Uric acid reducing composition and preparation thereof

A uric acid-lowering technology and composition, applied in the field of uric acid-lowering composition and its preparations, can solve problems such as neutropenia, patient pain, and threats to health, and achieve the goal of reducing blood uric acid levels, good uric acid-lowering effects, and promoting uric acid excretion Effect

Active Publication Date: 2016-03-09
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have a good curative effect on the treatment of gout, they all show certain toxic and side effects in clinical practice. Among them, the adverse reactions of febuxostat include abnormal liver function, diarrhea, headache, joint-related signs and symptoms and muscle pain. Bone / connective tissue symptoms; allopurinol common adverse reactions such as rash, diarrhea, abdominal pain, low fever, transient transaminase elevation or neutropenia; colchicine is highly toxic, common nausea, vomiting, diarrhea, abdominal pain, gastrointestinal reactions, Hematuria, oliguria, direct inhibitory effect on bone marrow, causing agranulocytosis, aplastic anemia, etc.; benzbromarone can cause neutropenia; probenecid common gastrointestinal reactions, rash, fever and other adverse reactions, long-term The use of these drugs brings great pain to patients, threatens health and affects quality of life

Method used

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  • Uric acid reducing composition and preparation thereof
  • Uric acid reducing composition and preparation thereof
  • Uric acid reducing composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 uric acid lowering test

[0045] 1. Materials and methods

[0046] Experimental animals: male SD rats of SPF grade, weighing 180±10 g, were provided by Guangdong Medical Experimental Animal Center (permit number: SYXK (Guangdong) 2013-0002).

[0047] Test group: The test is divided into blank control group, model group, benzbromarone control group, first control group, second control group, third control group, first test group, and second test group, with 10 animals in each group rat.

[0048] Administration route: intragastric administration (consistent with the intended clinical administration route for humans). Administration volume: 10ml / kg. Dosing time: Gastrointestinal administration of therapeutic drugs at the same time as modeling, and intragastric administration according to body weight once a day in the morning. Administration period: continuous administration for 28 days.

[0049] Drug preparation: ready-to-use and ready-to-use, weigh a cer...

Embodiment 2

[0073] Embodiment 2 lowering uric acid test

[0074] 1. Materials and methods

[0075] Experimental animals: male SD rats of SPF grade, weighing 180±10 g, were provided by Guangdong Medical Experimental Animal Center (permit number: SYXK (Guangdong) 2013-0002).

[0076] Test group: The test is divided into blank control group, model group, benzbromarone control group, first control group, second control group, third control group, first test group, and second test group, with 10 animals in each group rat.

[0077] Administration route: intragastric administration (consistent with the intended clinical administration route for humans). Administration volume: 10ml / kg. Dosing time: Gastrointestinal administration of therapeutic drugs at the same time as modeling, and intragastric administration according to body weight once a day in the morning. Administration period: continuous administration for 28 days.

[0078] Drug preparation: ready-to-use and ready-to-use, weigh a cer...

Embodiment 3

[0104] Embodiment 3 lowering uric acid test

[0105] 1. Materials and methods

[0106] Experimental animals: male SD rats of SPF grade, weighing 180±10 g, were provided by Guangdong Medical Experimental Animal Center (permit number: SYXK (Guangdong) 2013-0002).

[0107] Test groups: The test was divided into blank control group, model group, benzbromarone control group, first control group to sixth control group, first test group to sixth test group, with 10 rats in each group.

[0108] Administration route: intragastric administration (consistent with the intended clinical administration route for humans). Administration volume: 1.5ml / 100g. Dosing time: Gastrointestinal administration of therapeutic drugs at the same time as modeling, and intragastric administration according to body weight once a day in the morning. Administration period: continuous administration for 28 days.

[0109] Drug preparation: ready-to-use and ready-to-use, weigh a certain amount of the test su...

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Abstract

The invention relates to the technical field of health products, and especially relates to a uric acid reducing composition and a preparation thereof. The uric acid reducing composition comprises skipjack tuna extract and dietary fibers. The skipjack tuna extract and the dietary fibers are combined and then used, so the dosage is reduced, and the uric acid reducing effect is good.

Description

technical field [0001] The invention relates to the technical field of health products, in particular to a uric acid-lowering composition and its preparation. Background technique [0002] With the improvement of people's living standards and changes in eating habits, the incidence of hyperuricemia and gout in my country has been increasing year by year in recent years. Hyperuricemia is a disease in which blood uric acid exceeds the normal value due to purine metabolism disorder and / or uric acid excretion disorder, and it does not show any symptoms clinically. When the human body is in the condition of hyperuricemia for a long time, uric acid is precipitated in the joints, soft tissues, cartilage and kidneys in the form of sodium salt, causing human organ and tissue lesions, leading to gout, and causing serious complications, including gouty Arthritis, gouty nephropathy, gouty kidney stones, gouty heart disease, gouty hypertension, etc., patients have joint pain, renal coli...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61P19/06A61K31/733
CPCA61K9/2027A61K31/733A61K35/60A61K2300/00
Inventor 汪玉芳黄远英殷光玲袁根良
Owner BY HEALTH CO LTD
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