Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of mulberry twig flavone and diphenyl ethylene extract in preventing or treating hyperuricemia symptoms and uarthritis

A stilbene-based, hyperuricemia technology, applied in application, medical preparations containing active ingredients, food science, etc., can solve the problems of not finding the quality of ingredients, monitoring, etc., and achieve significant uric acid lowering effect and efficacy. Well-defined effects

Inactive Publication Date: 2009-08-12
ZHEJIANG CONBA PHARMA +1
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Sangzhi has a good clinical basis, it has not been able to find appropriate ingredients for quality control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of mulberry twig flavone and diphenyl ethylene extract in preventing or treating hyperuricemia symptoms and uarthritis
  • Application of mulberry twig flavone and diphenyl ethylene extract in preventing or treating hyperuricemia symptoms and uarthritis
  • Application of mulberry twig flavone and diphenyl ethylene extract in preventing or treating hyperuricemia symptoms and uarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Mori flavonoids and stilbenes extracts:

[0028] (1) Take dry mulberry branches, heat reflux three times, add 7 times of 60% ethanol each time, 2 hours each time, combine the extracts, filter, and concentrate the filtrate under reduced pressure to contain 0.5g of medicinal materials per ml of liquid medicine, let it cool , filter, and discard the dregs.

[0029] (2) Take the filtrate, and elute with distilled water of 2-6 times the volume of the column bed at a flow rate of 1-4BV / h on a pretreated HPD-600 macroporous adsorption resin column, with a flow rate of 1--4BV / h, discard the water eluent, and then elute with 60% ethanol with 2-6 times the volume of the column bed at a speed of 1-4BV / h, collect the eluent, recycle the ethanol and concentrate to a thick paste, and depressurize Dry to get dry extract.

[0030] (3) Taking mulberry glycoside as a reference substance, the content of stilbenes in the flavonoids of Morus alba and the stilbenes in the s...

Embodiment 2

[0033] Effects of Mori flavonoids and stilbenes extracts on hyperuricemia and normal mice:

[0034] Oxonic acid potassium salt is a uricase inhibitor, which can induce and inhibit the decomposition of uric acid, increase the serum uric acid level in the body, and cause animal models of hyperuricemia. It is widely used in the world to evaluate the anti-hyperuricemia and gout effects of drugs. The present invention also uses hyperuricemia model animals to verify the uric acid-lowering curative effect of the drug, and the curative effect is reliable and remarkable.

[0035] 1. Experimental animals: Kunming mice, male, weighing 24±2g.

[0036] 2. Drug preparation: Mori flavonoids and stilbene extract (ER) (the content of flavonoids is 30%-70% and the content of stilbenes is 30%-70%), allopurinol is dispersed in physiological In saline, for intragastric administration, the dosages are 300 mg / kg for the low dose and 600 mg / kg for the high dose, and Apu=5 mg / kg.

[0037] 3. Experim...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the components of mulberry branch flavone and stilbenes extract and a novel application thereof. According to the results of animal experiments, the mulberry branch flavone and stilbenes extract has no obvious effect on inhibiting the uric acid in the normal blood of normal animals, but reducing the uric acid in the blood of hyperuricemia model animals, thereby ensuring good safety. By compounding the mulberry branch flavone and stilbenes extract with relevant auxiliary materials, medicaments or health-care food and the combination of the medicaments or the health-care food with the compound being the active component for curing and controlling hyperuricemia and uarthritis can be prepared on the basis of the conventional preparation method, and have stable curative effect, are safe and reliable.

Description

technical field [0001] The present invention relates to mulberry flavonoids and stilbenes extracts, in particular to the components of mulberry flavonoids and stilbenes extracts and their new application in the preparation of medicines or health food for preventing or treating hyperuricemia and gout, And a medicine or health food composition for preventing or treating hyperuricemia and gout with the compound as an active ingredient. Background technique [0002] Gout is a group of metabolic diseases caused by the metabolic disorder of purine substances, excessive production of uric acid or decreased excretion of uric acid, and continuous increase of blood uric acid concentration, resulting in the deposition of urate crystals in soft tissues. Its clinical manifestations are recurrent arthritis, tophi formation and joint deformity, severe cases can lead to joint movement disorders, and can cause chronic interstitial nephritis and uric acid nephrolithiasis when the kidney is in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K31/352A61P19/06A23L1/30A23L33/105
Inventor 孔令东胡季强王彩萍胡林水黄正标张宪郑珺王星
Owner ZHEJIANG CONBA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com