79results about How to "Significant effect of lowering uric acid" patented technology

The invention relates to a method for preparing bonito stick protein hydrolysate with an effect of reducing uric acid. The method comprises the following main steps of raw material heat treatment, restriction digestion, membrane separation-anion exchange chromatography-gel filtration chromatography separation, concentration and spray drying so as to obtain the bonito stick protein hydrolysate with an effect of reducing uric acid. The amino acid analysis indicates that the zymolyte peptide fragment primary amino acid sequence contains four amino acids, namely histidine, arginine, lysine and threonine, the total mass content of the four amino acids is 70 percent of the total amino acid content of zymolyte. MALDI-TOF-MS mass spectrum determines that the molecular weight of the main peptide effective ingredient is less than 700Da. In-vitro uric acid reduction experiments prove that the bonito stick protein hydrolysate has a remarkable effect of inhibiting generation of uric acid, and has an inhibition rate over 50 percent; an oteracil potassium molded hyperuricemic rat animal model indicates that the bonito stick protein hydrolysate can be used for remarkably reducing the level of serum uric acid and serum creatinine of rats, and shows a relatively good kidney protecting effect.

The invention provides a method for preparing a cordyceps militaris water extract. Water which is rich in resources and low in price serves as a solvent, and the aims of reducing the production cost and avoiding pollution of organic solvents are achieved. The cordyceps militaris water extract prepared by the method can be used for preparing medicines, health care products or auxiliary agents for reducing the uric acid level and improving the gout diseases.

The invention discloses a method for preparing biological active peptide with an effect of reducing trioxypurine by using walnut protein. The method comprises the following steps: watering and grinding the walnut protein; adding alkaline protease and cellulose; deactivating enzyme and centrifuging when the degree of hydrolysis achieves 10-15%, so as to obtain walnut protein enzymatic hydrolysate; filtering the enzymatic hydrolysate by virtue of an ultrafiltration membrane and strong acid gel type cation exchange resin, so as to obtain the biological active peptide with the effect of reducing trioxypurine. The biological active peptide is prepared by combining biological enzymolysis with a chromatographic separation technology; the target active peptide has a significant effect of reducing trioxypurine. An animal experiment in rats proves that the peptide for reducing trioxypurine prepared by the method disclosed by the invention can be used for significantly reducing the serum creatinine level of the rat, and has a certain degree of protective effect on the renal function of the rat, and strong activity of reducing the trioxypurine.

The invention relates to medicinal and edible tablets for reducing uric acid and a preparation method of the medicinal and edible tablets. The medicinal and edible tablets comprise a main constituentand an auxiliary material, wherein the main constituent comprises components in parts by weight as follows: 0.33 g of cichorium intybus powder, 0.01 g of fructus gardeniae powder, 0.01 g of folium mori, 0.01 g of radix puerariae, 0.01 g of rhizoma smilacis glabrae and 0.08 g of celery seeds, and the auxiliary material comprises components of 0.04 g of curcumin, 0.014 g of maltodextrin, 0.012 g ofvegetable fat powder, 0.002 g of magnesium stearate, 0.05 ml of palm oil and 0.05 ml of vegetable oil. The medicinal and edible tablets taste good, the preparation method is simple and practicable, and wide popularization can be facilitated; the medicinal and edible tablets have obvious effect, are high in pertinence and convenient to take and store and do not affect blood pressure, blood sugar and blood fat, and the preparation method is simple and practicable.

The invention discloses a probiotic strain for reducing blood uric acid, a composition and application of the probiotic strain. The purine reduction capacity of probiotics is screened under the condition of rich culture media for the first time, a culture environment relatively simulating human intestinal tracts is obtained, lactobacillus reuteri KLR-1 is obtained, the preservation number of the lactobacillus reuteri KLR-1 is CGMCC No.18699, a lactobacillus reuteri strain is lactobacillus reuteri KLR-3, the preservation number of the lactobacillus reuteri KLR-3 is CGMCC No.18700, a lactobacillus reuteri strain is lactobacillus reuteri KLR-13, the preservation number of the lactobacillus reuteri KLR-3 is CGMCC No.19329, meanwhile, the probiotic composition provided by the invention contains at least one of the above-mentioned probiotics. In an animal model, the probiotics or the composition has an obvious uric acid reducing effect, the probiotics are mutually coordinated, and the blood uric acid reducing effect of the composition is obviously superior to that of single probiotics; as a new means for reducing blood uric acid and treating gout, the probiotic strain and the composition have a wide application prospect.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of a polyacetylene compound to lowering of uric acid. The polyacetylene compound has astructure shown in a formula (I): R1 and R2 are defined as in the specification. The new application of the polyacetylene compound to lowering of the uric acid is found through a hyperuricemia animalmodel. The polyacetylene compound has the significant effect on lowering the uric acid in a body, and can be used as a potential drug lowering the uric acid or treating gout.

The invention discloses a Cordyceps militaris extract and a preparation method thereof. The method comprises the following steps: drying a Cordyceps militaris raw material until the water content is 15-25%, and performing vacuum low-temperature puffing treatment; mixing the vacuum low-temperature puffed raw material with water according to a mass ratio of 1:(15-20), adjusting the pH value to 4-6,and sequentially performing ultrahigh-pressure treatment and ultrasonic extraction; performing centrifuging to obtain a precipitate and a liquid, and collecting the liquid to obtain a first intermediate; performing supercritical extraction on the precipitate, and collecting the obtained extract to obtain a second intermediate; and mixing the first intermediate with the second intermediate, and concentrating the obtained mixture to obtain the Cordyceps militaris extract. The preparation method can quickly and effectively improve active components in the extracted Cordyceps militaris and reducethe damages to the active components in the extraction process. The Cordyceps militaris extract prepared by the preparation method has high content of cordycepin, cordyceps polysaccharides and adenosine, and has remarkable antitumor activity and uric acid lowering effect.

The invention discloses an extract for artificially cultured phellinus igniarius fruiting bodies as well as a preparation method and application for the extract. The preparation method comprises the following steps of selecting Sangdu No. 1 as a phellinus igniarius strain, adopting a bagging cultivation method in imitating a wild condition under a forest, harvesting the fruiting bodies when the color of the fruiting bodies changes from yellow to brown or dark brown, and obtaining the phellinus igniarius fruiting bodies; and crushing the phellinus igniarius fruiting bodies into powder, soakingthe powder with an ethanol aqueous solution, performing reflux extraction, performing vacuum concentration on an extracting solution until an ethanol smell does not exist, and performing vacuum dryingto obtain the extract for the artificially cultured phellinus igniarius fruiting bodies. The extract disclosed by the invention is capable of improving and relieving kidney injury of a mouse with hyperuricemia and increasing uric acid excretion, is moderate in effect and less in side effects and can be used for preparing the drug and the health-care product for preventing and treating the hyperuricemia and gout.

The invention provides a traditional Chinese medicinal effective part for decreasing uric acid as well as a preparation method and application thereof. The traditional Chinese medicinal effective part is total flavone and a diphenylheptane diarylheptanoid obtained by being extracted and separated from alpinia officinarum hance, and is prepared from the following components of 35wt% to 80 wt% of galangin, 5wt% to 14wt% of galangin-3-O-methyl ether, 1wt% to 7wt% of kaempferol-4'-O-methyl ether and 2wt% to 10wt% of 1-phenyl-7-(3'-methoxyl-4'-hydroxyl)-5-ol-3-heptanone; the sum of the components does not exceed 100 percent. The effective part prepared and obtained by the preparation method provided by the invention is definite and is high in purity. According to the whole preparation method, except for ethanol, other organic solvents are not used; the preparation method is environment-friendly and pollution-free. The industrialized mass production is easily realized in the whole production process. In-vitro and in-vivo pharmacodynamic experiments and preliminary clinical experiments all show that an alpinia-officinarum-hance effective part prepared and obtained by the preparation method provided by the invention has an obvious uric acid decreasing effect. The traditional Chinese medicinal effective part has a quite good effect on a patient suffering from hyperuricemia or gout.

The invention belongs to the field of medicines or health products, and particularly relates to a novel use of sesquiterpenoid in reducing uric acid. The sesquiterpenoid has a structure represented byformula (I): wherein X, R1-R11 are as defined in the description of the invention. Through an animal model of hyperuricemia, the sesquiterpenoid of the invention is found to promote uric acid excretion in vivo, has an obvious effect of reducing uric acid, and can be used as a potential medicine for reducing uric acid or treating gout.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of a polyacetylene compound to treating of gout. The polyacetylene compound has a structure shown in a formula (I): R1, R2, R3, and R4 are defined as in the specification. The new application of the polyacetylene compound to treating of gout is found through a hyperuricemia animal model. The polyacetylene compound has the significant effect on lowering the uric acid in a body, and can be used as a potential drug lowering the uric acid or treating gout.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of sesquiterpenoids to uric acid lowering. The sesquiterpenoids include the structure shown in a formula (I) (please see the specification for the formula (I)), wherein R1, R2, R3 and R4 are shown as definitions of a specification of the invention. Through a hyperuricemia animal model,it is found that the sesquiterpenoids promote uric acid excretion in vivo, has the significant uric acid lowering effect, and can serve as a potential drug for lowering uric acid or treating gout.

Disclosed are miracle fruit composite tea with a uric acid reducing effect and a preparation method thereof. The composite tea is prepared from, by weight, 10-25 parts of miracle fruit leaves, 2-6 parts of chicory, 5-15 parts of rhizoma smilacis glabrae, 15-30 parts of radix pueraiae, 1-4 parts of mulberry leaves and 5-15 parts of fructus crataegi. The preparation method of the composite tea comprises the following steps of 1, weighing all the raw materials by weight, and then sending all the raw materials into a mixer to be unevenly mixed to obtain a mixture; 2, separately bagging the mixturewith filter paper, and sealing openings to prepare tea bags, wherein the mixture in each bag weighs 30 g; 3, loading one tea bag and boiled water in a water boiling container separately, wherein eachtea bag is matched with 1,000 ml of boiled water; conducting decoction for 10 minutes, and drinking the tea after cooling. After long-term use, the obtained composite tea can eliminate the symptoms such as redness, heat, swelling and pain of the joints of gout patients, reduce the concentration of uric acid and have the advantage of the uric acid reducing effect.

The invention relates to a preparation method for Citrus reticulata Blanco extracts, and application of the Citrus reticulata Blanco extracts to uric acid lowering. The preparation method comprises the following steps: (1) crushing dried Citrus reticulata Blanco; (2) carrying out extraction through ethanol at a temperature of 0-75 DEG C and then carrying out filtering separation on filter residuesand a filtrate, and repeating the above process for 1-3 times, wherein the volume weight ratio of the ethanol and the Citrus reticulata Blanco ranges from 1:1 to 20:1; and (3) mixing the filtrates obtained through step (2), carrying out distillation concentration on the mixture until each gram of the Citrus reticulata Blanco contains less than 100mL of liquid, and carrying out baking or freeze-drying to obtain Citrus reticulata Blanco ethanol extracts. The method further comprises the following optional steps: (4) carrying out extraction on Citrus reticulata Blanco residues, which are obtained after the ethanol extraction, at a temperature of 0-100 DEG C by using water as a solvent and then carrying out filtering separation on filter residues and a filtrate, and repeating the above process for 1-3 times; and (5) mixing the filtrates obtained through step (4), carrying out distillation concentration on the mixture until each gram of the Citrus reticulata Blanco contains less than 100mLof liquid, and carrying out baking or freeze-drying to obtain Citrus reticulata Blanco water extracts. The preparation method and the application provided by the invention have the advantages that the Citrus reticulata Blanco extracts have remarkable uric acid lowering effects and little side effects, so that a new orientation is provided for solutions to the problem of serious side effects of the conventional anti-gout drugs.

The invention belongs to the field of medicines, healthcare products or food and particularly relates to a medicine composition with an effect of reducing uric acid as well as a preparation method andpurpose thereof. The medicine composition comprises the following raw material medicines in parts by weight: 3-78 parts of tea polyphenol, 1-38 parts of a radix clematidis extract, 1-30 parts of an atractylodes rhizome extract, 1-28 parts of a mulberry leaf extract and 1-26 parts of a rhizoma alismatis extract. The medicine composition with the effect of reducing the uric acid as well as the preparation method and the purpose thereof provided by the invention have the beneficial effects that the composition of the raw material medicines and the ratio among all the raw material medicines are fully considered, so that all the raw material medicines cooperate and interact with one another under a certain ratio, therefore, the effect of reducing the uric acid is realized; the medicine composition not only has the significant effect of reducing the uric acid, but also is less in toxic and side effects and higher in safety; the medicine composition only contains five raw material medicinesand is simple in composition and lower in cost.

The invention discloses an application of a garcinia xanthochymus leaf extract. The garcinia xanthochymus leaf extract contains a total-flavonoid extract of garcinia xanthochymus leaves and is used for preparing drugs for reducing uric acid and resisting gout. According to the application, discovered by researches, alcohol extracts of the garcinia xanthochymus leaves, total-flavonoid parts and compounds thereof, i.e., Fukugiside, Fukugetin and Bilobetin have an extremely remarkable uric acid reducing effect which is more obvious than that of all known uric acid reducing plant extracts and even far superior to that of a positive drug, i.e., allopurinol; the garcinia xanthochymus leaf extract further has a relatively good gout resisting action and truly achieves the aims of safety and effectiveness, thereby having development and application prospects.

The invention discloses lemon soda water and a production method thereof. The lemon soda water is produced by adding 1-20g of baking soda and 20-100g of a lemon extract into 1000mL of purified water. The production method comprises the following steps: firstly uniformly mixing the baking soda and the purified water in a blending tank, then adding the lemon extract into a mixed solution, stirring for 10-15min at a high speed, sterilizing for 1-2min at the temperature of 90-100 DEG C, and finally filling to obtain the lemon soda water, wherein preparation of the lemon extract comprises the following steps: selecting lemon fruits, cleaning, sterilizing, needling to prepare cold-milled peel oil, juicing, preforming enzymatic hydrolysis, refining, performing centrifugal separation, performing vacuum concentration, freezing, performing vacuum freeze drying, and crushing and sieving. The soda water prepared by the preparation method provided by the invention is clear and transparent, not only is good in mouth feel and relatively good in palatability, but also has fragrance and flavor of lemon, is suitable for long-term storage, is free of precipitates and suspended matters during storage, is high in product stability and high in nutritional value, and has a very good application prospect and a very good market prospect.

The invention belongs to the fields of medicines, health care products or food, and in particular relates to a pharmaceutical composition with the effect of lowering uric acid, a preparation method and application thereof. The raw materials of the pharmaceutical composition include: 5-50 parts by weight of vine tea extract, 1-45 parts by weight of Clematis clematis extract, 2-49 parts by weight of honeysuckle vine extract, 1-40 parts by weight of lovage extract, 0.5-32 parts by weight of the extract. The present invention fully considers the composition of raw materials and the ratio of each raw drug, so that each raw drug cooperates and acts together under a specific ratio, thereby exerting the effect of lowering uric acid; the pharmaceutical composition not only has significant The uric acid-lowering effect has less toxic and side effects and higher safety; the pharmaceutical composition only includes 5 kinds of raw materials, and the composition is simple and the cost is low.

The invention discloses a health-care food for reducing uric acid. The health-care food is prepared from the following raw material medicine components in parts by weight: 10-18 parts of gordon euryale seeds, 8-12 parts of coix seeds, 10-15 parts of poria cocos, 12-18 parts of cordyceps militaris, 3-6 parts of hawthorns, 8-10 parts of Chinese yams, 8-12 parts of cape jasmine fruits, 8-10 parts of galangal, 4-8 parts of dandelions, 8-10 parts of radix puerariae and 3-6 parts of licorice roots. According to the health-care food for reducing uric acid, the gordon euryale seeds, the coix seeds and the poria cocos are adopted as monarch drugs, the gordon euryale seeds have the effects of tonifying spleen and removing dampness, the coix seeds have the effects of tonifying spleen and lung, clearing heat and promoting diuresis, and the poria cocos has the effects of excreting dampness and promoting diuresis, benefiting spleen and harmonizing stomach and calming heart and tranquilizing mind; the cordyceps militaris, the hawthorns, the Chinese yams and the cape jasmine fruits are used as ministerial drugs to achieve the effects of benefiting lung, supplementing marrow, stopping bleeding, reducing phlegm, tonifying kidney, securing essence, tonifying spleen, stopping diarrhea, eliminating dampness, arresting leucorrhea, promoting digestion, invigorating stomach, promoting qi circulation and dissipating blood stasis, and the uric acid reducing effect is remarkable. When the health-care food is used for chronic reduction of uric acid, the effect is equivalent to that of allopurinol (an existing uric acid reduction drug); and when the health-care food is used for acute reduction of serum uric acid, and the effect is slightly weaker than that of allopurinol.

The invention belongs to the field of medicines, healthcare products or food and particularly relates to a medicine composition with an effect of reducing uric acid as well as a preparation method andpurpose thereof. The medicine composition comprises the following raw material medicines in parts by weight: 1-91 parts of tea polyphenol, 1-44 parts of a vine tea extract, 1-42 parts of a radix clematidis extract and 1-31 parts of a mulberry leaf extract. The medicine composition with the effect of reducing the uric acid as well as the preparation method and the purpose thereof provided by the invention have the beneficial effects that the composition of the raw material medicines and the ratio among all the raw material medicines are fully considered, so that all the raw material medicinescooperate and interact with one another under a certain ratio, therefore, the effect of reducing the uric acid is realized; the medicine composition not only has the significant effect of reducing theuric acid, but also is less in toxic and side effects and higher in safety; the medicine composition only contains four raw material medicines and is simple in composition and lower in cost.

The invention discloses the components of mulberry branch flavone and stilbenes extract and a novel application thereof. According to the results of animal experiments, the mulberry branch flavone and stilbenes extract has no obvious effect on inhibiting the uric acid in the normal blood of normal animals, but reducing the uric acid in the blood of hyperuricemia model animals, thereby ensuring good safety. By compounding the mulberry branch flavone and stilbenes extract with relevant auxiliary materials, medicaments or health-care food and the combination of the medicaments or the health-care food with the compound being the active component for curing and controlling hyperuricemia and uarthritis can be prepared on the basis of the conventional preparation method, and have stable curative effect, are safe and reliable.

The invention relates to the technical field of glycoside compounds, and particularly relates to a glycoside compound derived from raw medicinal materials, an extraction method and application thereof. The glycoside compound is a carbohydrate derivative containing a carbon ring, and the structural formula of the glycoside compound is shown as a formula (I). The preparation method comprises the steps that the raw medicinal materials are decocted with water, and liquid medicine is filtered and concentrated to obtain extract; the extract is decocted and concentrated to obtain a dry extract semi-finished product, and the dry extract semi-finished product is taken out after standing and dried to obtain raw dry extract; and the raw dry extract is extracted with an alcohol solvent, and separationis conducted through macroporous resin, reversed phase column chromatography and preparative high performance liquid chromatography in sequence to obtain the glycoside compound. The glycoside compound derived from the raw medicinal materials has a significant uric acid reducing effect, the high blood uric acid level of an animal model mouse can be restored to a normal level only through a low dosage, proliferation of hepatoma carcinoma cells can be effectively inhibited, and therefore the glycoside compound can be applied to a pharmaceutical preparation for inhibiting proliferation of the hepatoma carcinoma cells.

The invention relates to an extract preparing method and application of an extract in the aspect of preparing medicines / health care products for treating / controlling high-uric-acid related diseases, in particular to a poria-cocos-extract preparing method and application of a poria cocos extract in the aspect of preparing medicines / health care products for treating / controlling high-uric-acid related diseases. The poria-cocos-extract preparing method and application have the advantages that the preparing technology of the poria cocos extract is simple, and the cost is low; ethyl alcohol or wateror a mixed solvent of ethyl alcohol and water serves as a solvent for extracting poria cocos, the pollution or residual problem of an organic solvent is solved, and safe and environment-friendly effects are achieved; the poria cocos extract has a remarkable uric-acid reducing effect, is small in side effect, can be used for preparing a medicine for reliving a gout disease, and provides a new direction for improving a phenomenon of a large side effect of a present gout disease medicine.

The invention discloses a diet suitable for people with gout and hyperuricemia. The diet comprises the following materials by weight of 1.5-3 g of cordyceps militaris powder; 3-5 g of coix seed powder; 1-3 g of poria cocos powder; 2-5 g of small red bean powder; 1-3g of kudzuvine root powder; 0.5-3 g of cinnamon powder; 4-5 g of Chinese yam powder; 8-10 g of composite fruit and vegetable powder (1.5-3 g of celery seed powder, 2-4 g of cherry powder and 1.5-3 g of grape seed powder); 0.01-1 g of compound vitamin; 0.01-1 g of composite mineral; and 0.5-1 g of a sweetening agent. According to theinvention, medicinal and edible new resource foods are used as raw materials, a modern food processing technology is used as a basis, and components beneficial to reducing uric acid, dispelling wind,eliminating dampness and improving arthritis as well as vitamins and minerals necessary for target people every day are added. By inhibiting the activity of xanthine oxidase, the generation of the uric acid is reduced, the solubility of the uric acid in urine is increased, and the discharge of the uric acid is promoted. The preparation process is simple, and the diet has no side effect and is convenient to carry and take.

The invention relates to a pediococcus acidilactici GQ01 derived from wolfberry enzyme and having uric acid reducing effect, the name of the pediococcus acidilactici is GQ01, the classification name of the pediococcus acidilactici is pediococcus acidilactici, the preservation number of the pediococcus acidilactici is CGMCC No.21609, the preservation date of the pediococcus acidilactici is January 13, 2021, and the preservation unit of the pediococcus acidilactici is China General Microbiological Culture Collection Center, which is located at Institute of Biology, Chinese Academy of Sciences, No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. The pediococcus acidilactici GQ01 disclosed by the invention is derived from the natural wolfberry enzyme, enriches the microbial composition in the fermented food, and has positive significance in promoting the development and industrial production of the fermented food such as the enzyme and the like. The pediococcus acidilactici GQ01 has better acid resistance and cholate resistance, has an obvious uric acid reducing effect, and can relieve side reactions such as inflammation caused by hyperuricemia.

The invention relates to a preparation method of a paecilomyces hepiali active substance, the prepared active substance and an application of the active substance. The method comprises the following steps: crushing dried fermented paecilomyces hepiali mycelia, preferably conducting superfine grinding, so that paecilomyces hepiali superfine powder is obtained; adding the crushed paecilomyces hepiali mycelia to an extracting solvent, implementing extracting at 60-100 DEG C for 1-3 times for 1-3h, filtering filtrates, and combining the filtered filtrates; and concentrating the obtained combined filtrate, and implementing drying so as to obtain a paecilomyces hepiali extract, wherein the paecilomyces hepiali active substance is the obtained paecilomyces hepiali superfine powder or the obtainedpaecilomyces hepiali extract or a mixture (compound) of various extracts. The preparation process of the paecilomyces hepiali active substance is high in extraction ratio, high in active substance content and low in cost; the active substance is obvious in uric acid lowering effect, obvious in therapeutic effect and low in generated side effects; and the problem that natural cordyceps sinensis resource is scarce is solved.

The invention belongs to the technical field of biology, and relates to a dendranthema indicum extract and application. A method for preparing the dendranthema indicum extract comprises the followingsteps: drying and smashing a dendranthema indicum raw material, adding ethanol, carrying out reflux extraction, carrying out solid-liquid separation after extracting, and collecting filtrate; removingthe ethanol in the filtrate through vacuum concentration, then sequentially adding petroleum ether and ethyl acetate for extracting, and concentrating an ethyl acetate layer into concrete, thus obtaining the dendranthema indicum extract. The dendranthema indicum extract disclosed by the invention has an obvious serum uric acid reducing function.