Application and preparation method of garcinia xanthochymus leaf extract

The technology of leaf extract and human face fruit is applied in the field of human face fruit leaf extract and its preparation, and can solve the problems of small toxic and side effects, obvious toxic and side effects, and toxic and side effects of human body.

Active Publication Date: 2016-11-09
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, Western medicines have clear targets and mechanisms for treating hyperuricemia and gout, but they have obvious toxic and side effects. The mechanism of action needs to be elucidated

Method used

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  • Application and preparation method of garcinia xanthochymus leaf extract
  • Application and preparation method of garcinia xanthochymus leaf extract
  • Application and preparation method of garcinia xanthochymus leaf extract

Examples

Experimental program
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Effect test

Embodiment 1

[0026] The preparation of embodiment 1 Fructus Fructus Leaf Alcoholic Extract

[0027] Lemongrass leaves were purchased from Xishuangbanna, Yunnan, and were identified as dry leaves of Garciniaxanthochymus, a plant of the genus Garciniaxanthochymus. After the medicinal material is dried, pulverize it with a pulverizer, pass through a 20-mesh sieve, and extract twice with an ethanol solution with a concentration of 60% by volume. The reflux time is 2h and 1.5h once, and the two extracts are filtered and combined, and the ethanol is recovered to obtain the ethanol extract of Pistachio japonicus leaves.

Embodiment 2

[0028] The preparation of the total flavonoids extract of embodiment 2 Foliage leaves

[0029] The ethanol extract of Fructus Fructus Leaf in Example 1 was enriched by HPD100 macroporous adsorption resin, and the total flavonoids of Fructus Fructus Fructus leaves were refined; the purification process of HPD100 macroporous adsorption resin was as follows: adding water Regulating concentration is 0.01g medical material / ml, simultaneously with the NaHCO concentration of 10% 3 Adjust the pH to 8, adsorb on the HPD100 resin column, and first elute with 3 times the column volume of water, then 2 times the column volume of 30% ethanol, and then 3 times the column volume of 60% ethanol. Collecting 60% ethanol eluate, recovering under reduced pressure to a minimum volume, and then freeze-drying to obtain the total flavonoids fraction of the leaves of Pistachio japonicus;

Embodiment 3

[0030] Example 3 Determination of the content of various components in the total flavonoids parts of the leaves of Fructus Fructus

[0031] The total flavonoid extract of Fructus saponifolia leaves in Example 2 is characterized in that it should contain 3 kinds of flavonoids, and the 3 kinds of flavonoids are: Fukiside, Fukugetin, Fukugiside and Ginkgo. And the sum of the mass of the three compounds should not be less than 50% of the mass of the total flavonoids. These three compounds were determined by high-performance liquid chromatography, and the sum of their total mass accounted for 55% of the total flavonoids in the leaves of Mikora japonica.

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Abstract

The invention discloses an application of a garcinia xanthochymus leaf extract. The garcinia xanthochymus leaf extract contains a total-flavonoid extract of garcinia xanthochymus leaves and is used for preparing drugs for reducing uric acid and resisting gout. According to the application, discovered by researches, alcohol extracts of the garcinia xanthochymus leaves, total-flavonoid parts and compounds thereof, i.e., Fukugiside, Fukugetin and Bilobetin have an extremely remarkable uric acid reducing effect which is more obvious than that of all known uric acid reducing plant extracts and even far superior to that of a positive drug, i.e., allopurinol; the garcinia xanthochymus leaf extract further has a relatively good gout resisting action and truly achieves the aims of safety and effectiveness, thereby having development and application prospects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to an extract of the leaves of the fruit and its preparation method and application. Background technique [0002] The most representative feature of hyperuricemia is that the uric acid in the circulating blood is higher than the normal level (greater than 7.0mg / dl) and maintained for a long time. With the continuous development of social economy and technological level, the average life expectancy of human beings has also increased compared with the past, followed by the problem of social aging. With economic development, the improvement of people's dietary status has reached a level that cannot be surpassed. Excessive nutritional intake has created many senile diseases, such as hypertension, atherosclerosis, diabetes, and hyperlipidemia. The high prevalence of these diseases all bring burdens to people's quality of life and social development. A large num...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185C07D311/32C07D311/36C07D311/40A61K31/352A61K31/353A61P19/06
CPCA61K31/352A61K31/353A61K36/185A61K2236/333A61K2236/55C07D311/32C07D311/36C07D311/40A61K2300/00
Inventor 陈旅翼杨光忠
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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