

Application of sunflower disc hydrolysis compound powder in preparing of food, medicine or food and medicine composition for preventing, curing or relieving blood uric acid rising-related diseases belongs to the technical field of biological medicine. According to the sunflower disc hydrolysis compound powder, by a method of hydrolyzing a soak solution of a sunflower disc with enzyme, on the basis of not damaging original components of the sunflower disc as much as possible, plant large molecules in the sunflower disc are hydrolyzed into micro-molecule polypeptide. It is found for the first time in research that the sunflower disc hydrolysis compound powder has an action of preventing rising of blood uric acid in animals, and also has a potential action of reducing high uric acid formed in blood. Therefore, the sunflower disc hydrolysis compound powder should be applied in preparing of food, medicine or food and medicine composition for relieving or curing gout.

The present invention relates to lactic acid bacteria with an effect of uric acid level reducing in blood. According to the present invention, various lactic acid bacteria are cultured in the presence of a purine; a consumption amount of the purine and a production amount of purine decomposition products are determined; multiple lactic acid bacteria with significant purine decomposing abilities are selected; the selected lactic acid bacteria are adopted to orally feed rats, general statuses and serum uric acid levels of the rats are determined, and influence on the serum uric acid level due to the lactic acid bacteria feeding is researched, wherein the selected lactic acid bacteria are judged as the lactic acid bacteria having high purine decomposing abilities, and the rats are fed with a purine-containing feed; and two lactic acid bacteria capable of significantly inhibiting serum uric acid level increasing are found, wherein the two lactic acid bacteria are Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779.

The invention discloses substitutional tea with the uric acid reducing effect and a preparation method thereof. The substitutional tea is prepared from the following raw materials in parts by weight:10-60 parts of chicory, 40-110 parts of corn stigma, 20-100 parts of radix puerariae, 1-12 parts of rhizoma polygonati, 1-15 parts of poria cocos, 0.1-2 parts of celery seeds, 1-10 parts of emblic leafflower fruits, 300-500 parts of semen coicis, 0.5-3 parts of marine fish oligopeptide, 0.5-3 parts of seaweed extract, 0.5-3 parts of cherry powder, 30-80 parts of fructus momordicae grosvenori, 20-70 parts of fructus crataegi, 10-35 parts of horseradish tree leaves, 20-60 parts of cranberries and 20-80 parts of honeysuckle flower, wherein part of the raw materials are extracted and then granulated and are mixed and packaged with other raw materials so as to form the substitutional tea. The substitute tea with the uric acid reducing effect has the advantages that the raw materials such as leaves, rhizomes, flowers, fruits, seeds and functional factors of a food source are scientifically proportioned, aiming at different forming reasons of uric acid, adjuvant materials are not added, in addition, the use is convenient, the taste is good, the substitutional tea has no toxic and side effects after being drunk for a long time, is suitable for being drunk by people suffering from hyperuricemia for a long time and has very good uric acid reducing effect.

The invention discloses a preparation method for 1, 3, 7, 9-tetramethyluric acid, which relates to a preparation method for purine biology alkalies compound in the chemical field. Specifically, fruits of Camellia assamica var.kucha are used as raw materials, water is used for extraction, and the extracting solution is extracted from chloroform or dichloromethane; after the chloroform or dichloromethane is recycled, the ethanol solution with a volume percentage concentration of 50 to 100 percent or methanol is used as a solvent to be re-crystallized, and the 1, 3, 7, 9-tetramethyluric acid with 99 percent purity can be obtained. The preparation method for the 1, 3, 7, 9-tetramethyluric acid has the beneficial effects: 1. the preparation method has the advantage of waste utilization; 2. the preparation method with the advantages of simple technological process, little solvent usage, economy and time saving can realize industrialized production; 3. the product is high in purity and high in yield.

The invention discloses a preparation method of a ferrocenyl carbon nanotube composite material and application thereof and belongs to the technical field of synthesis of inorganic materials. The preparation method of the composite material comprises the following steps: firstly carrying out oxidization and amination on carbon nanotubes and carrying out acylation on ferrocenecarboxylic acid, then taking triethylamine as an acid-binding agent in a dichloromethane solvent, and enabling the carbon nanotubes subjected to amination to react with activated ferrocenylformyl chloride to prepare the composite material. The preparation method of the composit material is simple and is mild in reaction condition; the product is convenient to separate and purify and stable in structure. The composite material takes the carbon nanotubes with large specific surface area and high conductivity as support materials; ferrocenyl derivatives which can be used as electron media and provided with excellent electrochemical reversibility are covalently coupled on the surfaces of the carbon nanotubes, so that the composite material is excellent in effect of redox reaction for electrochemically catalyzing dopamine; the common interference matters including ascorbic acid and uric acid have no interference on detection of dopamine; the composite material is wide in linear response range and high in sensitivity and repeatability for detection of dopamine.

The invention relates to a palladium nanoparticle / carbon nanofiber compound, a preparation method and an application thereof in electrocatalysis. The compound is directly prepared by a one-step electrospinning method. An electrode modified by the compound is used for direct eectrochemical detection on hydrogen peroxide, beta-nicotinamide adenine dinucleotide, dopamine, ascorbic acid and lithic acid. The electrode modified by the compound has the linear range from 0.2 micrometer to 20 millimetres and the detection limit of 0.2 micrometer when being used for the detection on the hydrogen peroxide and has the linear range of 0.2-716.6 micrometers and the detection limit of 0.2 micrometer when being used for the detection on the beta- nicotinamide adenine dinucleotide; and the peak-peak potential differences between the ascorbic acid and the dopamine, the dopamine and the lithic acid as well as the ascorbic acid and the lithic acid are respectively 244mV, 148 mV and 392 mV, thereby showingthat the modified electrode can be used for simultaneous eectrochemical detection of three substances. The compound can be used in the fields of catalysis, fuel cells and sensing.

The present invention provides a new application of Fraxinus general counmarin and aesculetin as the extractives of Chinese medicine material cortex Fraxini. The said two has obvious effects of stopping pain, resisting inflammation and reducing blood uric acid. They has obvious curative effect on acute and chronic gout and no obvious toxic side-effect. The present invention also provides a simple preparation process of Fraxinus general coumarin, and that is a Fraxinus general coumarin concentrating and purifying process.

A method for relieving or preventing symptoms associated with uric acid crystals, comprising consuming a formulation that supports three or more processes, the processes comprising:1) one that inhibits formation of uric acid in the body;2) one that increases elimination of uric acid from the body; and3) one that interferes with formation of uric acid crystals in the body.A formulation, comprising: an extract of celery; an extract of cherry; and a lithium salt. Also, a process to make a formulation, comprising mixing together:i. a material that inhibits formation of uric acid in a body;ii. a material that increases elimination of uric acid from the body;iii. a material that interferes with formation of uric acid crystals in the body; and forming the mixture into a medicament.

Provided is a method for obtaining a lactic acid bacterium having a property of reducing a serum uric acid level. The present invention relates to: a method for screening for a lactic acid bacterium, which comprises determining the amount of a purine body incorporated in each of lactic acid bacteria in a culture medium containing the purine body and then screening for a lactic acid bacterium having a property of trapping the purine body among the lactic acid bacteria employing the amount as a measure; and a purine body trapping agent for reducing a serum uric acid level, which comprises a lactic acid bacterium obtained by the method.

The invention relates to a composition for reducing uric acid and application thereof. Ocean fish oligopeptide powder, moringa oleifera leaf powder, acerola cherry concentrates and green plum extract are used as raw materials and matched with various edible auxiliary materials to prepare the composition. The composition is prepared from, by weight, 5-35% of ocean fish oligopeptide powder, 5-45% of moringa oleifera leaf powder, 2-15% of acerola cherry concentrates, 5-30% of green plum extract and the balance edible auxiliary materials. The food raw materials are selected and synergistically take effects by means of scientific compatibility, so that the composition is high in uric acid reducing speed, remarkable in effect, safe and free from side effects.

The invention discloses a konjac flour-containing mixture and a preparation method thereof. The konjac flour-containing mixture is prepared from the following components in percentage by weight: 20-40% of konjac flour, 10-20% of celery powder, 2-8% of hawthorn fruit powder and 40-60% of giant salamander powder. The preparation method comprises the following steps: sequentially carrying out quick-freezing, drying and crushing on celeries, and grinding into ultra micro fine powder with a size of more than 200 meshes; processing and crushing hawthorn fruits by using the conventional drug preparation method, and grinding into ultra micro fine powder with a size of more than 200 meshes; defatting living giant salamanders, removing the lungs and intestinal canals of the living giant salamanders, carrying out vacuum freeze-drying, and crushing and grinding into nano fine powder; and finally, mixing the three kinds of powder with konjac fine flour sold in the market according to the ratio above so as to obtain the konjac flour-containing mixture which is a nutrient health-care product. The konjac flour-containing mixture disclosed by the invention has the effects of tonifying the spleen, promoting appetite, relaxing the bowels, losing weight, reducing blood fat and blood sugar, neutralizing uric acid and the like. The preparation method preserves various nutrient components. The commodity type mixture is convenient to eat, and easy to enable people to eat frequently and continuously.

The invention discloses a composition for promoting uric acid metabolism, improving gout and protecting joints, which is prepared from the following raw materials in parts by weight: 1-2 parts of marine fish oligopeptide, 2-3 parts of an olive fruit extract, 25-35 parts of a celery seed extract, 8-12 parts of a sour cherry extract and 0.3-0.7 part of a turmeric extract. The composition for promoting uric acid metabolism, improving gout and protecting joints has better uric acid reduction effect through the synergistic effect of each raw material, the reduction effect is obvious, the treatmenteffect is obvious and treatment time is short, through the mixing of raw materials, the effect is better than that of singly using one medicament or a plurality of medicaments, the synergistic effectis achieved, gout and joint inflammation caused by gout are effectively treated, the life quality of a patient is improved, and no side effect is caused; the preparation method of the composition is simple and can be produced on a large scale.

The present invention relates to a composition comprising an effective amount or an effective amount of one or more dipeptides consisting of histidine or the functional equivalent thereof and alanine or the functional equivalent thereof for reducing uric acid in a subject. The invention also provides a method for the treatment of gout or the amelioration of symptoms related to a high level of uric acid comprising the step of administering or applying the above-mentioned dipeptides to a subject.

The invention relates to the technical field of uric acid detection, in particular to a uric acid detection reagent. A reagent R1 is prepared from a buffer solution, 4-aminoantipyrine, BSA, sucrose, trehalose, peroxidase, ascorbic acid oxidase, bilirubin oxidase, alkylphenol ethoxylates (APEO) and a preservative; a reagent R2 is prepared from a buffer solution, TOOS uricase.BSA sucrose.trehalose alkylphenol ethoxylates (APEO) and a preservative. The PIPES (piperazine-1,4-bisethanesulfonic acid) solution is adopted, the stabilizer BSA, sucrose and trehalose are added, and the stability of the reagent is greatly improved; the novel surfactant alkylphenol ethoxylates (APEO) is adopted, and therefore not only is the determination property of the product significantly improved, but also the stability and anti-interference capacity of the reagent are improved.

A uric acid absorbent is prepared through dissolving cellulose in NaOH solution, adding cross-linking agent, polymerizing reaction, proportionally adding cyclodextrin, reaction, drying, and pulverizing. It has high adsorptive speed and power to uric acid.

The invention relates to a low-temperature modified foaming agent and a preparation method thereof. The foaming agent employs a zinc cyanuric acid as a modifier, and 1-10 parts by weight of zinc cyanuric acid are added into 100 parts by weight of the foaming agent, so that decomposition temperature of a high-temperature foaming agent can be reduced effectively, and the foaming agent can adapt to processing conditions of various rubber products; meanwhile, the zinc cyanuric acid is a heat stabilizer for a plurality of kinds of rubbers, in this way, addition of the zinc cyanuric acid can both lead the foaming agent to be adapt to processing temperatures of rubber plastics and thermally stabilize rubber products.

The invention provides a preparation method of a nano-porous gold / carbon fiber paper composite sensing electrode (NPG / Ni / CFP) and application of the electrode to electrochemical detection of uric acidand dopamine under the condition that ascorbic acid exits. The preparation method comprises the steps that thin-layer metallic nickel is pre-deposited on carbon fiber paper (CFP) to obtain an Ni / CFPcomposite electrode, then a gold-tin alloy thin film is electro-deposited to obtain an AuSn / Ni / CFP composite electrode, then the AuSn / Ni / CFP composite electrode is placed in an alkaline corrosive liquid to be subjected to dealloying completely, and the composite electrode NPG / Ni / CFP is obtained. The preparation method has the advantages of being simple in preparation technology, low in cost, easyand convenient to use, good in stability and the like; and the composite electrode has high selectivity, high stability and anti-interference capability, can be used for determining the uric acid andthe dopamine separately or simultaneously and has a low detection limit and high sensitivity.

The invention discloses an adhesive for cigarettes. The adhesive is prepared from the following components in parts by weight: 30-40 parts of cassava starch, 30-40 parts of carboxymethyl starch, 5-10 parts of isocyanate, 2-5 parts of sodium trimetaphosphate, 0.1-0.5 part of uric acid, 10-30 parts of polyvinyl alcohol, 10-15 parts of bentonite, 0.1-0.5 part of sodium dodecyl sulfate and 150-200 parts of water. The invention also provides a preparation method for the adhesive for the cigarettes. The adhesive for the cigarettes is a cigarette adhesive prepared by oxidation, cross linking and polyvinyl alcohol modification of the starch, each performance of the adhesive accords with the index of the cigarette adhesive, and the adhesive has good performance and has the characteristics of corrosion resistance, low cost, no harm to a human body, simple process and the like.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of a polyacetylene compound to lowering of uric acid. The polyacetylene compound has astructure shown in a formula (I): R1 and R2 are defined as in the specification. The new application of the polyacetylene compound to lowering of the uric acid is found through a hyperuricemia animalmodel. The polyacetylene compound has the significant effect on lowering the uric acid in a body, and can be used as a potential drug lowering the uric acid or treating gout.

The present invention relates to a celery seed extract, a preparation and a preparation method thereof. The preparation method comprises: taking dried celery seeds, and carrying out reflux extraction 1-2 times with 2-4 times the volume of an ethanol aqueous solution with a volume fraction of 95%; collecting the extraction liquids, and carrying out pressure reducing concentration to obtain a thick extract; suspending the thick extract in water having the volume 0.5-1 time the volume of the raw material, extracting 2-4 times with an extraction reagent, and combining the organic phases after completing the extracting to obtain a crude extract; weighing silica gel having the mass of 35-55 times the mass of the crude extract, activating for 1 h at a temperature of 130 DEG C, and loading into a chromatography column; taking the crude extract, and injecting in a concentration of 0.2-0.5 g / ml; and carrying out gradient elution with petroleum ether-dichloromethane-ethyl acetate, collecting the flow, and carrying out pressure reducing concentration to obtain the celery seed extract. According to the present invention, the preparation method has characteristics of simple preparation process, less extraction number, and high yield; and the obtained celery seed extract has the good serum uric acid lowering effect.

The invention discloses a building fireproof material that is a fireproof coating; the fireproof coating is prepared from: composite base resin, pentaerythritol, ammonium polyphosphate, calcined kaolin, calcined vermiculite powder, hydroxypropyl methyl cellulose, a leveling agent, sodium fluorosilicate, uric acid, waterglass, borax, potassium sulfate, copper sulfate, a flame retardant and p-phenylenediamine. The building fireproof material is reasonable in formulation, and the prepared coating may effectively attach to the surface of a building material, is good in sun-screening and waterproof effects, rarely fades and has good fireproof effect.

The invention relates to the technical field of health products, and especially relates to a uric acid reducing composition and a preparation thereof. The uric acid reducing composition comprises skipjack tuna extract and dietary fibers. The skipjack tuna extract and the dietary fibers are combined and then used, so the dosage is reduced, and the uric acid reducing effect is good.

The invention discloses a novel fluorescent probe, its preparation method and its application in detecting uric acid. Take diethylenetriaminepentaacetic acid, acetic anhydride, and pyridine, stir and heat at 65°C for 24 hours, cool, filter, wash, and dry, and the obtained diethylenetriaminepentaacetic dianhydride and triethylamine, DMF, 2,6‑ Diaminopurine, mix well, heat and stir at a constant temperature of 100°C for 24h, cool, filter, and dry, and the obtained diethylenetriaminepentaacetic acid-bis(2,6-diaminopurine) is dissolved in Tris-HCl buffer solution with pH=7.4 , mixed with Tb(NO3)3·6H2O, filtered, and the filtrate was heated or placed for a long time to obtain the target product. TbШ‑dtpa‑bis (2,6‑Diaminopurine) was used as a probe combined with a fluorescent method to detect uric acid. The method of the invention is simple and novel, has high efficiency and low cost, and can be applied in actual urine samples.

The invention discloses a uric acid electrochemical sensor based on an active copper carbon point and an application thereof. The application comprises the following steps: adding a high molecular polymer rich in carboxyl and cupric salt into a reaction container, putting the reaction container in a hydrothermal reaction kettle, performing a reaction for 2-18h at 200-240 DEG C, performing centrifugalization and dialysis and purification to obtain an active copper carbon dot-containing solution; by adopting a three-electrode system, taking a glass carbon electrode as a working electrode, a platinum wire electrode as a counter electrode and a saturated mercurous chloride electrode as a reference electrode, putting the pre-treated glass carbon electrode in the active copper carbon dot-containing solution, and performing scan round at the scanning speed of 50-500mV / s in a potential range of 0-2V by means of an electrodeposition method. Compared with the prior art, the nanomaterial containing the active copper carbon dots not only has a large specific surface area of the carbon dots and a high electron transmission rate, but also a promoting action on the electron transfer rate on a matrix on an electrode interface by active copper and very strong selectivity on uric acid.

The invention discloses a preparation method of a meteng fruit meal bioactivity peptide with a uric acid reducing effect, which comprises the following steps:(1) pretreatment of meteng seed meal: crushing, degreasing, removing an organic reagent, and soaking in water to obtain a meteng seed meal solution;(2) protease enzymolysis: heating to 40-60 DEG C, adjusting pH to 2-11, adding protease for hydrolysis, then inactivating enzyme at high temperature, centrifuging, and taking supernatant to obtain crude enzymolysis solution;(3) fermentation of bacillus lactis DU-106: inoculating the fermentation seed solution to the crude enzymolysis solution of maitenu protein, stirring and mixing uniformly, and fermenting at 25-35 DEG C for 2-7 days;(4) neutralization and filteration: adjusting the pH value of the cooled hydrolysate to be neutral, and filtering to obtain enzymolysis solution; (5) membrane separation: carrying out ultrafiltration membrane filtration, evaporation concentration and freeze drying. According to the invention, protease enzymolysis, lactic acid bacillus DU-106 fermentation and ultrafiltration separation technologies are utilized to prepare the meteng fruit meal bioactive peptide, so that the meteng fruit meal bioactive peptide has an obvious uric acid reducing effect; and the meteng fruit meal is leftovers generated after the meteng fruit is pressed into oil, so that the method has the advantages of simple process, low production cost and no pollution.