Prepn and application in preparing medicine of Fraxinus general coumarin

A technology of total coumarin and Qinpi, applied in the field of preparation of Qinpi total coumarin, can solve problems such as different, difficult to control the quality of Chinese patent medicines, and difficult to determine active ingredients

Inactive Publication Date: 2003-02-26
CHENGDU DIKANG PHARMA INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently used traditional Chinese medicines are mainly compound prescriptions, and no single Chinese medicine extract has been reported as a preparation for the treatment of gout. Due to the complexity of traditional Chinese medicine and compound prescriptions, it is difficult to determine the active ingredients. Therefore, it is difficult to accurately evaluate the clinical efficacy. The content of traditional Chinese medicine ingredients varies from place to place and batches, making it difficult to control the quality of Chinese patent medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Take 100 kg of Qin peel, cut into granules, add water for extraction three times, concentrate the water extract into an extract, add 3.5 times the amount of ethanol, alcohol precipitation, filtration, the ethanol recovery solvent is concentrated into an extract with a specific gravity of 1.1, and then placed Refrigerate at 8°C for 10 hours, filter, collect the precipitate, and dry to obtain 2.15 kg of total coumarin from Qinpi.

Embodiment 2

[0086] Take 100 kg of Qin bark, cut into granules, add water to extract three times, concentrate the water extract into an extract, add 5 times the amount of ethanol, alcohol precipitation, filtration, the ethanol recovery solvent is concentrated into an extract with a specific gravity of 1.2, and then placed Refrigerate at 12°C for 12 hours, filter, collect the precipitate, and dry to obtain 2.22 kg of total coumarin from Qinpi.

Embodiment 3

[0088] 2kg of total coumarin from Qin Bark obtained in Example 1 or Example 2, or other methods known to those skilled in the art, such as alcohol extraction and alcohol precipitation, or alcohol extraction, are used to prepare extracts and then concentrated by macroporous resin adsorption. Qinpi total coumarin, according to the conventional preparation method, adding appropriate excipients to make Qinpi total coumarin capsules with a specification of 200 mg / capsule.

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PUM

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Abstract

The present invention provides a new application of Fraxinus general counmarin and aesculetin as the extractives of Chinese medicine material cortex Fraxini. The said two has obvious effects of stopping pain, resisting inflammation and reducing blood uric acid. They has obvious curative effect on acute and chronic gout and no obvious toxic side-effect. The present invention also provides a simple preparation process of Fraxinus general coumarin, and that is a Fraxinus general coumarin concentrating and purifying process.

Description

Technical field: [0001] The present invention relates to a preparation method and application of an extract of Qin bark, in particular to a preparation method of total coumarin from Qin bark and its use in the pharmaceutical field. Background technique: [0002] Gout is the basic cause of the continuous increase of blood uric acid caused by the disorder of purine metabolism or the decrease of uric acid excretion, which causes various pathological diseases. It belongs to metabolic rheumatism. This disease belongs to the categories of TCM arthralgia, gout, and Lijie. It refers to the symptoms of external evil blocking the meridians, coagulation of qi and blood, and deficiency of the liver and kidneys, causing joint muscle pain, numbness, stress, and unfavorable flexion and extension. Hyperuricemia is the basis of the pathogenesis of gout. It is a different stage of the same disease as gout, and is a pre-state of gout. The clinical features of gout are hyperuricemia, repeated episod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K36/00A61P19/06C07D311/08
CPCC07D311/08A61K36/63A61K31/37A61P19/06
Inventor 杨安东赵军宁
Owner CHENGDU DIKANG PHARMA INST
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